Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study / Magdalena SCHÃœTZ in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1431-1443 Titre : Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study Type de document : texte imprimé Auteurs : Magdalena SCHÃœTZ, Auteur ; Sara BOXHOORN, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Hannah MÖSSINGER, Auteur ; Christine M. FREITAG, Auteur ; Christina LUCKHARDT, Auteur Article en page(s) : p.1431-1443 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The ability to infer intentions from observed behavior and predict actions based on this inference, known as intention attribution (IA), has been hypothesized to be impaired in individuals with autism spectrum disorder (ASD). The underlying neural processes, however, have not been conclusively determined. The aim of this study was to examine the neural signature of IA in children and adolescents with ASD, and to elucidate potential links to contextual updating processes using electroencephalography. Results did not indicate that IA or early contextual updating was impaired in ASD. However, there was evidence of aberrant processing of expectation violations in ASD, particularly if the expectation was based on IA. Results are discussed within the context of impaired predictive coding in ASD. En ligne : https://doi.org/10.1007/s10803-021-05358-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study [texte imprimé] / Magdalena SCHÃœTZ, Auteur ; Sara BOXHOORN, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Hannah MÖSSINGER, Auteur ; Christine M. FREITAG, Auteur ; Christina LUCKHARDT, Auteur . - p.1431-1443. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1431-1443 Index. décimale : PER Périodiques Résumé : The ability to infer intentions from observed behavior and predict actions based on this inference, known as intention attribution (IA), has been hypothesized to be impaired in individuals with autism spectrum disorder (ASD). The underlying neural processes, however, have not been conclusively determined. The aim of this study was to examine the neural signature of IA in children and adolescents with ASD, and to elucidate potential links to contextual updating processes using electroencephalography. Results did not indicate that IA or early contextual updating was impaired in ASD. However, there was evidence of aberrant processing of expectation violations in ASD, particularly if the expectation was based on IA. Results are discussed within the context of impaired predictive coding in ASD. En ligne : https://doi.org/10.1007/s10803-021-05358-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study / Nico BAST in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 41 Titre : Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study Type de document : texte imprimé Auteurs : Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J H JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Grainne M MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J H JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Grainne M MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : 41 Langues : Anglais (eng) Mots-clés : Humans  Male  Electroencephalography/methods  Female  Autistic Disorder/physiopathology  Adult  Locus Coeruleus/physiopathology/metabolism  Young Adult  Pupil/physiology  Auditory Perception  Adolescent  Acoustic Stimulation  Up-Regulation  Case-Control Studies  Arousal  Auditory oddball paradigm  Autism spectrum condition  Mismatch negativity  Predictive coding  Pupillometry  (where appropriate) and their parent/legal guardian provided written informed  consent. Ethical approval for this study was obtained through ethics committees  at each site (King’s College London—London Queen Square Health Research Authority  Research Ethics Committee: 13/LO/1156  Autism Research Centre, University of  Cambridge—London Queen Square Health Research Authority Research Ethics  Committee: 13/LO/1156  Radboud University Medical Centre—Quality and Safety  Committee on Research Involving Human Subjects Arnhem-Nijmegen: 2013/455,  University Medical Centre Utrecht—- Quality and Safety Committee on Research  Involving Human Subjects Arnhem-Nijmegen: 2013/455  Central Insitute of Mental  Health—University Medical Mannheim, Medical Ethics Commission II: 2014-540N-MA  Universita Campus Bio-Medica De Roma—Medical Ethics Committee: 18/14 PAR ComET  CBM  Karolinska Intitute – Central Ethical Review Board: 32–2010). Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing requires selectivity to salient sensory input. Many autistic individuals report different sensory processing, which has been associated with altered sensory selectivity. The locus-coeruleus norepinephrine (LC-NE) system modulates the neuronal gain of sensory input, which represents a neurophysiological mechanism of sensory selectivity. In autistic individuals, we hypothesized that LC-NE tonic upregulation reduces sensory selectivity and underlies different sensory processing. METHODS: Autistic (n = 139) and non-autistic (n = 98) individuals were assessed during a passive auditory oddball task with pupillometry and electroencephalography. For every trial, a baseline pupil size (BPS) assessed LC-NE tonic activity that coincides with current arousal, while a stimulus-evoked pupillary response (SEPR) assessed LC-NE phasic activity that estimated sensory selectivity. Electroencephalography assessed amplitudes of mismatch negativity (MMN-amp) that estimated pre-attentive change detection as a brain-activity readout of sensory selectivity. Measures were modeled between groups within the task by combining Frequentist and Bayesian approaches. RESULTS: Across groups, higher BPS was associated with more negative MMN-amp to standards and oddballs. A more