Parent-mediated intervention tends to improve parent-child engagement, and behavioral outcomes of toddlers with ASD-positive screening: A randomized crossover trial / Audrée Jeanne BEAUDOIN in Research in Autism Spectrum Disorders, 66 (October 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 66 (October 2019) . - p.101416 Titre : Parent-mediated intervention tends to improve parent-child engagement, and behavioral outcomes of toddlers with ASD-positive screening: A randomized crossover trial Type de document : Texte imprimé et/ou numérique Auteurs : Audrée Jeanne BEAUDOIN, Auteur ; Guillaume SEBIRE, Auteur ; Mélanie COUTURE, Auteur Article en page(s) : p.101416 Langues : Anglais (eng) Mots-clés : Parent coaching  Caregiver  Parent-child interaction  Infant  Early intervention Index. décimale : PER Périodiques Résumé : Background By participating in parent-mediated interventions, parents develop skills to promote their toddler’s development. Knowing that the potential mediating role of a parent’s behavior has been poorly assessed, our objective was to measure the effects of a parent-mediated intervention on the developmental outcome of toddlers (12–30 months) at risk for autism spectrum disorder (ASD), and on parent-child interactions. Methods Randomized crossover trial using a 12-week parent-mediated intervention (adapted from the parent delivery of the Early Start Denver Model and the Social Communication Emotion Regulation Transaction Support) and measuring its impact on parent-child dyadic engagement and child development. Results The intervention resulted in improved toddlers’ motor skills (p?=?.005; ES?=?.60) and a trend toward improvement in social adaptive behaviors (p?=?.053; ES?=?.45) compared to the Waitlist group. There was also a trend toward improved parent-child engagement during the Intervention (p?=?.010; ES?=?.77), that did not significantly differ from the change in the Waitlist group (p?=?.221). Conclusions This study highlights potential benefits in motor and social skills for children at risk of ASD, as well as in parent-child engagement. En ligne : https://doi.org/10.1016/j.rasd.2019.101416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Parent-mediated intervention tends to improve parent-child engagement, and behavioral outcomes of toddlers with ASD-positive screening: A randomized crossover trial [Texte imprimé et/ou numérique] / Audrée Jeanne BEAUDOIN, Auteur ; Guillaume SEBIRE, Auteur ; Mélanie COUTURE, Auteur . - p.101416. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 66 (October 2019) . - p.101416 Mots-clés : Parent coaching  Caregiver  Parent-child interaction  Infant  Early intervention Index. décimale : PER Périodiques Résumé : Background By participating in parent-mediated interventions, parents develop skills to promote their toddler’s development. Knowing that the potential mediating role of a parent’s behavior has been poorly assessed, our objective was to measure the effects of a parent-mediated intervention on the developmental outcome of toddlers (12–30 months) at risk for autism spectrum disorder (ASD), and on parent-child interactions. Methods Randomized crossover trial using a 12-week parent-mediated intervention (adapted from the parent delivery of the Early Start Denver Model and the Social Communication Emotion Regulation Transaction Support) and measuring its impact on parent-child dyadic engagement and child development. Results The intervention resulted in improved toddlers’ motor skills (p?=?.005; ES?=?.60) and a trend toward improvement in social adaptive behaviors (p?=?.053; ES?=?.45) compared to the Waitlist group. There was also a trend toward improved parent-child engagement during the Intervention (p?=?.010; ES?=?.77), that did not significantly differ from the change in the Waitlist group (p?=?.221). Conclusions This study highlights potential benefits in motor and social skills for children at risk of ASD, as well as in parent-child engagement. En ligne : https://doi.org/10.1016/j.rasd.2019.101416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation / Marie-Julie ALLARD in Autism Research, 10-2 (February 2017)  

