Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression / Patricia P. SILVEIRA in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1601-1617 Titre : Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression Type de document : Texte imprimé et/ou numérique Auteurs : Patricia P. SILVEIRA, Auteur ; Irina POKHVISNEVA, Auteur ; Carine PARENT, Auteur ; Shirong CAI, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.1601-1617 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323 [article] Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression [Texte imprimé et/ou numérique] / Patricia P. SILVEIRA, Auteur ; Irina POKHVISNEVA, Auteur ; Carine PARENT, Auteur ; Shirong CAI, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Anne RIFKIN-GRABOI, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur . - p.1601-1617. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1601-1617 Index. décimale : PER Périodiques Résumé : While many studies focus on the association between early life adversity and the later risk for psychopathology, few simultaneously explore diverse forms of environmental adversity. Moreover, those studies that examined the cumulative impact of early life adversity focus uniquely on postnatal influences. The objective of this study was to focus on the fetal period of development to construct and validate a cumulative prenatal adversity score in relation to a wide range of neurodevelopmental outcomes. We also examined the interaction of this adversity score with a biologically informed genetic score based on the serotonin transporter gene. Prenatal adversities were computed in two community birth cohorts using information on health during pregnancy, birth weight, gestational age, income, domestic violence/sexual abuse, marital strain, as well as maternal smoking, anxiety, and depression. A genetic score based on genes coexpressed with the serotonin transporter in the amygdala, hippocampus, and prefrontal cortex during prenatal life was constructed with an emphasis on functionally relevant single nucleotide polymorphisms, that is, expression quantitative trait loci. Prenatal adversities predicted a wide range of developmental and behavioral alterations in children as young as 2 years of age in both cohorts. There were interactions between the genetic score and adversities for several domains of the Child Behavior Checklist (CBCL), with pervasive developmental problems remaining significant adjustment for multiple comparisons. Scores combining different prenatal adverse exposures predict childhood behavior and interact with the genetic background to influence the risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579417001262 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=323

Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder / Lawrence M. CHEN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1810-1821 Titre : Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence M. CHEN, Auteur ; Marieke S. TOLLENAAR, Auteur ; Shantala A. HARI DASS, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Irina POKHVISNEVA, Auteur ; Helene GAUDREAU, Auteur ; Carine PARENT, Auteur ; Josie DIORIO, Auteur ; Lisa M. MCEWEN, Auteur ; Julia L. MACISAAC, Auteur ; Michael S. KOBOR, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur ; Patricia P. SILVEIRA, Auteur ; Sherif KARAMA, Auteur ; Michael J. MEANEY, Auteur ; Kieran J. O'DONNELL, Auteur Article en page(s) : p.1810-1821 Langues : Anglais (eng) Mots-clés : *Attention Deficit Disorder with Hyperactivity/genetics  Child  Depression/genetics  Female  Genomics  Humans  Mental Health  Mothers  Pregnancy  *adhd  *child development  *gene by environment (GxE)  *perinatal mental health  *polygenic risk score Index. décimale : PER Périodiques Résumé : Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health. En ligne : http://dx.doi.org/10.1017/s0954579420001418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Maternal antenatal depression and child mental health: Moderation by genomic risk for attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Lawrence M. CHEN, Auteur ; Marieke S. TOLLENAAR, Auteur ; Shantala A. HARI DASS, Auteur ; Andrée-Anne BOUVETTE-TURCOT, Auteur ; Irina POKHVISNEVA, Auteur ; Helene GAUDREAU, Auteur ; Carine PARENT, Auteur ; Josie DIORIO, Auteur ; Lisa M. MCEWEN, Auteur ; Julia L. MACISAAC, Auteur ; Michael S. KOBOR, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur ; Patricia P. SILVEIRA, Auteur ; Sherif KARAMA, Auteur ; Michael J. MEANEY, Auteur ; Kieran J. O'DONNELL, Auteur . - p.1810-1821. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1810-1821 Mots-clés : *Attention Deficit Disorder with Hyperactivity/genetics  Child  Depression/genetics  Female  Genomics  Humans  Mental Health  Mothers  Pregnancy  *adhd  *child development  *gene by environment (GxE)  *perinatal mental health  *polygenic risk score Index. décimale : PER Périodiques Résumé : Maternal antenatal depression strongly influences child mental health but with considerable inter-individual variation that is, in part, linked to genotype. The challenge is to effectively capture the genotypic influence. We outline a novel approach to describe genomic susceptibility to maternal antenatal depression focusing on child emotional/behavioral difficulties. Two cohorts provided measures of maternal depression, child genetic variation, and child mental health symptoms. We constructed a conventional polygenic risk score (PRS) for attention-deficit/hyperactivity disorder (ADHD) (PRSADHD) that significantly moderated the association between maternal antenatal depression and internalizing problems at 60 months (p = 2.94 × 10-4, R2 = .18). We then constructed an interaction PRS (xPRS) based on a subset of those single nucleotide polymorphisms from the PRSADHD that most accounted for the moderation of the association between maternal antenatal depression and child outcome. The interaction between maternal antenatal depression and this xPRS accounted for a larger proportion of the variance in child emotional/behavioral problems than models based on any PRSADHD (p = 5.50 × 10-9, R2 = .27), with similar findings in the replication cohort. The xPRS was significantly enriched for genes involved in neuronal development and synaptic function. Our study illustrates a novel approach to the study of genotypic moderation on the impact of maternal antenatal depression on child mental health and highlights the utility of the xPRS approach. These findings advance our understanding of individual differences in the developmental origins of mental health. En ligne : http://dx.doi.org/10.1017/s0954579420001418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age / Kieran J. O'DONNELL in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1255-1266 Titre : Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age Type de document : Texte imprimé et/ou numérique Auteurs : Kieran J. O'DONNELL, Auteur ; Vivette GLOVER, Auteur ; Joanna D. HOLBROOK, Auteur ; Thomas G. O'CONNOR, Auteur Année de publication : 2014 Article en page(s) : p.1255-1266 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Multiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, using the Avon Longitudinal Study of Parents and Children population cohort. Internalizing symptoms were assessed from 4 to 13 years of age using the Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with the adolescents was conducted at age 15 years (n = 4,704). Obstetric and psychosocial risk and postnatal maternal symptoms were included as covariates. Results show that prenatal maternal anxiety predicted internalizing symptoms, including with the diagnostic assessment at 15 years. There was a main effect of two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing symptoms up to age 13. There was also genetic moderation of the prenatal anxiety effect by different BDNF polymorphisms (rs11030121 and rs7124442), although significant effects were limited to preadolescence. The findings suggest a role for BDNF gene–environment interactions in individual vulnerability to the effects of prenatal anxiety on child internalizing symptoms. En ligne : http://dx.doi.org/10.1017/S095457941400100X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245 [article] Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age [Texte imprimé et/ou numérique] / Kieran J. O'DONNELL, Auteur ; Vivette GLOVER, Auteur ; Joanna D. HOLBROOK, Auteur ; Thomas G. O'CONNOR, Auteur . - 2014 . - p.1255-1266. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 2) (November 2014) . - p.1255-1266 Index. décimale : PER Périodiques Résumé : Multiple behavioral and health outcomes, including internalizing symptoms, may be predicted from prenatal maternal anxiety, depression, or stress. However, not all children are affected, and those that are can be affected in different ways. Here we test the hypothesis that the effects of prenatal anxiety are moderated by genetic variation in the child's brain-derived neurotrophic factor (BDNF) gene, using the Avon Longitudinal Study of Parents and Children population cohort. Internalizing symptoms were assessed from 4 to 13 years of age using the Strengths and Difficulties Questionnaire (n = 8,584); a clinical interview with the adolescents was conducted at age 15 years (n = 4,704). Obstetric and psychosocial risk and postnatal maternal symptoms were included as covariates. Results show that prenatal maternal anxiety predicted internalizing symptoms, including with the diagnostic assessment at 15 years. There was a main effect of two BDNF polymorphisms (rs6265 [val66met] and rs11030104) on internalizing symptoms up to age 13. There was also genetic moderation of the prenatal anxiety effect by different BDNF polymorphisms (rs11030121 and rs7124442), although significant effects were limited to preadolescence. The findings suggest a role for BDNF gene–environment interactions in individual vulnerability to the effects of prenatal anxiety on child internalizing symptoms. En ligne : http://dx.doi.org/10.1017/S095457941400100X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=245