negative MMN-amp to standards was associated with a higher SEPR to standards. Controlling for these associations, autistic versus non-autistic individuals showed a higher SEPR in response to standards. In addition, a positive association of BPS and SEPR to standards was specific to autistic individuals. With task progression, autistic versus non-autistic individuals showed a higher initial increase and subsequently steeper decrease of BPS. This was supported by Bayesian posterior distribution estimates. LIMITATIONS: A short trial duration required concatenating trials to epochs and applying a linear-time invariant filter to capture the slow pupil changes. Without an LC-NE manipulation, we cannot rule out that pupil changes are evoked by other cortical pathways than the LC-NE. CONCLUSIONS: Across groups, LC-NE tonic upregulation is emphasized as a general mechanism that un-specifically increases pre-attentive change detection to all sensory stimuli, which then increases sensory selectivity to frequent stimuli. In autistic individuals, different sensory processing is characterized by increased sensory selectivity to frequent stimuli. This is likely caused by an LC-NE tonic upregulation. It associates autistic sensory processing with increased arousal upregulation that increases sensory selectivity to inconspicuous auditory information. En ligne : https://dx.doi.org/10.1186/s13229-025-00678-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study [texte imprimé] / Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J H JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Grainne M MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur ; Jumana AHMAD, Auteur ; Luke MASON, Auteur ; Emily J H JONES, Auteur ; Magdalena MATYJEK, Auteur ; Leonie POLZER, Auteur ; Christina LUCKHARDT, Auteur ; Anna Katharina MÃœLLER, Auteur ; Grainne M MCALONAN, Auteur ; Tobias BANASCHEWSKI, Auteur ; Sarah BAUMEISTER, Auteur ; Eva LOTH, Auteur ; Christine M. FREITAG, Auteur . - 41. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 41 Mots-clés : Humans  Male  Electroencephalography/methods  Female  Autistic Disorder/physiopathology  Adult  Locus Coeruleus/physiopathology/metabolism  Young Adult  Pupil/physiology  Auditory Perception  Adolescent  Acoustic Stimulation  Up-Regulation  Case-Control Studies  Arousal  Auditory oddball paradigm  Autism spectrum condition  Mismatch negativity  Predictive coding  Pupillometry  (where appropriate) and their parent/legal guardian provided written informed  consent. Ethical approval for this study was obtained through ethics committees  at each site (King’s College London—London Queen Square Health Research Authority  Research Ethics Committee: 13/LO/1156  Autism Research Centre, University of  Cambridge—London Queen Square Health Research Authority Research Ethics  Committee: 13/LO/1156  Radboud University Medical Centre—Quality and Safety  Committee on Research Involving Human Subjects Arnhem-Nijmegen: 2013/455,  University Medical Centre Utrecht—- Quality and Safety Committee on Research  Involving Human Subjects Arnhem-Nijmegen: 2013/455  Central Insitute of Mental  Health—University Medical Mannheim, Medical Ethics Commission II: 2014-540N-MA  Universita Campus Bio-Medica De Roma—Medical Ethics Committee: 18/14 PAR ComET  CBM  Karolinska Intitute – Central Ethical Review Board: 32–2010). Consent for  publication: Not applicable. Competing interests: The authors declare no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing requires selectivity to salient sensory input. Many autistic individuals report different sensory processing, which has been associated with altered sensory selectivity. The locus-coeruleus norepinephrine (LC-NE) system modulates the neuronal gain of sensory input, which represents a neurophysiological mechanism of sensory selectivity. In autistic individuals, we hypothesized that LC-NE tonic upregulation reduces sensory selectivity and underlies different sensory processing. METHODS: Autistic (n = 139) and non-autistic (n = 98) individuals were assessed during a passive auditory oddball task with pupillometry and electroencephalography. For every trial, a baseline pupil size (BPS) assessed LC-NE tonic activity that coincides with current arousal, while a stimulus-evoked pupillary response (SEPR) assessed LC-NE phasic activity that estimated sensory selectivity. Electroencephalography assessed amplitudes of mismatch negativity (MMN-amp) that estimated pre-attentive change detection as a brain-activity readout of sensory selectivity. Measures were modeled between groups within the task by combining Frequentist and Bayesian approaches. RESULTS: Across groups, higher BPS was associated with more negative MMN-amp to standards and oddballs. A more negative MMN-amp to standards was associated with a higher SEPR to standards. Controlling for these associations, autistic versus non-autistic individuals showed a higher SEPR in response to standards. In addition, a positive association of BPS and SEPR to standards was specific to autistic individuals. With task progression, autistic versus non-autistic individuals showed a higher initial increase and subsequently steeper decrease of BPS. This was supported by Bayesian posterior distribution estimates. LIMITATIONS: A short trial duration required concatenating trials to epochs and applying a linear-time invariant filter to capture the slow pupil changes. Without an LC-NE manipulation, we cannot rule out that pupil changes are evoked by other cortical pathways than the LC-NE. CONCLUSIONS: Across groups, LC-NE tonic upregulation is emphasized as a general mechanism that un-specifically increases pre-attentive change detection to all sensory stimuli, which then increases sensory selectivity to frequent stimuli. In