Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement / L. K. PAUL in Journal of Neurodevelopmental Disorders, 3-1 (March 2011)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.3-27 Titre : Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement Type de document : Texte imprimé et/ou numérique Auteurs : L. K. PAUL, Auteur Article en page(s) : p.3-27 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)-the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome). En ligne : http://dx.doi.org/10.1007/s11689-010-9059-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement [Texte imprimé et/ou numérique] / L. K. PAUL, Auteur . - p.3-27. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 3-1 (March 2011) . - p.3-27 Index. décimale : PER Périodiques Résumé : This review provides an overview of the involvement of the corpus callosum (CC) in a variety of developmental disorders that are currently defined exclusively by genetics, developmental insult, and/or behavior. I begin with a general review of CC development, connectivity, and function, followed by discussion of the research methods typically utilized to study the callosum. The bulk of the review concentrates on specific developmental disorders, beginning with agenesis of the corpus callosum (AgCC)-the only condition diagnosed exclusively by callosal anatomy. This is followed by a review of several genetic disorders that commonly result in social impairments and/or psychopathology similar to AgCC (neurofibromatosis-1, Turner syndrome, 22q11.2 deletion syndrome, Williams yndrome, and fragile X) and two forms of prenatal injury (premature birth, fetal alcohol syndrome) known to impact callosal development. Finally, I examine callosal involvement in several common developmental disorders defined exclusively by behavioral patterns (developmental language delay, dyslexia, attention-deficit hyperactive disorder, autism spectrum disorders, and Tourette syndrome). En ligne : http://dx.doi.org/10.1007/s11689-010-9059-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Does bilateral damage to the human amygdala produce autistic symptoms? / L. K. PAUL in Journal of Neurodevelopmental Disorders, 2-3 (September 2010)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.165-173 Titre : Does bilateral damage to the human amygdala produce autistic symptoms? Type de document : Texte imprimé et/ou numérique Auteurs : L. K. PAUL, Auteur ; C. CORSELLO, Auteur ; D. TRANEL, Auteur ; Ralph ADOLPHS, Auteur Article en page(s) : p.165-173 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A leading neurological hypothesis for autism postulates amygdala dysfunction. This hypothesis has considerable support from anatomical and neuroimaging studies. Individuals with bilateral amygdala lesions show impairments in some aspects of social cognition. These impairments bear intriguing similarity to those reported in people with autism, such as impaired recognition of emotion in faces, impaired theory of mind abilities, failure to fixate eyes in faces, and difficulties in regulating personal space distance to others. Yet such neurological cases have never before been assessed directly to see if they meet criteria for autism spectrum disorders (ASD). Here we undertook such an investigation in two rare participants with developmental-onset bilateral amygdala lesions. We administered a comprehensive clinical examination, as well as the Autism Diagnostic Observation Schedule (ADOS), the Social Responsiveness Scale (SRS), together with several other standardized questionnaires. Results from the two individuals with amygdala lesions were compared with published norms from both healthy populations as well as from people with ASD. Neither participant with amygdala lesions showed any evidence of autism across the array of different measures. The findings demonstrate that amygdala lesions in isolation are not sufficient for producing autistic symptoms. We suggest instead that it may be abnormal connectivity between the amygdala and other structures that contributes to autistic symptoms at a network level. En ligne : http://dx.doi.org/10.1007/s11689-010-9056-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342 [article] Does bilateral damage to the human amygdala produce autistic symptoms? [Texte imprimé et/ou numérique] / L. K. PAUL, Auteur ; C. CORSELLO, Auteur ; D. TRANEL, Auteur ; Ralph ADOLPHS, Auteur . - p.165-173. