An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior / E. CONRADT in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.881-890 Titre : An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior Type de document : Texte imprimé et/ou numérique Auteurs : E. CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; S. E. CROWELL, Auteur ; C. MONK, Auteur ; M. S. KOBOR, Auteur Article en page(s) : p.881-890 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior [Texte imprimé et/ou numérique] / E. CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; S. E. CROWELL, Auteur ; C. MONK, Auteur ; M. S. KOBOR, Auteur . - p.881-890. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.881-890 Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised / H. C. GUSTAFSSON in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.773-785 Titre : Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised Type de document : Texte imprimé et/ou numérique Auteurs : H. C. GUSTAFSSON, Auteur ; S. H. GOODMAN, Auteur ; T. FENG, Auteur ; J. CHOI, Auteur ; S. LEE, Auteur ; D. J. NEWPORT, Auteur ; B. KNIGHT, Auteur ; B. PINGETON, Auteur ; Z. N. STOWE, Auteur ; C. MONK, Auteur Article en page(s) : p.773-785 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychotropic medication use and psychiatric symptoms during pregnancy each are associated with adverse neurodevelopmental outcomes in offspring. Commonly, studies considering medication effects do not adequately assess symptoms, nor evaluate children when the effects are believed to occur, the fetal period. This study examined maternal serotonin reuptake inhibitor and polypharmacy use in relation to serial assessments of five indices of fetal neurobehavior and Bayley Scales of Infant Development at 12 months in N = 161 socioeconomically advantaged, non-Hispanic White women with a shared risk phenotype, diagnosed major depressive disorder. On average fetuses showed the expected development over gestation. In contrast, infant average Bayley psychomotor and mental development scores were low (M = 84.10 and M = 89.92, range of normal limits 85-114) with rates of delay more than 2-3 times what would be expected based on this measure's normative data. Controlling for prenatal and postnatal depressive symptoms, prenatal medication effects on neurobehavioral development were largely undetected in the fetus and infant. Mental health care directed primarily at symptoms may not address the additional psychosocial needs of women parenting infants. Speculatively, prenatal serotonin reuptake inhibitor exposure may act as a plasticity rather than risk factor, potentially enhancing receptivity to a nonoptimal postnatal environment in some mother-infant dyads. En ligne : http://dx.doi.org/10.1017/s0954579418000639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] Major depressive disorder during pregnancy: Psychiatric medications have minimal effects on the fetus and infant yet development is compromised [Texte imprimé et/ou numérique] / H. C. GUSTAFSSON, Auteur ; S. H. GOODMAN, Auteur ; T. FENG, Auteur ; J. CHOI, Auteur ; S. LEE, Auteur ; D. J. NEWPORT, Auteur ; B. KNIGHT, Auteur ; B. PINGETON, Auteur ; Z. N. STOWE, Auteur ; C. MONK, Auteur . - p.773-785. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.773-785 Index. décimale : PER Périodiques Résumé : Psychotropic medication use and psychiatric symptoms during pregnancy each are associated with adverse neurodevelopmental outcomes in offspring. Commonly, studies considering medication effects do not adequately assess symptoms, nor evaluate children when the effects are believed to occur, the fetal period. This study examined maternal serotonin reuptake inhibitor and polypharmacy use in relation to serial assessments of five indices of fetal neurobehavior and Bayley Scales of Infant Development at 12 months in N = 161 socioeconomically advantaged, non-Hispanic White women with a shared risk phenotype, diagnosed major depressive disorder. On average fetuses showed the expected development over gestation. In contrast, infant average Bayley psychomotor and mental development scores were low (M = 84.10 and M = 89.92, range of normal limits 85-114) with rates of delay more than 2-3 times what would be expected based on this measure's normative data. Controlling for prenatal and postnatal depressive symptoms, prenatal medication effects on neurobehavioral development were largely undetected in the fetus and infant. Mental health care directed primarily at symptoms may not address the additional psychosocial needs of women parenting infants. Speculatively, prenatal serotonin reuptake inhibitor exposure may act as a plasticity rather than risk factor, potentially enhancing receptivity to a nonoptimal postnatal environment in some mother-infant dyads. En ligne : http://dx.doi.org/10.1017/s0954579418000639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure / P. SCORZA in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.119-132 Titre : Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure Type de document : Texte imprimé et/ou numérique Auteurs : P. SCORZA, Auteur ; C. S. DUARTE, Auteur ; A. E. HIPWELL, Auteur ; J. POSNER, Auteur ; A. ORTIN, Auteur ; Glorisa CANINO, Auteur ; C. MONK, Auteur Article en page(s) : p.119-132 Langues : Anglais (eng) Mots-clés : Development  adversity  early life experience  endocrinology  epigenetics  gene-environment interaction  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. METHODS: We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood direct exposures to stress stemming from socioeconomic disadvantage and adversity. RESULTS: Animal models point to epigenetic mechanisms by which traits that could contribute to disadvantage may be transmitted across generations. However, epigenetic pathways of parental childhood experiences influencing child outcomes in the next generation are only beginning to be studied in humans. With a focus on translational research, we point to design features and methodological considerations for human cohort studies to be able to test the intergenerational transmission hypothesis, and we illustrate this with existing longitudinal studies. CONCLUSIONS: Epigenetic intergenerational transmission, if at play in human populations, could have policy implications in terms of reducing the continuation of disadvantage across generations. Further research is needed to address this gap in the understanding of the perpetuation of compromised lives across generations. En ligne : http://dx.doi.org/10.1111/jcpp.12877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure [Texte imprimé et/ou numérique] / P. SCORZA, Auteur ; C. S. DUARTE, Auteur ; A. E. HIPWELL, Auteur ; J. POSNER, Auteur ; A. ORTIN, Auteur ; Glorisa CANINO, Auteur ; C. MONK, Auteur . - p.119-132. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.119-132 Mots-clés : Development  adversity  early life experience  endocrinology  epigenetics  gene-environment interaction  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. METHODS: We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood direct exposures to stress stemming from socioeconomic disadvantage and adversity. RESULTS: Animal models point to epigenetic mechanisms by which traits that could contribute to disadvantage may be transmitted across generations. However, epigenetic pathways of parental childhood experiences influencing child outcomes in the next generation are only beginning to be studied in humans. With a focus on translational research, we point to design features and methodological considerations for human cohort studies to be able to test the intergenerational transmission hypothesis, and we illustrate this with existing longitudinal studies. CONCLUSIONS: Epigenetic intergenerational transmission, if at play in human populations, could have policy implications in terms of reducing the continuation of disadvantage across generations. Further research is needed to address this gap in the understanding of the perpetuation of compromised lives across generations. En ligne : http://dx.doi.org/10.1111/jcpp.12877 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

---

1 (1 - 3 / 3)