An Investigation of Gelotophobia in Individuals with a Diagnosis of High-Functioning Autism Spectrum Disorder / G. LEADER in Journal of Autism and Developmental Disorders, 48-12 (December 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4155-4166 Titre : An Investigation of Gelotophobia in Individuals with a Diagnosis of High-Functioning Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : G. LEADER, Auteur ; S. GRENNAN, Auteur ; J. L. CHEN, Auteur ; A. MANNION, Auteur Article en page(s) : p.4155-4166 Langues : Anglais (eng) Mots-clés : Fear of being laughed at  Gelotophobia  High-functioning autism spectrum disorder  Laughter  Teasing Index. décimale : PER Périodiques Résumé : Samson et al. (Journal of Autism and Developmental Disorders 41:475-483, 2011) conducted the first empirical investigation examining the fear of being laughed at (gelotophobia) and its prevalence in individuals with high-functioning autism spectrum disorder (hfASD). The present research examined gelotophobia in relation to social functioning, perceived social support, life satisfaction and quality of life (QoL) in individuals with hfASD, including past experiences of bullying and the presence of comorbid psychopathology. Participants were 103 adults with a clinical diagnosis of hfASD and 137 typically developing controls. Individuals with hfASD presented with higher rates of gelotophobia symptomatology in comparison to controls (87.4 vs. 22.6% respectively). It was also found that social functioning, past experiences of bullying, anxiety and life satisfaction were predictors of gelotophobia amongst individuals with hfASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3661-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] An Investigation of Gelotophobia in Individuals with a Diagnosis of High-Functioning Autism Spectrum Disorder [Texte imprimé et/ou numérique] / G. LEADER, Auteur ; S. GRENNAN, Auteur ; J. L. CHEN, Auteur ; A. MANNION, Auteur . - p.4155-4166. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-12 (December 2018) . - p.4155-4166 Mots-clés : Fear of being laughed at  Gelotophobia  High-functioning autism spectrum disorder  Laughter  Teasing Index. décimale : PER Périodiques Résumé : Samson et al. (Journal of Autism and Developmental Disorders 41:475-483, 2011) conducted the first empirical investigation examining the fear of being laughed at (gelotophobia) and its prevalence in individuals with high-functioning autism spectrum disorder (hfASD). The present research examined gelotophobia in relation to social functioning, perceived social support, life satisfaction and quality of life (QoL) in individuals with hfASD, including past experiences of bullying and the presence of comorbid psychopathology. Participants were 103 adults with a clinical diagnosis of hfASD and 137 typically developing controls. Individuals with hfASD presented with higher rates of gelotophobia symptomatology in comparison to controls (87.4 vs. 22.6% respectively). It was also found that social functioning, past experiences of bullying, anxiety and life satisfaction were predictors of gelotophobia amongst individuals with hfASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3661-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Bio-collections in autism research / J. REILLY in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 34p. Titre : Bio-collections in autism research Type de document : Texte imprimé et/ou numérique Auteurs : J. REILLY, Auteur ; L. GALLAGHER, Auteur ; J. L. CHEN, Auteur ; G. LEADER, Auteur ; S. SHEN, Auteur Article en page(s) : 34p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding the genetic basis for ASD, critically supported through the establishment of ASD bio-collections and application in research. Here, we summarise a selection of major ASD bio-collections and their associated findings. Collectively, these include mapping ASD candidate genes, assessing the nature and frequency of gene mutations and their association with ASD clinical subgroups, insights into related molecular pathways such as the synapses, chromatin remodelling, transcription and ASD-related brain regions. We also briefly review emerging studies on the use of induced pluripotent stem cells (iPSCs) to potentially model ASD in culture. These provide deeper insight into ASD progression during development and could generate human cell models for drug screening. Finally, we provide perspectives concerning the utilities of ASD bio-collections and limitations, and highlight considerations in setting up a new bio-collection for ASD research. En ligne : http://dx.doi.org/10.1186/s13229-017-0154-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Bio-collections in autism research [Texte imprimé et/ou numérique] / J. REILLY, Auteur ; L. GALLAGHER, Auteur ; J. L. CHEN, Auteur ; G. LEADER, Auteur ; S. SHEN, Auteur . - 34p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 34p. Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding the genetic basis for ASD, critically supported through the establishment of ASD bio-collections and application in research. Here, we summarise a selection of major ASD bio-collections and their associated findings. Collectively, these include mapping ASD candidate genes, assessing the nature and frequency of gene mutations and their association with ASD clinical subgroups, insights into related molecular pathways such as the synapses, chromatin remodelling, transcription and ASD-related brain regions. We also briefly review emerging studies on the use of induced pluripotent stem cells (iPSCs) to potentially model ASD in culture. These provide deeper insight into ASD progression during development and could generate human cell models for drug screening. Finally, we provide perspectives concerning the utilities of ASD bio-collections and limitations, and highlight considerations in setting up a new bio-collection for ASD research. En ligne : http://dx.doi.org/10.1186/s13229-017-0154-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

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