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Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents / Hannah KLUSMANN ; Tory EISENLOHR-MOUL ; Kayla BARESICH ; Susan GIRDLER in Development and Psychopathology, 36-2 (May 2024)
[article]
Titre : Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Hannah KLUSMANN, Auteur ; Tory EISENLOHR-MOUL, Auteur ; Kayla BARESICH, Auteur ; Susan GIRDLER, Auteur Article en page(s) : p.821-833 Langues : Anglais (eng) Mots-clés : depression female puberty sex hormones stress Index. décimale : PER Périodiques Résumé : Female adolescents have a greatly increased risk of depression starting at puberty, which continues throughout the reproductive lifespan. Sex hormone fluctuation has been highlighted as a key proximal precipitating factor in the development of mood disorders tied to reproductive events; however, hormone-induced affective state change is poorly understood in the pubertal transition. The present study investigated the impact of recent stressful life events on the relationship between sex hormone change and affective symptoms in peripubertal female participants. Thirty-five peripubertal participants (ages 11-14, premenarchal, or within 1 year of menarche) completed an assessment of stressful life events, and provided weekly salivary hormone collections [estrone, testosterone, dehydroepiandrosterone (DHEA)] and mood assessments for 8 weeks. Linear mixed models tested whether stressful life events provided a context in which within-person changes in hormones predicted weekly affective symptoms. Results indicated that exposure to stressful life events proximal to the pubertal transition influenced the directional effects of hormone change on affective symptoms. Specifically, greater affective symptoms were associated with increases in hormones in a high stress context and decreases in hormones in a low stress context. These findings provide support for stress-related hormone sensitivity as a diathesis for precipitating affective symptoms in the presence of pronounced peripubertal hormone flux. En ligne : https://dx.doi.org/10.1017/S095457942300010X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528
in Development and Psychopathology > 36-2 (May 2024) . - p.821-833[article] Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents [Texte imprimé et/ou numérique] / Hannah KLUSMANN, Auteur ; Tory EISENLOHR-MOUL, Auteur ; Kayla BARESICH, Auteur ; Susan GIRDLER, Auteur . - p.821-833.
Langues : Anglais (eng)
in Development and Psychopathology > 36-2 (May 2024) . - p.821-833
Mots-clés : depression female puberty sex hormones stress Index. décimale : PER Périodiques Résumé : Female adolescents have a greatly increased risk of depression starting at puberty, which continues throughout the reproductive lifespan. Sex hormone fluctuation has been highlighted as a key proximal precipitating factor in the development of mood disorders tied to reproductive events; however, hormone-induced affective state change is poorly understood in the pubertal transition. The present study investigated the impact of recent stressful life events on the relationship between sex hormone change and affective symptoms in peripubertal female participants. Thirty-five peripubertal participants (ages 11-14, premenarchal, or within 1 year of menarche) completed an assessment of stressful life events, and provided weekly salivary hormone collections [estrone, testosterone, dehydroepiandrosterone (DHEA)] and mood assessments for 8 weeks. Linear mixed models tested whether stressful life events provided a context in which within-person changes in hormones predicted weekly affective symptoms. Results indicated that exposure to stressful life events proximal to the pubertal transition influenced the directional effects of hormone change on affective symptoms. Specifically, greater affective symptoms were associated with increases in hormones in a high stress context and decreases in hormones in a low stress context. These findings provide support for stress-related hormone sensitivity as a diathesis for precipitating affective symptoms in the presence of pronounced peripubertal hormone flux. En ligne : https://dx.doi.org/10.1017/S095457942300010X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences / A. RYNKIEWICZ in Molecular Autism, 7 (2016)
[article]
