Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators / Josiane BOURQUE in Journal of Child Psychology and Psychiatry, 58-12 (December 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1360-1369 Titre : Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators Type de document : Texte imprimé et/ou numérique Auteurs : Josiane BOURQUE, Auteur ; Mohammad H. AFZALI, Auteur ; Maeve O'LEARY-BARRETT, Auteur ; Patricia CONROD, Auteur Article en page(s) : p.1360-1369 Langues : Anglais (eng) Mots-clés : Psychotic-like experiences  trajectory  cannabis use  mediation  depression symptoms  anxiety symptoms  cognitive function Index. décimale : PER Périodiques Résumé : Background The authors sought to model the different trajectories of psychotic-like experiences (PLE) during adolescence and to examine whether the longitudinal relationship between cannabis use and PLE is mediated by changes in cognitive development and/or change in anxiety or depression symptoms. Methods A total of 2,566 youths were assessed every year for 4-years (from 13- to 16-years of age) on clinical, substance use and cognitive development outcomes. Latent class growth models identified three trajectories of PLE: low decreasing (83.9%), high decreasing (7.9%), and moderate increasing class (8.2%). We conducted logistic regressions to investigate whether baseline levels and growth in cannabis use were associated with PLE trajectory membership. Then, we examined the effects of potential mediators (growth in cognition and anxiety/depression) on the relationship between growth in cannabis use and PLE trajectory. Results A steeper growth in cannabis use from 13- to 16-years was associated with a higher likelihood of being assigned to the moderate increasing trajectory of PLE [odds ratio, 2.59; 95% confidence interval (CI), 1.11–6.03], when controlling for cumulative cigarette use. Growth in depression symptoms, not anxiety or change in cognitive functioning, mediated the relationship between growth in cannabis use and the PLE moderate increasing group (indirect effect: 0.07; 95% CI, 0.03–0.11). Conclusions Depression symptoms partially mediated the longitudinal link between cannabis use and PLE in adolescents, suggesting that there may be a preventative effect to be gained from targeting depression symptoms, in addition to attempting to prevent cannabis use in youth presenting increasing psychotic experiences. En ligne : http://dx.doi.org/10.1111/jcpp.12765 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators [Texte imprimé et/ou numérique] / Josiane BOURQUE, Auteur ; Mohammad H. AFZALI, Auteur ; Maeve O'LEARY-BARRETT, Auteur ; Patricia CONROD, Auteur . - p.1360-1369. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-12 (December 2017) . - p.1360-1369 Mots-clés : Psychotic-like experiences  trajectory  cannabis use  mediation  depression symptoms  anxiety symptoms  cognitive function Index. décimale : PER Périodiques Résumé : Background The authors sought to model the different trajectories of psychotic-like experiences (PLE) during adolescence and to examine whether the longitudinal relationship between cannabis use and PLE is mediated by changes in cognitive development and/or change in anxiety or depression symptoms. Methods A total of 2,566 youths were assessed every year for 4-years (from 13- to 16-years of age) on clinical, substance use and cognitive development outcomes. Latent class growth models identified three trajectories of PLE: low decreasing (83.9%), high decreasing (7.9%), and moderate increasing class (8.2%). We conducted logistic regressions to investigate whether baseline levels and growth in cannabis use were associated with PLE trajectory membership. Then, we examined the effects of potential mediators (growth in cognition and anxiety/depression) on the relationship between growth in cannabis use and PLE trajectory. Results A steeper growth in cannabis use from 13- to 16-years was associated with a higher likelihood of being assigned to the moderate increasing trajectory of PLE [odds ratio, 2.59; 95% confidence interval (CI), 1.11–6.03], when controlling for cumulative cigarette use. Growth in depression symptoms, not anxiety or change in cognitive functioning, mediated the relationship between growth in cannabis use and the PLE moderate increasing group (indirect effect: 0.07; 95% CI, 0.03–0.11). Conclusions Depression symptoms partially mediated the longitudinal link between cannabis use and PLE in adolescents, suggesting that there may be a preventative effect to be gained from targeting depression symptoms, in addition to attempting to prevent cannabis use in youth presenting increasing psychotic experiences. En ligne : http://dx.doi.org/10.1111/jcpp.12765 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences / Roxane ASSAF in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1495-1504 Titre : Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences Type de document : Texte imprimé et/ou numérique Auteurs : Roxane ASSAF, Auteur ; Julien OUELLET, Auteur ; Josiane BOURQUE, Auteur ; Emmanuel STIP, Auteur ; Marco LEYTON, Auteur ; Patricia CONROD, Auteur ; Stéphane POTVIN, Auteur Article en page(s) : p.1495-1504 Langues : Anglais (eng) Mots-clés : neuroimaging  psychosis risk  psychotic experiences  resting state Index. décimale : PER Périodiques Résumé : Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth (n = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders. En ligne : https://www.cambridge.org/core/product/19434E0667E840EA40DBE5932D1F3E54 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Resting-state alterations in emotion salience and default-mode network connectivity in atypical trajectories of psychotic-like experiences [Texte imprimé et/ou numérique] / Roxane ASSAF, Auteur ; Julien OUELLET, Auteur ; Josiane BOURQUE, Auteur ; Emmanuel STIP, Auteur ; Marco LEYTON, Auteur ; Patricia CONROD, Auteur ; Stéphane POTVIN, Auteur . - p.1495-1504. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1495-1504 Mots-clés : neuroimaging  psychosis risk  psychotic experiences  resting state Index. décimale : PER Périodiques Résumé : Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth (n = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders. En ligne : https://www.cambridge.org/core/product/19434E0667E840EA40DBE5932D1F3E54 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

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