An initial trial of OPT-In-Early: An online training program for caregivers of autistic children / Yael G DAI in Autism, 27-6 (August 2023)  

Public ISBD [article]  inAutism > 27-6 (August 2023) . - p.1601-1615 Titre : An initial trial of OPT-In-Early: An online training program for caregivers of autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Yael G DAI, Auteur ; Rebecca P THOMAS, Auteur ; Lynn BRENNAN, Auteur ; My-Linh LUU, Auteur ; Jamie HUGHES-LIKA, Auteur ; Molly REILLY, Auteur ; Paula MORENO, Auteur ; Brenda OBE, Auteur ; Kelli B AHMED, Auteur ; Leandra N BERRY, Auteur ; Robin P GOIN-KOCHEL, Auteur ; Molly S HELT, Auteur ; Marianne L BARTON, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L ROBINS, Auteur ; Deborah A FEIN, Auteur Article en page(s) : p.1601-1615 Langues : Anglais (eng) Mots-clés : autistic;online training;parent training;self-directed;telehealth Index. décimale : PER Périodiques Résumé : Online Parent Training in Early Behavioral Intervention (OPT-In-Early) is a self-directed resource for caregivers of autistic children. Sixty-three parent-child dyads from three states in were randomized to the OPT-In-Early or treatment as usual group. Parents in both groups completed baseline and post-treatment visits, which were targeted for 4?months apart but allowed to go up to 6?months. Compared to parents in the treatment as usual group, parents randomized to OPT-In-Early learned more evidence-based intervention principles from baseline to post-treatment and were rated by observers blind to group and time as increasing their use of these strategies during brief semi-structured interactions with their children. Parent participation in OPT-In-Early did not significantly influence children?s social communication as coded from one observation session. Results suggest that parents acquired knowledge and skills in intervention techniques from OPT-In-Early. Longer trials may be needed for gains in child behavior.Lay abstractEarly intervention can help children learn language and improve social communication. However, many barriers, including the expense of services and an insufficient number of providers, prohibit families from accessing services when their children are young. We developed a comprehensive online program for caregivers of autistic children. The program, Online Parent Training in Early Behavioral Intervention (OPT-In-Early), uses text and video demonstrations to teach caregivers effective methods for improving their children?s language, social, and adaptive skills (e.g. using utensils, toilet training), and reducing their children?s disruptive behavior. Sixty-three parents from three states participated in the study. Half of the parents received access to the OPT-In-Early program. After 4?months, parents who had access to the OPT-In-Early program learned more effective intervention strategies, and started using these strategies during interactions with their children, than parents who did not receive access to the program. Parent participation in OPT-In-Early did not significantly influence children?s social communication compared to children whose parents did not have access to OPT-In-Early. A longer duration of parents using learned intervention skills with their children may be needed for children?s social communication skills to improve. En ligne : http://dx.doi.org/10.1177/13623613221142408 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509 [article] An initial trial of OPT-In-Early: An online training program for caregivers of autistic children [Texte imprimé et/ou numérique] / Yael G DAI, Auteur ; Rebecca P THOMAS, Auteur ; Lynn BRENNAN, Auteur ; My-Linh LUU, Auteur ; Jamie HUGHES-LIKA, Auteur ; Molly REILLY, Auteur ; Paula MORENO, Auteur ; Brenda OBE, Auteur ; Kelli B AHMED, Auteur ; Leandra N BERRY, Auteur ; Robin P GOIN-KOCHEL, Auteur ; Molly S HELT, Auteur ; Marianne L BARTON, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Diana L ROBINS, Auteur ; Deborah A FEIN, Auteur . - p.1601-1615. Langues : Anglais (eng) in Autism > 27-6 (August 2023) . - p.1601-1615 Mots-clés : autistic;online training;parent training;self-directed;telehealth Index. décimale : PER Périodiques Résumé : Online Parent Training in Early Behavioral Intervention (OPT-In-Early) is a self-directed resource for caregivers of autistic children. Sixty-three parent-child dyads from three states in were randomized to the OPT-In-Early or treatment as usual group. Parents in both groups completed baseline and post-treatment visits, which were targeted for 4?months apart but allowed to go up to 6?months. Compared to parents in the treatment as usual group, parents randomized to OPT-In-Early learned more evidence-based intervention principles from baseline to post-treatment and were rated by observers blind to group and time as increasing their use of these strategies during brief semi-structured interactions with their children. Parent participation in OPT-In-Early did not significantly influence children?s social communication as coded from one observation session. Results suggest that parents acquired knowledge and skills in intervention techniques from OPT-In-Early. Longer trials may be needed for gains in child behavior.Lay abstractEarly intervention can help children learn language and improve social communication. However, many barriers, including the expense of services and an insufficient number of providers, prohibit families from accessing services when their children are young. We developed a comprehensive online program for caregivers of autistic children. The program, Online Parent Training in Early Behavioral Intervention (OPT-In-Early), uses text and video demonstrations to teach caregivers effective methods for improving their children?s language, social, and adaptive skills (e.g. using utensils, toilet training), and reducing their children?s disruptive behavior. Sixty-three parents from three states participated in the study. Half of the parents received access to the OPT-In-Early program. After 4?months, parents who had access to the OPT-In-Early program learned more effective intervention strategies, and started using these strategies during interactions with their children, than parents who did not receive access to the program. Parent participation in OPT-In-Early did not significantly influence children?s social communication compared to children whose parents did not have access to OPT-In-Early. A longer duration of parents using learned intervention skills with their children may be needed for children?s social communication skills to improve. En ligne : http://dx.doi.org/10.1177/13623613221142408 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509

Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers / Caitlin M. HUDAC in Autism Research, 13-8 (August 2020)  

Public ISBD [article]  inAutism Research > 13-8 (August 2020) . - p.1300-1310 Titre : Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers Type de document : Texte imprimé et/ou numérique Auteurs : Caitlin M. HUDAC, Auteur ; Joanna BOVE, Auteur ; Shelley BARBER, Auteur ; Michael DUYZEND, Auteur ; Ari WALLACE, Auteur ; Christa Lese MARTIN, Auteur ; David H. LEDBETTER, Auteur ; Ellen HANSON, Auteur ; Robin P GOIN-KOCHEL, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Wendy K. CHUNG, Auteur ; Evan E. EICHLER, Auteur ; Raphael BERNIER, Auteur Article en page(s) : p.1300-1310 Langues : Anglais (eng) Mots-clés : 16p11.2 deletion  16p11.2 duplication  adaptive functioning  autism spectrum disorder  cognitive functioning  individual variability/heterogeneity Index. décimale : PER Périodiques Résumé : Individuals with 16p11.2 copy number variant (CNV) show considerable phenotypic heterogeneity. Although autism spectrum disorder (ASD) is reported in approximately 20-23% of individuals with 16p11.2 CNVs, ASD-associated symptoms are observed in those without a clinical ASD diagnosis. Previous work has shown that genetic variation and prenatal and perinatal birth complications influence ASD risk and symptom severity. This study examined the impact of genetic and environmental risk factors on phenotypic heterogeneity among 16p11.2 CNV carriers. Participants included individuals with a 16p11.2 deletion (N = 96) or duplication (N = 77) with exome sequencing from the Simons VIP study. The presence of prenatal factors, perinatal events, additional genetic events, and gender was studied. Regression analyses examined the contribution of each risk factor on ASD symptomatology, cognitive functioning, and adaptive abilities. For deletion carriers, perinatal and additional genetic events were associated with increased ASD symptomatology and decrements in cognitive and adaptive functioning. For duplication carriers, secondary genetic events were associated with greater cognitive impairments. Being female sex was a protective factor for both deletion and duplication carriers. Our findings suggest that ASD-associated risk factors contribute to the variability in symptom presentation in individuals with 16p11.2 CNVs. LAY SUMMARY: There are a wide range of autism spectrum disorder (ASD) symptoms and abilities observed for individuals with genetic changes of the 16p11.2 region. Here, we found perinatal complications contributed to more severe ASD symptoms (deletion carriers) and additional genetic mutations contributed to decreased cognitive abilities (deletion and duplication carriers). A potential protective factor was also observed for females with 16p11.2 variations. Autism Res 2020, 13: 1300-1310. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Evaluating heterogeneity in ASD symptomatology, cognitive ability, and adaptive functioning among 16p11.2 CNV carriers [Texte imprimé et/ou numérique] / Caitlin M. HUDAC, Auteur ; Joanna BOVE, Auteur ; Shelley BARBER, Auteur ; Michael DUYZEND, Auteur ; Ari WALLACE, Auteur ; Christa Lese MARTIN, Auteur ; David H. LEDBETTER, Auteur ; Ellen HANSON, Auteur ; Robin P GOIN-KOCHEL, Auteur ; LeeAnne GREEN SNYDER, Auteur ; Wendy K. CHUNG, Auteur ; Evan E. EICHLER, Auteur ; Raphael BERNIER, Auteur . - p.1300-1310. Langues : Anglais (eng) in Autism Research > 13-8 (August 2020) . - p.1300-1310 Mots-clés : 16p11.2 deletion  16p11.2 duplication  adaptive functioning  autism spectrum disorder  cognitive functioning  individual variability/heterogeneity Index. décimale : PER Périodiques Résumé : Individuals with 16p11.2 copy number variant (CNV) show considerable phenotypic heterogeneity. Although autism spectrum disorder (ASD) is reported in approximately 20-23% of individuals with 16p11.2 CNVs, ASD-associated symptoms are observed in those without a clinical ASD diagnosis. Previous work has shown that genetic variation and prenatal and perinatal birth complications influence ASD risk and symptom severity. This study examined the impact of genetic and environmental risk factors on phenotypic heterogeneity among 16p11.2 CNV carriers. Participants included individuals with a 16p11.2 deletion (N = 96) or duplication (N = 77) with exome sequencing from the Simons VIP study. The presence of prenatal factors, perinatal events, additional genetic events, and gender was studied. Regression analyses examined the contribution of each risk factor on ASD symptomatology, cognitive functioning, and adaptive abilities. For deletion carriers, perinatal and additional genetic events were associated with increased ASD symptomatology and decrements in cognitive and adaptive functioning. For duplication carriers, secondary genetic events were associated with greater cognitive impairments. Being female sex was a protective factor for both deletion and duplication carriers. Our findings suggest that ASD-associated risk factors contribute to the variability in symptom presentation in individuals with 16p11.2 CNVs. LAY SUMMARY: There are a wide range of autism spectrum disorder (ASD) symptoms and abilities observed for individuals with genetic changes of the 16p11.2 region. Here, we found perinatal complications contributed to more severe ASD symptoms (deletion carriers) and additional genetic mutations contributed to decreased cognitive abilities (deletion and duplication carriers). A potential protective factor was also observed for females with 16p11.2 variations. Autism Res 2020, 13: 1300-1310. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

