[article] 
inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2379-2395

Titre :	Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Laura A. SCHIEVE, Auteur ; L. TIAN, Auteur ; N. DOWLING, Auteur ; Lisa A. CROEN, Auteur ; J. HOOVER-FONG, Auteur ; A. ALEXANDER, Auteur ; S. K. SHAPIRA, Auteur
Article en page(s) :	p.2379-2395
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorder  Estradiol  Fetal development  Testosterone
Index. décimale :	PER Périodiques
Résumé :	The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3495-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

[article] Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development [Texte imprimé et/ou numérique] / Laura A. SCHIEVE, Auteur ; L. TIAN, Auteur ; N. DOWLING, Auteur ; Lisa A. CROEN, Auteur ; J. HOOVER-FONG, Auteur ; A. ALEXANDER, Auteur ; S. K. SHAPIRA, Auteur . - p.2379-2395.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2379-2395

Mots-clés :	Autism spectrum disorder  Estradiol  Fetal development  Testosterone
Index. décimale :	PER Périodiques
Résumé :	The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3495-z
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367