[article]
| Titre : |
Maternal risk factors vary between subpopulations of children with autism spectrum disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Genevieve GRIVAS, Auteur ; Richard E. FRYE, Auteur ; Juergen HAHN, Auteur |
| Article en page(s) : |
p.2038-2055 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Child Pregnancy Female Humans Autism Spectrum Disorder/complications/epidemiology/diagnosis Case-Control Studies Pregnancy Complications Risk Factors Immune System Diseases/complications Seizures/complications associated risk autism spectrum disorder co-occurring conditions logistic regression medical claims retrospective analysis subgroups |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Previous work identified three subgroups of children with ASD based upon co-occurring conditions (COCs) diagnosed during the first 5 years of life. This work examines prenatal risk factors, given by maternal medical claims, for each of the three subgroups: children with a High-Prevalence of COCs, children with mainly developmental delay and seizures (DD/Seizure COCs), and children with a Low-Prevalence of COCs. While some risk factors are shared by all three subgroups, the majority of the factors identified for each subgroup were unique; infections, anti-inflammatory and other complex medications were associated with the High-Prevalence COCs group; immune deregulatory conditions such as asthma and joint disorders were associated with the DD/Seizure COCs group; and overall pregnancy complications were associated with the Low-Prevalence COCs group. Thus, we have found that the previously identified subgroups of children with ASD have distinct associated prenatal risk factors. As such, this work supports subgrouping children with ASD based upon COCs, which may provide a framework for elucidating some of the heterogeneity associated with ASD. |
| En ligne : |
http://dx.doi.org/10.1002/aur.2809 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 |
in Autism Research > 15-11 (November 2022) . - p.2038-2055
|
Maternal risk factors vary between subpopulations of children with autism spectrum disorder in Autism Research, 15-11 (November 2022)
