Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence / Amy E. MARGOLIS in Journal of Child Psychology and Psychiatry, 57-7 (July 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860 Titre : Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence Type de document : Texte imprimé et/ou numérique Auteurs : Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica P. PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur Article en page(s) : p.851-860 Langues : Anglais (eng) Mots-clés : Polycyclic aromatic hydrocarbons  self-regulation  prenatal exposure  social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence [Texte imprimé et/ou numérique] / Amy E. MARGOLIS, Auteur ; Julie B. HERBSTMAN, Auteur ; Katie S. DAVIS, Auteur ; Valerie K. THOMAS, Auteur ; Deliang TANG, Auteur ; Ya WANG, Auteur ; Shuang WANG, Auteur ; Frederica P. PERERA, Auteur ; Bradley S. PETERSON, Auteur ; Virginia A. RAUH, Auteur . - p.851-860. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-7 (July 2016) . - p.851-860 Mots-clés : Polycyclic aromatic hydrocarbons  self-regulation  prenatal exposure  social competence Index. décimale : PER Périodiques Résumé : Background We evaluated the influence of prenatal exposure to widespread urban air pollutants on the development of self-regulation and social competence in a longitudinal prospective cohort of children born to nonsmoking minority women in New York City. Methods Air pollutant exposure was estimated categorically by level of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in maternal blood collected at delivery, providing a biomarker of maternal exposure to PAH over a 2- to 3-month period. Deficient emotional self-regulation (DESR) was defined as moderate elevations on three specific scales of the child behavior checklist (anxious/depressed, aggressive behavior, and attention problems). We used generalized estimating equations to assess the influence of prenatal exposure to PAH on DESR in children at 3–5, 7, 9, and 11 years of age, adjusted for gender and race/ethnicity. Next, we assessed the association of prenatal exposure to PAH with social competence, as measured by the social responsiveness scale (SRS), the association of impaired self-regulation with social competence, and whether impairment in self-regulation mediated the association of prenatal exposure to PAH with social competence. Results We detected a significant interaction (at p = .05) of exposure with time, in which the developmental trajectory of self-regulatory capacity was delayed in the exposed children. Multiple linear regression revealed a positive association between presence of PAH-DNA adducts and problems with social competence (p < .04), level of dysregulation and problems with social competence (p < .0001), and evidence that self-regulation mediates the association of prenatal exposure to PAH with social competence (p < .0007). Conclusions These data suggest that prenatal exposure to PAH produces long-lasting effects on self-regulatory capacities across early and middle childhood, and that these deficits point to emerging social problems with real-world consequences for high-risk adolescent behaviors in this minority urban cohort. En ligne : http://dx.doi.org/10.1111/jcpp.12548 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood / David PAGLIACCIO in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1253-1265 Titre : Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood Type de document : Texte imprimé et/ou numérique Auteurs : David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Frederica PERERA, Auteur ; Deliang TANG, Auteur ; Jeff GOLDSMITH, Auteur ; Bradley S. PETERSON, Auteur ; Virginia RAUH, Auteur ; Amy E. MARGOLIS, Auteur Article en page(s) : p.1253-1265 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder  adversity  child behavior checklist  child development  toxicants Index. décimale : PER Périodiques Résumé : BACKGROUND: Risk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. Prenatal PAH exposure is linked to adverse physical, behavioral, and cognitive outcomes as well as increasing psychiatric risk. It is unclear whether environmental exposures, like PAH, magnify the effects of exposure to early life stress (ELS), a critical risk factor for psychopathology. The current work aimed to test potential interactions between prenatal PAH exposure and psychosocial/socioeconomic stress on psychiatric symptoms in school-age children. METHODS: Data were from the Columbia Center for Children's Environmental Health Mothers and Newborns longitudinal birth cohort study. Prenatal PAH exposure was ascertained though air monitoring during pregnancy and maternal PAH-DNA adducts at delivery. Mothers reported on ELS (child age 5) and on child psychiatric symptoms across childhood (child age 5, 7, 9, and 11) using the Child Behavior Checklist (CBCL). RESULTS: Significant prenatal airborne PAH × ELS interactions (FDR-corrected) predicted CBCL Attention (? = 0.22, t(307) = 3.47, p < .001, p(fdr ) = .003) and Thought Problems T-scores (? = 0.21, t(307) = 3.29, p = .001, p(fdr ) = .004) at age 11 (n = 319). Relative to those with lower exposure, children with higher prenatal PAH exposure exhibited stronger positive associations between ELS and CBCL Attention and Thought Problem T-scores. This interaction was also significant examining convergent ADHD measures (Conners, DuPaul) and examining maternal PAH-DNA adducts (? = 0.29, t(261) = 2.48, p = .01; n = 273). A three-way interaction with assessment wave indicated that the PAH × ELS interaction on Attention Problems was stronger later in development (? = 0.03, t(1,601) = 2.19, p = .03; n = 477). CONCLUSIONS: Prenatal exposure to PAH, a common neurotoxicant in air pollution, may magnify or sustain the effects of early life psychosocial/socioeconomic stress on psychiatric outcomes later in child development. This work highlights the critical role of air pollution exposure on child mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood [Texte imprimé et/ou numérique] / David PAGLIACCIO, Auteur ; Julie B. HERBSTMAN, Auteur ; Frederica PERERA, Auteur ; Deliang TANG, Auteur ; Jeff GOLDSMITH, Auteur ; Bradley S. PETERSON, Auteur ; Virginia RAUH, Auteur ; Amy E. MARGOLIS, Auteur . - p.1253-1265. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1253-1265 Mots-clés : Attention deficit hyperactivity disorder  adversity  child behavior checklist  child development  toxicants Index. décimale : PER Périodiques Résumé : BACKGROUND: Risk for childhood psychopathology is complex and multifactorial, implicating direct and interacting effects of familial and environmental factors. The role of environmental neurotoxicants in psychiatric risk is of growing concern, including polycyclic aromatic hydrocarbons (PAH), common in air pollution. Prenatal PAH exposure is linked to adverse physical, behavioral, and cognitive outcomes as well as increasing psychiatric risk. It is unclear whether environmental exposures, like PAH, magnify the effects of exposure to early life stress (ELS), a critical risk factor for psychopathology. The current work aimed to test potential interactions between prenatal PAH exposure and psychosocial/socioeconomic stress on psychiatric symptoms in school-age children. METHODS: Data were from the Columbia Center for Children's Environmental Health Mothers and Newborns longitudinal birth cohort study. Prenatal PAH exposure was ascertained though air monitoring during pregnancy and maternal PAH-DNA adducts at delivery. Mothers reported on ELS (child age 5) and on child psychiatric symptoms across childhood (child age 5, 7, 9, and 11) using the Child Behavior Checklist (CBCL). RESULTS: Significant prenatal airborne PAH × ELS interactions (FDR-corrected) predicted CBCL Attention (? = 0.22, t(307) = 3.47, p < .001, p(fdr ) = .003) and Thought Problems T-scores (? = 0.21, t(307) = 3.29, p = .001, p(fdr ) = .004) at age 11 (n = 319). Relative to those with lower exposure, children with higher prenatal PAH exposure exhibited stronger positive associations between ELS and CBCL Attention and Thought Problem T-scores. This interaction was also significant examining convergent ADHD measures (Conners, DuPaul) and examining maternal PAH-DNA adducts (? = 0.29, t(261) = 2.48, p = .01; n = 273). A three-way interaction with assessment wave indicated that the PAH × ELS interaction on Attention Problems was stronger later in development (? = 0.03, t(1,601) = 2.19, p = .03; n = 477). CONCLUSIONS: Prenatal exposure to PAH, a common neurotoxicant in air pollution, may magnify or sustain the effects of early life psychosocial/socioeconomic stress on psychiatric outcomes later in child development. This work highlights the critical role of air pollution exposure on child mental health. En ligne : http://dx.doi.org/10.1111/jcpp.13189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

---

1 (1 - 2 / 2)