Dépouillements

Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder / Kathryn CHADMAN ; Eric LONDON ; Thomas WISNIEWSKI ; Jerzy WEGIEL in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1300-1321 Titre : Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn CHADMAN, Auteur ; Eric LONDON, Auteur ; Thomas WISNIEWSKI, Auteur ; Jerzy WEGIEL, Auteur Article en page(s) : p.1300-1321 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This review highlights a key role of the serotonergic system in brain development and in distortions of normal brain development in early stages of fetal life resulting in cascades of abnormalities, including defects of neurogenesis, neuronal migration, neuronal growth, differentiation, and arborization, as well as defective neuronal circuit formation in the cortex, subcortical structures, brainstem, and cerebellum of autistic subjects. In autism, defects in regulation of neuronal growth are the most frequent and ubiquitous developmental changes associated with impaired neuron differentiation, smaller size, distorted shape, loss of spatial orientation, and distortion of cortex organization. Common developmental defects of the brain in autism include multiregional focal dysplastic changes contributing to local neuronal circuit distortion, epileptogenic activity, and epilepsy. There is a discrepancy between more than 500 reports demonstrating the contribution of the serotonergic system to autism's behavioral anomalies, highlighted by lack of studies of autistic subjects' brainstem raphe nuclei, the center of brain serotonergic innervation, and of the contribution of the serotonergic system to the diagnostic features of autism spectrum disorder (ASD). Discovery of severe fetal brainstem auditory system neuronal deficits and other anomalies leading to a spectrum of hearing deficits contributing to a cascade of behavioral alterations, including deficits of social and verbal communication in individuals with autism, is another argument to intensify postmortem studies of the type and topography of, and the severity of developmental defects in raphe nuclei and their contribution to abnormal brain development and to the broad spectrum of functional deficits and comorbid conditions in ASD. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Contribution of the serotonergic system to developmental brain abnormalities in autism spectrum disorder [Texte imprimé et/ou numérique] / Kathryn CHADMAN, Auteur ; Eric LONDON, Auteur ; Thomas WISNIEWSKI, Auteur ; Jerzy WEGIEL, Auteur . - p.1300-1321. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1300-1321 Index. décimale : PER Périodiques Résumé : Abstract This review highlights a key role of the serotonergic system in brain development and in distortions of normal brain development in early stages of fetal life resulting in cascades of abnormalities, including defects of neurogenesis, neuronal migration, neuronal growth, differentiation, and arborization, as well as defective neuronal circuit formation in the cortex, subcortical structures, brainstem, and cerebellum of autistic subjects. In autism, defects in regulation of neuronal growth are the most frequent and ubiquitous developmental changes associated with impaired neuron differentiation, smaller size, distorted shape, loss of spatial orientation, and distortion of cortex organization. Common developmental defects of the brain in autism include multiregional focal dysplastic changes contributing to local neuronal circuit distortion, epileptogenic activity, and epilepsy. There is a discrepancy between more than 500 reports demonstrating the contribution of the serotonergic system to autism's behavioral anomalies, highlighted by lack of studies of autistic subjects' brainstem raphe nuclei, the center of brain serotonergic innervation, and of the contribution of the serotonergic system to the diagnostic features of autism spectrum disorder (ASD). Discovery of severe fetal brainstem auditory system neuronal deficits and other anomalies leading to a spectrum of hearing deficits contributing to a cascade of behavioral alterations, including deficits of social and verbal communication in individuals with autism, is another argument to intensify postmortem studies of the type and topography of, and the severity of developmental defects in raphe nuclei and their contribution to abnormal brain development and to the broad spectrum of functional deficits and comorbid conditions in ASD. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3123 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Enhancing multi-site autism research through the development of a collaborative data platform / Jeffrey D. ROTH ; Kashia A. ROSENAU ; Patrick S. DWYER ; Alice A. KUO ; Julian A. MARTINEZ-AGOSTO in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1322-1327 Titre : Enhancing multi-site autism research through the development of a collaborative data platform Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey D. ROTH, Auteur ; Kashia A. ROSENAU, Auteur ; Patrick S. DWYER, Auteur ; Alice A. KUO, Auteur ; Julian A. MARTINEZ-AGOSTO, Auteur Article en page(s) : p.1322-1327 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Data repositories, particularly those storing data on vulnerable populations, increasingly need to carefully consider not only what data is being collected, but how it will be used. As such, the Autism Intervention Research Network on Physical Health (AIR-P) has created the Infrastructure for Collaborative Research (ICR) to establish standards on data collection practices in Autism repositories. The ICR will strive to encourage inter-site collaboration, amplify autistic voices, and widen accessibility to data. The ICR is staged as a three-tiered framework consisting of (1) a request for proposals system, (2) a REDCap-based data repository, and (3) public data dashboards to display aggregate de-identified data. Coupled with a review process including autistic and non-autistic researchers, this framework aims to propel the implementation of equitable autism research, enhance standardization within and between studies, and boost transparency and dissemination of findings. In addition, the inclusion of a contact registry that study participants can opt into creates the base for a robust participant pool. As such, researchers can leverage the platform to identify, reach, and distribute electronic materials to a greater proportion of potential participants who likely fall within their eligibility criteria. By incorporating practices that promote effective communication between researchers and participants, the ICR can facilitate research that is both considerate of and a benefit to autistic people. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Enhancing multi-site autism research through the development of a collaborative data platform [Texte imprimé et/ou numérique] / Jeffrey D. ROTH, Auteur ; Kashia A. ROSENAU, Auteur ; Patrick S. DWYER, Auteur ; Alice A. KUO, Auteur ; Julian A. MARTINEZ-AGOSTO, Auteur . - p.1322-1327. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1322-1327 Index. décimale : PER Périodiques Résumé : Abstract Data repositories, particularly those storing data on vulnerable populations, increasingly need to carefully consider not only what data is being collected, but how it will be used. As such, the Autism Intervention Research Network on Physical Health (AIR-P) has created the Infrastructure for Collaborative Research (ICR) to establish standards on data collection practices in Autism repositories. The ICR will strive to encourage inter-site collaboration, amplify autistic voices, and widen accessibility to data. The ICR is staged as a three-tiered framework consisting of (1) a request for proposals system, (2) a REDCap-based data repository, and (3) public data dashboards to display aggregate de-identified data. Coupled with a review process including autistic and non-autistic researchers, this framework aims to propel the implementation of equitable autism research, enhance standardization within and between studies, and boost transparency and dissemination of findings. In addition, the inclusion of a contact registry that study participants can opt into creates the base for a robust participant pool. As such, researchers can leverage the platform to identify, reach, and distribute electronic materials to a greater proportion of potential participants who likely fall within their eligibility criteria. By incorporating practices that promote effective communication between researchers and participants, the ICR can facilitate research that is both considerate of and a benefit to autistic people. