Development and validation of a machine learning-based tool to predict autism among children / Kim Steven BETTS in Autism Research, 16-5 (May 2023)  

Public ISBD [article]  inAutism Research > 16-5 (May 2023) . - p.941-952 Titre : Development and validation of a machine learning-based tool to predict autism among children Type de document : Texte imprimé et/ou numérique Auteurs : Kim Steven BETTS, Auteur ; Kevin CHAI, Auteur ; Steve KISELY, Auteur ; Rosa ALATI, Auteur Article en page(s) : p.941-952 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism is a lifelong condition for which intervention must occur as early as possible to improve social functioning. Thus, there is great interest in improving our ability to diagnose autism as early as possible. We take a novel approach to this challenge by combining machine learning with maternal and infant health administrative data to construct a prediction model capable of predicting autism disorder (defined as ICD10 84.0) in the general population. The sample included all mother-offspring pairs from the Australian state of New South Wales (NSW) between January 2003 and December 2005 (n = 262,650 offspring), linked across three health administrative data sets including the NSW perinatal data collection (PDC); the NSW admitted patient data collection (APDC) and the NSW mental health ambulatory data collection (MHADC). Our most successful model was able to predict autism disorder with an area under the receiver operating curve of 0.73, with the strongest risk factors for diagnoses found to include offspring gender, maternal age at birth, delivery analgesia, maternal prenatal tobacco disorders, and low 5-min APGAR score. Our findings indicate that the combination of machine learning and routinely collected admin data, with further refinement and increased accuracy than achieved by us, may play a role in the early detection of autism disorders. En ligne : http://dx.doi.org/https://doi.org/10.1002/aur.2912 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=503 [article] Development and validation of a machine learning-based tool to predict autism among children [Texte imprimé et/ou numérique] / Kim Steven BETTS, Auteur ; Kevin CHAI, Auteur ; Steve KISELY, Auteur ; Rosa ALATI, Auteur . - p.941-952. Langues : Anglais (eng) in Autism Research > 16-5 (May 2023) . - p.941-952 Index. décimale : PER Périodiques Résumé : Abstract Autism is a lifelong condition for which intervention must occur as early as possible to improve social functioning. Thus, there is great interest in improving our ability to diagnose autism as early as possible. We take a novel approach to this challenge by combining machine learning with maternal and infant health administrative data to construct a prediction model capable of predicting autism disorder (defined as ICD10 84.0) in the general population. The sample included all mother-offspring pairs from the Australian state of New South Wales (NSW) between January 2003 and December 2005 (n = 262,650 offspring), linked across three health administrative data sets including the NSW perinatal data collection (PDC); the NSW admitted patient data collection (APDC) and the NSW mental health ambulatory data collection (MHADC). Our most successful model was able to predict autism disorder with an area under the receiver operating curve of 0.73, with the strongest risk factors for diagnoses found to include offspring gender, maternal age at birth, delivery analgesia, maternal prenatal tobacco disorders, and low 5-min APGAR score. Our findings indicate that the combination of machine learning and routinely collected admin data, with further refinement and increased accuracy than achieved by us, may play a role in the early detection of autism disorders. En ligne : http://dx.doi.org/https://doi.org/10.1002/aur.2912 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=503

Do paternal arrest and imprisonment lead to child behaviour problems and substance use? A longitudinal analysis / Stuart A. KINNER in Journal of Child Psychology and Psychiatry, 48-11 (November 2007)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 48-11 (November 2007) . - p.1148–1156 Titre : Do paternal arrest and imprisonment lead to child behaviour problems and substance use? A longitudinal analysis Type de document : Texte imprimé et/ou numérique Auteurs : Stuart A. KINNER, Auteur ; Rosa ALATI, Auteur ; Jake M. NAJMAN, Auteur ; Gail M. WILLIAMS, Auteur Année de publication : 2007 Article en page(s) : p.1148–1156 Langues : Anglais (eng) Mots-clés : Paternal-imprisonment internalising externalising alcohol tobacco longitudinal-study Index. décimale : PER Périodiques Résumé : Children of prisoners are at increased risk of impaired health, behavioural problems and substance misuse; however, the causal pathways to these problems are unclear. Under some circumstances, parental imprisonment may result in improved outcomes for the child. This study investigates the impact of paternal arrest and imprisonment on child behaviour and substance use, as a function of child gender, and in the context of known social and familial risk factors. Methods: Longitudinal analysis of an Australian birth cohort (N = 2,399) recruited 1981–83, with child outcomes measured at age 14. Participants were recruited prenatally from a large, public hospital in Brisbane, Australia and followed up in the community. History of paternal arrest and imprisonment were based on maternal self-report, at age 14. Outcome measures included mother- and child-reported internalising and externalising behaviour (CBCL and YSR), and child self-reported alcohol and tobacco use. Results: In univariate analyses, paternal imprisonment was associated with maternal reports of increased child internalising (OR = 1.82, 95%CI 1.08–3.06) and externalising (OR = 2.24, 95%CI 1.41–3.57), and alcohol use (OR = 1.68, 95%CI 1.11–2.53) at age 14. However, controlling for socio-economic status, maternal mental health and substance use, parenting style and family adjustment, these associations became non-significant. For boys only, in the multivariate model paternal arrest but not imprisonment predicted alcohol (OR = 1.79, 95%CI 1.09–2.95) and tobacco (OR = 1.83, 95%CI 1.03–3.25) use at age 14. Conclusions: The association between paternal arrest and imprisonment and adverse outcomes in adolescence is accounted for by well-established social and familial risk factors. Paternal imprisonment may not, in itself, increase the risk for child behaviour and substance use problems. