[article]
Titre : |
Breastfeeding association with autism spectrum disorders: A case-control study from Lebanon |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Lama SHAMSEDINE, Auteur ; Aurelie MAILHAC, Auteur ; Alexandra BADAOUI, Auteur ; Rhawann EL HAKIM, Auteur ; Ramzi KIBBI, Auteur ; Hala OUEIDAT, Auteur ; Yolla YOUSSEF, Auteur ; Rose-Mary BOUSTANY, Auteur ; Mona NABULSI, Auteur |
Article en page(s) : |
101651 |
Langues : |
Anglais (eng) |
Mots-clés : |
Autism spectrum disorder breastfeeding Lebanon case-control |
Index. décimale : |
PER Périodiques |
Résumé : |
Background Autism spectrum disorders (ASD) in Lebanon are rising whereas breastfeeding is declining. This case-control study investigates the association between breastfeeding and ASD. Methods Children below 36 months recently diagnosed with ASD were matched to healthy controls by gender and gestational age. The association between ASD and breastfeeding was investigated in univariate and multivariate conditional logistic regression analyses, adjusting for the confounding effects of socio-demographic, pregnancy, and birth variables; parental characteristics, and family history. Results Cases (n?=?46) were older than controls (n?=?184), mean (SD) 31.6 (4.9) versus 25.5 (5.6) months, (p?0.001). ASD was associated with lack of exclusive breastfeeding in univariate (OR?=?0.37, 95% CI: 0.19 to 0.72) and multivariate regression analyses (OR?=?0.37, 95% CI: 0.16 to 0.88). There were no significant associations between ASD and the durations of exclusive breastfeeding or any breastfeeding. Other independent predictors of ASD in the adjusted analysis were the lack of intake of prenatal vitamins, advanced paternal age, lower paternal education, higher intake of drugs prenatally, and family history of ASD. Conclusions This study provides further evidence on the protective effect of exclusive breastfeeding against ASD. Future studies may help determine whether advising pregnant women to exclusively breastfeed their infants would reduce ASD, especially those at high risk for ASD such as those with a family history of ASD. Further research to understand the physiological basis of the protective effects of breastfeeding is essential, as well as studies that target the optimal duration of exclusive breastfeeding that can protect from ASD. |
En ligne : |
https://doi.org/10.1016/j.rasd.2020.101651 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 |
in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101651
[article] Breastfeeding association with autism spectrum disorders: A case-control study from Lebanon [Texte imprimé et/ou numérique] / Lama SHAMSEDINE, Auteur ; Aurelie MAILHAC, Auteur ; Alexandra BADAOUI, Auteur ; Rhawann EL HAKIM, Auteur ; Ramzi KIBBI, Auteur ; Hala OUEIDAT, Auteur ; Yolla YOUSSEF, Auteur ; Rose-Mary BOUSTANY, Auteur ; Mona NABULSI, Auteur . - 101651. Langues : Anglais ( eng) in Research in Autism Spectrum Disorders > 78 (October 2020) . - 101651
Mots-clés : |
Autism spectrum disorder breastfeeding Lebanon case-control |
Index. décimale : |
PER Périodiques |
Résumé : |
Background Autism spectrum disorders (ASD) in Lebanon are rising whereas breastfeeding is declining. This case-control study investigates the association between breastfeeding and ASD. Methods Children below 36 months recently diagnosed with ASD were matched to healthy controls by gender and gestational age. The association between ASD and breastfeeding was investigated in univariate and multivariate conditional logistic regression analyses, adjusting for the confounding effects of socio-demographic, pregnancy, and birth variables; parental characteristics, and family history. Results Cases (n?=?46) were older than controls (n?=?184), mean (SD) 31.6 (4.9) versus 25.5 (5.6) months, (p?0.001). ASD was associated with lack of exclusive breastfeeding in univariate (OR?=?0.37, 95% CI: 0.19 to 0.72) and multivariate regression analyses (OR?=?0.37, 95% CI: 0.16 to 0.88). There were no significant associations between ASD and the durations of exclusive breastfeeding or any breastfeeding. Other independent predictors of ASD in the adjusted analysis were the lack of intake of prenatal vitamins, advanced paternal age, lower paternal education, higher intake of drugs prenatally, and family history of ASD. Conclusions This study provides further evidence on the protective effect of exclusive breastfeeding against ASD. Future studies may help determine whether advising pregnant women to exclusively breastfeed their infants would reduce ASD, especially those at high risk for ASD such as those with a family history of ASD. Further research to understand the physiological basis of the protective effects of breastfeeding is essential, as well as studies that target the optimal duration of exclusive breastfeeding that can protect from ASD. |
En ligne : |
https://doi.org/10.1016/j.rasd.2020.101651 |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 |
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