Infant muscle tone and childhood autistic traits: A longitudinal study in the general population / Fadila SERDAREVIC in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.757-768 Titre : Infant muscle tone and childhood autistic traits: A longitudinal study in the general population Type de document : texte imprimé Auteurs : Fadila SERDAREVIC, Auteur ; Akhgar GHASSABIAN, Auteur ; Tamara VAN BATENBURG-EDDES, Auteur ; Tonya WHITE, Auteur ; Laura M.E. BLANKEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.757-768 Langues : Anglais (eng) Mots-clés : infant muscle tone  autistic traits  autism spectrum disorder  prospective Index. décimale : PER Périodiques Résumé : In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years. We defined clinical PDP if scores were >98th percentile of the norm population. Diagnosis of autism spectrum disorder (ASD) was clinically confirmed in 30 children. We observed a modest association between overall neuromotor development in infants and autistic traits. Low muscle tone in infancy predicted autistic traits measured by SRS (adjusted beta = 0.05, 95% CI for B: 0.00–0.02, P = 0.01), and PDP (adjusted beta = 0.08, 95% CI for B: 0.04–0.10, P < 0.001). Similar results emerged for the association of low muscle tone and clinical PDP (adjusted OR = 1.36, 95% CI: 1.08–1.72, P = 0.01) at age 6 years. Results remained unchanged if adjusted for child intelligence. There was no association between high muscle tone and SRS or PDP. Exclusion of children with ASD diagnosis did not change the association. This large study showed a prospective association of infant muscle tone with autistic traits in childhood. Our findings suggest that early detection of low muscle tone might be a gateway to improve early diagnosis of ASD. En ligne : http://dx.doi.org/10.1002/aur.1739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Infant muscle tone and childhood autistic traits: A longitudinal study in the general population [texte imprimé] / Fadila SERDAREVIC, Auteur ; Akhgar GHASSABIAN, Auteur ; Tamara VAN BATENBURG-EDDES, Auteur ; Tonya WHITE, Auteur ; Laura M.E. BLANKEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur . - p.757-768. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.757-768 Mots-clés : infant muscle tone  autistic traits  autism spectrum disorder  prospective Index. décimale : PER Périodiques Résumé : In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years. We defined clinical PDP if scores were >98th percentile of the norm population. Diagnosis of autism spectrum disorder (ASD) was clinically confirmed in 30 children. We observed a modest association between overall neuromotor development in infants and autistic traits. Low muscle tone in infancy predicted autistic traits measured by SRS (adjusted beta = 0.05, 95% CI for B: 0.00–0.02, P = 0.01), and PDP (adjusted beta = 0.08, 95% CI for B: 0.04–0.10, P < 0.001). Similar results emerged for the association of low muscle tone and clinical PDP (adjusted OR = 1.36, 95% CI: 1.08–1.72, P = 0.01) at age 6 years. Results remained unchanged if adjusted for child intelligence. There was no association between high muscle tone and SRS or PDP. Exclusion of children with ASD diagnosis did not change the association. This large study showed a prospective association of infant muscle tone with autistic traits in childhood. Our findings suggest that early detection of low muscle tone might be a gateway to improve early diagnosis of ASD. En ligne : http://dx.doi.org/10.1002/aur.1739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study / Tamara VAN BATENBURG-EDDES in Journal of Child Psychology and Psychiatry, 54-5 (May 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.591-600 Titre : Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study Type de document : texte imprimé Auteurs : Tamara VAN BATENBURG-EDDES, Auteur ; M.J. BRION, Auteur ; Jens HENRICHS, Auteur ; Vincent W.V. JADDOE, Auteur ; A. HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Deborah LAWLOR, Auteur ; George DAVEY SMITH, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.591-600 Langues : Anglais (eng) Mots-clés : Parental depression or anxiety  child attention problems  cohort studies  intrauterine effect Index. décimale : PER Périodiques Résumé : Background: Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim: We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods: This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results: In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions: The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association. En ligne : http://dx.doi.org/10.1111/jcpp.12023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196 [article] Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study [texte imprimé] / Tamara VAN BATENBURG-EDDES, Auteur ; M.J. BRION, Auteur ; Jens HENRICHS, Auteur ; Vincent W.V. JADDOE, Auteur ; A. HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Deborah LAWLOR, Auteur ; George DAVEY SMITH, Auteur ; Henning TIEMEIER, Auteur . - p.591-600. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-5 (May 2013) . - p.591-600 Mots-clés : Parental depression or anxiety  child attention problems  cohort studies  intrauterine effect Index. décimale : PER Périodiques Résumé : Background: Maternal depression and anxiety during pregnancy have been associated with offspring-attention deficit problems. Aim: We explored possible intrauterine effects by comparing maternal and paternal symptoms during pregnancy, by investigating cross-cohort consistency, and by investigating whether parental symptoms in early childhood may explain any observed intrauterine effect. Methods: This study was conducted in two cohorts (Generation R, n = 2,280 and ALSPAC, n = 3,442). Pregnant women and their partners completed questionnaires to assess symptoms of depression and anxiety. Child attention problems were measured in Generation R at age 3 with the Child Behavior Checklist, and in ALSPAC at age 4 with the Strengths and Difficulties Questionnaire. Results: In both cohorts, antenatal maternal symptoms of depression (Generation R: OR 1.23, 95% CI 1.05–1.43; ALSPAC: OR 1.33, 95% CI 1.19–1.48) and anxiety (Generation R: OR 1.24, 95% CI 1.06–1.46; ALSPAC: OR 1.32, 95% CI 1.19–1.47) were associated with a higher risk of child attention problems. In ALSPAC, paternal depression was also associated with a higher risk of child attention problems (OR 1.11, 95% CI 1.00–1.24). After adjusting for maternal symptoms after giving birth, antenatal maternal depression and anxiety were no longer associated with child attention problems in Generation R. Moreover, there was little statistical evidence that antenatal maternal and paternal depression and anxiety had a substantially different effect on attention problems of the child. Conclusions: The apparent intrauterine effect of maternal depression and anxiety on offspring-behavioural problems may be partly explained by residual confounding. There was little evidence of a difference between the strength of associations of maternal and paternal symptoms during pregnancy with offspring-attention problems. That maternal symptoms after childbirth were also associated with offspring-behavioural problems may indicate a contribution of genetic influences to the association. En ligne : http://dx.doi.org/10.1111/jcpp.12023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=196

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