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism / G. PATTERSON ; K. K. CUMMINGS ; J. JUNG ; M. E. CAKAR ; L. ABBAS ; S. Y. BOOKHEIMER ; M. DAPRETTO ; S. A. GREEN in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1328-1343 Titre : Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism Type de document : Texte imprimé et/ou numérique Auteurs : G. PATTERSON, Auteur ; K. K. CUMMINGS, Auteur ; J. JUNG, Auteur ; M. E. CAKAR, Auteur ; L. ABBAS, Auteur ; S. Y. BOOKHEIMER, Auteur ; M. DAPRETTO, Auteur ; S. A. GREEN, Auteur Article en page(s) : p.1328-1343 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Although aversive responses to sensory stimuli are common in autism spectrum disorder (ASD), it remains unknown whether the social relevance of aversive sensory inputs affects their processing. We used functional magnetic resonance imaging (fMRI) to investigate neural responses to mildly aversive nonsocial and social sensory stimuli as well as how sensory over-responsivity (SOR) severity relates to these responses. Participants included 21 ASD and 25 typically-developing (TD) youth, aged 8.6-18.0?years. Results showed that TD youth exhibited significant neural discrimination of socially relevant versus irrelevant aversive sensory stimuli, particularly in the amygdala and orbitofrontal cortex (OFC), regions that are crucial for sensory and social processing. In contrast, ASD youth showed reduced neural discrimination of social versus nonsocial stimuli in the amygdala and OFC, as well as overall greater neural responses to nonsocial compared with social stimuli. Moreover, higher SOR in ASD was associated with heightened responses in sensory-motor regions to socially-relevant stimuli. These findings further our understanding of the relationship between sensory and social processing in ASD, suggesting limited attention to the social relevance compared with aversiveness level of sensory input in ASD versus TD youth, particularly in ASD youth with higher SOR. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism [Texte imprimé et/ou numérique] / G. PATTERSON, Auteur ; K. K. CUMMINGS, Auteur ; J. JUNG, Auteur ; M. E. CAKAR, Auteur ; L. ABBAS, Auteur ; S. Y. BOOKHEIMER, Auteur ; M. DAPRETTO, Auteur ; S. A. GREEN, Auteur . - p.1328-1343. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1328-1343 Index. décimale : PER Périodiques Résumé : Abstract Although aversive responses to sensory stimuli are common in autism spectrum disorder (ASD), it remains unknown whether the social relevance of aversive sensory inputs affects their processing. We used functional magnetic resonance imaging (fMRI) to investigate neural responses to mildly aversive nonsocial and social sensory stimuli as well as how sensory over-responsivity (SOR) severity relates to these responses. Participants included 21 ASD and 25 typically-developing (TD) youth, aged 8.6-18.0?years. Results showed that TD youth exhibited significant neural discrimination of socially relevant versus irrelevant aversive sensory stimuli, particularly in the amygdala and orbitofrontal cortex (OFC), regions that are crucial for sensory and social processing. In contrast, ASD youth showed reduced neural discrimination of social versus nonsocial stimuli in the amygdala and OFC, as well as overall greater neural responses to nonsocial compared with social stimuli. Moreover, higher SOR in ASD was associated with heightened responses in sensory-motor regions to socially-relevant stimuli. These findings further our understanding of the relationship between sensory and social processing in ASD, suggesting limited attention to the social relevance compared with aversiveness level of sensory input in ASD versus TD youth, particularly in ASD youth with higher SOR. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Sex-related patterns of functional brain networks in children and adolescents with autism spectrum disorder / Jingxuan WANG ; Yunna ZHOU ; Tong LI ; Baolin WU ; Xianshun YUAN ; Lin LI ; Rui QIN ; Hongzhu LIU ; Linglong CHEN ; Ximing WANG in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1344-1355 Titre : Sex-related patterns of functional brain networks in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jingxuan WANG, Auteur ; Yunna ZHOU, Auteur ; Tong LI, Auteur ; Baolin WU, Auteur ; Xianshun YUAN, Auteur ; Lin LI, Auteur ; Rui QIN, Auteur ; Hongzhu LIU, Auteur ; Linglong CHEN, Auteur ; Ximing WANG, Auteur Article en page(s) : p.1344-1355 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Although numerous studies have emphasized the male predominance in autism spectrum disorder (ASD), how sex differences are related to the topological organization of functional networks remains unclear. This study utilized imaging data from 86 ASD (43 females, aged 7-18?years) and 86 typically developing controls (TCs) (43 females, aged 7-18?years) obtained from Autism Brain Imaging Data Exchange databases, constructed individual whole-brain functional networks, used a graph theory analysis to compute topological metrics, and assessed sex-related differences in topological metrics using a 2?*?2 factorial design. At the global level, females with ASD exhibited significantly higher cluster coefficient and local efficiency than female TCs, while no significant difference was observed between males with ASD and male TCs. Meanwhile, the neurotypical sex differences in cluster coefficient and local efficiency observed in TCs were not present in ASD. At the nodal level, ASD exhibited abnormal nodal centrality in the left middle temporal gyrus. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Sex-related patterns of functional brain networks in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Jingxuan WANG, Auteur ; Yunna ZHOU, Auteur ; Tong LI, Auteur ; Baolin WU, Auteur ; Xianshun YUAN, Auteur ; Lin LI, Auteur ; Rui QIN, Auteur ; Hongzhu LIU, Auteur ; Linglong CHEN, Auteur ; Ximing WANG, Auteur . - p.1344-1355. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1344-1355 Index. décimale : PER Périodiques Résumé : Abstract Although numerous studies have emphasized the male predominance in autism spectrum disorder (ASD), how sex differences are related to the topological organization of functional networks remains unclear. This study utilized imaging data from 86 ASD (43 females, aged 7-18?years) and 86 typically developing controls (TCs) (43 females, aged 7-18?years) obtained from Autism Brain Imaging Data Exchange databases, constructed individual whole-brain functional networks, used a graph theory analysis to compute topological metrics, and assessed sex-related differences in topological metrics using a 2?*?2 factorial design. At the global level, females with ASD exhibited significantly higher cluster coefficient and local efficiency than female TCs, while no significant difference was observed between males with ASD and male TCs. Meanwhile, the neurotypical sex differences in cluster coefficient and local efficiency observed in TCs were not present in ASD. At the nodal level, ASD exhibited abnormal nodal centrality in the left middle temporal gyrus. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Comparison of propofol-esketamine versus propofol-sufentanil for deep sedation and analgesia in children with autism: A randomized double-blind clinical trial / Minghui ZHENG ; Qing LI ; Lixia XIONG ; Jinxiang FENG ; Xiaoyu LIU ; Guoxiang FAN ; Rupesh CHATURVEDI ; Faming ZHANG ; Ning YIN in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1356-1364 Titre : Comparison of propofol-esketamine versus propofol-sufentanil for deep sedation and analgesia in children with autism: A randomized double-blind clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Minghui ZHENG, Auteur ; Qing LI, Auteur ; Lixia XIONG, Auteur ; Jinxiang FENG, Auteur ; Xiaoyu LIU, Auteur ; Guoxiang FAN, Auteur ; Rupesh CHATURVEDI, Auteur ; Faming ZHANG, Auteur ; Ning YIN, Auteur Article en page(s) : p.1356-1364 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Propofol sedation, routinely used for endoscopic procedures, is safe and acceptable for children. Adjuvants, such as esketamine or sufentanil, are commonly added to improve the efficacy and safety of propofol sedation. This study aimed to compare the clinical efficacy and safety of propofol-esketamine (PE) versus propofol-sufentanil (PS) for deep sedation and analgesia in children with autism undergoing colonoscopy procedure. One hundred and twenty-four children with autism undergoing colonoscopy procedure were included in the study. Patients were randomly assigned to receive one of the two adjuvants: esketamine (0.3?mg/kg) or sufentanil (0.2??g/kg), subsequently administered propofol 2.0?mg/kg to induce anesthesia. Additional doses of propofol (0.5-1.0?mg/kg) were administered as needed to ensure patient tolerance for the remaining duration of the procedure. Movement during the procedure, hemodynamic variables, the total dose of propofol, recovery time, and adverse events were recorded. The PE group exhibited a significantly lower incidence of severe movement during the procedure compared with the PS group (14.52% vs. 32.26%, p = 0.020). The PE group showed significantly lower incidence of respiratory depression, hypotension, and severe injection pain of propofol than the PS group during the procedure (all p < 0.05). The mean arterial pressure (MAP) decreased significantly after anesthesia induction in the PS group and remained lower than baseline (all p < 0.05). Compared with the combination of low-dose sufentanil (0.2??g/mg) with propofol, the low-dose esketamine (0.3?mg/kg) combined with propofol provided more stable hemodynamics, higher quality of sedation, and fewer adverse events in children with autism undergoing colonoscopy procedure. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Comparison of propofol-esketamine versus propofol-sufentanil for deep sedation and analgesia in children with autism: A randomized double-blind clinical trial [Texte imprimé et/ou numérique] / Minghui ZHENG, Auteur ; Qing LI, Auteur ; Lixia XIONG, Auteur ; Jinxiang FENG, Auteur ; Xiaoyu LIU, Auteur ; Guoxiang FAN, Auteur ; Rupesh CHATURVEDI, Auteur ; Faming ZHANG, Auteur ; Ning YIN, Auteur . - p.1356-1364. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1356-1364 Index. décimale : PER Périodiques Résumé : Abstract Propofol sedation, routinely used for endoscopic procedures, is safe and acceptable for children. Adjuvants, such as esketamine or sufentanil, are commonly added to improve the efficacy and safety of propofol sedation. This study aimed to compare the clinical efficacy and safety of propofol-esketamine (PE) versus propofol-sufentanil (PS) for deep sedation and analgesia in children with autism undergoing colonoscopy procedure. One hundred and twenty-four children with autism undergoing colonoscopy procedure were included in the study. Patients were randomly assigned to receive one of the two adjuvants: esketamine (0.3?mg/kg) or sufentanil (0.2??g/kg), subsequently administered propofol 2.0?mg/kg to induce anesthesia. Additional doses of propofol (0.5-1.0?mg/kg) were administered as needed to ensure patient tolerance for the remaining duration of the procedure. Movement during the procedure, hemodynamic variables, the total dose of propofol, recovery time, and adverse events were recorded. The PE group exhibited a significantly lower incidence of severe movement during the procedure compared with the PS group (14.52% vs. 32.26%, p = 0.020). The PE group showed significantly lower incidence of respiratory depression, hypotension, and severe injection pain of propofol than the PS group during the procedure (all p < 0.05). The mean arterial pressure (MAP) decreased significantly after anesthesia induction in the PS group and remained lower than baseline (all p < 0.05). Compared with the combination of low-dose sufentanil (0.2??g/mg) with propofol, the low-dose esketamine (0.3?mg/kg) combined with propofol provided more stable hemodynamics, higher quality of sedation, and fewer adverse events in children with autism undergoing colonoscopy procedure. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3172 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Endophenotyping social cognition in the broader autism phenotype / Tarishi DESAI ; Cherie GREEN ; Krysta TREVIS ; Natasha BROWN ; Martin DELATYCKI ; Ingrid SCHEFFER ; Sarah WILSON in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1365-1380 Titre : Endophenotyping social cognition in the broader autism phenotype Type de document : Texte imprimé et/ou numérique Auteurs : Tarishi DESAI, Auteur ; Cherie GREEN, Auteur ; Krysta TREVIS, Auteur ; Natasha BROWN, Auteur ; Martin DELATYCKI, Auteur ; Ingrid SCHEFFER, Auteur ; Sarah WILSON, Auteur Article en page(s) : p.1365-1380 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Relatives of individuals with autism spectrum disorder (ASD) may display milder social traits of the broader autism phenotype (BAP) providing potential endophenotypic markers of genetic risk for ASD. We performed a case-control comparison to quantify social cognition and pragmatic language difficulties in the BAP (n = 25 cases; n = 33 controls) using the Faux Pas test (FPT) and the Goldman-Eisler Cartoon task. Using deep phenotyping we then examined patterns of inheritance of social cognition in two large multiplex families and the spectrum of performance in 32 additional families (159 members; n = 51 ASD, n = 87 BAP, n = 21 unaffected). BAP individuals showed significantly poorer FPT performance and reduced verbal fluency with the absence of a compression effect in social discourse compared to controls. In multiplex families, we observed reduced FPT performance in 89% of autistic family members, 63% of BAP relatives and 50% of unaffected relatives. Across all affected families, there was a graded spectrum of difficulties, with ASD individuals showing the most severe FPT difficulties, followed by the BAP and unaffected relatives compared to community controls. We conclude that relatives of probands show an inherited pattern of graded difficulties in social cognition with atypical faux pas detection in social discourse providing a novel candidate endophenotype for ASD. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Endophenotyping social cognition in the broader autism phenotype [Texte imprimé et/ou numérique] / Tarishi DESAI, Auteur ; Cherie GREEN, Auteur ; Krysta TREVIS, Auteur ; Natasha BROWN, Auteur ; Martin DELATYCKI, Auteur ; Ingrid SCHEFFER, Auteur ; Sarah WILSON, Auteur . - p.1365-1380. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1365-1380 Index. décimale : PER Périodiques Résumé : Abstract Relatives of individuals with autism spectrum disorder (ASD) may display milder social traits of the broader autism phenotype (BAP) providing potential endophenotypic markers of genetic risk for ASD. We performed a case-control comparison to quantify social cognition and pragmatic language difficulties in the BAP (n = 25 cases; n = 33 controls) using the Faux Pas test (FPT) and the Goldman-Eisler Cartoon task. Using deep phenotyping we then examined patterns of inheritance of social cognition in two large multiplex families and the spectrum of performance in 32 additional families (159 members; n = 51 ASD, n = 87 BAP, n = 21 unaffected). BAP individuals showed significantly poorer FPT performance and reduced verbal fluency with the absence of a compression effect in social discourse compared to controls. In multiplex families, we observed reduced FPT performance in 89% of autistic family members, 63% of BAP relatives and 50% of unaffected relatives. Across all affected families, there was a graded spectrum of difficulties, with ASD individuals showing the most severe FPT difficulties, followed by the BAP and unaffected relatives compared to community controls. We conclude that relatives of probands show an inherited pattern of graded difficulties in social cognition with atypical faux pas detection in social discourse providing a novel candidate endophenotype for ASD. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Face-to-face live eye-tracking in toddlers with autism: Feasibility and impact of familiarity and face covering / Maureen BUTLER ; Chitra BANARJEE ; Alexandra BOXBERGER ; Katherine ALL ; Suzanne MACARI ; Katarzyna CHAWARSKA in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1381-1390 Titre : Face-to-face live eye-tracking in toddlers with autism: Feasibility and impact of familiarity and face covering Type de document : Texte imprimé et/ou numérique Auteurs : Maureen BUTLER, Auteur ; Chitra BANARJEE, Auteur ; Alexandra BOXBERGER, Auteur ; Katherine ALL, Auteur ; Suzanne MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1381-1390 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Studies utilizing eye-tracking methods have potential to promptly capture real-world dynamics of one of the core areas of vulnerability in autism spectrum disorders (ASD), selective social attention. So far, no studies have successfully reported utilizing the method to examine social attention in toddlers with neurodevelopmental vulnerabilities in real world and challenging settings such as an interactive face-to-face. This study examined the feasibility and validity of live eye-tracking method in response to live interaction occurring in several contexts in toddlers with and without ASD. Forty-seven toddlers with ASD, with atypical development (ATYP), or typically developing (TD), underwent a 30-s live eye-tracking procedure during a face-to-face interaction with a masked stranger using child-directed-speech (16 ASD, 14 ATYP, 17 TD; Mage = 23.44?months, SD = 6.02). Out of this group of toddlers, 29 (10 ASD, 8 ATYP, 11 TD, Mage = 21.97?months, SD = 5.76) underwent the same procedure with one of their maskless parent. Task completion rate, calibration accuracy, and affective response (feasibility measures) as well as attention to the task and the social partner (validity measures) were examined. Task completion rate and calibration accuracy were excellent. Despite the challenging context of face-to-face interaction, the toddlers exhibited a neutral affect, and high attention to the task and the speaker. As anticipated, toddlers with ASD looked less at the social partner compared with control groups. However, attention was comparable between the Stranger and Parent conditions, indicating that the effect was consistent regardless of presence of face covering or the familiarity of the interactive partner. The study demonstrates the high feasibility and validity of a live eye-tracking task involving face-to-face interaction in neurodiverse toddlers with social vulnerabilities. The effect of diminished attention to social partners in toddlers with autism is robust and present when interacting with an unfamiliar person and parent. The results suggest that a brief live eye-tracking method constitutes a promising ecologically valid candidate biomarker and potential intervention outcome in autism. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Face-to-face live eye-tracking in toddlers with autism: Feasibility and impact of familiarity and face covering [Texte imprimé et/ou numérique] / Maureen BUTLER, Auteur ; Chitra BANARJEE, Auteur ; Alexandra BOXBERGER, Auteur ; Katherine ALL, Auteur ; Suzanne MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1381-1390. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1381-1390 Index. décimale : PER Périodiques Résumé : Abstract Studies utilizing eye-tracking methods have potential to promptly capture real-world dynamics of one of the core areas of vulnerability in autism spectrum disorders (ASD), selective social attention. So far, no studies have successfully reported utilizing the method to examine social attention in toddlers with neurodevelopmental vulnerabilities in real world and challenging settings such as an interactive face-to-face. This study examined the feasibility and validity of live eye-tracking method in response to live interaction occurring in several contexts in toddlers with and without ASD. Forty-seven toddlers with ASD, with atypical development (ATYP), or typically developing (TD), underwent a 30-s live eye-tracking procedure during a face-to-face interaction with a masked stranger using child-directed-speech (16 ASD, 14 ATYP, 17 TD; Mage = 23.44?months, SD = 6.02). Out of this group of toddlers, 29 (10 ASD, 8 ATYP, 11 TD, Mage = 21.97?months, SD = 5.76) underwent the same procedure with one of their maskless parent. Task completion rate, calibration accuracy, and affective response (feasibility measures) as well as attention to the task and the social partner (validity measures) were examined. Task completion rate and calibration accuracy were excellent. Despite the challenging context of face-to-face interaction, the toddlers exhibited a neutral affect, and high attention to the task and the speaker. As anticipated, toddlers with ASD looked less at the social partner compared with control groups. However, attention was comparable between the Stranger and Parent conditions, indicating that the effect was consistent regardless of presence of face covering or the familiarity of the interactive partner. The study demonstrates the high feasibility and validity of a live eye-tracking task involving face-to-face interaction in neurodiverse toddlers with social vulnerabilities. The effect of diminished attention to social partners in toddlers with autism is robust and present when interacting with an unfamiliar person and parent. The results suggest that a brief live eye-tracking method constitutes a promising ecologically valid candidate biomarker and potential intervention outcome in autism. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Exploring the mediating effect of camouflaging and the moderating effect of autistic identity on the relationship between autistic traits and mental wellbeing / Sarah CASSIDY ; Jacqui RODGERS in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1391-1406 Titre : Exploring the mediating effect of camouflaging and the moderating effect of autistic identity on the relationship between autistic traits and mental wellbeing Type de document : Texte imprimé et/ou numérique Auteurs : Sarah CASSIDY, Auteur ; Jacqui RODGERS, Auteur Article en page(s) : p.1391-1406 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Mental health difficulties are prevalent among autistic adults. Camouflaging (behaving differently to fit in) may be a mechanism by which autistic traits and mental health difficulties relate to each other, but little research has considered the role of different facets of camouflaging. Additionally, autistic identity might buffer against camouflaging and mental health difficulties. This research aims to explore the mediating effects of camouflaging behaviours on the relationship between autistic traits and both positive and negative mental wellbeing, as well as how autistic identity might moderate the relationship between autistic traits and camouflaging, and also mental health. Data were available for 627 autistic adults, recruited through volunteer databases and social media. Participants completed measures of autistic traits, anxiety, depression, positive wellbeing, camouflaging behaviours (compensating for difficulties, masking, and assimilating/putting on an act) and autistic identity. Mediation and moderated mediation models were tested, applying 95% bootstrapped CIs (10,000 resamples) and including age, gender and diagnosis as covariates. There were no significant direct effects between autistic traits and mental wellbeing. Assimilation was a significant mediator of all mental wellbeing measures, and compensation was a significant mediator of positive wellbeing only. Autistic identity was not a significant moderator. Assimilation and compensation should be considered when offering psychological interventions to support mental wellbeing of autistic people. Additional research into external drivers of camouflaging (e.g. stigma) and mechanisms by which camouflaging impacts mental wellbeing, such as autonomy, authenticity, skill mastery and community, may identify other areas of support. Concurrently, societal change is necessary to reduce the need to camouflage. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Exploring the mediating effect of camouflaging and the moderating effect of autistic identity on the relationship between autistic traits and mental wellbeing [Texte imprimé et/ou numérique] / Sarah CASSIDY, Auteur ; Jacqui RODGERS, Auteur . - p.1391-1406. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1391-1406 Index. décimale : PER Périodiques Résumé : Abstract Mental health difficulties are prevalent among autistic adults. Camouflaging (behaving differently to fit in) may be a mechanism by which autistic traits and mental health difficulties relate to each other, but little research has considered the role of different facets of camouflaging. Additionally, autistic identity might buffer against camouflaging and mental health difficulties. This research aims to explore the mediating effects of camouflaging behaviours on the relationship between autistic traits and both positive and negative mental wellbeing, as well as how autistic identity might moderate the relationship between autistic traits and camouflaging, and also mental health. Data were available for 627 autistic adults, recruited through volunteer databases and social media. Participants completed measures of autistic traits, anxiety, depression, positive wellbeing, camouflaging behaviours (compensating for difficulties, masking, and assimilating/putting on an act) and autistic identity. Mediation and moderated mediation models were tested, applying 95% bootstrapped CIs (10,000 resamples) and including age, gender and diagnosis as covariates. There were no significant direct effects between autistic traits and mental wellbeing. Assimilation was a significant mediator of all mental wellbeing measures, and compensation was a significant mediator of positive wellbeing only. Autistic identity was not a significant moderator. Assimilation and compensation should be considered when offering psychological interventions to support mental wellbeing of autistic people. Additional research into external drivers of camouflaging (e.g. stigma) and mechanisms by which camouflaging impacts mental wellbeing, such as autonomy, authenticity, skill mastery and community, may identify other areas of support. Concurrently, societal change is necessary to reduce the need to camouflage. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Gender diversity in a Chinese community sample and its associations with autism traits / Sylvia Yun SHI ; Hoi Ching LEI ; Cho Lam NGAN ; Doug P. VANDERLAAN ; Wang Ivy WONG in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1407-1416 Titre : Gender diversity in a Chinese community sample and its associations with autism traits Type de document : Texte imprimé et/ou numérique Auteurs : Sylvia Yun SHI, Auteur ; Hoi Ching LEI, Auteur ; Cho Lam NGAN, Auteur ; Doug P. VANDERLAAN, Auteur ; Wang Ivy WONG, Auteur Article en page(s) : p.1407-1416 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Emerging evidence suggests that gender dysphoria or gender diversity (GD) intersects frequently with autism spectrum disorder or autism traits. However, the magnitude and interpretation of this link continue to be debated. Most child studies on this topic were performed in clinical populations, and little is known about the generalizability of this co-occurrence to the broader community, especially to non-Western samples. Also, little is known about whether specific subdomains of autism are more strongly associated with GD. Therefore, we investigated GD and its association with autism traits in a Chinese community sample of 4-12-year-olds (N = 379; 51% birth-assigned girls). Parents provided information about GD characteristics using the standardized Gender Identity Questionnaire for Children and autism traits using the Chinese version of the Autism-Spectrum Quotient-Children. In addition, broader behavioral and emotional challenges were measured by the Behavior Problem Index (BPI) to account for psychological challenges other than autism traits. In this community sample of Chinese children, increased GD was associated with increased autism traits, even after accounting for the BPI. Of the four subscales, the Imagination and Patterns subscales in birth-assigned girls and the Imagination subscale in birth-assigned boys were especially associated with GD. These findings indicate that the association between GD and autism traits generalizes to a nonclinical, non-Western sample. Clinicians and researchers working with clinical as well as community children should thus pay attention to the co-occurrence of GD and autism traits, in and outside the West. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Gender diversity in a Chinese community sample and its associations with autism traits [Texte imprimé et/ou numérique] / Sylvia Yun SHI, Auteur ; Hoi Ching LEI, Auteur ; Cho Lam NGAN, Auteur ; Doug P. VANDERLAAN, Auteur ; Wang Ivy WONG, Auteur . - p.1407-1416. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1407-1416 Index. décimale : PER Périodiques Résumé : Abstract Emerging evidence suggests that gender dysphoria or gender diversity (GD) intersects frequently with autism spectrum disorder or autism traits. However, the magnitude and interpretation of this link continue to be debated. Most child studies on this topic were performed in clinical populations, and little is known about the generalizability of this co-occurrence to the broader community, especially to non-Western samples. Also, little is known about whether specific subdomains of autism are more strongly associated with GD. Therefore, we investigated GD and its association with autism traits in a Chinese community sample of 4-12-year-olds (N = 379; 51% birth-assigned girls). Parents provided information about GD characteristics using the standardized Gender Identity Questionnaire for Children and autism traits using the Chinese version of the Autism-Spectrum Quotient-Children. In addition, broader behavioral and emotional challenges were measured by the Behavior Problem Index (BPI) to account for psychological challenges other than autism traits. In this community sample of Chinese children, increased GD was associated with increased autism traits, even after accounting for the BPI. Of the four subscales, the Imagination and Patterns subscales in birth-assigned girls and the Imagination subscale in birth-assigned boys were especially associated with GD. These findings indicate that the association between GD and autism traits generalizes to a nonclinical, non-Western sample. Clinicians and researchers working with clinical as well as community children should thus pay attention to the co-occurrence of GD and autism traits, in and outside the West. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Measuring and validating autistic burnout / Amanda L. RICHDALE ; Xia LI ; Cheryl DISSANAYAKE in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1417-1449 Titre : Measuring and validating autistic burnout Type de document : Texte imprimé et/ou numérique Auteurs : Amanda L. RICHDALE, Auteur ; Xia LI, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : p.1417-1449 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Researchers have begun to explore the characteristics and risk factors for autistic burnout, but assessment tools are lacking. Our study comprehensively examined and compared the psychometric properties of the unpublished 27-item AASPIRE Autistic Burnout Measure (ABM), and personal and work scales of the Copenhagen Burnout Inventory (CBI) to evaluate their efficacy as screening measures for autistic burnout, with a group of 238 autistic adults. Exploratory factor analyses (EFA) revealed a 4-factor structure for the ABM and a 2-factor structure for the CBI personal scale (CBI-P). Factorial validity and dimensionality were examined with four exploratory models which indicated a unidimensional structure for the ABM with an overarching 'Autistic Burnout' construct, and multidimensional CBI-P structure comprising two subscales and overarching 'Personal Burnout' construct. Other reliability and validity indicators included Spearman correlations, analysis of variance, receiver operating characteristics, sensitivity, specificity, and intra-class correlations (ICC). The ABM and CBI-P were strongly correlated with depression, anxiety, stress, and fatigue. Unexpectedly, correlations between the burnout measures and camouflaging, and wellbeing measures were moderate. Potential overlap between burnout and depression and fatigue was examined through EFA, which supported convergent validity of the ABM and depression measure, while correlations and ICC analyses revealed mixed results. We concluded that the ABM and the CBI-P Emotional Exhaustion subscale were valid preliminary screening tools for autistic burnout. Testing with larger and more diverse autistic samples is required to further examine the psychometric properties of the ABM, and to understand the relationships between autistic burnout and depression, and masking. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Measuring and validating autistic burnout [Texte imprimé et/ou numérique] / Amanda L. RICHDALE, Auteur ; Xia LI, Auteur ; Cheryl DISSANAYAKE, Auteur . - p.1417-1449. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1417-1449 Index. décimale : PER Périodiques Résumé : Abstract Researchers have begun to explore the characteristics and risk factors for autistic burnout, but assessment tools are lacking. Our study comprehensively examined and compared the psychometric properties of the unpublished 27-item AASPIRE Autistic Burnout Measure (ABM), and personal and work scales of the Copenhagen Burnout Inventory (CBI) to evaluate their efficacy as screening measures for autistic burnout, with a group of 238 autistic adults. Exploratory factor analyses (EFA) revealed a 4-factor structure for the ABM and a 2-factor structure for the CBI personal scale (CBI-P). Factorial validity and dimensionality were examined with four exploratory models which indicated a unidimensional structure for the ABM with an overarching 'Autistic Burnout' construct, and multidimensional CBI-P structure comprising two subscales and overarching 'Personal Burnout' construct. Other reliability and validity indicators included Spearman correlations, analysis of variance, receiver operating characteristics, sensitivity, specificity, and intra-class correlations (ICC). The ABM and CBI-P were strongly correlated with depression, anxiety, stress, and fatigue. Unexpectedly, correlations between the burnout measures and camouflaging, and wellbeing measures were moderate. Potential overlap between burnout and depression and fatigue was examined through EFA, which supported convergent validity of the ABM and depression measure, while correlations and ICC analyses revealed mixed results. We concluded that the ABM and the CBI-P Emotional Exhaustion subscale were valid preliminary screening tools for autistic burnout. Testing with larger and more diverse autistic samples is required to further examine the psychometric properties of the ABM, and to understand the relationships between autistic burnout and depression, and masking. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study / Rachael A. MUSCATELLO ; Melissa CYPERSKI ; Eleonora SADIKOVA ; E. Kale EDMISTON ; Trey William MCGONIGLE ; Rachel CALVOSA ; Simon VANDEKAR in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1450-1463 Titre : Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Melissa CYPERSKI, Auteur ; Eleonora SADIKOVA, Auteur ; E. Kale EDMISTON, Auteur ; Trey William MCGONIGLE, Auteur ; Rachel CALVOSA, Auteur ; Simon VANDEKAR, Auteur Article en page(s) : p.1450-1463 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Recent research in autism spectrum disorder (ASD) has suggested a higher prevalence of gender diversity in individuals diagnosed with ASD. Adolescence is a critical period for the consolidation of gender identity, yet the extent to which the experience of gender diversity is stable over adolescence and puberty in autistic youth is poorly understood. The aim of the study was to examine the consistency of gender diversity using the gender diversity screening questionnaire for self- and parent-report of youth (GDSQ-S, GDSQ-P) over a four-year longitudinal study of pubertal development in youth with ASD (N = 140, 36 assigned-female-at birth (AFAB)) and typical development (TD, N = 104, 58 assigned-male-at-birth [AMAB]) and their parents. The extent to which diagnosis (ASD vs. TD), assigned sex (AFAB vs. AMAB) and developmental level (age, puberty) predict GDSQ trajectory over time was explored. There was a significant diagnosis by sex-assigned-at-birth by age interaction for GDSQ-S Gender Diversity, p = 0.002, showing higher scores in autistic AFAB youth over adolescence, and TD AFAB showing initially lower, then increasing levels over adolescence. For GDSQ-P, Gender Incongruence was significantly different between the groups, p = 0.032, showing higher incongruence for autistic AFAB around age 10, decreasing between age 12-14 before increasing again, while TD AFAB evidence the inverse trend. AMAB trends were stable. The significant diagnostic, developmental and sex-based differences indicate AFAB youth experience greater gender diversity that evolves over development. Findings suggest gender identity formation is nuanced and may be influenced by pubertal progression, hormonal patterns, and psychosocial factors. Results underscore the need for enhanced understanding of the unique, dynamic profiles of females-assigned-at-birth. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Melissa CYPERSKI, Auteur ; Eleonora SADIKOVA, Auteur ; E. Kale EDMISTON, Auteur ; Trey William MCGONIGLE, Auteur ; Rachel CALVOSA, Auteur ; Simon VANDEKAR, Auteur . - p.1450-1463. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1450-1463 Index. décimale : PER Périodiques Résumé : Abstract Recent research in autism spectrum disorder (ASD) has suggested a higher prevalence of gender diversity in individuals diagnosed with ASD. Adolescence is a critical period for the consolidation of gender identity, yet the extent to which the experience of gender diversity is stable over adolescence and puberty in autistic youth is poorly understood. The aim of the study was to examine the consistency of gender diversity using the gender diversity screening questionnaire for self- and parent-report of youth (GDSQ-S, GDSQ-P) over a four-year longitudinal study of pubertal development in youth with ASD (N = 140, 36 assigned-female-at birth (AFAB)) and typical development (TD, N = 104, 58 assigned-male-at-birth [AMAB]) and their parents. The extent to which diagnosis (ASD vs. TD), assigned sex (AFAB vs. AMAB) and developmental level (age, puberty) predict GDSQ trajectory over time was explored. There was a significant diagnosis by sex-assigned-at-birth by age interaction for GDSQ-S Gender Diversity, p = 0.002, showing higher scores in autistic AFAB youth over adolescence, and TD AFAB showing initially lower, then increasing levels over adolescence. For GDSQ-P, Gender Incongruence was significantly different between the groups, p = 0.032, showing higher incongruence for autistic AFAB around age 10, decreasing between age 12-14 before increasing again, while TD AFAB evidence the inverse trend. AMAB trends were stable. The significant diagnostic, developmental and sex-based differences indicate AFAB youth experience greater gender diversity that evolves over development. Findings suggest gender identity formation is nuanced and may be influenced by pubertal progression, hormonal patterns, and psychosocial factors. Results underscore the need for enhanced understanding of the unique, dynamic profiles of females-assigned-at-birth. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Autistic adults exhibit typical sensitivity to changes in interpersonal distance / Bayparvah Kaur GEHDU ; Clare PRESS ; Katie L. H. GRAY ; Richard COOK in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1464-1474 Titre : Autistic adults exhibit typical sensitivity to changes in interpersonal distance Type de document : Texte imprimé et/ou numérique Auteurs : Bayparvah Kaur GEHDU, Auteur ; Clare PRESS, Auteur ; Katie L. H. GRAY, Auteur ; Richard COOK, Auteur Article en page(s) : p.1464-1474 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The visual processing differences seen in autism often impede individuals' visual perception of the social world. In particular, many autistic people exhibit poor face recognition. Here, we sought to determine whether autistic adults also show impaired perception of dyadic social interactions-a class of stimulus thought to engage face-like visual processing. Our focus was the perception of interpersonal distance. Participants completed distance change detection tasks, in which they had to make perceptual decisions about the distance between two actors. On half of the trials, participants judged whether the actors moved closer together; on the other half, whether they moved further apart. In a nonsocial control task, participants made similar judgments about two grandfather clocks. We also assessed participants' face recognition ability using standardized measures. The autistic and nonautistic observers showed similar levels of perceptual sensitivity to changes in interpersonal distance when viewing social interactions. As expected, however, the autistic observers showed clear signs of impaired face recognition. Despite putative similarities between the visual processing of faces and dyadic social interactions, our results suggest that these two facets of social vision may dissociate. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Autistic adults exhibit typical sensitivity to changes in interpersonal distance [Texte imprimé et/ou numérique] / Bayparvah Kaur GEHDU, Auteur ; Clare PRESS, Auteur ; Katie L. H. GRAY, Auteur ; Richard COOK, Auteur . - p.1464-1474. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1464-1474 Index. décimale : PER Périodiques Résumé : Abstract The visual processing differences seen in autism often impede individuals' visual perception of the social world. In particular, many autistic people exhibit poor face recognition. Here, we sought to determine whether autistic adults also show impaired perception of dyadic social interactions-a class of stimulus thought to engage face-like visual processing. Our focus was the perception of interpersonal distance. Participants completed distance change detection tasks, in which they had to make perceptual decisions about the distance between two actors. On half of the trials, participants judged whether the actors moved closer together; on the other half, whether they moved further apart. In a nonsocial control task, participants made similar judgments about two grandfather clocks. We also assessed participants' face recognition ability using standardized measures. The autistic and nonautistic observers showed similar levels of perceptual sensitivity to changes in interpersonal distance when viewing social interactions. As expected, however, the autistic observers showed clear signs of impaired face recognition. Despite putative similarities between the visual processing of faces and dyadic social interactions, our results suggest that these two facets of social vision may dissociate. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3164 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Child and caregiver predictors of primary caregiver participation in families of school-aged Autistic children / Josephine BARBARO ; Katy UNWIN ; Megan CLARK ; Rachel JELLETT ; Perrin DATE ; Melanie MUNIANDY ; Cheryl DISSANAYAKE in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1475-1486 Titre : Child and caregiver predictors of primary caregiver participation in families of school-aged Autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Josephine BARBARO, Auteur ; Katy UNWIN, Auteur ; Megan CLARK, Auteur ; Rachel JELLETT, Auteur ; Perrin DATE, Auteur ; Melanie MUNIANDY, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : p.1475-1486 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Engaging in meaningful activities (e.g., leisure, spiritual, fitness) significantly affects caregivers' quality of life (QoL), yet the determinants of participation in caregivers of Autistic children remain largely unknown. The current study examined child and caregiver correlates of primary caregiver participation in meaningful activities. One hundred and six primary caregivers of Autistic children (7-12?years) were recruited from three unique cohorts of Autistic children in this cross-sectional study. Primary caregivers completed online questionnaires measuring occupational gaps (i.e., desired activities caregivers are not participating in), QoL, parenting stress, perceived family outcomes, and social support. In addition to undertaking direct assessments of children's cognition and language, primary caregivers also reported on their child's adaptive behavior, social-emotional skills, and participation. Caregivers reporting fewer occupational gaps (i.e., ?2 desired activities) were more likely to have Autistic children with no co-occurring conditions, who were older, and with better adaptive behaviors, social-emotional skills, and more frequent home and school participation, compared to caregivers reporting many gaps (i.e., ?3 desired activities). Caregivers with fewer occupational gaps also reported improved QoL, parenting stress, social support, perceived community inclusiveness, and family outcomes. Logistic regression analysis identified child age, child adaptive behavior, social-emotional skills, home participation, and the caregivers' perceived family outcomes and QoL as important predictors of their occupational gaps. The findings demonstrate that caregiver participation in desired activities was associated with increased functional ability and independence of the child, as well as their perceived capacity to meet their child's needs. Supporting parents' sense of efficacy in meeting their children's needs and building their skills and knowledge will serve to improve both caregiver and child outcomes. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3166 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Child and caregiver predictors of primary caregiver participation in families of school-aged Autistic children [Texte imprimé et/ou numérique] / Josephine BARBARO, Auteur ; Katy UNWIN, Auteur ; Megan CLARK, Auteur ; Rachel JELLETT, Auteur ; Perrin DATE, Auteur ; Melanie MUNIANDY, Auteur ; Cheryl DISSANAYAKE, Auteur . - p.1475-1486. