Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder / Ann OLINCY in Journal of Autism and Developmental Disorders, 46-12 (December 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3812-3817 Titre : Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ann OLINCY, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Lynn JOHNSON, Auteur ; William R. KEM, Auteur ; Robert FREEDMAN, Auteur Article en page(s) : p.3812-3817 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Attention  Sensory gating  Receptors nicotinic Index. décimale : PER Périodiques Résumé : Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor’s expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational receptor-specific partial agonist drug would increase the inhibitory functions of the gene and thereby increase patients’ attention. An electrophysiological biomarker, P50 inhibition, verified the intended neurobiological effect of the agonist, and neuropsychological testing verified a primary cognitive effect. Both patients perceived increased attention in their self-ratings. Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2890-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Brief Report: Initial Trial of Alpha7-Nicotinic Receptor Stimulation in Two Adult Patients with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Ann OLINCY, Auteur ; Audrey BLAKELEY-SMITH, Auteur ; Lynn JOHNSON, Auteur ; William R. KEM, Auteur ; Robert FREEDMAN, Auteur . - p.3812-3817. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-12 (December 2016) . - p.3812-3817 Mots-clés : Autism spectrum disorder  Attention  Sensory gating  Receptors nicotinic Index. décimale : PER Périodiques Résumé : Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor’s expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational receptor-specific partial agonist drug would increase the inhibitory functions of the gene and thereby increase patients’ attention. An electrophysiological biomarker, P50 inhibition, verified the intended neurobiological effect of the agonist, and neuropsychological testing verified a primary cognitive effect. Both patients perceived increased attention in their self-ratings. Alpha7-nicotinic receptor agonists, currently the target of drug development in schizophrenia and Alzheimer Disease, may also have positive clinical effects in autism spectrum disorder. En ligne : http://dx.doi.org/10.1007/s10803-016-2890-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

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