An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1305-1317 Titre : An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur Article en page(s) : p.1305-1317 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In the present investigation, differential methylation analyses of the whole genome were conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7% Black, M age = 9.40 years), 54.4% of whom had a history of child maltreatment. In the context of a summer research camp, DNA samples via saliva were obtained. Using GenomeStudio, Methylation Module, and the Illumina Custom Model, differential methylation analyses revealed a pattern of greater methylation at low methylation sites (n = 197 sites) and medium methylation sites (n = 730 sites) and less methylation at high methylation sites (n = 907 sites) among maltreated children. The mean difference in methylation between the maltreated and nonmaltreated children was 6.2%. The relative risk of maltreatment with known disease biomarkers was also investigated using GenoGo MetaCore Software. A large number of network objects previously associated with mental health, cancer, cardiovascular systems, and immune functioning were identified evidencing differential methylation among maltreated and nonmaltreated children. Site-specific analyses were also conducted for aldehyde dehydrogenase 2 (ALDH2), ankyrin repeat and kinase domain containing 1 (ANKK1), and nuclear receptor subfamily 3, group C, member 1 (NR3C1) genes, and the results highlight the importance of considering gender and the developmental timing of maltreatment. For ALDH2, the results indicated that maltreated girls evidenced significantly lower methylation compared to nonmaltreated girls, and maltreated boys evidenced significantly higher methylation compared to nonmaltreated boys. Moreover, early onset–not recently maltreated boys evidenced significantly higher methylation at ALDH2 compared to nonmaltreated boys. Similarly, children with early onset–nonrecent maltreatment evidenced significantly higher methylation compared to nonmaltreated children at ANKK1. The site-specific results were not altered by controlling for genotypic variation of respective genes. The findings demonstrate increased risk for adverse physical and mental health outcomes associated with differences in methylation in maltreated children and indicate differences among maltreated children related to developmental timing of maltreatment and gender in genes involved in mental health functioning. En ligne : http://dx.doi.org/10.1017/s0954579416000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur . - p.1305-1317. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1305-1317 Index. décimale : PER Périodiques Résumé : In the present investigation, differential methylation analyses of the whole genome were conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7% Black, M age = 9.40 years), 54.4% of whom had a history of child maltreatment. In the context of a summer research camp, DNA samples via saliva were obtained. Using GenomeStudio, Methylation Module, and the Illumina Custom Model, differential methylation analyses revealed a pattern of greater methylation at low methylation sites (n = 197 sites) and medium methylation sites (n = 730 sites) and less methylation at high methylation sites (n = 907 sites) among maltreated children. The mean difference in methylation between the maltreated and nonmaltreated children was 6.2%. The relative risk of maltreatment with known disease biomarkers was also investigated using GenoGo MetaCore Software. A large number of network objects previously associated with mental health, cancer, cardiovascular systems, and immune functioning were identified evidencing differential methylation among maltreated and nonmaltreated children. Site-specific analyses were also conducted for aldehyde dehydrogenase 2 (ALDH2), ankyrin repeat and kinase domain containing 1 (ANKK1), and nuclear receptor subfamily 3, group C, member 1 (NR3C1) genes, and the results highlight the importance of considering gender and the developmental timing of maltreatment. For ALDH2, the results indicated that maltreated girls evidenced significantly lower methylation compared to nonmaltreated girls, and maltreated boys evidenced significantly higher methylation compared to nonmaltreated boys. Moreover, early onset–not recently maltreated boys evidenced significantly higher methylation at ALDH2 compared to nonmaltreated boys. Similarly, children with early onset–nonrecent maltreatment evidenced significantly higher methylation compared to nonmaltreated children at ANKK1. The site-specific results were not altered by controlling for genotypic variation of respective genes. The findings demonstrate increased risk for adverse physical and mental health outcomes associated with differences in methylation in maltreated children and indicate differences among maltreated children related to developmental timing of maltreatment and gender in genes involved in mental health functioning. En ligne : http://dx.doi.org/10.1017/s0954579416000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Attachment security mediates the longitudinal association between child–parent psychotherapy and peer relations for toddlers of depressed mothers / Danielle J. GUILD in Development and Psychopathology, 29-2 (May 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-2 (May 2017) . - p.587-600 Titre : Attachment security mediates the longitudinal association between child–parent psychotherapy and peer relations for toddlers of depressed mothers Type de document : Texte imprimé et/ou numérique Auteurs : Danielle J. GUILD, Auteur ; Sheree L. TOTH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.587-600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Numerous investigations have demonstrated that child–parent psychotherapy (CPP) promotes secure attachment between mothers and offspring. However, the role of postintervention attachment security as it relates to long-term child outcomes has never been evaluated. The