Are There Enhanced MBP Autoantibodies in Autism? / Jane E. LIBBEY in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332 Titre : Are There Enhanced MBP Autoantibodies in Autism? Type de document : texte imprimé Auteurs : Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.324-332 Langues : Anglais (eng) Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 [article] Are There Enhanced MBP Autoantibodies in Autism? [texte imprimé] / Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.324-332. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332 Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318

DSM-IV-Defined Asperger Syndrome: Cognitive, Behavioral and Early History Differentiation from High-Functioning Autism / Sally OZONOFF in Autism, 4-1 (March 2000)  

Public ISBD [article]  inAutism > 4-1 (March 2000) . - p.29-46 Titre : DSM-IV-Defined Asperger Syndrome: Cognitive, Behavioral and Early History Differentiation from High-Functioning Autism Type de document : texte imprimé Auteurs : Sally OZONOFF, Auteur ; Mikle SOUTH, Auteur ; Judith N. MILLER, Auteur Article en page(s) : p.29-46 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study compared 2 3 children with high-functioning autism with 12 children with Asperger syndrome, both defined according to strict DSM-IV diagnostic criteria. The groups were well matched on chronological age, gender and intellectual ability. Three possible sources of difference between Asperger syndrome and highfunctioning autism were examined: cognitive function, current symptomatology and early history. We found few group differences in current presentation and cognitive function, but many early history differences. The Asperger syndrome group generally demonstrated less severe early symptoms, a milder developmental course and better out-come than the high-functioning autism group. Many of the group dif-ferences appeared secondary to the initial group definition process, however. Overall, the results suggest that Asperger syndrome and high-functioning autism involve the same fundamental symptomatology, differing only in degree or severity. En ligne : http://dx.doi.org/10.1177/1362361300041003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=208 [article] DSM-IV-Defined Asperger Syndrome: Cognitive, Behavioral and Early History Differentiation from High-Functioning Autism [texte imprimé] / Sally OZONOFF, Auteur ; Mikle SOUTH, Auteur ; Judith N. MILLER, Auteur . - p.29-46. Langues : Anglais (eng) in Autism > 4-1 (March 2000) . - p.29-46 Index. décimale : PER Périodiques Résumé : This study compared 2 3 children with high-functioning autism with 12 children with Asperger syndrome, both defined according to strict DSM-IV diagnostic criteria. The groups were well matched on chronological age, gender and intellectual ability. Three possible sources of difference between Asperger syndrome and highfunctioning autism were examined: cognitive function, current symptomatology and early history. We found few group differences in current presentation and cognitive function, but many early history differences. The Asperger syndrome group generally demonstrated less severe early symptoms, a milder developmental course and better out-come than the high-functioning autism group. Many of the group dif-ferences appeared secondary to the initial group definition process, however. Overall, the results suggest that Asperger syndrome and high-functioning autism involve the same fundamental symptomatology, differing only in degree or severity. En ligne : http://dx.doi.org/10.1177/1362361300041003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=208

How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? / Nikki J. KIRKMAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341 Titre : How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? Type de document : texte imprimé Auteurs : Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.333-341 Langues : Anglais (eng) Mots-clés : Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome. En ligne : http://dx.doi.org/10.1007/s10803-007-0398-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 [article] How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? [texte imprimé] / Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.333-341. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341 Mots-clés : Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome. En ligne : http://dx.doi.org/10.1007/s10803-007-0398-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318

Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) / Andrew J. O. WHITEHOUSE in Autism, 14-6 (November 2010)  

Public ISBD [article]  inAutism > 14-6 (November 2010) . - p.559-574 Titre : Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) Type de document : texte imprimé Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Hilary H. COON, Auteur ; Judith N. MILLER, Auteur ; Bryanna SALISBURY, Auteur ; Dorothy V. M. BISHOP, Auteur Année de publication : 2010 Article en page(s) : p.559-574 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated whether the Communication Checklist — Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic oddities (e.g. excessive talking), while the Social Engagement subscale picks up on those behaviours that reflect a more passive communication style (e.g. failure to engage in social interactions). CC-A data were collected for 69 autism probands, 238 parents of autism probands and 187 typical participants. The CC-A proved sensitive to the communication difficulties of autism probands and a proportion of their parents. The majority of parents who demonstrated the broader phenotype scored poorly on either the Pragmatic Skills or Social Engagement scale only. The Social Engagement scale was particularly sensitive to the difficulties of the parents, indicating that social-communicative passivity may be an important part of the broader autism phenotype. The findings provide evidence for the existence of more constrained pragmatic phenotypes in autism. Molecular genetic studies in this area may benefit from stratifying samples according to these phenotypes. En ligne : http://dx.doi.org/10.1177/1362361310382107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Narrowing the broader autism phenotype: A study using the Communication Checklist - Adult Version (CC-A) [texte imprimé] / Andrew J. O. WHITEHOUSE, Auteur ; Hilary H. COON, Auteur ; Judith N. MILLER, Auteur ; Bryanna SALISBURY, Auteur ; Dorothy V. M. BISHOP, Auteur . - 2010 . - p.559-574. Langues : Anglais (eng) in Autism > 14-6 (November 2010) . - p.559-574 Index. décimale : PER Périodiques Résumé : This study investigated whether the Communication Checklist — Adult (CC-A) could identify subtypes of social and communication dysfunction in autism probands and their parents. The CC-A is divided into subscales measuring linguistic ability as well as two aspects of social communication: the Pragmatic Skills subscale assesses the level of pragmatic oddities (e.g. excessive talking), while the Social Engagement subscale picks up on those behaviours that reflect a more passive communication style (e.g. failure to engage in social interactions). CC-A data were collected for 69 autism probands, 238 parents of autism probands and 187 typical participants. The CC-A proved sensitive to the communication difficulties of autism probands and a proportion of their parents. The majority of parents who demonstrated the broader phenotype scored poorly on either the Pragmatic Skills or Social Engagement scale only. The Social Engagement scale was particularly sensitive to the difficulties of the parents, indicating that social-communicative passivity may be an important part of the broader autism phenotype. The findings provide evidence for the existence of more constrained pragmatic phenotypes in autism. Molecular genetic studies in this area may benefit from stratifying samples according to these phenotypes. En ligne : http://dx.doi.org/10.1177/1362361310382107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Twenty-year outcome for individuals with autism and average or near-average cognitive abilities / Megan A. FARLEY in Autism Research, 2-2 (April 2009)  

