[article] 
inJournal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1532-1538

Titre :	A Randomized, Placebo-Controlled, Blinded, Crossover, Pilot Study of the Effects of Dextromethorphan/Quinidine for the Treatment of Neurobehavioral Symptoms in Adults with Autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Michael CHEZ, Auteur ; Shawn KILE, Auteur ; Christopher LEPAGE, Auteur ; Carol PARISE, Auteur ; Bobbie BENABIDES, Auteur ; Andrea HANKINS, Auteur
Article en page(s) :	p.1532-1538
Langues :	Anglais (eng)
Mots-clés :	Adults  Aggression  Autism spectrum disorder  Dextromethorphan  Irritability  Placebo controlled crossover trial  Quinidine
Index. décimale :	PER Périodiques
Résumé :	Prior studies have demonstrated successful irritability treatment using dopaminergic antagonists in autistic patients. The purpose of this pilot study was to assess the effect of dextromethorphan/quinidine (DM/Q) in autistic adults (18-60 years of age). This was a randomized, blinded, crossover, study of 14 patients randomized to DM/Q or a placebo for 8 weeks, washed out for 4 weeks, then crossed over to the opposite treatment. There were no serious adverse events. Subjects were significantly lower on the Aberrant Behavioral Checklist for Irritability (ABC-IR) (F1,10 = 7.42; p = 0.021). Improvements in aggression and Clinical Global Impression were also seen. The findings suggest that DM/Q is well-tolerated and associated with improvements in irritability and aggression in adults with autism.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3703-x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

[article] A Randomized, Placebo-Controlled, Blinded, Crossover, Pilot Study of the Effects of Dextromethorphan/Quinidine for the Treatment of Neurobehavioral Symptoms in Adults with Autism [Texte imprimé et/ou numérique] / Michael CHEZ, Auteur ; Shawn KILE, Auteur ; Christopher LEPAGE, Auteur ; Carol PARISE, Auteur ; Bobbie BENABIDES, Auteur ; Andrea HANKINS, Auteur . - p.1532-1538.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1532-1538

Mots-clés :	Adults  Aggression  Autism spectrum disorder  Dextromethorphan  Irritability  Placebo controlled crossover trial  Quinidine
Index. décimale :	PER Périodiques
Résumé :	Prior studies have demonstrated successful irritability treatment using dopaminergic antagonists in autistic patients. The purpose of this pilot study was to assess the effect of dextromethorphan/quinidine (DM/Q) in autistic adults (18-60 years of age). This was a randomized, blinded, crossover, study of 14 patients randomized to DM/Q or a placebo for 8 weeks, washed out for 4 weeks, then crossed over to the opposite treatment. There were no serious adverse events. Subjects were significantly lower on the Aberrant Behavioral Checklist for Irritability (ABC-IR) (F1,10 = 7.42; p = 0.021). Improvements in aggression and Clinical Global Impression were also seen. The findings suggest that DM/Q is well-tolerated and associated with improvements in irritability and aggression in adults with autism.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3703-x
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422