Musings on the puzzle piece / Robin P GOIN-KOCHEL in Autism, 20-2 (February 2016)  

Public ISBD [article]  inAutism > 20-2 (February 2016) . - p.250 Titre : Musings on the puzzle piece Type de document : Texte imprimé et/ou numérique Auteurs : Robin P GOIN-KOCHEL, Auteur Article en page(s) : p.250 Langues : Anglais (eng) Mots-clés : autism  puzzle  symbol Index. décimale : PER Périodiques Résumé : Following is a brief musing on Roy Grinker’s discussion of what the puzzle piece symbolizes for autism during his presentation at the 2015 International Meeting for Autism Research. In his words, “The puzzle piece is ubiquitous.” It likely holds a different meaning for each of us, and this is how one autism researcher sees it. En ligne : http://dx.doi.org/10.1177/1362361315602135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Musings on the puzzle piece [Texte imprimé et/ou numérique] / Robin P GOIN-KOCHEL, Auteur . - p.250. Langues : Anglais (eng) in Autism > 20-2 (February 2016) . - p.250 Mots-clés : autism  puzzle  symbol Index. décimale : PER Périodiques Résumé : Following is a brief musing on Roy Grinker’s discussion of what the puzzle piece symbolizes for autism during his presentation at the 2015 International Meeting for Autism Research. In his words, “The puzzle piece is ubiquitous.” It likely holds a different meaning for each of us, and this is how one autism researcher sees it. En ligne : http://dx.doi.org/10.1177/1362361315602135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Neurocognitive and Neurobehavioral Phenotype of Youth with Schaaf-Yang Syndrome / Molly Mishler THOMASON in Journal of Autism and Developmental Disorders, 50-7 (July 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2491-2500 Titre : Neurocognitive and Neurobehavioral Phenotype of Youth with Schaaf-Yang Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Molly Mishler THOMASON, Auteur ; John MCCARTHY, Auteur ; Robin P GOIN-KOCHEL, Auteur ; Lauren R. DOWELL, Auteur ; Christian P. SCHAAF, Auteur ; Leandra N. BERRY, Auteur Article en page(s) : p.2491-2500 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior  Magel2  Neurodevelopment  Prader-Willi syndrome  Schaaf-Yang syndrome Index. décimale : PER Périodiques Résumé : Truncating variants of the MAGEL2 gene, one of the protein-coding genes within the Prader-Willi syndrome (PWS) critical region on chromosome 15q11, cause Schaaf-Yang syndrome (SYS)-a neurodevelopmental disorder that shares several clinical features with PWS. The current study sought to characterize the neurobehavioral phenotype of SYS in a sample of 9 patients with molecularly-confirmed SYS. Participants received an assessment of developmental/intellectual functioning, adaptive functioning, autism symptomatology, and behavioral/emotional functioning. Compared to individuals with PWS, patients with SYS manifested more severe cognitive deficits, no obsessions or compulsions, and increased rates of autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-018-3775-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Neurocognitive and Neurobehavioral Phenotype of Youth with Schaaf-Yang Syndrome [Texte imprimé et/ou numérique] / Molly Mishler THOMASON, Auteur ; John MCCARTHY, Auteur ; Robin P GOIN-KOCHEL, Auteur ; Lauren R. DOWELL, Auteur ; Christian P. SCHAAF, Auteur ; Leandra N. BERRY, Auteur . - p.2491-2500. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2491-2500 Mots-clés : Autism spectrum disorder  Behavior  Magel2  Neurodevelopment  Prader-Willi syndrome  Schaaf-Yang syndrome Index. décimale : PER Périodiques Résumé : Truncating variants of the MAGEL2 gene, one of the protein-coding genes within the Prader-Willi syndrome (PWS) critical region on chromosome 15q11, cause Schaaf-Yang syndrome (SYS)-a neurodevelopmental disorder that shares several clinical features with PWS. The current study sought to characterize the neurobehavioral phenotype of SYS in a sample of 9 patients with molecularly-confirmed SYS. Participants received an assessment of developmental/intellectual functioning, adaptive functioning, autism symptomatology, and behavioral/emotional functioning. Compared to individuals with PWS, patients with SYS manifested more severe cognitive deficits, no obsessions or compulsions, and increased rates of autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-018-3775-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

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