present study therefore examined postintervention attachment status as a mediator of the association between CPP for depressed mothers and their offspring and subsequent peer relations among offspring. Depressed mothers and their toddlers were randomized to receive CPP (n = 45) or to a control group (n = 55). A prior investigation with this sample indicated that offspring who received CPP attained significantly higher rates of secure attachment postintervention, whereas insecure attachment continued to predominate for offspring in the control group. The present study examined follow-up data of teachers’ reports on participants’ competence with classroom peers when they were approximately 9 years old. Findings indicated that children who received CPP were more likely to evidence secure attachments at postintervention, which in turn was associated with more positive peer relationships at age 9. En ligne : http://dx.doi.org/10.1017/s0954579417000207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Attachment security mediates the longitudinal association between child–parent psychotherapy and peer relations for toddlers of depressed mothers [Texte imprimé et/ou numérique] / Danielle J. GUILD, Auteur ; Sheree L. TOTH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur . - p.587-600. Langues : Anglais (eng) in Development and Psychopathology > 29-2 (May 2017) . - p.587-600 Index. décimale : PER Périodiques Résumé : Numerous investigations have demonstrated that child–parent psychotherapy (CPP) promotes secure attachment between mothers and offspring. However, the role of postintervention attachment security as it relates to long-term child outcomes has never been evaluated. The present study therefore examined postintervention attachment status as a mediator of the association between CPP for depressed mothers and their offspring and subsequent peer relations among offspring. Depressed mothers and their toddlers were randomized to receive CPP (n = 45) or to a control group (n = 55). A prior investigation with this sample indicated that offspring who received CPP attained significantly higher rates of secure attachment postintervention, whereas insecure attachment continued to predominate for offspring in the control group. The present study examined follow-up data of teachers’ reports on participants’ competence with classroom peers when they were approximately 9 years old. Findings indicated that children who received CPP were more likely to evidence secure attachments at postintervention, which in turn was associated with more positive peer relationships at age 9. En ligne : http://dx.doi.org/10.1017/s0954579417000207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Autobiographical memory functioning among abused, neglected, and nonmaltreated children: the overgeneral memory effect / Kristin VALENTINO in Journal of Child Psychology and Psychiatry, 50-8 (August 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.1029-1038 Titre : Autobiographical memory functioning among abused, neglected, and nonmaltreated children: the overgeneral memory effect Type de document : Texte imprimé et/ou numérique Auteurs : Kristin VALENTINO, Auteur ; Dante CICCHETTI, Auteur ; Sheree L. TOTH, Auteur Année de publication : 2009 Article en page(s) : p.1029-1038 Langues : Anglais (eng) Mots-clés : Child-abuse maltreatment autobiographical-memory overgeneral-memory self-representations depression Index. décimale : PER Périodiques Résumé : Background: This investigation addresses whether there are differences in the form and content of autobiographical memory recall as a function of maltreatment, and examines the roles of self-system functioning and psychopathology in autobiographical memory processes. Methods: Autobiographical memory for positive and negative nontraumatic events was evaluated among abused, neglected, and nonmaltreated school-aged children. Results: Abused children's memories were more overgeneral and contained more negative self-representations than did those of the nonmaltreated children. Negative self-representations and depression were significantly related to overgeneral memory, but did not mediate the relation between abuse and overgeneral memory. Conclusions: The meaning of these findings for models of memory and for the development of overgenerality is emphasized. Moreover, the clinical implications of the current research are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02072.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788 [article] Autobiographical memory functioning among abused, neglected, and nonmaltreated children: the overgeneral memory effect [Texte imprimé et/ou numérique] / Kristin VALENTINO, Auteur ; Dante CICCHETTI, Auteur ; Sheree L. TOTH, Auteur . - 2009 . - p.1029-1038. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-8 (August 2009) . - p.1029-1038 Mots-clés : Child-abuse maltreatment autobiographical-memory overgeneral-memory self-representations depression Index. décimale : PER Périodiques Résumé : Background: This investigation addresses whether there are differences in the form and content of autobiographical memory recall as a function of maltreatment, and examines the roles of self-system functioning and psychopathology in autobiographical memory processes. Methods: Autobiographical memory for positive and negative nontraumatic events was evaluated among abused, neglected, and nonmaltreated school-aged children. Results: Abused children's memories were more overgeneral and contained more negative self-representations than did those of the nonmaltreated children. Negative self-representations and depression were significantly related to overgeneral memory, but did not mediate the relation between abuse and overgeneral memory. Conclusions: The meaning of these findings for models of memory and for the development of overgenerality is emphasized. Moreover, the clinical implications of the current research are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02072.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=788