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01785.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Do paternal arrest and imprisonment lead to child behaviour problems and substance use? A longitudinal analysis [Texte imprimé et/ou numérique] / Stuart A. KINNER, Auteur ; Rosa ALATI, Auteur ; Jake M. NAJMAN, Auteur ; Gail M. WILLIAMS, Auteur . - 2007 . - p.1148–1156. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 48-11 (November 2007) . - p.1148–1156 Mots-clés : Paternal-imprisonment internalising externalising alcohol tobacco longitudinal-study Index. décimale : PER Périodiques Résumé : Children of prisoners are at increased risk of impaired health, behavioural problems and substance misuse; however, the causal pathways to these problems are unclear. Under some circumstances, parental imprisonment may result in improved outcomes for the child. This study investigates the impact of paternal arrest and imprisonment on child behaviour and substance use, as a function of child gender, and in the context of known social and familial risk factors. Methods: Longitudinal analysis of an Australian birth cohort (N = 2,399) recruited 1981–83, with child outcomes measured at age 14. Participants were recruited prenatally from a large, public hospital in Brisbane, Australia and followed up in the community. History of paternal arrest and imprisonment were based on maternal self-report, at age 14. Outcome measures included mother- and child-reported internalising and externalising behaviour (CBCL and YSR), and child self-reported alcohol and tobacco use. Results: In univariate analyses, paternal imprisonment was associated with maternal reports of increased child internalising (OR = 1.82, 95%CI 1.08–3.06) and externalising (OR = 2.24, 95%CI 1.41–3.57), and alcohol use (OR = 1.68, 95%CI 1.11–2.53) at age 14. However, controlling for socio-economic status, maternal mental health and substance use, parenting style and family adjustment, these associations became non-significant. For boys only, in the multivariate model paternal arrest but not imprisonment predicted alcohol (OR = 1.79, 95%CI 1.09–2.95) and tobacco (OR = 1.83, 95%CI 1.03–3.25) use at age 14. Conclusions: The association between paternal arrest and imprisonment and adverse outcomes in adolescence is accounted for by well-established social and familial risk factors. Paternal imprisonment may not, in itself, increase the risk for child behaviour and substance use problems. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01785.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Exploring the relationships between pathogen-specific prenatal infections requiring inpatient admission and domains of offspring behaviour at age 5 / Steve KISELY ; Rosa ALATI in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1213-1222 Titre : Exploring the relationships between pathogen-specific prenatal infections requiring inpatient admission and domains of offspring behaviour at age 5 Type de document : Texte imprimé et/ou numérique Auteurs : Steve KISELY, Auteur ; Rosa ALATI, Auteur Article en page(s) : p.1213-1222 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Research exploring the relationship between prenatal infection and child behavioural outcomes would benefit from further studies utilising full-population samples with the scale to investigate specific infections and to employ robust designs. We tested the association among several common infections requiring inpatient admission during and after pregnancy with a range of childhood behavioural outcomes, to determine whether any negative impact was specific to the period of foetal development. Methods The sample included all mother-offspring pairs from the Australian state of New South Wales (NSW) for whom the child commenced their first year of full-time schooling in 2009 (~age 5?years; n = 77,302 offspring), with records linked across four health administrative data sets including the NSW perinatal data collection (PDC), the NSW admitted patient data collection (APDC) and the NSW component of the 2009 Australian Early Development Census (AEDC). Multivariable linear regression was used to test associations between a number of infections requiring inpatient admission during and after pregnancy with a range of teacher assessed behavioural outcomes. Results Associations specific to the prenatal period were only found for streptococcus A although this would need to be reproduced in external samples given the low prevalence. Otherwise, 12 out of 15 selected infections either showed no association prenatally or also demonstrated associations in the 12?months after pregnancy. For example, prenatal hepatitis C, influenza and urinary E. coli infections were associated with lower scores of several domains of childhood behaviour, but even stronger associations were found when these same maternal infections occurred after pregnancy. Conclusions The prenatal infections we tested appeared not to impact childhood behaviour by altering foetal neurodevelopment. Rather, the strong associations we found among infections occurring during and after pregnancy point to either residual socioeconomic/lifestyle factors or a shared familial/genetic liability between infections and behavioural problems. En ligne : https://doi.org/10.1111/jcpp.13964 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Exploring the relationships between pathogen-specific prenatal infections requiring inpatient admission and domains of offspring behaviour at age 5 [Texte imprimé et/ou numérique] / Steve KISELY, Auteur ; Rosa ALATI, Auteur . - p.1213-1222. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1213-1222 Index. décimale : PER Périodiques Résumé : Background Research exploring the relationship between prenatal infection and child behavioural outcomes would benefit from further studies utilising full-population samples with the scale to investigate specific infections and to employ robust designs. We tested the association among several common infections requiring inpatient admission during and after pregnancy with a range of childhood behavioural outcomes, to determine whether any negative impact was specific to the period of foetal development. Methods The sample included all mother-offspring pairs from the Australian state of New South Wales (NSW) for whom the child commenced their first year of full-time schooling in 2009 (~age 5?years; n = 77,302 offspring), with records linked across four health administrative data sets including the NSW perinatal data collection (PDC), the NSW admitted patient data collection (APDC) and the NSW component of the 2009 Australian Early Development Census (AEDC). Multivariable linear regression was used to test associations between a number of infections requiring inpatient admission during and after pregnancy with a range of teacher assessed behavioural outcomes. Results Associations specific to the prenatal period were only found for streptococcus A although this would need to be reproduced in external samples given the low prevalence. Otherwise, 12 out of 15 selected infections either showed no association prenatally or also demonstrated associations in the 12?months after pregnancy. For example, prenatal hepatitis C, influenza and urinary E. coli infections were associated with lower scores of several domains of childhood behaviour, but even stronger associations were found when these same maternal infections occurred after pregnancy. Conclusions The prenatal infections we tested appeared not to impact childhood behaviour by altering foetal neurodevelopment. Rather, the strong associations we found among infections occurring during and after pregnancy point to either residual socioeconomic/lifestyle factors or a shared familial/genetic liability between infections and behavioural problems. En ligne : https://doi.org/10.1111/jcpp.13964 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Hypertensive disorders of pregnancy and the risk of offspring depression in childhood: Findings from the Avon Longitudinal Study of Parents and Children / Berihun Assefa DACHEW in Development and Psychopathology, 32-3 (August 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-3 (August 2020) . - p.845-851 Titre : Hypertensive disorders of pregnancy and the risk of offspring depression in childhood: Findings from the Avon Longitudinal Study of Parents and Children Type de document : Texte imprimé et/ou numérique Auteurs : Berihun Assefa DACHEW, Auteur ; James G. SCOTT, Auteur ; Kim S. BETTS, Auteur ; Abdullah MAMUN, Auteur ; Rosa ALATI, Auteur Article en page(s) : p.845-851 Langues : Anglais (eng) Mots-clés : Alspac  childhood depression  hypertensive disorders of pregnancy  offspring Index. décimale : PER Périodiques Résumé : Hypertensive disorders of pregnancy (HDP) may increase the risk of offspring depression in childhood. Low birth weight is also associated with increased risk of mental health problems, including depression. This study sought to investigate (a) whether there is an association between HDP and the risk of depression in childhood and (b) whether low birth weight mediates this association. The current study is based on the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective, population-based study that has followed a cohort of offspring since their mothers were pregnant (n = 6,739). Depression at the age of 7 years was diagnosed using parent reports via the Development and Well-Being Assessment (DAWBA). Log-binomial regression and mediation analyses were used. Children exposed to HDP were 2.3 times more likely to have a depression diagnosis compared with nonexposed children, adjusted Risk Ratio [RR], 2.31; 95% CI, [1.20, 4.47]. Low birth weight was a weak mediator of this association. Results were adjusted for confounding variables including antenatal depression and anxiety during pregnancy.This study suggests that fetal exposure to maternal hypertensive disorders of pregnancy increased the risk of childhood depression. The study adds to the evidence suggesting that the uterine environment is a critical determinant of neurodevelopmental and psychiatric outcomes. En ligne : http://dx.doi.org/10.1017/s0954579419000944 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Hypertensive disorders of pregnancy and the risk of offspring depression in childhood: Findings from the Avon Longitudinal Study of Parents and Children [Texte imprimé et/ou numérique] / Berihun Assefa DACHEW, Auteur ; James G. SCOTT, Auteur ; Kim S. BETTS, Auteur ; Abdullah MAMUN, Auteur ; Rosa ALATI, Auteur . - p.845-851. Langues : Anglais (eng) in Development and Psychopathology > 32-3 (August 2020) . - p.845-851 Mots-clés : Alspac  childhood depression  hypertensive disorders of pregnancy  offspring Index. décimale : PER Périodiques Résumé : Hypertensive disorders of pregnancy (HDP) may increase the risk of offspring depression in childhood. Low birth weight is also associated with increased risk of mental health problems, including depression. This study sought to investigate (a) whether there is an association between HDP and the risk of depression in childhood and (b) whether low birth weight mediates this association. The current study is based on the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective, population-based study that has followed a cohort of offspring since their mothers were pregnant (n = 6,739). Depression at the age of 7 years was diagnosed using parent reports via the Development and Well-Being Assessment (DAWBA). Log-binomial regression and mediation analyses were used. Children exposed to HDP were 2.3 times more likely to have a depression diagnosis compared with nonexposed children, adjusted Risk Ratio [RR], 2.31; 95% CI, [1.20, 4.47]. Low birth weight was a weak mediator of this association. Results were adjusted for confounding variables including antenatal depression and anxiety during pregnancy.This study suggests that fetal exposure to maternal hypertensive disorders of pregnancy increased the risk of childhood depression. The study adds to the evidence suggesting that the uterine environment is a critical determinant of neurodevelopmental and psychiatric outcomes. En ligne : http://dx.doi.org/10.1017/s0954579419000944 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Interpregnancy interval and the risk of oppositional defiant disorder in offspring / Berihun Assefa DACHEW in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.891-898 Titre : Interpregnancy interval and the risk of oppositional defiant disorder in offspring Type de document : Texte imprimé et/ou numérique Auteurs : Berihun Assefa DACHEW, Auteur ; Gavin PEREIRA, Auteur ; Gizachew Assefa TESSEMA, Auteur ; Gursimran Kaur DHAMRAIT, Auteur ; Rosa ALATI, Auteur Article en page(s) : p.891-898 Langues : Anglais (eng) Mots-clés : ALSPAC  interpregnancy interval  offspring  oppositional defiant disorder Index. décimale : PER Périodiques Résumé : The study aimed to investigate the association between interpregnancy interval (IPI) and parent-reported oppositional defiant disorder (ODD) in offspring at 7 and 10 years of age. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing population-based longitudinal study based in Bristol, United Kingdom (UK). Data included in the analysis consisted of more than 3200 mothers and their singleton children. The association between IPI and ODD was determined using a series of log-binomial regression analyses. We found that children of mothers with short IPI (<6 months) were 2.4 times as likely to have a diagnosis of ODD at 7 and 10 years compared to mothers with IPI of 18-23 months (RR = 2.45; 95%CI: 1.24-4.81 and RR = 2.40; 95% CI: 1.08-5.33), respectively. We found no evidence of associations between other IPI categories and risk of ODD in offspring in both age groups. Adjustment for a wide range of confounders, including maternal mental health, and comorbid ADHD did not alter the findings. This study suggests that the risk of ODD is higher among children born following short IPI (<6 months). Future large prospective studies are needed to elucidate the mechanisms explaining this association. En ligne : http://dx.doi.org/10.1017/S095457942200013X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Interpregnancy interval and the risk of oppositional defiant disorder in offspring [Texte imprimé et/ou numérique] / Berihun Assefa DACHEW, Auteur ; Gavin PEREIRA, Auteur ; Gizachew Assefa TESSEMA, Auteur ; Gursimran Kaur DHAMRAIT, Auteur ; Rosa ALATI, Auteur . - p.891-898. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.891-898 Mots-clés : ALSPAC  interpregnancy interval  offspring  oppositional defiant disorder Index. décimale : PER Périodiques Résumé : The study aimed to investigate the association between interpregnancy interval (IPI) and parent-reported oppositional defiant disorder (ODD) in offspring at 7 and 10 years of age. We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing population-based longitudinal study based in Bristol, United Kingdom (UK). Data included in the analysis consisted of more than 3200 mothers and their singleton children. The association between IPI and ODD was determined using a series of log-binomial regression analyses. We found that children of mothers with short IPI (<6 months) were 2.4 times as likely to have a diagnosis of ODD at 7 and 10 years compared to mothers with IPI of 18-23 months (RR = 2.45; 95%CI: 1.24-4.81 and RR = 2.40; 95% CI: 1.08-5.33), respectively. We found no evidence of associations between other IPI categories and risk of ODD in offspring in both age groups. Adjustment for a wide range of confounders, including maternal mental health, and comorbid ADHD did not alter the findings. This study suggests that the risk of ODD is higher among children born following short IPI (<6 months). Future large prospective studies are needed to elucidate the mechanisms explaining this association. En ligne : http://dx.doi.org/10.1017/S095457942200013X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

The role of maternal prenatal thyroid function on offspring depression: Findings from the ALSPAC cohort / Dagnachew Muluye FETENE in Development and Psychopathology, 32-1 (February 2020)  

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