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1475-1486 Index. décimale : PER Périodiques Résumé : Abstract Engaging in meaningful activities (e.g., leisure, spiritual, fitness) significantly affects caregivers' quality of life (QoL), yet the determinants of participation in caregivers of Autistic children remain largely unknown. The current study examined child and caregiver correlates of primary caregiver participation in meaningful activities. One hundred and six primary caregivers of Autistic children (7-12?years) were recruited from three unique cohorts of Autistic children in this cross-sectional study. Primary caregivers completed online questionnaires measuring occupational gaps (i.e., desired activities caregivers are not participating in), QoL, parenting stress, perceived family outcomes, and social support. In addition to undertaking direct assessments of children's cognition and language, primary caregivers also reported on their child's adaptive behavior, social-emotional skills, and participation. Caregivers reporting fewer occupational gaps (i.e., ?2 desired activities) were more likely to have Autistic children with no co-occurring conditions, who were older, and with better adaptive behaviors, social-emotional skills, and more frequent home and school participation, compared to caregivers reporting many gaps (i.e., ?3 desired activities). Caregivers with fewer occupational gaps also reported improved QoL, parenting stress, social support, perceived community inclusiveness, and family outcomes. Logistic regression analysis identified child age, child adaptive behavior, social-emotional skills, home participation, and the caregivers' perceived family outcomes and QoL as important predictors of their occupational gaps. The findings demonstrate that caregiver participation in desired activities was associated with increased functional ability and independence of the child, as well as their perceived capacity to meet their child's needs. Supporting parents' sense of efficacy in meeting their children's needs and building their skills and knowledge will serve to improve both caregiver and child outcomes. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3166 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Categorizing and identifying preferred interests in autistic toddlers / Kirsty L. COULTER ; Rebecca P. THOMAS ; Marianne L. BARTON ; Diana L. ROBINS ; Deborah A. FEIN in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1487-1500 Titre : Categorizing and identifying preferred interests in autistic toddlers Type de document : Texte imprimé et/ou numérique Auteurs : Kirsty L. COULTER, Auteur ; Rebecca P. THOMAS, Auteur ; Marianne L. BARTON, Auteur ; Diana L. ROBINS, Auteur ; Deborah A. FEIN, Auteur Article en page(s) : p.1487-1500 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Preferred interests are characteristic of autism spectrum disorder and are reported by parents starting at an early age. However, limited research has explored the presentation of preferred interests in toddlerhood. Previous literature suggests that both the intensity and type of preferred interests held by autistic individuals differ from those held by peers with developmental delay and no diagnosis and that autistic interests are more unusual in nature. While preferred interests are seen in typical child development, previous research suggests that the presence of preferred interests in children with no diagnosis declines with age. Literature also indicates that the sex and cognitive ability of autistic children influences preferred interests. Identification of early preferred interests commonly held by autistic toddlers could serve as a useful clinical indicator of future diagnosis. This article explored whether diagnostic group, age, sex, and cognitive ability predict the likelihood that parents reported preferred interests in children aged 12-36?months with diagnoses of autism, developmental delay, and those with no diagnosis. Additionally, we explored potential diagnostic group differences in interest type. Results suggest that diagnostic group, but not age, sex, or cognitive ability, predicts the likelihood that parents report preferred interests. No differences in the type of interests among diagnostic groups were identified. These results support the use of preferred interests as an early sign of autism but suggest that interest type may not be a helpful clinical indicator of autism in toddlerhood. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Categorizing and identifying preferred interests in autistic toddlers [Texte imprimé et/ou numérique] / Kirsty L. COULTER, Auteur ; Rebecca P. THOMAS, Auteur ; Marianne L. BARTON, Auteur ; Diana L. ROBINS, Auteur ; Deborah A. FEIN, Auteur . - p.1487-1500. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1487-1500 Index. décimale : PER Périodiques Résumé : Abstract Preferred interests are characteristic of autism spectrum disorder and are reported by parents starting at an early age. However, limited research has explored the presentation of preferred interests in toddlerhood. Previous literature suggests that both the intensity and type of preferred interests held by autistic individuals differ from those held by peers with developmental delay and no diagnosis and that autistic interests are more unusual in nature. While preferred interests are seen in typical child development, previous research suggests that the presence of preferred interests in children with no diagnosis declines with age. Literature also indicates that the sex and cognitive ability of autistic children influences preferred interests. Identification of early preferred interests commonly held by autistic toddlers could serve as a useful clinical indicator of future diagnosis. This article explored whether diagnostic group, age, sex, and cognitive ability predict the likelihood that parents reported preferred interests in children aged 12-36?months with diagnoses of autism, developmental delay, and those with no diagnosis. Additionally, we explored potential diagnostic group differences in interest type. Results suggest that diagnostic group, but not age, sex, or cognitive ability, predicts the likelihood that parents report preferred interests. No differences in the type of interests among diagnostic groups were identified. These results support the use of preferred interests as an early sign of autism but suggest that interest type may not be a helpful clinical indicator of autism in toddlerhood. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Mid-childhood autism sibling recurrence in infants with a family history of autism / Rowan ARTHUR ; Greg PASCO ; Elizabeth SHEPHARD ; Bosiljka MILOSAVLJEVIC ; Jannath Begum ALI ; Andrew PICKLES ; Mark H. JOHNSON ; Emily J. H. JONES ; Tony CHARMAN ; The BASIS/STAARS TEAM in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1501-1514 Titre : Mid-childhood autism sibling recurrence in infants with a family history of autism Type de document : Texte imprimé et/ou numérique Auteurs : Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur Article en page(s) : p.1501-1514 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3?years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3?years and mid-childhood (6 to 12?years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3?years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3?years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3?years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Mid-childhood autism sibling recurrence in infants with a family history of autism [Texte imprimé et/ou numérique] / Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Tony CHARMAN, Auteur ; The BASIS/STAARS TEAM, Auteur . - p.1501-1514. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1501-1514 Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3?years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3?years and mid-childhood (6 to 12?years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3?years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3?years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3?years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533