Titre : An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences Type de document : Texte imprimé et/ou numérique Auteurs : A. RYNKIEWICZ, Auteur ; B. SCHULLER, Auteur ; E. MARCHI, Auteur ; S. PIANA, Auteur ; A. CAMURRI, Auteur ; A. LASSALLE, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Asperger Syndrome/diagnosis/psychology Autistic Disorder/diagnosis/psychology Child Child, Preschool Communication Disorders/diagnosis/etiology Culture Diagnosis, Computer-Assisted/methods Diagnostic Errors Emotions Facial Expression Female Fixation, Ocular Gestures Humans Male Parents Poland Psychomotor Performance Severity of Illness Index Sex Characteristics Sex Factors Social Behavior Software Stereotyped Behavior Surveys and Questionnaires Ados-2 Computer application Diagnosis Females with autism Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (autism) are diagnosed more frequently in boys than in girls. Females with autism may have been under-identified due to not only a male-biased understanding of autism but also females' camouflaging. The study describes a new technique that allows automated coding of non-verbal mode of communication (gestures) and offers the possibility of objective, evaluation of gestures, independent of human judgment. The EyesWeb software platform and the Kinect sensor during two demonstration activities of ADOS-2 (Autism Diagnostic Observation Schedule, Second Edition) were used. METHODS: The study group consisted of 33 high-functioning Polish girls and boys with formal diagnosis of autism or Asperger syndrome aged 5-10, with fluent speech, IQ average and above and their parents (girls with autism, n = 16; boys with autism, n = 17). All children were assessed during two demonstration activities of Module 3 of ADOS-2, administered in Polish, and coded using Polish codes. Children were also assessed with Polish versions of the Eyes and Faces Tests. Parents provided information on the author-reviewed Polish research translation of SCQ (Social Communication Questionnaire, Current and Lifetime) and Polish version of AQ Child (Autism Spectrum Quotient, Child). RESULTS: Girls with autism tended to use gestures more vividly as compared to boys with autism during two demonstration activities of ADOS-2. Girls with autism made significantly more mistakes than boys with autism on the Faces Test. All children with autism had high scores in AQ Child, which confirmed the presence of autistic traits in this group. The current communication skills of boys with autism reported by parents in SCQ were significantly better than those of girls with autism. However, both girls with autism and boys with autism improved in the social and communication abilities over the lifetime. The number of stereotypic behaviours in boys significantly decreased over life whereas it remained at a comparable level in girls with autism. CONCLUSIONS: High-functioning females with autism might present better on non-verbal (gestures) mode of communication than boys with autism. It may camouflage other diagnostic features. It poses risk of under-diagnosis or not receiving the appropriate diagnosis for this population. Further research is required to examine this phenomenon so appropriate gender revisions to the diagnostic assessments might be implemented. En ligne : http://dx.doi.org/10.1186/s13229-016-0073-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329
in Molecular Autism > 7 (2016) . - 10p.[article] An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences [Texte imprimé et/ou numérique] / A. RYNKIEWICZ, Auteur ; B. SCHULLER, Auteur ; E. MARCHI, Auteur ; S. PIANA, Auteur ; A. CAMURRI, Auteur ; A. LASSALLE, Auteur ; Simon BARON-COHEN, Auteur . - 10p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 10p.
Mots-clés : Asperger Syndrome/diagnosis/psychology Autistic Disorder/diagnosis/psychology Child Child, Preschool Communication Disorders/diagnosis/etiology Culture Diagnosis, Computer-Assisted/methods Diagnostic Errors Emotions Facial Expression Female Fixation, Ocular Gestures Humans Male Parents Poland Psychomotor Performance Severity of Illness Index Sex Characteristics Sex Factors Social Behavior Software Stereotyped Behavior Surveys and Questionnaires Ados-2 Computer application Diagnosis Females with autism Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum conditions (autism) are diagnosed more frequently in boys than in girls. Females with autism may have been under-identified due to not only a male-biased understanding of autism but also females' camouflaging. The study describes a new technique that allows automated coding of non-verbal mode of communication (gestures) and offers the possibility of objective, evaluation of gestures, independent of human judgment. The EyesWeb software platform and the Kinect sensor during two demonstration activities of ADOS-2 (Autism Diagnostic Observation Schedule, Second Edition) were used. METHODS: The study group consisted of 33 high-functioning Polish girls and boys with formal diagnosis of autism or Asperger syndrome aged 5-10, with fluent speech, IQ average and above and their parents (girls with autism, n = 16; boys with autism, n = 17). All children were assessed during two demonstration activities of Module 3 of ADOS-2, administered in Polish, and coded using Polish codes. Children were also assessed with Polish versions of the Eyes and Faces Tests. Parents provided information on the author-reviewed Polish research translation of SCQ (Social Communication Questionnaire, Current and Lifetime) and Polish version of AQ Child (Autism Spectrum Quotient, Child). RESULTS: Girls with autism tended to use gestures more vividly as compared to boys with autism during two demonstration activities of ADOS-2. Girls with autism made significantly more mistakes than boys with autism on the Faces Test. All children with autism had high scores in AQ Child, which confirmed the presence of autistic traits in this group. The current communication skills of boys with autism reported by parents in SCQ were significantly better than those of girls with autism. However, both girls with autism and boys with autism improved in the social and communication abilities over the lifetime. The number of stereotypic behaviours in boys significantly decreased over life whereas it remained at a comparable level in girls with autism. CONCLUSIONS: High-functioning females with autism might present better on non-verbal (gestures) mode of communication than boys with autism. It may camouflage other diagnostic features. It poses risk of under-diagnosis or not receiving the appropriate diagnosis for this population. Further research is required to examine this phenomenon so appropriate gender revisions to the diagnostic assessments might be implemented. En ligne : http://dx.doi.org/10.1186/s13229-016-0073-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 Phenotypic differences between female and male individuals with suspicion of autism spectrum disorder / Sanna STROTH in Molecular Autism, 13 (2022)
[article]
Titre : Phenotypic differences between female and male individuals with suspicion of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sanna STROTH, Auteur ; Johannes TAUSCHER, Auteur ; Nicole WOLFF, Auteur ; Charlotte KÜPPER, Auteur ; Luise POUSTKA, Auteur ; Stefan ROEPKE, Auteur ; Veit ROESSNER, Auteur ; Dominik HEIDER, Auteur ; Inge KAMP-BECKER, Auteur Article en page(s) : 11 p. Langues : Anglais (eng) Mots-clés : Affect Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Intellectual Disability/diagnosis Male Adi-r Ados Asd Diagnostics Female autism Phenotype Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is a common developmental disorder, our knowledge about a behavioral and neurobiological female phenotype is still scarce. As the conceptualization and understanding of ASD are mainly based on the investigation of male individuals, females with ASD may not be adequately identified by routine clinical diagnostics. The present machine learning approach aimed to identify diagnostic information from the Autism Diagnostic Observation Schedule (ADOS) that discriminates best between ASD and non-ASD in females and males. METHODS: Random forests (RF) were used to discover patterns of symptoms in diagnostic data from the ADOS (modules 3 and 4) in 1057 participants with ASD (18.1% female) and 1230 participants with non-ASD (17.9% % female). Predictive performances of reduced feature models were explored and compared between females and males without intellectual disabilities. RESULTS: Reduced feature models relied on considerably fewer features from the ADOS in females compared to males, while still yielding similar classification performance (e.g., sensitivity, specificity). LIMITATIONS: As in previous studies, the current sample of females with ASD is smaller than the male sample and thus, females may still be underrepresented, limiting the statistical power to detect small to moderate effects. CONCLUSION: Our results do not suggest the need for new or altered diagnostic algorithms for females with ASD. Although we identified some phenotypic differences between females and males, the existing diagnostic tools seem to sufficiently capture the core autistic features in both groups. En ligne : http://dx.doi.org/10.1186/s13229-022-00491-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Molecular Autism > 13 (2022) . - 11 p.[article] Phenotypic differences between female and male individuals with suspicion of autism spectrum disorder [Texte imprimé et/ou numérique] / Sanna STROTH, Auteur ; Johannes TAUSCHER, Auteur ; Nicole WOLFF, Auteur ; Charlotte KÜPPER, Auteur ; Luise POUSTKA, Auteur ; Stefan ROEPKE, Auteur ; Veit ROESSNER, Auteur ; Dominik HEIDER, Auteur ; Inge KAMP-BECKER, Auteur . - 11 p.
Langues : Anglais (eng)
in Molecular Autism > 13 (2022) . - 11 p.
