Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder / Takashi ITAHASHI in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-14 Titre : Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder Type de document : texte imprimé Auteurs : Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder [texte imprimé] / Takashi ITAHASHI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Motoaki NAKAMURA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Akira IWANAMI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - p.1-14. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-14 Index. décimale : PER Périodiques Résumé : Previous autism research has hypothesized that abnormalities of functional connectivity in autism spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state functional magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) connectivity in the adult ASD brain, short-range (or local) connectivity has been investigated in less depth. Furthermore, the possible relationship between functional connectivity and brain activity level during the resting state remains unclear. En ligne : http://dx.doi.org/10.1186/s13229-015-0026-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation / Takashi YAMADA in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 41p. Titre : Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation Type de document : texte imprimé Auteurs : Takashi YAMADA, Auteur ; Takashi ITAHASHI, Auteur ; Motoaki NAKAMURA, Auteur ; Hiromi WATANABE, Auteur ; Miho KURODA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur Article en page(s) : 41p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology  Brain Mapping/methods  Case-Control Studies  Cerebral Cortex/diagnostic imaging/pathology/physiopathology  Cluster Analysis  Functional Laterality  Humans  Image Interpretation, Computer-Assisted  Magnetic Resonance Imaging  Male  Middle Aged  Nerve Net/diagnostic imaging/pathology/physiopathology  Neural Pathways/diagnostic imaging/pathology/physiopathology  Autism spectrum disorder  Connectivity-based functional parcellation  Insula  Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Altered functional organization within the insular cortex in adult males with high-functioning autism spectrum disorder: evidence from connectivity-based parcellation [texte imprimé] / Takashi YAMADA, Auteur ; Takashi ITAHASHI, Auteur ; Motoaki NAKAMURA, Auteur ; Hiromi WATANABE, Auteur ; Miho KURODA, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Nobumasa KATO, Auteur ; Ryu-ichiro HASHIMOTO, Auteur . - 41p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 41p. Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging/pathology/physiopathology  Brain Mapping/methods  Case-Control Studies  Cerebral Cortex/diagnostic imaging/pathology/physiopathology  Cluster Analysis  Functional Laterality  Humans  Image Interpretation, Computer-Assisted  Magnetic Resonance Imaging  Male  Middle Aged  Nerve Net/diagnostic imaging/pathology/physiopathology  Neural Pathways/diagnostic imaging/pathology/physiopathology  Autism spectrum disorder  Connectivity-based functional parcellation  Insula  Resting-state functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns of connectivity with other brain regions. Such diverse connectivity patterns are thought to underlie a wide range of insular functions, including cognitive, affective, and sensorimotor processing, many of which are abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies of ASD have shown structural and functional abnormalities in the insula, possible alterations in the sub-regional organization of the insula and the functional characteristics of each sub-region have not been examined in the ASD brain. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 36 adult males with ASD and 38 matched typically developed (TD) controls. A data-driven clustering analysis was applied to rs-fMRI data of voxels in the left and right insula to automatically group voxels with similar intrinsic connectivity pattern into a cluster. After determining the optimal number of clusters based on information theoretic measures of variation of information and mutual information, functional parcellation patterns in both the left and the right insula were compared between the TD and ASD groups. Furthermore, functional profiles of each sub-region were meta-analytically decoded using Neurosynth and were compared between the groups. RESULTS: We observed notable alterations in the anterior sector of the left insula and the middle ventral sub-region of the right insula in the ASD brain. Meta-analytic decoding revealed that whereas the anterior sector of the left insula contained two functionally differentiated sub-regions for cognitive, sensorimotor, and emotional/affective functions in TD brain, only a single functional cluster for cognitive and sensorimotor functions was identified in the anterior sector in the ASD brain. In the right insula, the middle ventral sub-region, which is primarily specialized for sensory- and auditory-related functions, showed a significant volumetric increase in the ASD brain compared with the TD brain. CONCLUSIONS: The results indicate an altered organization of sub-regions