Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development / Edwa FRIEDLANDER in Autism Research, 12-7 (July 2019)  

Public ISBD [article]  inAutism Research > 12-7 (July 2019) . - p.1087-1100 Titre : Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development Type de document : texte imprimé Auteurs : Edwa FRIEDLANDER, Auteur ; Nurit YIRMIYA, Auteur ; Efrat LAIBA, Auteur ; Ayelet HAREL-GADASSI, Auteur ; Maya YAARI, Auteur ; Ohad FELDSTEIN, Auteur ; David MANKUTA, Auteur ; Salomon ISRAEL, Auteur Année de publication : 2019 Article en page(s) : p.1087-1100 Langues : Anglais (eng) Mots-clés : Oxtr  autism spectrum disorder  gene-environment interaction  oxytocin  oxytocin receptor antagonist  oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development [texte imprimé] / Edwa FRIEDLANDER, Auteur ; Nurit YIRMIYA, Auteur ; Efrat LAIBA, Auteur ; Ayelet HAREL-GADASSI, Auteur ; Maya YAARI, Auteur ; Ohad FELDSTEIN, Auteur ; David MANKUTA, Auteur ; Salomon ISRAEL, Auteur . - 2019 . - p.1087-1100. Langues : Anglais (eng) in Autism Research > 12-7 (July 2019) . - p.1087-1100 Mots-clés : Oxtr  autism spectrum disorder  gene-environment interaction  oxytocin  oxytocin receptor antagonist  oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study / Ayelet HAREL-GADASSI in Autism Research and Treatment, 2018 (2018)  

Public ISBD [article]  inAutism Research and Treatment > 2018 (2018) . - 9p. Titre : Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study Type de document : texte imprimé Auteurs : Ayelet HAREL-GADASSI, Auteur ; Edwa FRIEDLANDER, Auteur ; Maya YAARI, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: The aim of this study was to examine the long-term risk for autism spectrum disorders (ASD) in individuals who are born preterm and full-term using both observational instruments and parental reports. Neonatal risk factors and developmental characteristics associated with ASD risk were also examined. METHOD: Participants included 110 preterm children (born at a gestational age of ≤ 34 weeks) and 39 full-term children assessed at ages 18, 24, and 36 months. The Autism Diagnostic Observation Schedule, the Modified Checklist for Autism in Toddlers, the Autism Diagnostic Interview-Revised, the Social Communication Questionnaire, and the Mullen Scales of Early Learning were administered. RESULTS AND CONCLUSIONS: The long-term risk for ASD was higher when parental reports were employed compared to observational instruments. At 18 and 24 months, a higher long-term risk for ASD was found for preterm children compared to full-term children. At 36 months, only one preterm child and one full-term child met the cutoff for ASD based on the ADOS, yet clinical judgment and parental reports supported an ASD diagnosis for the preterm child only. Earlier gestational age and lower general developmental abilities were associated with elevated ASD risk among preterm children. En ligne : http://dx.doi.org/10.1155/2018/8316212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study [texte imprimé] / Ayelet HAREL-GADASSI, Auteur ; Edwa FRIEDLANDER, Auteur ; Maya YAARI, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur . - 9p. Langues : Anglais (eng) in Autism Research and Treatment > 2018 (2018) . - 9p. Index. décimale : PER Périodiques Résumé : BACKGROUND: The aim of this study was to examine the long-term risk for autism spectrum disorders (ASD) in individuals who are born preterm and full-term using both observational instruments and parental reports. Neonatal risk factors and developmental characteristics associated with ASD risk were also examined. METHOD: Participants included 110 preterm children (born at a gestational age of ≤ 34 weeks) and 39 full-term children assessed at ages 18, 24, and 36 months. The Autism Diagnostic Observation Schedule, the Modified Checklist for Autism in Toddlers, the Autism Diagnostic Interview-Revised, the Social Communication Questionnaire, and the Mullen Scales of Early Learning were administered. RESULTS AND CONCLUSIONS: The long-term risk for ASD was higher when parental reports were employed compared to observational instruments. At 18 and 24 months, a higher long-term risk for ASD was found for preterm children compared to full-term children. At 36 months, only one preterm child and one full-term child met the cutoff for ASD based on the ADOS, yet clinical judgment and parental reports supported an ASD diagnosis for the preterm child only. Earlier gestational age and lower general developmental abilities were associated with elevated ASD risk among preterm children. En ligne : http://dx.doi.org/10.1155/2018/8316212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Stability of early risk assessment for autism spectrum disorder in preterm infants / Maya YAARI in Autism, 20-7 (October 2016)  

Public ISBD [article]  inAutism > 20-7 (October 2016) . - p.856-867 Titre : Stability of early risk assessment for autism spectrum disorder in preterm infants Type de document : texte imprimé Auteurs : Maya YAARI, Auteur ; Neta YITZHAK, Auteur ; Ayelet HAREL, Auteur ; Edwa FRIEDLANDER, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Ifat GAMLIEL, Auteur ; Nurit YIRMIYA, Auteur Article en page(s) : p.856-867 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  development  early diagnosis  preterm  screening Index. décimale : PER Périodiques Résumé : Stability and change in early autism spectrum disorder risk were examined in a cohort of 99 preterm infants (⩽34 weeks of gestation) using the Autism Observation Scale for Infants at 8 and 12 months and the Autism Diagnostic Observation Schedule—Toddler Module at 18 months. A total of 21 infants were identified at risk by the Autism Observation Scale for Infants at 8 months, and 9 were identified at risk at 12 months, including 4 children who were not previously identified. At 18 months, eight children were identified at risk for autism spectrum disorder using the Autism Diagnostic Observation Schedule—Toddler Module, only half of whom had been identified using the original Autism Observation Scale for Infants cutoffs. Results are discussed in relation to early trajectories of autism spectrum disorder risk among preterm infants as well as identifying social-communication deficiencies associated with the early preterm behavioral phenotype. En ligne : http://dx.doi.org/10.1177/1362361315614758 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 [article] Stability of early risk assessment for autism spectrum disorder in preterm infants [texte imprimé] / Maya YAARI, Auteur ; Neta YITZHAK, Auteur ; Ayelet HAREL, Auteur ; Edwa FRIEDLANDER, Auteur ; Benjamin BAR-OZ, Auteur ; Smadar EVENTOV-FRIEDMAN, Auteur ; David MANKUTA, Auteur ; Ifat GAMLIEL, Auteur ; Nurit YIRMIYA, Auteur . - p.856-867. Langues : Anglais (eng) in Autism > 20-7 (October 2016) . - p.856-867 Mots-clés : autism spectrum disorders  development  early diagnosis  preterm  screening Index. décimale : PER Périodiques Résumé : Stability and change in early autism spectrum disorder risk were examined in a cohort of 99 preterm infants (⩽34 weeks of gestation) using the Autism Observation Scale for Infants at 8 and 12 months and the Autism Diagnostic Observation Schedule—Toddler Module at 18 months. A total of 21 infants were identified at risk by the Autism Observation Scale for Infants at 8 months, and 9 were identified at risk at 12 months, including 4 children who were not previously identified. At 18 months, eight children were identified at risk for autism spectrum disorder using the Autism Diagnostic Observation Schedule—Toddler Module, only half of whom had been identified using the original Autism Observation Scale for Infants cutoffs. Results are discussed in relation to early trajectories of autism spectrum disorder risk among preterm infants as well as identifying social-communication deficiencies associated with the early preterm behavioral phenotype. En ligne : http://dx.doi.org/10.1177/1362361315614758 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293

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