Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder / R. Joanne JAO KEEHN in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.130-143 Titre : Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder Type de document : texte imprimé Auteurs : R. Joanne JAO KEEHN, Auteur ; Sandra S. SANCHEZ, Auteur ; Claire R. STEWART, Auteur ; Weiqi ZHAO, Auteur ; Emily L. GRENESKO-STEVENS, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur Article en page(s) : p.130-143 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  development  visual  auditory  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are pervasive developmental disorders characterized by impairments in language development and social interaction, along with restricted and stereotyped behaviors. These behaviors often include atypical responses to sensory stimuli; some children with ASD are easily overwhelmed by sensory stimuli, while others may seem unaware of their environment. Vision and audition are two sensory modalities important for social interactions and language, and are differentially affected in ASD. In the present study, 16 children and adolescents with ASD and 16 typically developing (TD) participants matched for age, gender, nonverbal IQ, and handedness were tested using a mixed event-related/blocked functional magnetic resonance imaging paradigm to examine basic perceptual processes that may form the foundation for later-developing cognitive abilities. Auditory (high or low pitch) and visual conditions (dot located high or low in the display) were presented, and participants indicated whether the stimuli were “high” or “low.” Results for the auditory condition showed downregulated activity of the visual cortex in the TD group, but upregulation in the ASD group. This atypical activity in visual cortex was associated with autism symptomatology. These findings suggest atypical crossmodal (auditory-visual) modulation linked to sociocommunicative deficits in ASD, in agreement with the general hypothesis of low-level sensorimotor impairments affecting core symptomatology. En ligne : http://dx.doi.org/10.1002/aur.1636 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder [texte imprimé] / R. Joanne JAO KEEHN, Auteur ; Sandra S. SANCHEZ, Auteur ; Claire R. STEWART, Auteur ; Weiqi ZHAO, Auteur ; Emily L. GRENESKO-STEVENS, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur . - p.130-143. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.130-143 Mots-clés : autism spectrum disorders  development  visual  auditory  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are pervasive developmental disorders characterized by impairments in language development and social interaction, along with restricted and stereotyped behaviors. These behaviors often include atypical responses to sensory stimuli; some children with ASD are easily overwhelmed by sensory stimuli, while others may seem unaware of their environment. Vision and audition are two sensory modalities important for social interactions and language, and are differentially affected in ASD. In the present study, 16 children and adolescents with ASD and 16 typically developing (TD) participants matched for age, gender, nonverbal IQ, and handedness were tested using a mixed event-related/blocked functional magnetic resonance imaging paradigm to examine basic perceptual processes that may form the foundation for later-developing cognitive abilities. Auditory (high or low pitch) and visual conditions (dot located high or low in the display) were presented, and participants indicated whether the stimuli were “high” or “low.” Results for the auditory condition showed downregulated activity of the visual cortex in the TD group, but upregulation in the ASD group. This atypical activity in visual cortex was associated with autism symptomatology. These findings suggest atypical crossmodal (auditory-visual) modulation linked to sociocommunicative deficits in ASD, in agreement with the general hypothesis of low-level sensorimotor impairments affecting core symptomatology. En ligne : http://dx.doi.org/10.1002/aur.1636 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

The language network in autism: Atypical functional connectivity with default mode and visual regions / Y. GAO in Autism Research, 12-9 (September 2019)  

Public ISBD [article]  inAutism Research > 12-9 (September 2019) . - p.1344-1355 Titre : The language network in autism: Atypical functional connectivity with default mode and visual regions Type de document : texte imprimé Auteurs : Y. GAO, Auteur ; A. LINKE, Auteur ; R. Joanne JAO KEEHN, Auteur ; S. PUNYAMURTHULA, Auteur ; A. JAHEDI, Auteur ; K. GATES, Auteur ; I. FISHMAN, Auteur ; R. A. MULLER, Auteur Article en page(s) : p.1344-1355 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  default mode  language  resting-state functional magnetic resonance imaging  visual cortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are neurodevelopmental disorders associated with atypical brain connectivity. Although language abilities vary widely, they are impaired or atypical in most children with ASDs. Underlying brain mechanisms, however, are not fully understood. The present study examined intrinsic functional connectivity (iFC) of the extended language network in a cohort of 52 children and adolescents with ASDs (ages 8-18 years), using resting-state functional magnetic resonance imaging. We found that, in comparison to typically developing peers (n = 50), children with ASDs showed increased connectivity between some language regions. In addition, seed-to-whole brain analyses revealed increased connectivity of language regions with posterior cingulate cortex (PCC) and visual regions in the ASD group. Post hoc effective connectivity analyses revealed a mediation effect of PCC on the iFC between bilateral inferior frontal and visual regions in an ASD subgroup. This finding qualifies and expands on previous reports of recruitment of visual areas in language processing in ASDs. In addition, increased iFC between PCC and visual regions was linked to lower language scores in this ASD subgroup, suggesting that increased connectivity with visual cortices, mediated by default mode regions, may be detrimental to language abilities. Autism Res 2019, 12: 1344-1355. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined the functional connectivity between regions of the language network in children with autism spectrum disorders (ASDs) compared to typically developing peers. We found connectivity to be intact between core language in the ASD group, but also showed abnormally increased connectivity between regions of an extended language network. Additionally, connectivity was increased with regions associated with brain networks responsible for self-reflection and visual processing. En ligne : http://dx.doi.org/10.1002/aur.2171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] The language network in autism: Atypical functional connectivity with default mode and visual regions [texte imprimé] / Y. GAO, Auteur ; A. LINKE, Auteur ; R. Joanne JAO KEEHN, Auteur ; S. PUNYAMURTHULA, Auteur ; A. JAHEDI, Auteur ; K. GATES, Auteur ; I. FISHMAN, Auteur ; R. A. MULLER, Auteur . - p.1344-1355. Langues : Anglais (eng) in Autism Research > 12-9 (September 2019) . - p.1344-1355 Mots-clés : autism spectrum disorders  default mode  language  resting-state functional magnetic resonance imaging  visual cortex Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) are neurodevelopmental disorders associated with atypical brain connectivity. Although language abilities vary widely, they are impaired or atypical in most children with ASDs. Underlying brain mechanisms, however, are not fully understood. The present study examined intrinsic functional connectivity (iFC) of the extended language network in a cohort of 52 children and adolescents with ASDs (ages 8-18 years), using resting-state functional magnetic resonance imaging. We found that, in comparison to typically developing peers (n = 50), children with ASDs showed increased connectivity between some language regions. In addition, seed-to-whole brain analyses revealed increased connectivity of language regions with posterior cingulate cortex (PCC) and visual regions in the ASD group. Post hoc effective connectivity analyses revealed a mediation effect of PCC on the iFC between bilateral inferior frontal and visual regions in an ASD subgroup. This finding qualifies and expands on previous reports of recruitment of visual areas in language processing in ASDs. In addition, increased iFC between PCC and visual regions was linked to lower language scores in this ASD subgroup, suggesting that increased connectivity with visual cortices, mediated by default mode regions, may be detrimental to language abilities. Autism Res 2019, 12: 1344-1355. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined the functional connectivity between regions of the language network in children with autism spectrum disorders (ASDs) compared to typically developing peers. We found connectivity to be intact between core language in the ASD group, but also showed abnormally increased connectivity between regions of an extended language network. Additionally, connectivity was increased with regions associated with brain networks responsible for self-reflection and visual processing. En ligne : http://dx.doi.org/10.1002/aur.2171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

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