in specific parts of the left and right insula of the ASD brain. The alterations in the left and right insula may constitute neural substrates underlying abnormalities in emotional/affective and sensory functions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0106-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Attitudes toward risk and ambiguity in patients with autism spectrum disorder / Junya FUJINO in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 45p. Titre : Attitudes toward risk and ambiguity in patients with autism spectrum disorder Type de document : texte imprimé Auteurs : Junya FUJINO, Auteur ; Shisei TEI, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Takashi ITAHASHI, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Rieko OKADA, Auteur ; Manabu KUBOTA, Auteur ; Motoaki NAKAMURA, Auteur ; Nobumasa KATO, Auteur ; Hidehiko TAKAHASHI, Auteur Article en page(s) : 45p. Langues : Anglais (eng) Mots-clés : Ambiguity  Autism spectrum disorder  Decision-making  Gain  Loss  Risk  Uncertainty Index. décimale : PER Périodiques Résumé : Although the ability to make optimal decisions under uncertainty is an integral part of everyday life, individuals with autism spectrum disorder (ASD) frequently report that they experience difficulties with this skill. In behavioral economics, researchers distinguish two types of uncertainty to understand decision-making in this setting: risk (known probabilities) and ambiguity (unknown probabilities). However, it remains unclear how individuals with ASD behave under risk and ambiguity, despite growing evidence of their altered decision-making under uncertainty. We therefore extended previous research by studying the attitudes of those with ASD toward risk and ambiguity in both positive and negative contexts (i.e., gain and loss). In gain contexts, no significant difference was observed between the groups in risk attitudes, but ambiguity aversion was attenuated in ASD. In loss contexts, ambiguity attitudes did not significantly differ between the groups, but the ASD participants were less risk-seeking compared with the controls. In addition, insensitivity to the context change under risk and ambiguity in ASD was both significantly associated with poor social skills. These results improve our understanding of altered decision-making under uncertainty by disentangling the attitudes toward risk and ambiguity in ASD individuals. Applying behavioral economic tools may provide insights into the mechanisms underlying behavioral disturbances in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0162-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Attitudes toward risk and ambiguity in patients with autism spectrum disorder [texte imprimé] / Junya FUJINO, Auteur ; Shisei TEI, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Takashi ITAHASHI, Auteur ; Haruhisa OHTA, Auteur ; Chieko KANAI, Auteur ; Rieko OKADA, Auteur ; Manabu KUBOTA, Auteur ; Motoaki NAKAMURA, Auteur ; Nobumasa KATO, Auteur ; Hidehiko TAKAHASHI, Auteur . - 45p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 45p. Mots-clés : Ambiguity  Autism spectrum disorder  Decision-making  Gain  Loss  Risk  Uncertainty Index. décimale : PER Périodiques Résumé : Although the ability to make optimal decisions under uncertainty is an integral part of everyday life, individuals with autism spectrum disorder (ASD) frequently report that they experience difficulties with this skill. In behavioral economics, researchers distinguish two types of uncertainty to understand decision-making in this setting: risk (known probabilities) and ambiguity (unknown probabilities). However, it remains unclear how individuals with ASD behave under risk and ambiguity, despite growing evidence of their altered decision-making under uncertainty. We therefore extended previous research by studying the attitudes of those with ASD toward risk and ambiguity in both positive and negative contexts (i.e., gain and loss). In gain contexts, no significant difference was observed between the groups in risk attitudes, but ambiguity aversion was attenuated in ASD. In loss contexts, ambiguity attitudes did not significantly differ between the groups, but the ASD participants were less risk-seeking compared with the controls. In addition, insensitivity to the context change under risk and ambiguity in ASD was both significantly associated with poor social skills. These results improve our understanding of altered decision-making under uncertainty by disentangling the attitudes toward risk and ambiguity in ASD individuals. Applying behavioral economic tools may provide insights into the mechanisms underlying behavioral disturbances in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0162-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Egocentric biases and atypical generosity in autistic individuals / Shisei TEI in Autism Research, 12-11 (November 2019)  