Mots-clés : Affect Autism Spectrum Disorder/diagnosis Autistic Disorder Female Humans Intellectual Disability/diagnosis Male Adi-r Ados Asd Diagnostics Female autism Phenotype Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is a common developmental disorder, our knowledge about a behavioral and neurobiological female phenotype is still scarce. As the conceptualization and understanding of ASD are mainly based on the investigation of male individuals, females with ASD may not be adequately identified by routine clinical diagnostics. The present machine learning approach aimed to identify diagnostic information from the Autism Diagnostic Observation Schedule (ADOS) that discriminates best between ASD and non-ASD in females and males. METHODS: Random forests (RF) were used to discover patterns of symptoms in diagnostic data from the ADOS (modules 3 and 4) in 1057 participants with ASD (18.1% female) and 1230 participants with non-ASD (17.9% % female). Predictive performances of reduced feature models were explored and compared between females and males without intellectual disabilities. RESULTS: Reduced feature models relied on considerably fewer features from the ADOS in females compared to males, while still yielding similar classification performance (e.g., sensitivity, specificity). LIMITATIONS: As in previous studies, the current sample of females with ASD is smaller than the male sample and thus, females may still be underrepresented, limiting the statistical power to detect small to moderate effects. CONCLUSION: Our results do not suggest the need for new or altered diagnostic algorithms for females with ASD. Although we identified some phenotypic differences between females and males, the existing diagnostic tools seem to sufficiently capture the core autistic features in both groups. En ligne : http://dx.doi.org/10.1186/s13229-022-00491-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study / J. LEI in Autism Research, 12-10 (October 2019)
[article]
Titre : Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study Type de document : Texte imprimé et/ou numérique Auteurs : J. LEI, Auteur ; E. LECARIE, Auteur ; J. JURAYJ, Auteur ; S. BOLAND, Auteur ; D. G. SUKHODOLSKY, Auteur ; Pamela VENTOLA, Auteur ; Kevin A. PELPHREY, Auteur ; R. J. JOU, Auteur Article en page(s) : p.1472-1483 Langues : Anglais (eng) Mots-clés : anisotropy autism spectrum disorder diffusion tensor imaging female motion sex characteristics Index. décimale : PER Périodiques Résumé : Previous studies using diffusion tensor imaging (DTI) to investigate white matter (WM) structural connectivity have suggested widespread, although inconsistent WM alterations in autism spectrum disorder (ASD), such as greater reductions in fractional anisotropy (FA). However, findings may lack generalizability because: (a) most have focused solely on the ASD male brain phenotype, and not sex-differences in WM integrity; (b) many lack stringent and transparent data quality control such as controlling for head motion in analysis. This study addressed both issues by using Tract-Based Spatial Statistics (TBSS) to separately compare WM differences in 81 ASD (56 male, 25 female; 4-21 years old) and 39 typically developing (TD; 23 males, 16 females; 5-18 years old) children and young people, carefully group-matched on sex, age, cognitive abilities, and head motion. ASD males and females were also matched on autism symptom severity. Two independent-raters completed a multistep scan quality assurance to remove images that were significantly distorted by motion artifacts before analysis. ASD females exhibited significant widespread reductions in FA compared to TD females, suggesting altered WM integrity. In contrast, no significant localized or widespread WM differences were found between ASD and TD males. This study highlights the importance of data quality control in DTI, and outlines important sex-differences in WM alterations in ASD females. Future studies can explore the extent to which neural structural differences might underlie sex-differences in ASD behavioral phenotype, and guide clinical interventions to be tailored toward the unique needs of ASD females and males. Autism Res 2019, 12: 1472-1483. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Previous Diffusion Tensor Imaging (DTI) studies have found atypical brain structural connectivity in males with autism, although findings are inconclusive in females with autism. To investigate potential sex-differences, we studied males and females with and without autism who showed a similar level of head movement during their brain scan. We found that females with autism had widespread atypical neural connectivity than females without autism, although not in males, highlighting sex-differences. En ligne : http://dx.doi.org/10.1002/aur.2180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Autism Research > 12-10 (October 2019) . - p.1472-1483[article] Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study [Texte imprimé et/ou numérique] / J. LEI, Auteur ; E. LECARIE, Auteur ; J. JURAYJ, Auteur ; S. BOLAND, Auteur ; D. G. SUKHODOLSKY, Auteur ; Pamela VENTOLA, Auteur ; Kevin A. PELPHREY, Auteur ; R. J. JOU, Auteur . - p.1472-1483.