Childhood maltreatment and its effect on neurocognitive functioning: Timing and chronicity matter / Raquel A. COWELL in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.521-533 Titre : Childhood maltreatment and its effect on neurocognitive functioning: Timing and chronicity matter Type de document : Texte imprimé et/ou numérique Auteurs : Raquel A. COWELL, Auteur ; Dante CICCHETTI, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur Article en page(s) : p.521-533 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Childhood maltreatment represents a complex stressor, with the developmental timing, duration, frequency, and type of maltreatment varying with each child (Barnett, Manly, & Cicchetti, 1993; Cicchetti & Manly, 2001). Multiple brain regions and neural circuits are disrupted by the experience of child maltreatment (Cicchetti & Toth, in press; DeBellis et al., 2002; McCrory & Viding, 2010; Teicher, Anderson, & Polcari, 2012). These neurobiological compromises indicate the impairment of a number of important cognitive functions, including working memory and inhibitory control. The present study extends prior research by examining the effect of childhood maltreatment on neurocognitive functioning based on developmental timing of maltreatment, including onset, chronicity, and recency, in a sample of 3- to 9-year-old nonmaltreated (n = 136) and maltreated children (n = 223). Maltreated children performed more poorly on inhibitory control and working-memory tasks than did nonmaltreated children. Group differences between maltreated children based on the timing of maltreatment and the chronicity of maltreatment also were evident. Specifically, children who were maltreated during infancy, and children with a chronic history of maltreatment, exhibited significantly poorer inhibitory control and working-memory performance than did children without a history of maltreatment. The results suggest that maltreatment occurring during infancy, a period of major brain organization, disrupts normative structure and function, and these deficits are further instantiated by the prolonged stress of chronic maltreatment during the early years of life. En ligne : http://dx.doi.org/10.1017/S0954579415000139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Childhood maltreatment and its effect on neurocognitive functioning: Timing and chronicity matter [Texte imprimé et/ou numérique] / Raquel A. COWELL, Auteur ; Dante CICCHETTI, Auteur ; Fred A. ROGOSCH, Auteur ; Sheree L. TOTH, Auteur . - p.521-533. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.521-533 Index. décimale : PER Périodiques Résumé : Childhood maltreatment represents a complex stressor, with the developmental timing, duration, frequency, and type of maltreatment varying with each child (Barnett, Manly, & Cicchetti, 1993; Cicchetti & Manly, 2001). Multiple brain regions and neural circuits are disrupted by the experience of child maltreatment (Cicchetti & Toth, in press; DeBellis et al., 2002; McCrory & Viding, 2010; Teicher, Anderson, & Polcari, 2012). These neurobiological compromises indicate the impairment of a number of important cognitive functions, including working memory and inhibitory control. The present study extends prior research by examining the effect of childhood maltreatment on neurocognitive functioning based on developmental timing of maltreatment, including onset, chronicity, and recency, in a sample of 3- to 9-year-old nonmaltreated (n = 136) and maltreated children (n = 223). Maltreated children performed more poorly on inhibitory control and working-memory tasks than did nonmaltreated children. Group differences between maltreated children based on the timing of maltreatment and the chronicity of maltreatment also were evident. Specifically, children who were maltreated during infancy, and children with a chronic history of maltreatment, exhibited significantly poorer inhibitory control and working-memory performance than did children without a history of maltreatment. The results suggest that maltreatment occurring during infancy, a period of major brain organization, disrupts normative structure and function, and these deficits are further instantiated by the prolonged stress of chronic maltreatment during the early years of life. En ligne : http://dx.doi.org/10.1017/S0954579415000139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Developmental pathways from child maltreatment to adolescent pregnancy: A multiple mediational model / Justin RUSSOTTI in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.142-156 Titre : Developmental pathways from child maltreatment to adolescent pregnancy: A multiple mediational model Type de document : Texte imprimé et/ou numérique Auteurs : Justin RUSSOTTI, Auteur ; Sarah A. FONT, Auteur ; Sheree L. TOTH, Auteur ; Jennie G. NOLL, Auteur Article en page(s) : p.142-156 Langues : Anglais (eng) Mots-clés : adolescent childbirth  adolescent pregnancy  child maltreatment Index. décimale : PER Périodiques Résumé : Adolescent pregnancy (AP) is a significant public health issue. Child maltreatment (CM) represents an established risk factor, yet little is known about the explanatory mechanisms linking the phenomena. Informed by developmental theory, this study prospectively tested seven multi-level, indirect pathways that could plausibly explain