Blood oxytocin concentration positively predicts contagious yawning behavior in children with autism spectrum disorder / M. G. MARISCAL in Autism Research, 12-8 (August 2019)  

Public ISBD [article]  inAutism Research > 12-8 (August 2019) . - p.1156-1161 Titre : Blood oxytocin concentration positively predicts contagious yawning behavior in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. G. MARISCAL, Auteur ; O. OZTAN, Auteur ; S. M. ROSE, Auteur ; R. A. LIBOVE, Auteur ; L. P. JACKSON, Auteur ; R. D. SUMIYOSHI, Auteur ; T. H. TRUJILLO, Auteur ; D. S. CARSON, Auteur ; J. M. PHILLIPS, Auteur ; J. P. GARNER, Auteur ; A. Y. HARDAN, Auteur ; Karen J. PARKER, Auteur Article en page(s) : p.1156-1161 Langues : Anglais (eng) Mots-clés : autism  contagion  empathy  oxytocin  social functioning  yawning Index. décimale : PER Périodiques Résumé : Research suggests that children with autism spectrum disorder (ASD) may have reduced empathy, as measured by an impaired contagious yawn response, compared to typically developing (TD) children. Other research has failed to replicate this finding, instead attributing this phenomenon to group differences in attention paid to yawn stimuli. A third possibility is that only a subgroup of children with ASD exhibits the impaired contagious yawn response, and that it can be identified biologically. Here we quantified blood concentrations of the "social" neuropeptide oxytocin (OXT) and evaluated yawning behavior and attention rates during a laboratory task in children with ASD (N = 34) and TD children (N = 30) aged 6-12 years. No group difference in contagious yawning behavior was found. However, a blood OXT concentration x group (ASD vs. TD) interaction positively predicted contagious yawning behavior (F1,50 = 7.4987; P = 0.0085). Specifically, blood OXT concentration was positively related to contagious yawning behavior in children with ASD, but not in TD children. This finding was not due to delayed perception of yawn stimuli and was observed whether attention paid to test stimuli and clinical symptom severity were included in the analysis or not. These findings suggest that only a biologically defined subset of children with ASD exhibits reduced empathy, as measured by the impaired contagious yawn response, and that prior conflicting reports of this behavioral phenomenon may be attributable, at least in part, to variable mean OXT concentrations across different ASD study cohorts. Autism Res 2019, 12: 1156-1161. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism may contagiously yawn (i.e., yawn in response to another's yawn) less often than people without autism. We find that people with autism who have lower levels of blood oxytocin (OXT), a hormone involved in social behavior and empathy, show decreased contagious yawning, but those who have higher blood OXT levels do not differ in contagious yawning from controls. This suggests that decreased contagious yawning may only occur in a biologically defined subset of people with autism. En ligne : http://dx.doi.org/10.1002/aur.2135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Blood oxytocin concentration positively predicts contagious yawning behavior in children with autism spectrum disorder [Texte imprimé et/ou numérique] / M. G. MARISCAL, Auteur ; O. OZTAN, Auteur ; S. M. ROSE, Auteur ; R. A. LIBOVE, Auteur ; L. P. JACKSON, Auteur ; R. D. SUMIYOSHI, Auteur ; T. H. TRUJILLO, Auteur ; D. S. CARSON, Auteur ; J. M. PHILLIPS, Auteur ; J. P. GARNER, Auteur ; A. Y. HARDAN, Auteur ; Karen J. PARKER, Auteur . - p.1156-1161. Langues : Anglais (eng) in Autism Research > 12-8 (August 2019) . - p.1156-1161 Mots-clés : autism  contagion  empathy  oxytocin  social functioning  yawning Index. décimale : PER Périodiques Résumé : Research suggests that children with autism spectrum disorder (ASD) may have reduced empathy, as measured by an impaired contagious yawn response, compared to typically developing (TD) children. Other research has failed to replicate this finding, instead attributing this phenomenon to group differences in attention paid to yawn stimuli. A third possibility is that only a subgroup of children with ASD exhibits the impaired contagious yawn response, and that it can be identified biologically. Here we quantified blood concentrations of the "social" neuropeptide oxytocin (OXT) and evaluated yawning behavior and attention rates during a laboratory task in children with ASD (N = 34) and TD children (N = 30) aged 6-12 years. No group difference in contagious yawning behavior was found. However, a blood OXT concentration x group (ASD vs. TD) interaction positively predicted contagious yawning behavior (F1,50 = 7.4987; P = 0.0085). Specifically, blood OXT concentration was positively related to contagious yawning behavior in children with ASD, but not in TD children. This finding was not due to delayed perception of yawn stimuli and was observed whether attention paid to test stimuli and clinical symptom severity were included in the analysis or not. These findings suggest that only a biologically defined subset of children with ASD exhibits reduced empathy, as measured by the impaired contagious yawn response, and that prior conflicting reports of this behavioral phenomenon may be attributable, at least in part, to variable mean OXT concentrations across different ASD study cohorts. Autism Res 2019, 12: 1156-1161. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism may contagiously yawn (i.e., yawn in response to another's yawn) less often than people without autism. We find that people with autism who have lower levels of blood oxytocin (OXT), a hormone involved in social behavior and empathy, show decreased contagious yawning, but those who have higher blood OXT levels do not differ in contagious yawning from controls. This suggests that decreased contagious yawning may only occur in a biologically defined subset of people with autism. En ligne : http://dx.doi.org/10.1002/aur.2135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Development of the Stanford Social Dimensions Scale: initial validation in autism spectrum disorder and in neurotypicals / J. M. PHILLIPS in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 48 p. Titre : Development of the Stanford Social Dimensions Scale: initial validation in autism spectrum disorder and in neurotypicals Type de document : Texte imprimé et/ou numérique Auteurs : J. M. PHILLIPS, Auteur ; M. ULJAREVIC, Auteur ; R. K. SCHUCK, Auteur ; S. SCHAPP, Auteur ; E. M. SOLOMON, Auteur ; E. SALZMAN, Auteur ; Lauren ALLERHAND, Auteur ; R. A. LIBOVE, Auteur ; T. W. FRAZIER, Auteur ; A. Y. HARDAN, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Social motivation  Social processing Index. décimale : PER Périodiques Résumé : Background: The aim of this paper was to provide an initial validation of a newly developed parent questionnaire-the Stanford Social Dimensions Scale (SSDS), designed to capture individual differences across several key social dimensions including social motivation in children and adolescents with and without psychiatric disorders. Methods: The initial validation sample was comprised of parents of 175 individuals with autism spectrum disorder (ASD) (35 females, 140 males; M age = 7.19 years, SD age = 3.96) and the replication sample consisted of 624 parents of children who were either typically developing or presented with a range of neurodevelopmental and neuropsychiatric disorders (302 females, 322 males; M age = 11.49 years, SDage = 4.48). Parents from both samples completed the SSDS and the Social Responsiveness Scale (SRS-2). Results: Exploratory Structural Equation Modeling indicated that a 5-factor model provided adequate to excellent fit to the data in the initial ASD sample (comparative fit index [CFI] = .940, Tucker-Lewis Index [TLI] = .919, root mean square error of approximation [RMSEA] = .048, standardized root mean square residual [SRMR] = .038). The identified factors were interpreted as Social Motivation, Social Affiliation, Expressive Social Communication, Social Recognition, and Unusual Approach. This factor structure was further confirmed in Sample 2 (CFI = 946, TLI = .930, RMSEA = .044, SRMR = .026). Internal consistency for all subscales was in the good to excellent range across both samples as indicated by Composite Reliability scores of >/= .72. Convergent and divergent validity was strong as indexed by the pattern of correlations with relevant SRS-2 and Child Behavior Checklist domains and with verbal and non-verbal intellectual functioning scores in Sample 1 and with the Need to Belong Scale and Child Social Preference Scale scores in Sample 2. Across both samples, females had higher social motivation and expressive social communication scores. Discriminant validity was strong given that across all SSDS subscales, the ASD sample had significantly higher impairment than both the typically developing group and the group with other clinical conditions, which in turn, had significantly higher impairment than the typically developing group. Conclusions: Our findings provide initial validation of a new scale designed to comprehensively capture individual differences in social motivation and other key social dimensions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-019-0298-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Development of the Stanford Social Dimensions Scale: initial validation in autism spectrum disorder and in neurotypicals [Texte imprimé et/ou numérique] / J. M. PHILLIPS, Auteur ; M. ULJAREVIC, Auteur ; R. K. SCHUCK, Auteur ; S. SCHAPP, Auteur ; E. M. SOLOMON, Auteur ; E. SALZMAN, Auteur ; Lauren ALLERHAND, Auteur ; R. A. LIBOVE, Auteur ; T. W. FRAZIER, Auteur ; A. Y. HARDAN, Auteur . - 48 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 48 p. Mots-clés : Autism spectrum disorder  Social motivation  Social processing Index. décimale : PER Périodiques Résumé : Background: The aim of this paper was to provide an initial validation of a newly developed parent questionnaire-the Stanford Social Dimensions Scale (SSDS), designed to capture individual differences across several key social dimensions including social motivation in children and adolescents with and without psychiatric disorders. Methods: The initial validation sample was comprised of parents of 175 individuals with autism spectrum disorder (ASD) (35 females, 140 males; M age = 7.19 years, SD age = 3.96) and the replication sample consisted of 624 parents of children who were either typically developing or presented with a range of neurodevelopmental