[article] 
inAutism > 24-2 (February 2020) . - p.364-373

Titre :	Psychosocial deficits across autism and schizotypal spectra are interactively modulated by excitatory and inhibitory neurotransmission
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Talitha C. FORD, Auteur ; David P. CREWTHER, Auteur ; Ahmad ABU-AKEL, Auteur
Article en page(s) :	p.364-373
Langues :	Anglais (eng)
Mots-clés :	Gaba  autism  glutamate  magnetic resonance spectroscopy  schizophrenia  social behavior  social cognition
Index. décimale :	PER Périodiques
Résumé :	Continued human and animal research has strengthened evidence for aberrant excitatory-inhibitory neural processes underlying autism and schizophrenia spectrum disorder psychopathology, particularly psychosocial functioning, in clinical and nonclinical populations. We investigated the extent to which autistic traits and schizotypal dimensions were modulated by the interactive relationship between excitatory glutamate and inhibitory GABA neurotransmitter concentrations in the social processing area of the superior temporal cortex using proton magnetic resonance spectroscopy. In total, 38 non-clinical participants (20 females; age range = 18-35 years, mean (standard deviation) = 23.22 (5.52)) completed the autism spectrum quotient and schizotypal personality questionnaire, and underwent proton magnetic resonance spectroscopy to quantify glutamate and GABA concentrations in the right and left superior temporal cortex. Regression analyses revealed that glutamate and GABA interactively modulated autistic social skills and schizotypal interpersonal features (pcorr < 0.05), such that those with high right superior temporal cortex glutamate but low GABA concentrations exhibited poorer social and interpersonal skills. These findings evidence an excitation-inhibition imbalance that is specific to psychosocial features across the autism and schizophrenia spectra.
En ligne :	http://dx.doi.org/10.1177/1362361319866030
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

[article] Psychosocial deficits across autism and schizotypal spectra are interactively modulated by excitatory and inhibitory neurotransmission [Texte imprimé et/ou numérique] / Talitha C. FORD, Auteur ; David P. CREWTHER, Auteur ; Ahmad ABU-AKEL, Auteur . - p.364-373.
Langues : Anglais (eng)
in Autism > 24-2 (February 2020) . - p.364-373

Mots-clés :	Gaba  autism  glutamate  magnetic resonance spectroscopy  schizophrenia  social behavior  social cognition
Index. décimale :	PER Périodiques
Résumé :	Continued human and animal research has strengthened evidence for aberrant excitatory-inhibitory neural processes underlying autism and schizophrenia spectrum disorder psychopathology, particularly psychosocial functioning, in clinical and nonclinical populations. We investigated the extent to which autistic traits and schizotypal dimensions were modulated by the interactive relationship between excitatory glutamate and inhibitory GABA neurotransmitter concentrations in the social processing area of the superior temporal cortex using proton magnetic resonance spectroscopy. In total, 38 non-clinical participants (20 females; age range = 18-35 years, mean (standard deviation) = 23.22 (5.52)) completed the autism spectrum quotient and schizotypal personality questionnaire, and underwent proton magnetic resonance spectroscopy to quantify glutamate and GABA concentrations in the right and left superior temporal cortex. Regression analyses revealed that glutamate and GABA interactively modulated autistic social skills and schizotypal interpersonal features (pcorr < 0.05), such that those with high right superior temporal cortex glutamate but low GABA concentrations exhibited poorer social and interpersonal skills. These findings evidence an excitation-inhibition imbalance that is specific to psychosocial features across the autism and schizophrenia spectra.
En ligne :	http://dx.doi.org/10.1177/1362361319866030
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415