Public ISBD [article]  inAutism Research > 10-2 (February 2017) . - p.233-245 Titre : A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation Type de document : Texte imprimé et/ou numérique Auteurs : Marie-Julie ALLARD, Auteur ; Julie D. BERGERON, Auteur ; Moogeh BAHARNOORI, Auteur ; Lalit K. SRIVASTAVA, Auteur ; Louis-Charles FORTIER, Auteur ; Claire POYART, Auteur ; Guillaume SEBIRE, Auteur Article en page(s) : p.233-245 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  behavior  chorioamnionitis  Group B Streptococcus  inflammation  prenatal infection Index. décimale : PER Périodiques Résumé : Group B Streptococcus (GBS) is a commensal bacterium present in the lower genital tract of 15–30% of healthy pregnant women. GBS is the leading cause of chorioamnionitis and cerebral injuries in newborns, occurring most often in the absence of maternofetal pathogen translocation. Despite GBS being the most frequent bacterium colonizing pregnant women, no preclinical studies have investigated the impact of end-gestational maternal GBS exposure on the offspring's brain development and its behavioral correlates. Our hypothesis is that GBS-induced gestational infection/inflammation has a deleterious neurodevelopmental impact on uninfected offspring. Our goal was to study the impact of maternal GBS infection on the placental and neurodevelopmental features in the offspring using a new preclinical rat model. GBS-exposed placentas exhibited chorioamnionitis characterized by the presence of Gram-positive cocci and polymorphonuclear cells, with the latter being significantly more prominent in the labyrinth of male offspring. GBS-exposed male offspring had reduced thickness of periventricular white matter. In addition, they exhibited autistic-like behaviors, such as abnormal social interaction and communication, impaired processing of sensory information and hyperactivity. Overall, these data show for the first time that gestational exposure to GBS plays an important role in the generation of neurodevelopmental abnormalities reminiscent of human autism spectrum disorders (ASD). These results provide new evidence in favor of the role of a common and modifiable infectious/inflammatory environmental factor in human ASD pathophysiology. En ligne : http://dx.doi.org/10.1002/aur.1647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation [Texte imprimé et/ou numérique] / Marie-Julie ALLARD, Auteur ; Julie D. BERGERON, Auteur ; Moogeh BAHARNOORI, Auteur ; Lalit K. SRIVASTAVA, Auteur ; Louis-Charles FORTIER, Auteur ; Claire POYART, Auteur ; Guillaume SEBIRE, Auteur . - p.233-245. Langues : Anglais (eng) in Autism Research > 10-2 (February 2017) . - p.233-245 Mots-clés : autism spectrum disorders  behavior  chorioamnionitis  Group B Streptococcus  inflammation  prenatal infection Index. décimale : PER Périodiques Résumé : Group B Streptococcus (GBS) is a commensal bacterium present in the lower genital tract of 15–30% of healthy pregnant women. GBS is the leading cause of chorioamnionitis and cerebral injuries in newborns, occurring most often in the absence of maternofetal pathogen translocation. Despite GBS being the most frequent bacterium colonizing pregnant women, no preclinical studies have investigated the impact of end-gestational maternal GBS exposure on the offspring's brain development and its behavioral correlates. Our hypothesis is that GBS-induced gestational infection/inflammation has a deleterious neurodevelopmental impact on uninfected offspring. Our goal was to study the impact of maternal GBS infection on the placental and neurodevelopmental features in the offspring using a new preclinical rat model. GBS-exposed placentas exhibited chorioamnionitis characterized by the presence of Gram-positive cocci and polymorphonuclear cells, with the latter being significantly more prominent in the labyrinth of male offspring. GBS-exposed male offspring had reduced thickness of periventricular white matter. In addition, they exhibited autistic-like behaviors, such as abnormal social interaction and communication, impaired processing of sensory information and hyperactivity. Overall, these data show for the first time that gestational exposure to GBS plays an important role in the generation of neurodevelopmental abnormalities reminiscent of human autism spectrum disorders (ASD). These results provide new evidence in favor of the role of a common and modifiable infectious/inflammatory environmental factor in human ASD pathophysiology. En ligne : http://dx.doi.org/10.1002/aur.1647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

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