Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents / Alice STEPHENS in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.367-375 Titre : Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents Type de document : Texte imprimé et/ou numérique Auteurs : Alice STEPHENS, Auteur ; Judith ALLARDYCE, Auteur ; Bryony WEAVERS, Auteur ; Jessica LENNON, Auteur ; Rhys BEVAN JONES, Auteur ; Victoria POWELL, Auteur ; Olga EYRE, Auteur ; Robert POTTER, Auteur ; Valentina ESCOTT PRICE, Auteur ; David OSBORN, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur ; Ajay K. THAPAR, Auteur ; Jon HERON, Auteur ; Frances RICE, Auteur Article en page(s) : p.367-375 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions. Methods Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted risk score thresholds were associated with the greatest clinical benefit. Results The MDD risk prediction model discriminated between those adolescents who did and did not develop MDD in the development (C-statistic=.783, IQR (interquartile range)=.779, .778) and the validation samples (C-statistic=.722, IQR=â’.694, .741). Calibration in the validation sample was good to excellent (calibration intercept=.011, C-slope=.851). The MDD risk prediction model was superior to the simple comparison model where discrimination was no better than chance (C-statistic=.544, IQR=.536, .572). Decision curve analysis found that the highest clinical utility was at the lowest risk score thresholds (0.01-0.05). Conclusions The developed risk prediction model successfully discriminated adolescents who developed MDD from those who did not. In practice, this model could be further developed with user involvement into a tool to target individuals for low-intensity, selective preventive intervention. En ligne : https://doi.org/10.1111/jcpp.13704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents [Texte imprimé et/ou numérique] / Alice STEPHENS, Auteur ; Judith ALLARDYCE, Auteur ; Bryony WEAVERS, Auteur ; Jessica LENNON, Auteur ; Rhys BEVAN JONES, Auteur ; Victoria POWELL, Auteur ; Olga EYRE, Auteur ; Robert POTTER, Auteur ; Valentina ESCOTT PRICE, Auteur ; David OSBORN, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur ; Ajay K. THAPAR, Auteur ; Jon HERON, Auteur ; Frances RICE, Auteur . - p.367-375. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.367-375 Index. décimale : PER Périodiques Résumé : Background Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions. Methods Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted risk score thresholds were associated with the greatest clinical benefit. Results The MDD risk prediction model discriminated between those adolescents who did and did not develop MDD in the development (C-statistic=.783, IQR (interquartile range)=.779, .778) and the validation samples (C-statistic=.722, IQR=â’.694, .741). Calibration in the validation sample was good to excellent (calibration intercept=.011, C-slope=.851). The MDD risk prediction model was superior to the simple comparison model where discrimination was no better than chance (C-statistic=.544, IQR=.536, .572). Decision curve analysis found that the highest clinical utility was at the lowest risk score thresholds (0.01-0.05). Conclusions The developed risk prediction model successfully discriminated adolescents who developed MDD from those who did not. In practice, this model could be further developed with user involvement into a tool to target individuals for low-intensity, selective preventive intervention. En ligne : https://doi.org/10.1111/jcpp.13704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Examining the role of passive gene–environment correlation in childhood depression using a novel genetically sensitive design / Frances RICE in Development and Psychopathology, 25-1 (February 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-1 (February 2013) . - p.37-50 Titre : Examining the role of passive gene–environment