Langues : Anglais (eng)
in Autism Research > 12-10 (October 2019) . - p.1472-1483
Mots-clés : anisotropy autism spectrum disorder diffusion tensor imaging female motion sex characteristics Index. décimale : PER Périodiques Résumé : Previous studies using diffusion tensor imaging (DTI) to investigate white matter (WM) structural connectivity have suggested widespread, although inconsistent WM alterations in autism spectrum disorder (ASD), such as greater reductions in fractional anisotropy (FA). However, findings may lack generalizability because: (a) most have focused solely on the ASD male brain phenotype, and not sex-differences in WM integrity; (b) many lack stringent and transparent data quality control such as controlling for head motion in analysis. This study addressed both issues by using Tract-Based Spatial Statistics (TBSS) to separately compare WM differences in 81 ASD (56 male, 25 female; 4-21 years old) and 39 typically developing (TD; 23 males, 16 females; 5-18 years old) children and young people, carefully group-matched on sex, age, cognitive abilities, and head motion. ASD males and females were also matched on autism symptom severity. Two independent-raters completed a multistep scan quality assurance to remove images that were significantly distorted by motion artifacts before analysis. ASD females exhibited significant widespread reductions in FA compared to TD females, suggesting altered WM integrity. In contrast, no significant localized or widespread WM differences were found between ASD and TD males. This study highlights the importance of data quality control in DTI, and outlines important sex-differences in WM alterations in ASD females. Future studies can explore the extent to which neural structural differences might underlie sex-differences in ASD behavioral phenotype, and guide clinical interventions to be tailored toward the unique needs of ASD females and males. Autism Res 2019, 12: 1472-1483. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Previous Diffusion Tensor Imaging (DTI) studies have found atypical brain structural connectivity in males with autism, although findings are inconclusive in females with autism. To investigate potential sex-differences, we studied males and females with and without autism who showed a similar level of head movement during their brain scan. We found that females with autism had widespread atypical neural connectivity than females without autism, although not in males, highlighting sex-differences. En ligne : http://dx.doi.org/10.1002/aur.2180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 Autism presentation in female and Black populations: Examining the roles of identity, theory, and systemic inequalities / Maire Claire DIEMER in Autism, 26-8 (November 2022)
[article]
Titre : Autism presentation in female and Black populations: Examining the roles of identity, theory, and systemic inequalities Type de document : Texte imprimé et/ou numérique Auteurs : Maire Claire DIEMER, Auteur ; Emily D. GERSTEIN, Auteur ; April REGESTER, Auteur Article en page(s) : p.1931-1946 Langues : Anglais (eng) Mots-clés : Child Humans United States Female Child, Preschool Autistic Disorder/diagnosis Autism Spectrum Disorder/epidemiology Intellectual Disability Ethnicity Racial Groups African American autism spectrum disorders diagnosis diversity gender health disparity intellectual disability intersectional race systemic inequality Index. décimale : PER Périodiques Résumé : Although the prevalence of autism has been rising in recent years, disparities in diagnosis still remain. Female and Black populations in the United States are diagnosed later, are more likely to have an intellectual disability, and are excluded from research as well as services designed for autistic individuals. Autistic Black girls are effectively invisible in the current scientific literature. Intersectional theory, which looks at a person as a whole, examines models that are inclusive toward diverse gender, ability, and racial/ethnic backgrounds. This theory may be a useful approach to clinical and research work with autism so that practitioners may be most effective for the whole population of autistic people. The authors recommend research focusing on inclusion of autistic populations with intellectual disability and research studies that include evaluations as part of the procedure. Clinically, the authors recommend a focus on screening all young children for autism and improving provider knowledge in working with diverse autistic populations. En ligne : http://dx.doi.org/10.1177/13623613221113501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism > 26-8 (November 2022) . - p.1931-1946[article] Autism presentation in female and Black populations: Examining the roles of identity, theory, and systemic inequalities [Texte imprimé et/ou numérique] / Maire Claire DIEMER, Auteur ; Emily D. GERSTEIN, Auteur ; April REGESTER, Auteur . - p.1931-1946.
Langues : Anglais (eng)
in Autism > 26-8 (November 2022) . - p.1931-1946
Mots-clés : Child Humans United States Female Child, Preschool Autistic Disorder/diagnosis Autism Spectrum Disorder/epidemiology Intellectual Disability Ethnicity Racial Groups African American autism spectrum disorders diagnosis diversity gender health disparity intellectual disability intersectional race systemic inequality Index. décimale : PER Périodiques Résumé : Although the prevalence of autism has been rising in recent years, disparities in diagnosis still remain. Female and Black populations in the United States are diagnosed later, are more likely to have an intellectual disability, and are excluded from research as well as services designed for autistic individuals. Autistic Black girls are effectively invisible in the current scientific literature. Intersectional theory, which looks at a person as a whole, examines models that are inclusive toward diverse gender, ability, and racial/ethnic backgrounds. This theory may be a useful approach to clinical and research work with autism so that practitioners may be most effective for the whole population of autistic people. The authors recommend research focusing on inclusion of autistic populations with intellectual disability and research studies that include evaluations as part of the procedure. Clinically, the authors recommend a focus on screening all young children for autism and improving provider knowledge in working with diverse autistic populations. En ligne : http://dx.doi.org/10.1177/13623613221113501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Brief Report: Autistic Traits Predict Spectral Correlates of Vowel Intelligibility for Female Speakers / Jason BISHOP in Journal of Autism and Developmental Disorders, 52-5 (May 2022)
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