autistic individuals, different sensory processing is characterized by increased sensory selectivity to frequent stimuli. This is likely caused by an LC-NE tonic upregulation. It associates autistic sensory processing with increased arousal upregulation that increases sensory selectivity to inconspicuous auditory information. En ligne : https://dx.doi.org/10.1186/s13229-025-00678-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD / Christina LUCKHARDT in Journal of Autism and Developmental Disorders, 47-7 (July 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.1944-1955 Titre : Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD Type de document : texte imprimé Auteurs : Christina LUCKHARDT, Auteur ; Anne KRÖGER, Auteur ; Hannah CHOLEMKERY, Auteur ; Stephan BENDER, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : p.1944-1955 Langues : Anglais (eng) Mots-clés : ERP  Facial emotion recognition  Intentional processing  Autism  ASD Index. décimale : PER Périodiques Résumé : The underlying neural mechanisms of implicit and explicit facial emotion recognition (FER) were studied in children and adolescents with autism spectrum disorder (ASD) compared to matched typically developing controls (TDC). EEG was obtained from N = 21 ASD and N = 16 TDC. Task performance, visual (P100, N170) and cognitive (late positive potential) event-related-potentials, as well as coherence were compared across groups. TDC showed a task-dependent increase and a stronger lateralization of P100 amplitude during the explicit task and task-dependent modulation of intra-hemispheric coherence in the beta band. In contrast, the ASD group showed no task dependent modulation. Results indicate disruptions in early visual processing and top-down attentional processes as contributing factors to FER deficits in ASD. En ligne : https://doi.org/10.1007/s10803-017-3141-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313 [article] Neural Correlates of Explicit Versus Implicit Facial Emotion Processing in ASD [texte imprimé] / Christina LUCKHARDT, Auteur ; Anne KRÖGER, Auteur ; Hannah CHOLEMKERY, Auteur ; Stephan BENDER, Auteur ; Christine M. FREITAG, Auteur . - p.1944-1955. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-7 (July 2017) . - p.1944-1955 Mots-clés : ERP  Facial emotion recognition  Intentional processing  Autism  ASD Index. décimale : PER Périodiques Résumé : The underlying neural mechanisms of implicit and explicit facial emotion recognition (FER) were studied in children and adolescents with autism spectrum disorder (ASD) compared to matched typically developing controls (TDC). EEG was obtained from N = 21 ASD and N = 16 TDC. Task performance, visual (P100, N170) and cognitive (late positive potential) event-related-potentials, as well as coherence were compared across groups. TDC showed a task-dependent increase and a stronger lateralization of P100 amplitude during the explicit task and task-dependent modulation of intra-hemispheric coherence in the beta band. In contrast, the ASD group showed no task dependent modulation. Results indicate disruptions in early visual processing and top-down attentional processes as contributing factors to FER deficits in ASD. En ligne : https://doi.org/10.1007/s10803-017-3141-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=313

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study / Christina LUCKHARDT in Autism Research, 18-9 (September 2025)  

Public ISBD [article]  inAutism Research > 18-9 (September 2025) . - p.1861-1876 Titre : Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study Type de document : texte imprimé Auteurs : Christina LUCKHARDT, Auteur ; Magdalena SCHÃœTZ, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Sara BOXHOORN, Auteur ; Christine ECKER, Auteur ; Hanna MÖSSINGER, Auteur ; Julia SIEMANN, Auteur ; Fabienne SCHLECHTER, Auteur ; Miguel CASTELO-BRANCO, Auteur ; Helena C. PEREIRA, Auteur ; Marianne LATINUS, Auteur ; Camille RICOU, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo SALVADOR, Auteur ; Giulio RUFFINI, Auteur ; Rafal NOWAK, Auteur ; Michael SINIATCHKIN, Auteur ; Astrid DEMPFLE, Auteur ; Christine M. FREITAG, Auteur ; Magdalena SCHÃœTZ, Auteur Article en page(s) : p.1861-1876 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N=12) or sham (N=12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]=0.098; 95%-confidence interval [95% CI] 1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES=1.106; 95% CI 0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732). En ligne : https://doi.org/10.1002/aur.70084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study [texte imprimé] / Christina LUCKHARDT, Auteur ; Magdalena SCHÃœTZ, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Sara BOXHOORN, Auteur ; Christine ECKER, Auteur ; Hanna MÖSSINGER, Auteur ; Julia SIEMANN, Auteur ; Fabienne SCHLECHTER, Auteur ; Miguel CASTELO-BRANCO, Auteur ; Helena C. PEREIRA, Auteur ; Marianne LATINUS, Auteur ; Camille RICOU, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo SALVADOR, Auteur ; Giulio RUFFINI, Auteur ; Rafal NOWAK, Auteur ; Michael SINIATCHKIN, Auteur ; Astrid DEMPFLE, Auteur ; Christine M. FREITAG, Auteur ; Magdalena SCHÃœTZ, Auteur . - p.1861-1876. Langues : Anglais (eng) in Autism Research > 18-9 (September 2025) . - p.1861-1876 Index. décimale : PER Périodiques Résumé : ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N=12) or sham (N=12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]=0.098; 95%-confidence interval [95% CI] 1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES=1.106; 95% CI 0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732). En ligne : https://doi.org/10.1002/aur.70084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

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