correlation in childhood depression using a novel genetically sensitive design Type de document : Texte imprimé et/ou numérique Auteurs : Frances RICE, Auteur ; Gemma LEWIS, Auteur ; Gordon T. HAROLD, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.37-50 Index. décimale : PER Périodiques Résumé : Parental depression is associated with disruptions in the parent–child relationship, exposure to stressful family life events, and offspring depressive symptoms. Evidence suggests that intergenerational transmission of depression involves environmental and inherited contributions. We sought to evaluate the role of passive gene–environment correlation (rGE) in relation to depression, family life events that were due to parental behavior, and parental positivity in a sample where children varied in genetic relatedness to their rearing parents. Our study included 865 families with children born through assisted conception (444 related to both parents, 210 related to the mother only, 175 related to the father only, and 36 related to neither parent). Consistent with previous studies, the intergenerational transmission of depressive symptoms was largely due to environmental factors, although parent and child gender influenced results. Maternal and paternal depressive symptoms were associated with reduced positivity and increased parentally imposed life events regardless of parent–child relatedness. Results of path analysis were consistent with passive rGE for both maternal and paternal positivity in that positivity partially mediated the link between maternal/paternal depression and child depression only in genetically related parent–child pairs. Results also suggested passive rGE involving parentally imposed life events for mothers and fathers although passive rGE effects were smaller than for positivity. En ligne : http://dx.doi.org/10.1017/S0954579412000880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190 [article] Examining the role of passive gene–environment correlation in childhood depression using a novel genetically sensitive design [Texte imprimé et/ou numérique] / Frances RICE, Auteur ; Gemma LEWIS, Auteur ; Gordon T. HAROLD, Auteur ; Anita THAPAR, Auteur . - p.37-50. in Development and Psychopathology > 25-1 (February 2013) . - p.37-50 Index. décimale : PER Périodiques Résumé : Parental depression is associated with disruptions in the parent–child relationship, exposure to stressful family life events, and offspring depressive symptoms. Evidence suggests that intergenerational transmission of depression involves environmental and inherited contributions. We sought to evaluate the role of passive gene–environment correlation (rGE) in relation to depression, family life events that were due to parental behavior, and parental positivity in a sample where children varied in genetic relatedness to their rearing parents. Our study included 865 families with children born through assisted conception (444 related to both parents, 210 related to the mother only, 175 related to the father only, and 36 related to neither parent). Consistent with previous studies, the intergenerational transmission of depressive symptoms was largely due to environmental factors, although parent and child gender influenced results. Maternal and paternal depressive symptoms were associated with reduced positivity and increased parentally imposed life events regardless of parent–child relatedness. Results of path analysis were consistent with passive rGE for both maternal and paternal positivity in that positivity partially mediated the link between maternal/paternal depression and child depression only in genetically related parent–child pairs. Results also suggested passive rGE involving parentally imposed life events for mothers and fathers although passive rGE effects were smaller than for positivity. En ligne : http://dx.doi.org/10.1017/S0954579412000880 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=190

Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls / Lucy RIGLIN in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.97-109 Titre : Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls Type de document : Texte imprimé et/ou numérique Auteurs : Lucy RIGLIN, Auteur ; Stephan COLLISHAW, Auteur ; Katherine H. SHELTON, Auteur ; I. C. MCMANUS, Auteur ; Terry NG-KNIGHT, Auteur ; Ruth SELLERS, Auteur ; Ajay K. THAPAR, Auteur ; Norah FREDERICKSON, Auteur ; Frances RICE, Auteur Article en page(s) : p.97-109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology. En ligne : http://dx.doi.org/10.1017/S0954579415000310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls [Texte imprimé et/ou numérique] / Lucy RIGLIN, Auteur ; Stephan COLLISHAW, Auteur ; Katherine H. SHELTON, Auteur ; I. C. MCMANUS, Auteur ; Terry NG-KNIGHT, Auteur ; Ruth SELLERS, Auteur ; Ajay K. THAPAR, Auteur ; Norah FREDERICKSON, Auteur ; Frances RICE, Auteur . - p.97-109. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.97-109 Index. décimale : PER Périodiques Résumé : Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology. En ligne : http://dx.doi.org/10.1017/S0954579415000310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Interparental conflict, parent psychopathology, hostile parenting, and child antisocial behavior: Examining the role of maternal versus paternal influences using a novel genetically sensitive research design / Gordon T. HAROLD in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1283-1295 Titre : Interparental conflict, parent psychopathology, hostile parenting, and child antisocial behavior: Examining the role of maternal versus paternal influences using a novel genetically sensitive research design Type de document : Texte imprimé et/ou numérique Auteurs : Gordon T. HAROLD, Auteur ; Kit ELAM, Auteur ; Gemma LEWIS, Auteur ; Frances RICE, Auteur ; Anita THAPAR, Auteur Année de publication : 2012 Article en page(s) : p.1283-1295 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Past research has linked interparental conflict, parent psychopathology, hostile parenting, and externalizing behavior problems in childhood. However, few studies have examined these relationships while simultaneously allowing the contribution of common genetic factors underlying associations between family- and parent-level variables on child psychopathology to be controlled. Using the attributes of a genetically sensitive in vitro fertilization research design, the present study examined associations among interparental conflict, parents' antisocial behavior problems, parents' anxiety symptoms, and hostile parenting on children's antisocial behavior problems among genetically related and genetically unrelated mother–child and father–child groupings. Path analyses revealed that for genetically related mothers, interparental conflict and maternal antisocial behavior indirectly influenced child antisocial behavior through mother-to-child hostility. For genetically unrelated mothers, effects were apparent only for maternal antisocial behavior on child antisocial behavior through mother-to-child hostility. For both genetically related and genetically unrelated fathers and children, interparental conflict and paternal antisocial behavior influenced child antisocial behavior through father-to-child hostility. Effects of parental anxiety symptoms on child antisocial behavior were apparent only for genetically related mothers and children. Results are discussed with respect to the relative role of passive genotype–environment correlation as a possible confounding factor underlying family process influences on childhood psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579412000703 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Interparental conflict, parent psychopathology, hostile parenting, and child antisocial behavior: Examining the role of maternal versus paternal influences using a novel genetically sensitive research design [Texte imprimé et/ou numérique] / Gordon T. HAROLD, Auteur ; Kit ELAM, Auteur ; Gemma LEWIS, Auteur ; Frances RICE, Auteur ; Anita THAPAR, Auteur . - 2012 . - p.1283-1295. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1283-1295 Index. décimale : PER Périodiques Résumé : Past research has linked interparental conflict, parent psychopathology, hostile parenting, and externalizing behavior problems in childhood. However, few studies have examined these relationships while simultaneously allowing the contribution of common genetic factors underlying associations between family- and parent-level variables on child psychopathology to be controlled. Using the attributes of a genetically sensitive in vitro fertilization research design, the present study examined associations among interparental conflict, parents' antisocial behavior problems, parents' anxiety symptoms, and hostile parenting on children's antisocial behavior problems among genetically related and genetically unrelated mother–child and father–child groupings. Path analyses revealed that for genetically related mothers, interparental conflict and maternal antisocial behavior indirectly influenced child antisocial behavior through mother-to-child hostility. For genetically unrelated mothers, effects were apparent only for maternal antisocial behavior on child antisocial behavior through mother-to-child hostility. For both genetically related and genetically unrelated fathers and children, interparental conflict and paternal antisocial behavior influenced child antisocial behavior through father-to-child hostility. Effects of parental anxiety symptoms on child antisocial behavior were apparent only for genetically related mothers and children. Results are discussed with respect to the relative role of passive genotype–environment correlation as a possible confounding factor underlying family process influences on childhood psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579412000703 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment / Adhip RAWAL in Journal of Child Psychology and Psychiatry, 55-11 (November 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-11 (November 2014) . - p.1270-1278 Titre : A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment Type de document : Texte imprimé et/ou numérique Auteurs : Adhip RAWAL, Auteur ; Lucy RIGLIN, Auteur ; Terry NG-KNIGHT, Auteur ; Stephan COLLISHAW, Auteur ; Anita THAPAR, Auteur ; Frances RICE, Auteur Article en page(s) : p.1270-1278 Langues : Anglais (eng) Mots-clés : Depression  anxiety  adolescence  reward  decision-making Index. décimale : PER Périodiques Résumé : Background Adolescence is associated with developments in the reward system and increased rates of emotional disorders. Familial risk for depression may be associated with disruptions in the reward system. However, it is unclear how symptoms of depression and anxiety influence the development of reward-processing over adolescence and whether variation in the severity of parental depression is associated with hyposensitivity to reward in a high-risk sample. Methods We focused on risk-adjustment (adjusting decisions about reward according to the probability of obtaining reward) as this was hypothesized to improve over adolescence. In a one-year longitudinal sample (N = 197) of adolescent offspring of depressed parents, we examined how symptoms of depression and anxiety (generalized anxiety and social anxiety) influenced the development of risk-adjustment. We also examined how parental depression severity influenced adolescent risk-adjustment. Results Risk-adjustment improved over the course of the study indicating improved adjustment of reward-seeking to shifting contingencies. Depressive symptoms were associated with decreases in risk-adjustment over time while social anxiety symptoms were associated with increases in risk-adjustment over time. Specifically, depression was associated with reductions in reward-seeking at favourable reward probabilities only, whereas social anxiety (but not generalized anxiety) led to reductions in reward-seeking at low reward probabilities only. Parent depression severity was associated with lowered risk-adjustment in offspring and also influenced the longitudinal relationship between risk-adjustment and offspring depression. Conclusions Anxiety and depression distinctly alter the pattern of longitudinal change in reward-processing. Severity of parent depression was associated with alterations in adolescent offspring reward-processing in a high-risk sample. En ligne : http://dx.doi.org/10.1111/jcpp.12279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment [Texte imprimé et/ou numérique] / Adhip RAWAL, Auteur ; Lucy RIGLIN, Auteur ; Terry NG-KNIGHT, Auteur ; Stephan COLLISHAW, Auteur ; Anita THAPAR, Auteur ; Frances RICE, Auteur . - p.1270-1278. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-11 (November 2014) . - p.1270-1278 Mots-clés : Depression  anxiety  adolescence  reward  decision-making Index. décimale : PER Périodiques Résumé : Background Adolescence is associated with developments in the reward system and increased rates of emotional disorders. Familial risk for depression may be associated with disruptions in the reward system. However, it is unclear how symptoms of depression and anxiety influence the development of reward-processing over adolescence and whether variation in the severity of parental depression is associated with hyposensitivity to reward in a high-risk sample. Methods We focused on risk-adjustment (adjusting decisions about reward according to the probability of obtaining reward) as this was hypothesized to improve over adolescence. In a one-year longitudinal sample (N = 197) of adolescent offspring of depressed parents, we examined how symptoms of depression and anxiety (generalized anxiety and social anxiety) influenced the development of risk-adjustment. We also examined how parental depression severity influenced adolescent risk-adjustment. Results Risk-adjustment improved over the course of the study indicating improved adjustment of reward-seeking to shifting contingencies. Depressive symptoms were associated with decreases in risk-adjustment over time while social anxiety symptoms were associated with increases in risk-adjustment over time. Specifically, depression was associated with reductions in reward-seeking at favourable reward probabilities only, whereas social anxiety (but not generalized anxiety) led to reductions in reward-seeking at low reward probabilities only. Parent depression severity was associated with lowered risk-adjustment in offspring and also influenced the longitudinal relationship between risk-adjustment and offspring depression. Conclusions Anxiety and depression distinctly alter the pattern of longitudinal change in reward-processing. Severity of parent depression was associated with alterations in adolescent offspring reward-processing in a high-risk sample. En ligne : http://dx.doi.org/10.1111/jcpp.12279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation / Sarah NAZZARI in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

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Practitioner review: Co-design of digital mental health technologies with children and young people / Rhys BEVAN JONES in Journal of Child Psychology and Psychiatry, 61-8 (August 2020)  

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Profiling depression in childhood and adolescence: the role of conduct problems / Lucy RIGLIN in Journal of Child Psychology and Psychiatry, 57-4 (April 2016)  

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Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry / Joanna MARTIN ; Amy SHAKESHAFT ; Lucy RIGLIN ; Frances RICE ; Cathryn M. LEWIS ; Michael C. O'DONOVAN ; Anita THAPAR in Journal of Child Psychology and Psychiatry, 65-1 (January 2024)  

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The contribution of gene–environment interaction to psychopathology / Anita THAPAR in Development and Psychopathology, 19-4 (Fall 2007)  

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Trends in adolescent emotional problems in Wales between 2013 and 2019: the contribution of peer relationships / Graham MOORE ; Nicholas PAGE ; Catherine OLLERHEAD ; Jack PARKER ; Simon MURPHY ; Frances RICE ; Jessica M. ARMITAGE ; Stephan COLLISHAW in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

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