the relationship between CM and AP: (1) substance use (polysubstance use and frequency); (2) sexual risk behavior; (3) depressive symptoms; (4) posttraumatic stress disorder symptoms; (5) cognitive dysregulation; (6) pregnancy desire and difficulty expectancies; and (7) age at menarche. Data came from a prospective, longitudinal cohort study of 469 ethnically diverse, nulliparous adolescent females, designed to examine the impact of substantiated CM on reproductive outcomes such as pregnancy and childbirth (265 maltreated and 204 demographically matched comparison adolescents). A multiple-mediator structural equation model was conducted to simultaneously test multiple indirect effects while accounting for confounding variables. Maltreatment had an indirect effect on pregnancy via substance use and higher pregnancy desire/lower perceived difficulty. Findings represent a step towards elucidating pathways linking CM with AP. Recommendations are offered to prevent pregnancy by addressing the pregnancy-specific mechanisms that are part of the maltreatment sequelae. En ligne : https://doi.org/10.1017/S0954579421001395 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Developmental pathways from child maltreatment to adolescent pregnancy: A multiple mediational model [Texte imprimé et/ou numérique] / Justin RUSSOTTI, Auteur ; Sarah A. FONT, Auteur ; Sheree L. TOTH, Auteur ; Jennie G. NOLL, Auteur . - p.142-156. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.142-156 Mots-clés : adolescent childbirth  adolescent pregnancy  child maltreatment Index. décimale : PER Périodiques Résumé : Adolescent pregnancy (AP) is a significant public health issue. Child maltreatment (CM) represents an established risk factor, yet little is known about the explanatory mechanisms linking the phenomena. Informed by developmental theory, this study prospectively tested seven multi-level, indirect pathways that could plausibly explain the relationship between CM and AP: (1) substance use (polysubstance use and frequency); (2) sexual risk behavior; (3) depressive symptoms; (4) posttraumatic stress disorder symptoms; (5) cognitive dysregulation; (6) pregnancy desire and difficulty expectancies; and (7) age at menarche. Data came from a prospective, longitudinal cohort study of 469 ethnically diverse, nulliparous adolescent females, designed to examine the impact of substantiated CM on reproductive outcomes such as pregnancy and childbirth (265 maltreated and 204 demographically matched comparison adolescents). A multiple-mediator structural equation model was conducted to simultaneously test multiple indirect effects while accounting for confounding variables. Maltreatment had an indirect effect on pregnancy via substance use and higher pregnancy desire/lower perceived difficulty. Findings represent a step towards elucidating pathways linking CM with AP. Recommendations are offered to prevent pregnancy by addressing the pregnancy-specific mechanisms that are part of the maltreatment sequelae. En ligne : https://doi.org/10.1017/S0954579421001395 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Frontiers in translational research on trauma / Sheree L. TOTH in Development and Psychopathology, 23-2 (May 2011)  

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Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: Implications for differential susceptibility / Dante CICCHETTI in Development and Psychopathology, 27-1 (February 2015)  

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Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Impact of childhood maltreatment and resilience on behavioral and neural patterns of inhibitory control during emotional distraction / Lauren A. DEMERS in Development and Psychopathology, 34-4 (October 2022)  

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Intimate partner violence as a mechanism underlying the intergenerational transmission of maltreatment among economically disadvantaged mothers and their adolescent daughters / Tangeria R. ADAMS in Development and Psychopathology, 31-1 (February 2019)  

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Long-term consequences of childhood maltreatment: Altered amygdala functional connectivity / Kelly JEDD in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

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Maternal childhood maltreatment trauma resolution: Development of a novel narrative coding measure and implications for intergenerational parenting processes / Hannah G. SWERBENSKI in Development and Psychopathology, 36-4 (October 2024)  

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Mechanisms of change: Testing how preventative interventions impact psychological and physiological stress functioning in mothers in neglectful families / Sheree L. TOTH in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

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Multilevel developmental perspectives on child maltreatment / Dante CICCHETTI in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

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Normalizing the development of cortisol regulation in maltreated infants through preventive interventions / Dante CICCHETTI in Development and Psychopathology, 23-3 (August 2011)  

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