and neuropsychiatric disorders (302 females, 322 males; M age = 11.49 years, SDage = 4.48). Parents from both samples completed the SSDS and the Social Responsiveness Scale (SRS-2). Results: Exploratory Structural Equation Modeling indicated that a 5-factor model provided adequate to excellent fit to the data in the initial ASD sample (comparative fit index [CFI] = .940, Tucker-Lewis Index [TLI] = .919, root mean square error of approximation [RMSEA] = .048, standardized root mean square residual [SRMR] = .038). The identified factors were interpreted as Social Motivation, Social Affiliation, Expressive Social Communication, Social Recognition, and Unusual Approach. This factor structure was further confirmed in Sample 2 (CFI = 946, TLI = .930, RMSEA = .044, SRMR = .026). Internal consistency for all subscales was in the good to excellent range across both samples as indicated by Composite Reliability scores of >/= .72. Convergent and divergent validity was strong as indexed by the pattern of correlations with relevant SRS-2 and Child Behavior Checklist domains and with verbal and non-verbal intellectual functioning scores in Sample 1 and with the Need to Belong Scale and Child Social Preference Scale scores in Sample 2. Across both samples, females had higher social motivation and expressive social communication scores. Discriminant validity was strong given that across all SSDS subscales, the ASD sample had significantly higher impairment than both the typically developing group and the group with other clinical conditions, which in turn, had significantly higher impairment than the typically developing group. Conclusions: Our findings provide initial validation of a new scale designed to comprehensively capture individual differences in social motivation and other key social dimensions in ASD. En ligne : http://dx.doi.org/10.1186/s13229-019-0298-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

Effects of a parent-implemented Developmental Reciprocity Treatment Program for children with autism spectrum disorder / G. W. GENGOUX in Autism, 23-3 (April 2019)  

Public ISBD [article]  inAutism > 23-3 (April 2019) . - p.713-725 Titre : Effects of a parent-implemented Developmental Reciprocity Treatment Program for children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : G. W. GENGOUX, Auteur ; S. SCHAPP, Auteur ; S. BURTON, Auteur ; Christina M. ARDEL, Auteur ; R. A. LIBOVE, Auteur ; G. BALDI, Auteur ; Kari L. BERQUIST, Auteur ; J. M. PHILLIPS, Auteur ; A. Y. HARDAN, Auteur Article en page(s) : p.713-725 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  development  interventions-psychosocial/behavioral  preschool children Index. décimale : PER Périodiques Résumé : Developmental approaches to autism treatment aim to establish strong interpersonal relationships through joint play. These approaches have emerging empirical support; however, there is a need for further research documenting the procedures and demonstrating their effectiveness. This pilot study evaluated changes in parent behavior and child autism symptoms following a 12-week Developmental Reciprocity Treatment parent-training program. A total of 22 children with autism spectrum disorder between 2 and 6 years (mean age = 44.6 months, standard deviation = 12.7) and a primary caregiver participated in 12 weekly sessions of Developmental Reciprocity Treatment parent training, covering topics including introduction to developmental approaches, supporting attention and motivation, sensory regulation and sensory-social routines, imitation/building nonverbal communication, functional language development, and turn taking. Results indicated improvement in aspects of parent empowerment and social quality of life. Improvement in core autism symptoms was observed on the Social Responsiveness Scale total score (F(1,19): 5.550, p = 0.029), MacArthur-Bates Communicative Development Inventories number of words produced out of 680 (F(1,18): 18.104, p = 0.000), and two subscales of the Repetitive Behavior Scale, Revised (compulsive, p = 0.046 and restricted, p = 0.025). No differences in sensory sensitivity were observed on the Short Sensory Profile. Findings from this pilot study indicate that Developmental Reciprocity Treatment shows promise and suggest the need for future controlled trials of this developmentally based intervention. En ligne : http://dx.doi.org/10.1177/1362361318775538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392 [article] Effects of a parent-implemented Developmental Reciprocity Treatment Program for children with autism spectrum disorder [Texte imprimé et/ou numérique] / G. W. GENGOUX, Auteur ; S. SCHAPP, Auteur ; S. BURTON, Auteur ; Christina M. ARDEL, Auteur ; R. A. LIBOVE, Auteur ; G. BALDI, Auteur ; Kari L. BERQUIST, Auteur ; J. M. PHILLIPS, Auteur ; A. Y. HARDAN, Auteur . - p.713-725. Langues : Anglais (eng) in Autism > 23-3 (April 2019) . - p.713-725 Mots-clés : autism spectrum disorders  development  interventions-psychosocial/behavioral  preschool children Index. décimale : PER Périodiques Résumé : Developmental approaches to autism treatment aim to establish strong interpersonal relationships through joint play. These approaches have emerging empirical support; however, there is a need for further research