Emerging depression in adolescence coincides with accelerated frontal cortical thinning / Marieke G. N. BOS in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.994-1002 Titre : Emerging depression in adolescence coincides with accelerated frontal cortical thinning Type de document : Texte imprimé et/ou numérique Auteurs : Marieke G. N. BOS, Auteur ; Sabine PETERS, Auteur ; Ferdi C. KAMP, Auteur ; Eveline A. CRONE, Auteur ; Christian K. TAMNES, Auteur Article en page(s) : p.994-1002 Langues : Anglais (eng) Mots-clés : Adolescence  brain development  longitudinal  depression  MRI  cerebral cortex Index. décimale : PER Périodiques Résumé : Background Adolescence is a transition period characterized by heightened emotional reactivity, which for some sets the stage for emerging depressive symptoms. Prior studies suggest that adolescent depression is associated with deviant cortical and subcortical brain structure. Longitudinal studies are, however, currently scarce, but critical to detect which adolescents are at risk for developing depressive symptoms. Methods In this longitudinal study, a community sample of 205 participants underwent magnetic resonance imaging (MRI) in three biennial waves (522 scans) spanning 5 years across ages 8?25 years. Depressive symptomatology was assessed using self-report at the third time point. Mixed models were used to examine the relations between structural brain development, specifically regional change in cortical thickness, surface area and subcortical volumes (hippocampus and amygdala), and depressive symptoms. Results Accelerated frontal lobe cortical thinning was observed in adolescents who developed depressive symptoms at the third time point. This effect remained after controlling for parent-reported affective problems at the first time point. Moreover, the effect was driven by specific lateral orbitofrontal and precentral regions. In addition, differential developmental trajectories of parietal cortical thickness and surface area in several regions were found for participants reporting higher depressive symptomatology, but these results did not survive correction for multiple comparisons. Volumes or developmental volume changes in hippocampus or amygdala were not related to depressive symptoms. Conclusions This study showed that emerging depression is associated with cortical thinning in frontal regions within individuals. These findings move beyond detecting cross-sectional correlations and set the stage for early detection, which may inform future intervention. En ligne : https://doi.org/10.1111/jcpp.12895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Emerging depression in adolescence coincides with accelerated frontal cortical thinning [Texte imprimé et/ou numérique] / Marieke G. N. BOS, Auteur ; Sabine PETERS, Auteur ; Ferdi C. KAMP, Auteur ; Eveline A. CRONE, Auteur ; Christian K. TAMNES, Auteur . - p.994-1002. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.994-1002 Mots-clés : Adolescence  brain development  longitudinal  depression  MRI  cerebral cortex Index. décimale : PER Périodiques Résumé : Background Adolescence is a transition period characterized by heightened emotional reactivity, which for some sets the stage for emerging depressive symptoms. Prior studies suggest that adolescent depression is associated with deviant cortical and subcortical brain structure. Longitudinal studies are, however, currently scarce, but critical to detect which adolescents are at risk for developing depressive symptoms. Methods In this longitudinal study, a community sample of 205 participants underwent magnetic resonance imaging (MRI) in three biennial waves (522 scans) spanning 5 years across ages 8?25 years. Depressive symptomatology was assessed using self-report at the third time point. Mixed models were used to examine the relations between structural brain development, specifically regional change in cortical thickness, surface area and subcortical volumes (hippocampus and amygdala), and depressive symptoms. Results Accelerated frontal lobe cortical thinning was observed in adolescents who developed depressive symptoms at the third time point. This effect remained after controlling for parent-reported affective problems at the first time point. Moreover, the effect was driven by specific lateral orbitofrontal and precentral regions. In addition, differential developmental trajectories of parietal cortical thickness and surface area in several regions were found for participants reporting higher depressive symptomatology, but these results did not survive correction for multiple comparisons. Volumes or developmental volume changes in hippocampus or amygdala were not related to depressive symptoms. Conclusions This study showed that emerging depression is associated with cortical thinning in frontal regions within individuals. These findings move beyond detecting cross-sectional correlations and set the stage for early detection, which may inform future intervention. En ligne : https://doi.org/10.1111/jcpp.12895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