Polygenic differential susceptibility to prenatal adversity / Jay BELSKY in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.439-441 Titre : Polygenic differential susceptibility to prenatal adversity Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Irina POKHVISNEVA, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur ; Patricia P. SILVEIRA, Auteur Article en page(s) : p.439-441 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter–gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis–stress or differential–susceptibility related processes. Analyses of the regions of significance and proportion of interaction index are consistent with the diathesis–stress model, seemingly because of the truncated nature of the adversity score (which did not extend to supportive/positive prenatal experiences/exposures); in contrast, the proportion (of cases) affected index favors the differential–susceptibility model. These results suggest the need for future studies to extend measurement of the prenatal environment to highly supportive experiences and exposures. En ligne : http://dx.doi.org/10.1017/S0954579418000378 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Polygenic differential susceptibility to prenatal adversity [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Irina POKHVISNEVA, Auteur ; Anu Sathyan Sathyapalan REMA, Auteur ; Birit F. P. BROEKMAN, Auteur ; Michael PLUESS, Auteur ; Kieran J. O'DONNELL, Auteur ; Michael J. MEANEY, Auteur ; Patricia P. SILVEIRA, Auteur . - p.439-441. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.439-441 Index. décimale : PER Périodiques Résumé : A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter–gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis–stress or differential–susceptibility related processes. Analyses of the regions of significance and proportion of interaction index are consistent with the diathesis–stress model, seemingly because of the truncated nature of the adversity score (which did not extend to supportive/positive prenatal experiences/exposures); in contrast, the proportion (of cases) affected index favors the differential–susceptibility model. These results suggest the need for future studies to extend measurement of the prenatal environment to highly supportive experiences and exposures. En ligne : http://dx.doi.org/10.1017/S0954579418000378 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development / Léa C. PERRET in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.388-396 Titre : Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development Type de document : Texte imprimé et/ou numérique Auteurs : Léa C. PERRET, Auteur ; Michel BOIVIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F. M. ANDLAUER, Auteur ; Stéphane PAQUIN, Auteur ; Stéphanie LANGEVIN, Auteur ; Alain GIRARD, Auteur ; Gustavo TURECKI, Auteur ; Kieran J. O'DONNELL, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Jean-Philippe GOUIN, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur Article en page(s) : p.388-396 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depression) in the context of peer victimisation and depressive symptoms in adolescence. Methods The sample included 748 participants born in 1997/98 from the Quebec Longitudinal Study of Child Development with genotype data and prospectively collected information on peer victimisation (12-13 years) obtained from both self- and teacher-reports, as well as self-reported depressive symptoms (15-17 years). The PRS-depression was based on the genome-wide association meta-analysis of broad depression by Howard et al. (2019). Results Self- and teacher-reported peer victimisation in early adolescence were both associated with depressive symptoms in adolescence (Î2=0.34, p < .001; Î2=0.14, p=.001 respectively), and this association remained significant when accounting for PRS-depression (Î2=0.33, p < .001; Î2=0.13, p=.002 respectively). PRS-depression was independently associated with depressive symptoms, but there was no significant PRS-depression by peer victimisation interaction (self-reported and teacher-reported). PRS-depression was correlated with self-reported, but not teacher-reported, peer victimisation. Conclusions Our findings suggested that a partial measure of an individual's genetic predisposition to depression, as measured by PRS-depression, and being exposed to peer victimisation (self- and teacher-reported) were independently associated with depressive symptoms in adolescence. Furthermore, PRS-depression did not exacerbate the risk of depressive symptoms among adolescents who had been peer victimised. Lastly, we