[article]
| Titre : |
Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Roseriet BEIJERS, Auteur ; Kieran J. O?DONNELL, Auteur ; Carolina DE WEERTH, Auteur ; Marieke S. TOLLENAAR, Auteur |
| Article en page(s) : |
p.967-978 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
NR3C1 externalizing internalizing maternal sensitivity methylation |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The early caregiving environment can have lasting effects on child mental health. Animal models suggest that glucocorticoid receptor gene (NR3C1) DNA methylation plays a mediating role in linking more responsive caregiving to improved behavioral outcomes by its impact on the stress regulatory system. In this longitudinal study, we examined whether children?s NR3C1 methylation levels mediate an effect of maternal sensitivity in infancy on levels of child internalizing and externalizing behavior in a community sample. Maternal sensitivity of 145 mothers was rated at infant age 5 weeks, 12 months, and 30 months by observing mother-infant interactions. Buccal DNA methylation was assessed in the same children at age 6 years and maternal-reported internalizing and externalizing behavior was assessed at age 6 and 10 years. Higher sensitivity at age 5 weeks significantly predicted lower DNA methylation levels at two NR3C1 CpG loci, although methylation levels at these loci did not mediate an effect of maternal sensitivity on levels of child internalizing and externalizing behavior. Overall, the study provides evidence that maternal sensitivity in early infancy is associated with DNA methylation levels at loci involved in stress regulation, but the significance of this finding for child mental health remains unclear. |
| En ligne : |
https://dx.doi.org/10.1017/S0954579423000226 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 |
in Development and Psychopathology > 36-2 (May 2024) . - p.967-978
[article] Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? [Texte imprimé et/ou numérique] / Roseriet BEIJERS, Auteur ; Kieran J. O?DONNELL, Auteur ; Carolina DE WEERTH, Auteur ; Marieke S. TOLLENAAR, Auteur . - p.967-978. Langues : Anglais ( eng) in Development and Psychopathology > 36-2 (May 2024) . - p.967-978
| Mots-clés : |
NR3C1 externalizing internalizing maternal sensitivity methylation |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The early caregiving environment can have lasting effects on child mental health. Animal models suggest that glucocorticoid receptor gene (NR3C1) DNA methylation plays a mediating role in linking more responsive caregiving to improved behavioral outcomes by its impact on the stress regulatory system. In this longitudinal study, we examined whether children?s NR3C1 methylation levels mediate an effect of maternal sensitivity in infancy on levels of child internalizing and externalizing behavior in a community sample. Maternal sensitivity of 145 mothers was rated at infant age 5 weeks, 12 months, and 30 months by observing mother-infant interactions. Buccal DNA methylation was assessed in the same children at age 6 years and maternal-reported internalizing and externalizing behavior was assessed at age 6 and 10 years. Higher sensitivity at age 5 weeks significantly predicted lower DNA methylation levels at two NR3C1 CpG loci, although methylation levels at these loci did not mediate an effect of maternal sensitivity on levels of child internalizing and externalizing behavior. Overall, the study provides evidence that maternal sensitivity in early infancy is associated with DNA methylation levels at loci involved in stress regulation, but the significance of this finding for child mental health remains unclear. |
| En ligne : |
https://dx.doi.org/10.1017/S0954579423000226 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 |
|
Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? in Development and Psychopathology, 36-2 (May 2024)