documenting the procedures and demonstrating their effectiveness. This pilot study evaluated changes in parent behavior and child autism symptoms following a 12-week Developmental Reciprocity Treatment parent-training program. A total of 22 children with autism spectrum disorder between 2 and 6 years (mean age = 44.6 months, standard deviation = 12.7) and a primary caregiver participated in 12 weekly sessions of Developmental Reciprocity Treatment parent training, covering topics including introduction to developmental approaches, supporting attention and motivation, sensory regulation and sensory-social routines, imitation/building nonverbal communication, functional language development, and turn taking. Results indicated improvement in aspects of parent empowerment and social quality of life. Improvement in core autism symptoms was observed on the Social Responsiveness Scale total score (F(1,19): 5.550, p = 0.029), MacArthur-Bates Communicative Development Inventories number of words produced out of 680 (F(1,18): 18.104, p = 0.000), and two subscales of the Repetitive Behavior Scale, Revised (compulsive, p = 0.046 and restricted, p = 0.025). No differences in sensory sensitivity were observed on the Short Sensory Profile. Findings from this pilot study indicate that Developmental Reciprocity Treatment shows promise and suggest the need for future controlled trials of this developmentally based intervention. En ligne : http://dx.doi.org/10.1177/1362361318775538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392

Plasma anandamide concentrations are lower in children with autism spectrum disorder / Debra S. KARHSON in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 18p. Titre : Plasma anandamide concentrations are lower in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Debra S. KARHSON, Auteur ; K. M. KRASINSKA, Auteur ; J. A. DALLAIRE, Auteur ; R. A. LIBOVE, Auteur ; J. M. PHILLIPS, Auteur ; A. S. CHIEN, Auteur ; J. P. GARNER, Auteur ; A. Y. HARDAN, Auteur ; Karen J. PARKER, Auteur Article en page(s) : 18p. Langues : Anglais (eng) Mots-clés : Anandamide  Autism spectrum disorder  Blood biomarker  Cannabinoid Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent models of ASD. Despite this promising preclinical evidence, no clinical studies to date have tested whether endocannabinoids are dysregulated in individuals with ASD. Here, we addressed this critical gap in knowledge by optimizing liquid chromatography-tandem mass spectrometry methodology to quantitatively analyze anandamide concentrations in banked blood samples collected from a cohort of children with and without ASD (N = 112). Findings: Anandamide concentrations significantly differentiated ASD cases (N = 59) from controls (N = 53), such that children with lower anandamide concentrations were more likely to have ASD (p = 0.041). In keeping with this notion, anandamide concentrations were also significantly lower in ASD compared to control children (p = 0.034). Conclusions: These findings are the first empirical human data to translate preclinical rodent findings to confirm a link between plasma anandamide concentrations in children with ASD. Although preliminary, these data suggest that impaired anandamide signaling may be involved in the pathophysiology of ASD. En ligne : http://dx.doi.org/10.1186/s13229-018-0203-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Plasma anandamide concentrations are lower in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Debra S. KARHSON, Auteur ; K. M. KRASINSKA, Auteur ; J. A. DALLAIRE, Auteur ; R. A. LIBOVE, Auteur ; J. M. PHILLIPS, Auteur ; A. S. CHIEN, Auteur ; J. P. GARNER, Auteur ; A. Y. HARDAN, Auteur ; Karen J. PARKER, Auteur . - 18p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 18p. Mots-clés : Anandamide  Autism spectrum disorder  Blood biomarker  Cannabinoid Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms of ASD remain poorly understood, recent preclinical research has implicated the endogenous cannabinoid (or endocannabinoid), anandamide, as a significant neuromodulator in rodent models of ASD. Despite this promising preclinical evidence, no clinical studies to date have tested whether endocannabinoids are dysregulated in individuals with ASD. Here, we addressed this critical gap in knowledge by optimizing liquid chromatography-tandem mass spectrometry methodology to quantitatively analyze anandamide concentrations in banked blood samples collected from a cohort of children with and without ASD (N = 112). Findings: Anandamide concentrations significantly differentiated ASD cases (N = 59) from controls (N = 53), such that children with lower anandamide concentrations were more likely to have ASD (p = 0.041). In keeping with this notion, anandamide concentrations were also significantly lower in ASD compared to control children (p = 0.034). Conclusions: These findings are the first empirical human data to translate preclinical rodent findings to confirm a link between plasma anandamide concentrations in children with ASD. Although preliminary, these data suggest that impaired anandamide signaling may be involved in the pathophysiology of ASD. En ligne : http://dx.doi.org/10.1186/s13229-018-0203-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

---

1 (1 - 4 / 4)