Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder / Chen CHEN in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1155-1162 Titre : Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder Type de document : texte imprimé Auteurs : Chen CHEN, Auteur ; Yi-Dong SHEN, Auteur ; Guang-Lei XUN, Auteur ; Wei-Xiong CAI, Auteur ; Li-Juan SHI, Auteur ; Lu XIAO, Auteur ; Ren-Rong WU, Auteur ; Jing-Ping ZHAO, Auteur ; Jian-Jun OU, Auteur Article en page(s) : p.1155-1162 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  aggressive behaviors  treatable risk factors  sleep problems  ADHD symptoms Index. décimale : PER Périodiques Résumé : Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research – Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P = 0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P < 0.01), while the ASD group had higher scores on Physical Aggression Against Self (P = 0.006). The linear regression model demonstrated that the aggressive behaviors of children with ASD were significantly associated with two treatable factors: sleep problems and ADHD symptoms. These findings have substantial clinical implications: treatment of these two risk factors may be helpful in managing aggressive behavior in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1751 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder [texte imprimé] / Chen CHEN, Auteur ; Yi-Dong SHEN, Auteur ; Guang-Lei XUN, Auteur ; Wei-Xiong CAI, Auteur ; Li-Juan SHI, Auteur ; Lu XIAO, Auteur ; Ren-Rong WU, Auteur ; Jing-Ping ZHAO, Auteur ; Jian-Jun OU, Auteur . - p.1155-1162. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1155-1162 Mots-clés : autism spectrum disorder  aggressive behaviors  treatable risk factors  sleep problems  ADHD symptoms Index. décimale : PER Périodiques Résumé : Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research – Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P = 0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P < 0.01), while the ASD group had higher scores on Physical Aggression Against Self (P = 0.006). The linear regression model demonstrated that the aggressive behaviors of children with ASD were significantly associated with two treatable factors: sleep problems and ADHD symptoms. These findings have substantial clinical implications: treatment of these two risk factors may be helpful in managing aggressive behavior in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1751 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder / Jiang ZHU in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128 Titre : Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.3116-3128 Langues : Anglais (eng) Mots-clés : Amino Acids/metabolism  Autism Spectrum Disorder/diagnosis  Child  Humans  Intestines  Metabolome  Metabolomics/methods  Vitamins  Autism  Children  Metabolism  Metabolomics  Symptoms  Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder [texte imprimé] / Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur . - p.3116-3128. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128 Mots-clés : Amino Acids/metabolism  Autism Spectrum Disorder/diagnosis  Child  Humans  Intestines  Metabolome  Metabolomics/methods  Vitamins  Autism  Children  Metabolism  Metabolomics  Symptoms  Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

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