Public ISBD [article]  inAutism Research > 12-11 (November 2019) . - p.1598-1608 Titre : Egocentric biases and atypical generosity in autistic individuals Type de document : texte imprimé Auteurs : Shisei TEI, Auteur ; Junya FUJINO, Auteur ; Takashi ITAHASHI, Auteur ; Yuta AOKI, Auteur ; Haruhisa OHTA, Auteur ; Manabu KUBOTA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Motoaki NAKAMURA, Auteur ; Nobumasa KATO, Auteur ; Hidehiko TAKAHASHI, Auteur Article en page(s) : p.1598-1608 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  decision making  egocentrism  perspective taking  social cognition Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum conditions (ASCs) often experience difficulty and confusion in acknowledging others' perspectives and arguably exhibit egocentricity. However, whether this egocentricity necessarily results in selfish behavior during social situations remains a matter of debate. To study this relationship, we used computerized visuospatial perspective-taking task (VPT) and social-discounting task (SDT), derived from cognitive psychology and behavioral economics, and examined egocentric and other-oriented judgments in participants with ASCs (mean age 29.0 +/- 4.2 years) and a group of matched typically developing (TD) controls (30.8 +/- 8.5). The response time in VPT showed altered perspective-taking in the ASCs group compared with the TD group that involved in enhanced self-other intrusion and condition-insensitive response. Regardless of self/other perspective judgments, responses were relatively slower and consistent in duration in the ASCs group compared with the TD group. Social discounting was attenuated rather than steep discounting in the ASCs group. Their discounting was comparatively more consistent, irrespective of the task condition (i.e., self-other closeness-level). In effect, ASCs group exhibited more generous decisions than the TD group in this task. Finally, those with more egocentric perspective intrusion in VPT paradoxically showed more generous behaviors in SDT in the ASCs group. Our findings suggest that having ASCs does not always exhibit selfish behavior during interpersonal communication. Reduced flexibility in distinguishing self/other perspective and shifting decision-rules might account for this unique relationship between egocentricity and apparently generous behaviors. These results extend the recent suggestion that more careful attention should be paid to the idea of egocentricity in individuals with ASCs. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We aimed to examine whether seeing the world from another person's point of view and being generous toward other people are related in autistic and nonautistic people. We used a visual perspective-taking task and a social task in which individuals made decisions about how to divide a sum of money with others. Our results suggest that being autistic does not always make someone bad at seeing the world from another's viewpoint, and that autistic people may make fairer social decisions toward unfamiliar people because of lower bias. En ligne : http://dx.doi.org/10.1002/aur.2130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411 [article] Egocentric biases and atypical generosity in autistic individuals [texte imprimé] / Shisei TEI, Auteur ; Junya FUJINO, Auteur ; Takashi ITAHASHI, Auteur ; Yuta AOKI, Auteur ; Haruhisa OHTA, Auteur ; Manabu KUBOTA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Motoaki NAKAMURA, Auteur ; Nobumasa KATO, Auteur ; Hidehiko TAKAHASHI, Auteur . - p.1598-1608. Langues : Anglais (eng) in Autism Research > 12-11 (November 2019) . - p.1598-1608 Mots-clés : autism spectrum disorders  decision making  egocentrism  perspective taking  social cognition Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum conditions (ASCs) often experience difficulty and confusion in acknowledging others' perspectives and arguably exhibit egocentricity. However, whether this egocentricity necessarily results in selfish behavior during social situations remains a matter of debate. To study this relationship, we used computerized visuospatial perspective-taking task (VPT) and social-discounting task (SDT), derived from cognitive psychology and behavioral economics, and examined egocentric and other-oriented judgments in participants with ASCs (mean age 29.0 +/- 4.2 years) and a group of matched typically developing (TD) controls (30.8 +/- 8.5). The response time in VPT showed altered perspective-taking in the ASCs group compared with the TD group that involved in enhanced self-other intrusion and condition-insensitive response. Regardless of self/other perspective judgments, responses were relatively slower and consistent in duration in the ASCs group compared with the TD group. Social discounting was attenuated rather than steep discounting in the ASCs group. Their discounting was comparatively more consistent, irrespective of the task condition (i.e., self-other closeness-level). In effect, ASCs group exhibited more generous decisions than the TD group in this task. Finally, those with more egocentric perspective intrusion in VPT paradoxically showed more generous behaviors in SDT in the ASCs group. Our findings suggest that having ASCs does not always exhibit selfish behavior during interpersonal communication. Reduced flexibility in distinguishing self/other perspective and shifting decision-rules might account for this unique relationship between egocentricity and apparently generous behaviors. These results extend the recent suggestion that more careful attention should be paid to the idea of egocentricity in individuals with ASCs. Autism Res 2019. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We aimed to examine whether seeing the world from another person's point of view and being generous toward other people are related in autistic and nonautistic people. We used a visual perspective-taking task and a social task in which individuals made decisions about how to divide a sum of money with others. Our results suggest that being autistic does not always make someone bad at seeing the world from another's viewpoint, and that autistic people may make fairer social decisions toward unfamiliar people because of lower bias. En ligne : http://dx.doi.org/10.1002/aur.2130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=411

Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) / Yuko TAKAYAMA in Research in Autism Spectrum Disorders, 8-4 (April 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-4 (April 2014) . - p.347-353 Titre : Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) Type de document : texte imprimé Auteurs : Yuko TAKAYAMA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Taisei ONO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur Article en page(s) : p.347-353 Mots-clés : Autism spectrum disorders  Sensory sensitivity  Glasgow Sensory Questionnaire  Autism spectrum quotient Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) often have sensory processing abnormalities. However, limited measures that assess these problems in adults with ASD have been developed till date, particularly in Japan. Robertson and Simmons (2012) developed a self-rating scale to investigate sensory sensitivity: the Glasgow Sensory Questionnaire (GSQ). In the present study, we developed a Japanese version of GSQ and investigated sensory abnormalities in adults with ASD. We compared results of the Japanese version of GSQ in adults between an ASD group (n = 64) and a control group (n = 70). In addition, we also administered these individuals with the autism spectrum quotient (AQ), which is a questionnaire for assessing autistic traits. The Japanese version of GSQ scores was significantly higher in the ASD group than that in the control group. The total GSQ score and each sensory subscale showed a positive correlation with AQ in the total study sample. These results indicate that individuals with pronounced autistic traits have more frequent and extreme sensory processing problems compared with that in individuals with less pronounced autistic traits. We also assessed validity of the new test. Cronbach's α of the questionnaire was calculated, and its high value indicates that the Japanese version of GSQ has high reliability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226 [article] Standardization of the Japanese version of the Glasgow Sensory Questionnaire (GSQ) [texte imprimé] / Yuko TAKAYAMA, Auteur ; Ryu-ichiro HASHIMOTO, Auteur ; Masayuki TANI, Auteur ; Chieko KANAI, Auteur ; Takashi YAMADA, Auteur ; Hiromi WATANABE, Auteur ; Taisei ONO, Auteur ; Nobumasa KATO, Auteur ; Akira IWANAMI, Auteur . - p.347-353. in Research in Autism Spectrum Disorders > 8-4 (April 2014) . - p.347-353 Mots-clés : Autism spectrum disorders  Sensory sensitivity  Glasgow Sensory Questionnaire  Autism spectrum quotient Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorders (ASD) often have sensory processing abnormalities. However, limited measures that assess these problems in adults with ASD have been developed till date, particularly in Japan. Robertson and Simmons (2012) developed a self-rating scale to investigate sensory sensitivity: the Glasgow Sensory Questionnaire (GSQ). In the present study, we developed a Japanese version of GSQ and investigated sensory abnormalities in adults with ASD. We compared results of the Japanese version of GSQ in adults between an ASD group (n = 64) and a control group (n = 70). In addition, we also administered these individuals with the autism spectrum quotient (AQ), which is a questionnaire for assessing autistic traits. The Japanese version of GSQ scores was significantly higher in the ASD group than that in the control group. The total GSQ score and each sensory subscale showed a positive correlation with AQ in the total study sample. These results indicate that individuals with pronounced autistic traits have more frequent and extreme sensory processing problems compared with that in individuals with less pronounced autistic traits. We also assessed validity of the new test. Cronbach's α of the questionnaire was calculated, and its high value indicates that the Japanese version of GSQ has high reliability. En ligne : http://dx.doi.org/10.1016/j.rasd.2013.12.017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=226

Sunk Cost Effect in Individuals with Autism Spectrum Disorder / Junya FUJINO in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

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White matter alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder in relation to sensory profile / Haruhisa OHTA in Molecular Autism, 11 (2020)  

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