[article] 
inAutism > 25-8 (November 2021) . - p.2238-2253

Titre :	Neuronal and glial cell number is altered in a cortical layer-specific manner in autism
Type de document :	texte imprimé
Auteurs :	Carmen FALCONE, Auteur ; Natalie-Ya MEVISES, Auteur ; Tiffany HONG, Auteur ; Brett DUFOUR, Auteur ; Xiaohui CHEN, Auteur ; Stephen C. NOCTOR, Auteur ; Verónica MARTÍNEZ-CERDEÑO, Auteur
Année de publication :	2021
Article en page(s) :	p.2238-2253
Langues :	Anglais (eng)
Mots-clés :	Autism Spectrum Disorder  Autistic Disorder  Cell Count  Cerebral Cortex  Humans  Neuroglia  Neurons  anatomy  autism  cerebral cortex  postmortem
Index. décimale :	PER Périodiques
Résumé :	The cerebral cortex affected with autism spectrum disorder presents changes in the number of neurons and glia cells, possibly leading to a dysregulation of brain circuits and affecting behavior. However, little is known about cell number alteration in specific layers of the cortex in autism spectrum disorder. We found an increase in the number of neurons and a decrease in the number of astrocytes in specific layers of the prefrontal cortex in postmortem human brains from autism spectrum disorder cases. We hypothesize that this may be due to a failure in neural stem cells to shift differentiation from neurons to glial cells during prenatal brain development. These data provide key anatomical findings that contribute to the bases of autism spectrum disorder pathogenesis.
En ligne :	http://dx.doi.org/10.1177/13623613211014408
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

[article] Neuronal and glial cell number is altered in a cortical layer-specific manner in autism [texte imprimé] / Carmen FALCONE, Auteur ; Natalie-Ya MEVISES, Auteur ; Tiffany HONG, Auteur ; Brett DUFOUR, Auteur ; Xiaohui CHEN, Auteur ; Stephen C. NOCTOR, Auteur ; Verónica MARTÍNEZ-CERDEÑO, Auteur . - 2021 . - p.2238-2253.
Langues : Anglais (eng)
in Autism > 25-8 (November 2021) . - p.2238-2253

Mots-clés :	Autism Spectrum Disorder  Autistic Disorder  Cell Count  Cerebral Cortex  Humans  Neuroglia  Neurons  anatomy  autism  cerebral cortex  postmortem
Index. décimale :	PER Périodiques
Résumé :	The cerebral cortex affected with autism spectrum disorder presents changes in the number of neurons and glia cells, possibly leading to a dysregulation of brain circuits and affecting behavior. However, little is known about cell number alteration in specific layers of the cortex in autism spectrum disorder. We found an increase in the number of neurons and a decrease in the number of astrocytes in specific layers of the prefrontal cortex in postmortem human brains from autism spectrum disorder cases. We hypothesize that this may be due to a failure in neural stem cells to shift differentiation from neurons to glial cells during prenatal brain development. These data provide key anatomical findings that contribute to the bases of autism spectrum disorder pathogenesis.
En ligne :	http://dx.doi.org/10.1177/13623613211014408
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451