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 2-3 (September 2010) . - p.165-173 Index. décimale : PER Périodiques Résumé : A leading neurological hypothesis for autism postulates amygdala dysfunction. This hypothesis has considerable support from anatomical and neuroimaging studies. Individuals with bilateral amygdala lesions show impairments in some aspects of social cognition. These impairments bear intriguing similarity to those reported in people with autism, such as impaired recognition of emotion in faces, impaired theory of mind abilities, failure to fixate eyes in faces, and difficulties in regulating personal space distance to others. Yet such neurological cases have never before been assessed directly to see if they meet criteria for autism spectrum disorders (ASD). Here we undertook such an investigation in two rare participants with developmental-onset bilateral amygdala lesions. We administered a comprehensive clinical examination, as well as the Autism Diagnostic Observation Schedule (ADOS), the Social Responsiveness Scale (SRS), together with several other standardized questionnaires. Results from the two individuals with amygdala lesions were compared with published norms from both healthy populations as well as from people with ASD. Neither participant with amygdala lesions showed any evidence of autism across the array of different measures. The findings demonstrate that amygdala lesions in isolation are not sufficient for producing autistic symptoms. We suggest instead that it may be abnormal connectivity between the amygdala and other structures that contributes to autistic symptoms at a network level. En ligne : http://dx.doi.org/10.1007/s11689-010-9056-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=342

Facial emotion recognition in agenesis of the corpus callosum / M. W. BRIDGMAN in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.32 Titre : Facial emotion recognition in agenesis of the corpus callosum Type de document : Texte imprimé et/ou numérique Auteurs : M. W. BRIDGMAN, Auteur ; W. S. BROWN, Auteur ; M. L. SPEZIO, Auteur ; M. K. LEONARD, Auteur ; Ralph ADOLPHS, Auteur ; L. K. PAUL, Auteur Article en page(s) : p.32 Langues : Anglais (eng) Mots-clés : Corpus callosum  Corpus callosum agenesis  Facial emotion Index. décimale : PER Périodiques Résumé : BACKGROUND: Impaired social functioning is a common symptom of individuals with developmental disruptions in callosal connectivity. Among these developmental conditions, agenesis of the corpus callosum provides the most extreme and clearly identifiable example of callosal disconnection. To date, deficits in nonliteral language comprehension, humor, theory of mind, and social reasoning have been documented in agenesis of the corpus callosum. Here, we examined a basic social ability as yet not investigated in this population: recognition of facial emotion and its association with social gaze. METHODS: Nine individuals with callosal agenesis and nine matched controls completed four tasks involving emotional faces: emotion recognition from upright and inverted faces, gender recognition, and passive viewing. Eye-tracking data were collected concurrently on all four tasks and analyzed according to designated facial regions of interest. RESULTS: Individuals with callosal agenesis exhibited impairments in recognizing emotions from upright faces, in particular lower accuracy for fear and anger, and these impairments were directly associated with diminished attention to the eye region. The callosal agenesis group exhibited greater consistency in emotion recognition across conditions (upright vs. inverted), with poorest performance for fear identification in both conditions. The callosal agenesis group also had atypical facial scanning (lower fractional dwell time in the eye region) during gender naming and passive viewing of faces, but they did not differ from controls on gender naming performance. The pattern of results did not differ when taking into account full-scale intelligence quotient or presence of autism spectrum symptoms. CONCLUSIONS: Agenesis of the corpus callosum results in a pattern of atypical facial scanning characterized by diminished attention to the eyes. This pattern suggests that reduced callosal connectivity may contribute to the development and maintenance of emotion processing deficits involving reduced attention to others' eyes. En ligne : http://dx.doi.org/10.1186/1866-1955-6-32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 [article] Facial emotion recognition in agenesis of the corpus callosum [Texte imprimé et/ou numérique] / M. W. BRIDGMAN, Auteur ; W. S. BROWN, Auteur ; M. L. SPEZIO, Auteur ; M. K. LEONARD, Auteur ; Ralph ADOLPHS, Auteur ; L. K. PAUL, Auteur . - p.32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.32 Mots-clés : Corpus callosum  Corpus callosum agenesis  Facial emotion Index. décimale : PER Périodiques Résumé : BACKGROUND: Impaired social functioning is a common symptom of individuals with developmental disruptions in callosal connectivity. Among these developmental conditions, agenesis of the corpus callosum provides the most extreme and clearly identifiable example of callosal disconnection. To date, deficits in nonliteral language comprehension, humor, theory of mind, and social reasoning have been documented in agenesis of the corpus