The role of pubertal development in the association between trauma and internalising symptoms in female youth / Niamh MACSWEENEY in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1197-1208 Titre : The role of pubertal development in the association between trauma and internalising symptoms in female youth Type de document : Texte imprimé et/ou numérique Auteurs : Niamh MACSWEENEY, Auteur ; Phoebe THOMSON, Auteur ; Tilmann VON SOEST, Auteur ; Christian K. TAMNES, Auteur ; Divyangana RAKESH, Auteur Article en page(s) : p.1197-1208 Langues : Anglais (eng) Mots-clés : Trauma  puberty  internalising symptoms  pubertal timing  pubertal tempo  longitudinal Index. décimale : PER Périodiques Résumé : Background Exposure to trauma in childhood is associated with an increased risk for internalising symptoms. Alterations in pubertal development has been proposed as a potential mechanism underpinning this association. However, longitudinal studies, which are needed to examine pubertal development over time, are scarce. The goal of this pre-registered study was to examine how trauma exposure shapes the timing and tempo of pubertal development, and in turn contributes to risk for internalising symptoms in female youth. Methods Using the largest longitudinal sample to date, we characterised profiles of pubertal development across four time points in female youth from the Adolescent Brain Cognitive Development (ABCD) Study (N?=?4,225, age range?=?9?14?years) using latent profile analysis. Pubertal development was assessed using the Pubertal Development Scale (at four time points). Trauma exposure was quantified using the post-traumatic stress disorder subscale from the parent-report Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5 (at baseline), and internalising symptoms were assessed using the self-report Brief Problem Monitor (at 3-year follow-up). Results Pubertal development could be grouped into three latent classes: early starters (9% of sample), typical developers (76%) and slow developers (15%). The early starters demonstrated higher levels of trauma exposure compared to typical developers and slow developers, while slow developers showed the least exposure to trauma. Youth with greater exposure to trauma were at an increased risk for internalising symptoms at ages 12?14?years, and this association was mediated by a higher pubertal status at ages 9?10?years, but not by a faster pubertal tempo. Conclusions Accelerated pubertal development, characterised by an earlier age of onset but not a higher pubertal tempo in the transition from late childhood to early adolescence, may be a mechanism through which trauma exposure in childhood increases risk for internalising symptoms in female youth. En ligne : https://doi.org/10.1111/jcpp.14139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565 [article] The role of pubertal development in the association between trauma and internalising symptoms in female youth [Texte imprimé et/ou numérique] / Niamh MACSWEENEY, Auteur ; Phoebe THOMSON, Auteur ; Tilmann VON SOEST, Auteur ; Christian K. TAMNES, Auteur ; Divyangana RAKESH, Auteur . - p.1197-1208. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1197-1208 Mots-clés : Trauma  puberty  internalising symptoms  pubertal timing  pubertal tempo  longitudinal Index. décimale : PER Périodiques Résumé : Background Exposure to trauma in childhood is associated with an increased risk for internalising symptoms. Alterations in pubertal development has been proposed as a potential mechanism underpinning this association. However, longitudinal studies, which are needed to examine pubertal development over time, are scarce. The goal of this pre-registered study was to examine how trauma exposure shapes the timing and tempo of pubertal development, and in turn contributes to risk for internalising symptoms in female youth. Methods Using the largest longitudinal sample to date, we characterised profiles of pubertal development across four time points in female youth from the Adolescent Brain Cognitive Development (ABCD) Study (N?=?4,225, age range?=?9?14?years) using latent profile analysis. Pubertal development was assessed using the Pubertal Development Scale (at four time points). Trauma exposure was quantified using the post-traumatic stress disorder subscale from the parent-report Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5 (at baseline), and internalising symptoms were assessed using the self-report Brief Problem Monitor (at 3-year follow-up). Results Pubertal development could be grouped into three latent classes: early starters (9% of sample), typical developers (76%) and slow developers (15%). The early starters demonstrated higher levels of trauma exposure compared to typical developers and slow developers, while slow developers showed the least exposure to trauma. Youth with greater exposure to trauma were at an increased risk for internalising symptoms at ages 12?14?years, and this association was mediated by a higher pubertal status at ages 9?10?years, but not by a faster pubertal tempo. Conclusions Accelerated pubertal development, characterised by an earlier age of onset but not a higher pubertal tempo in the transition from late childhood to early adolescence, may be a mechanism through which trauma exposure in childhood increases risk for internalising symptoms in female youth. En ligne : https://doi.org/10.1111/jcpp.14139 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=565

---

1 (1 - 2 / 2)