Public ISBD [article]  inAutism Research > 2-2 (April 2009) . - p.109-118 Titre : Twenty-year outcome for individuals with autism and average or near-average cognitive abilities Type de document : texte imprimé Auteurs : Megan A. FARLEY, Auteur ; Eric FOMBONNE, Auteur ; William M. MCMAHON, Auteur ; Edward R. RITVO, Auteur ; Judith N. MILLER, Auteur ; William R. JENSON, Auteur ; Michael GARDNER, Auteur ; Heidi BLOCK, Auteur ; Carmen B. PINGREE, Auteur Année de publication : 2009 Article en page(s) : p.109-118 Langues : Anglais (eng) Mots-clés : autism adult outcome longitudinal Index. décimale : PER Périodiques Résumé : Previous studies found substantial variability in adult outcome for people with autism whose cognitive functioning was within the near-average and average ranges. This study examined adult outcome for 41 such individuals (38 men and 3 women) originally identified through an epidemiological survey of autism in Utah. Mean age at the time of their previous cognitive assessment was 7.2 years (SD=4.1, range=3.1-25.9 years) and at follow-up was 32.5 years (SD=5.7 years, range=22.3-46.4 years). Outcome measures included standardized assessments of diagnostic status, cognitive ability, and adaptive behavior. Additional information collected concerned demographic variables, indicators of independence, social relationships, medical and psychiatric conditions, and social service use. Outcomes for this sample were better than outcomes described in previous work on individuals with similar cognitive functioning. For example, half of the participants were rated as Very Good or Good on a global outcome measure. As in previous studies, there was considerable variability in measured cognitive ability over time. Over half of the sample had large gains or losses of cognitive ability of greater than 1 standard deviation. Cognitive gain was associated with better outcome, as was better adaptive functioning. While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome. En ligne : http://dx.doi.org/10.1002/aur.69 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=936 [article] Twenty-year outcome for individuals with autism and average or near-average cognitive abilities [texte imprimé] / Megan A. FARLEY, Auteur ; Eric FOMBONNE, Auteur ; William M. MCMAHON, Auteur ; Edward R. RITVO, Auteur ; Judith N. MILLER, Auteur ; William R. JENSON, Auteur ; Michael GARDNER, Auteur ; Heidi BLOCK, Auteur ; Carmen B. PINGREE, Auteur . - 2009 . - p.109-118. Langues : Anglais (eng) in Autism Research > 2-2 (April 2009) . - p.109-118 Mots-clés : autism adult outcome longitudinal Index. décimale : PER Périodiques Résumé : Previous studies found substantial variability in adult outcome for people with autism whose cognitive functioning was within the near-average and average ranges. This study examined adult outcome for 41 such individuals (38 men and 3 women) originally identified through an epidemiological survey of autism in Utah. Mean age at the time of their previous cognitive assessment was 7.2 years (SD=4.1, range=3.1-25.9 years) and at follow-up was 32.5 years (SD=5.7 years, range=22.3-46.4 years). Outcome measures included standardized assessments of diagnostic status, cognitive ability, and adaptive behavior. Additional information collected concerned demographic variables, indicators of independence, social relationships, medical and psychiatric conditions, and social service use. Outcomes for this sample were better than outcomes described in previous work on individuals with similar cognitive functioning. For example, half of the participants were rated as Very Good or Good on a global outcome measure. As in previous studies, there was considerable variability in measured cognitive ability over time. Over half of the sample had large gains or losses of cognitive ability of greater than 1 standard deviation. Cognitive gain was associated with better outcome, as was better adaptive functioning. While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome. En ligne : http://dx.doi.org/10.1002/aur.69 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=936

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