found evidence of a gene-environment correlation between PRS-depression and self-reported peer victimisation. Future studies are needed to replicate this finding and to further understand the role of genetic predispositions in experiencing depressive symptoms following peer victimisation. En ligne : https://doi.org/10.1111/jcpp.13706 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Polygenic risk score and peer victimisation independently predict depressive symptoms in adolescence: results from the Quebec Longitudinal Study of Children Development [Texte imprimé et/ou numérique] / Léa C. PERRET, Auteur ; Michel BOIVIN, Auteur ; Geneviève MORNEAU-VAILLANCOURT, Auteur ; Till F. M. ANDLAUER, Auteur ; Stéphane PAQUIN, Auteur ; Stéphanie LANGEVIN, Auteur ; Alain GIRARD, Auteur ; Gustavo TURECKI, Auteur ; Kieran J. O'DONNELL, Auteur ; Richard E. TREMBLAY, Auteur ; Sylvana M. CÔTÉ, Auteur ; Jean-Philippe GOUIN, Auteur ; Isabelle OUELLET-MORIN, Auteur ; Marie-Claude GEOFFROY, Auteur . - p.388-396. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.388-396 Index. décimale : PER Périodiques Résumé : Background Peer victimisation has been associated with depressive symptoms during adolescence, however not all peer victimised adolescents will exhibit such symptoms. This study tested whether having a genetic predisposition to developing depression increased the risk of experiencing depressive symptoms in peer victimised youth. To date, no study has explored such gene-environment interaction using a polygenic risk score for depression (PRS-depression) in the context of peer victimisation and depressive symptoms in adolescence. Methods The sample included 748 participants born in 1997/98 from the Quebec Longitudinal Study of Child Development with genotype data and prospectively collected information on peer victimisation (12-13 years) obtained from both self- and teacher-reports, as well as self-reported depressive symptoms (15-17 years). The PRS-depression was based on the genome-wide association meta-analysis of broad depression by Howard et al. (2019). Results Self- and teacher-reported peer victimisation in early adolescence were both associated with depressive symptoms in adolescence (Î2=0.34, p < .001; Î2=0.14, p=.001 respectively), and this association remained significant when accounting for PRS-depression (Î2=0.33, p < .001; Î2=0.13, p=.002 respectively). PRS-depression was independently associated with depressive symptoms, but there was no significant PRS-depression by peer victimisation interaction (self-reported and teacher-reported). PRS-depression was correlated with self-reported, but not teacher-reported, peer victimisation. Conclusions Our findings suggested that a partial measure of an individual's genetic predisposition to depression, as measured by PRS-depression, and being exposed to peer victimisation (self- and teacher-reported) were independently associated with depressive symptoms in adolescence. Furthermore, PRS-depression did not exacerbate the risk of depressive symptoms among adolescents who had been peer victimised. Lastly, we found evidence of a gene-environment correlation between PRS-depression and self-reported peer victimisation. Future studies are needed to replicate this finding and to further understand the role of genetic predispositions in experiencing depressive symptoms following peer victimisation. En ligne : https://doi.org/10.1111/jcpp.13706 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology-A global perspective / V. GLOVER in Development and Psychopathology, 30-3 (August 2018)  

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Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age / Bonnie AUYEUNG in Molecular Autism, (December 2012)  

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Randomized controlled trial of Family Connects: Effects on child emergency medical care from birth to 24 months / W. B. GOODMAN in Development and Psychopathology, 31-5 (December 2019)  

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Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways / Chad E. SHENK in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

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The early care environment and DNA methylome variation in childhood / E. GARG in Development and Psychopathology, 30-3 (August 2018)  

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The persisting effect of maternal mood in pregnancy on childhood psychopathology / Kieran J. O'DONNELL in Development and Psychopathology, 26-2 (May 2014)  

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