[article]
| Titre : |
C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur |
| Article en page(s) : |
p.101500 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism spectrum disorder Typically developing controls C-C motif chemokine receptor 6 Peripheral blood mononuclear cells Pro-inflammatory mediators |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-?+, CCR6+/tumor necrosis factor-?+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-?B p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. |
| En ligne : |
https://doi.org/10.1016/j.rasd.2019.101500 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 |
in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101500
[article] C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism [Texte imprimé et/ou numérique] / Mushtaq A. ANSARI, Auteur ; Saleh A. BAKHEET, Auteur ; Laila Y. AL-AYADHI, Auteur ; Mohammad R. KHAN, Auteur ; Sabry M. ATTIA, Auteur ; Sheikh F. AHMAD, Auteur . - p.101500. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101500
| Mots-clés : |
Autism spectrum disorder Typically developing controls C-C motif chemokine receptor 6 Peripheral blood mononuclear cells Pro-inflammatory mediators |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Autism spectrum disorder (ASD) is a heterogeneous disorder associated with immune abnormalities. C-C motif chemokine receptor 6 (CCR6) has central roles in neuroinflammatory disorders. However, CCR6 expression in ASD is unclear. Here, we examined CCR6 expression in children with ASD. Children with ASD had significantly increased numbers of CCR6+/interferon-?+, CCR6+/tumor necrosis factor-?+, CCR6+/interleukin (IL)-9+, CCR6+/IL-22+, CCR6+/nuclear factor-?B p65+, and CCR6+/nitric oxide synthase 2+ cells compared with typically developing controls (TDs). Moreover, children with ASD showed increased CCR6 mRNA/protein levels compared with TDs. Thus, CCR6 upregulated pro-inflammatory mediators associated with immune dysfunction in children with ASD, suggesting contributions to ASD development. |
| En ligne : |
https://doi.org/10.1016/j.rasd.2019.101500 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 |
|
C-C motif chemokine receptor 6-mediated pro-inflammatory mediator expression is associated with immune dysfunction in children with autism in Research in Autism Spectrum Disorders, 71 (March 2020)
