[article]
| Titre : |
Mid-childhood autism sibling recurrence in infants with a family history of autism |
| Type de document : |
texte imprimé |
| Auteurs : |
Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur |
| Article en page(s) : |
p.1501-1514 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies. |
| En ligne : |
https://dx.doi.org/https://doi.org/10.1002/aur.3182 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 |
in Autism Research > 17-7 (July 2024) . - p.1501-1514
[article] Mid-childhood autism sibling recurrence in infants with a family history of autism [texte imprimé] / Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur . - p.1501-1514. Langues : Anglais ( eng) in Autism Research > 17-7 (July 2024) . - p.1501-1514
| Index. décimale : |
PER Périodiques |
| Résumé : |
Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies. |
| En ligne : |
https://dx.doi.org/https://doi.org/10.1002/aur.3182 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 |
|  |
Mid-childhood autism sibling recurrence in infants with a family history of autism in Autism Research, 17-7 (July 2024)
