[article] 
inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3634-3645

Titre :	Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Lisa D. WIGGINS, Auteur ; L. H. TIAN, Auteur ; S. E. LEVY, Auteur ; C. RICE, Auteur ; L. C. LEE, Auteur ; Laura A. SCHIEVE, Auteur ; J. PANDEY, Auteur ; J. DANIELS, Auteur ; Lisa BLASKEY, Auteur ; S. HEPBURN, Auteur ; R. LANDA, Auteur ; R. EDMONDSON-PRETZEL, Auteur ; W. THOMPSON, Auteur
Article en page(s) :	p.3634-3645
Langues :	Anglais (eng)
Mots-clés :	Autism  Autism spectrum disorder  Characterization  Phenotypes  Subgroups
Index. décimale :	PER Périodiques
Résumé :	The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
En ligne :	http://dx.doi.org/10.1007/s10803-017-3280-4
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325

[article] Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development [Texte imprimé et/ou numérique] / Lisa D. WIGGINS, Auteur ; L. H. TIAN, Auteur ; S. E. LEVY, Auteur ; C. RICE, Auteur ; L. C. LEE, Auteur ; Laura A. SCHIEVE, Auteur ; J. PANDEY, Auteur ; J. DANIELS, Auteur ; Lisa BLASKEY, Auteur ; S. HEPBURN, Auteur ; R. LANDA, Auteur ; R. EDMONDSON-PRETZEL, Auteur ; W. THOMPSON, Auteur . - p.3634-3645.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3634-3645

Mots-clés :	Autism  Autism spectrum disorder  Characterization  Phenotypes  Subgroups
Index. décimale :	PER Périodiques
Résumé :	The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed.
En ligne :	http://dx.doi.org/10.1007/s10803-017-3280-4
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325