callosum. Here, we examined a basic social ability as yet not investigated in this population: recognition of facial emotion and its association with social gaze. METHODS: Nine individuals with callosal agenesis and nine matched controls completed four tasks involving emotional faces: emotion recognition from upright and inverted faces, gender recognition, and passive viewing. Eye-tracking data were collected concurrently on all four tasks and analyzed according to designated facial regions of interest. RESULTS: Individuals with callosal agenesis exhibited impairments in recognizing emotions from upright faces, in particular lower accuracy for fear and anger, and these impairments were directly associated with diminished attention to the eye region. The callosal agenesis group exhibited greater consistency in emotion recognition across conditions (upright vs. inverted), with poorest performance for fear identification in both conditions. The callosal agenesis group also had atypical facial scanning (lower fractional dwell time in the eye region) during gender naming and passive viewing of faces, but they did not differ from controls on gender naming performance. The pattern of results did not differ when taking into account full-scale intelligence quotient or presence of autism spectrum symptoms. CONCLUSIONS: Agenesis of the corpus callosum results in a pattern of atypical facial scanning characterized by diminished attention to the eyes. This pattern suggests that reduced callosal connectivity may contribute to the development and maintenance of emotion processing deficits involving reduced attention to others' eyes. En ligne : http://dx.doi.org/10.1186/1866-1955-6-32 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346

Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling / T. RENTERIA-VAZQUEZ in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.569-583 Titre : Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling Type de document : Texte imprimé et/ou numérique Auteurs : T. RENTERIA-VAZQUEZ, Auteur ; W. S. BROWN, Auteur ; C. KANG, Auteur ; M. GRAVES, Auteur ; F. CASTELLI, Auteur ; L. K. PAUL, Auteur Article en page(s) : p.569-583 Langues : Anglais (eng) Mots-clés : Adult  Agenesis of Corpus Callosum  Autism Spectrum Disorder  Autistic Disorder  Corpus Callosum  Humans  Semantics  Agenesis of the corpus callosum  Autism  Mental attribution  Social inference Index. décimale : PER Périodiques Résumé : Impoverished capacity for social inference is one of several symptoms that are common to both agenesis of the corpus callosum (AgCC) and Autism Spectrum Disorder (ASD). This research compared the ability of 14 adults with AgCC, 13 high-functioning adults with ASD and 14 neurotypical controls to accurately attribute social meaning to the interactions of animated triangles. Descriptions of the animations were analyzed in three ways: subjective ratings, Linguistic Inquiry and Word Count, and topic modeling (Latent Dirichlet Allocation). Although subjective ratings indicated that all groups made similar inferences from the animations, the index of perplexity (atypicality of topic) generated from topic modeling revealed that inferences from individuals with AgCC or ASD displayed significantly less social imagination than those of controls. En ligne : http://dx.doi.org/10.1007/s10803-021-04957-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling [Texte imprimé et/ou numérique] / T. RENTERIA-VAZQUEZ, Auteur ; W. S. BROWN, Auteur ; C. KANG, Auteur ; M. GRAVES, Auteur ; F. CASTELLI, Auteur ; L. K. PAUL, Auteur . - p.569-583. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.569-583 Mots-clés : Adult  Agenesis of Corpus Callosum  Autism Spectrum Disorder  Autistic Disorder  Corpus Callosum  Humans  Semantics  Agenesis of the corpus callosum  Autism  Mental attribution  Social inference Index. décimale : PER Périodiques Résumé : Impoverished capacity for social inference is one of several symptoms that are common to both agenesis of the corpus callosum (AgCC) and Autism Spectrum Disorder (ASD). This research compared the ability of 14 adults with AgCC, 13 high-functioning adults with ASD and 14 neurotypical controls to accurately attribute social meaning to the interactions of animated triangles. Descriptions of the animations were analyzed in three ways: subjective ratings, Linguistic Inquiry and Word Count, and topic modeling (Latent Dirichlet Allocation). Although subjective ratings indicated that all groups made similar inferences from the animations, the index of perplexity (atypicality of topic) generated from topic modeling revealed that inferences from individuals with AgCC or ASD displayed significantly less social imagination than those of controls. En ligne : http://dx.doi.org/10.1007/s10803-021-04957-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

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