29 recherche sur le mot-clé 'puberty'

Associations between HPA axis reactivity and PTSD and depressive symptoms: Importance of maltreatment type and puberty / Sonya NEGRIFF in Development and Psychopathology, 35-1 (February 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-1 (February 2023) . - p.130-141 Titre : Associations between HPA axis reactivity and PTSD and depressive symptoms: Importance of maltreatment type and puberty Type de document : Texte imprimé et/ou numérique Auteurs : Sonya NEGRIFF, Auteur ; Elana B. GORDIS, Auteur ; Elizabeth J. SUSMAN, Auteur Article en page(s) : p.130-141 Langues : Anglais (eng) Mots-clés : cortisol  depression  maltreatment  PTSD  puberty Index. décimale : PER Périodiques Résumé : The functioning of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the etiology and maintenance of depressive and posttraumatic stress disorder (PTSD) symptoms. However, different maltreatment experiences as well as the increased sensitivity of the HPA axis during puberty may alter associations between the HPA axis and mental health. To address these gaps, the current study examined the potential bidirectional associations between cortisol reactivity to a stressor, PTSD symptoms, and depressive symptoms among early adolescents across two time points, 1 year apart (n = 454; Mage = 10.98 at Time 1 and Mage = 12.11 at Time 2). Multiple-group path models tested the pathways between cortiol reactivity and mental health prior to and during puberty, for different types of maltreatment . Overall, the results showed that associations between cortisol output and symptoms of PTSD and depression were driven by those in the midst of puberty. Specifically, higher cortisol output at Time 1 was linked with higher levels of subsequent PTSD and depressive symptoms for neglected youth who had reached puberty. However, depressive symptoms predicted subsequent lower cortisol output for the physical abuse and emotional abuse groups. These findings demonstrate longitudinal links between cortisol, depressive symptoms, and PTSD symptoms among youth with different types of maltreatment histories and highlight the need to consider the reorganization of the stress system during puberty in order to advance our understanding of the HPA axis and mental health. En ligne : https://doi.org/10.1017/S095457942100050X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Associations between HPA axis reactivity and PTSD and depressive symptoms: Importance of maltreatment type and puberty [Texte imprimé et/ou numérique] / Sonya NEGRIFF, Auteur ; Elana B. GORDIS, Auteur ; Elizabeth J. SUSMAN, Auteur . - p.130-141. Langues : Anglais (eng) in Development and Psychopathology > 35-1 (February 2023) . - p.130-141 Mots-clés : cortisol  depression  maltreatment  PTSD  puberty Index. décimale : PER Périodiques Résumé : The functioning of the hypothalamic-pituitary-adrenal (HPA) axis is implicated in the etiology and maintenance of depressive and posttraumatic stress disorder (PTSD) symptoms. However, different maltreatment experiences as well as the increased sensitivity of the HPA axis during puberty may alter associations between the HPA axis and mental health. To address these gaps, the current study examined the potential bidirectional associations between cortisol reactivity to a stressor, PTSD symptoms, and depressive symptoms among early adolescents across two time points, 1 year apart (n = 454; Mage = 10.98 at Time 1 and Mage = 12.11 at Time 2). Multiple-group path models tested the pathways between cortiol reactivity and mental health prior to and during puberty, for different types of maltreatment . Overall, the results showed that associations between cortisol output and symptoms of PTSD and depression were driven by those in the midst of puberty. Specifically, higher cortisol output at Time 1 was linked with higher levels of subsequent PTSD and depressive symptoms for neglected youth who had reached puberty. However, depressive symptoms predicted subsequent lower cortisol output for the physical abuse and emotional abuse groups. These findings demonstrate longitudinal links between cortisol, depressive symptoms, and PTSD symptoms among youth with different types of maltreatment histories and highlight the need to consider the reorganization of the stress system during puberty in order to advance our understanding of the HPA axis and mental health. En ligne : https://doi.org/10.1017/S095457942100050X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty / Nicole B. PERRY in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1854-1863 Titre : Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty Type de document : Texte imprimé et/ou numérique Auteurs : Nicole B. PERRY, Auteur ; Carrie E. DEPASQUALE, Auteur ; Bonny DONZELLA, Auteur ; Megan R. GUNNAR, Auteur Article en page(s) : p.1854-1863 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Hydrocortisone  Parents  *Problem Behavior  Puberty  Saliva  *Stress, Psychological  *cortisol  *externalizing  *institutions  *internalizing  *puberty  *stress Index. décimale : PER Périodiques Résumé : Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths' externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth. En ligne : http://dx.doi.org/10.1017/s0954579420001297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Associations between stress reactivity and behavior problems for previously institutionalized youth across puberty [Texte imprimé et/ou numérique] / Nicole B. PERRY, Auteur ; Carrie E. DEPASQUALE, Auteur ; Bonny DONZELLA, Auteur ; Megan R. GUNNAR, Auteur . - p.1854-1863. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1854-1863 Mots-clés : Adolescent  Humans  Hydrocortisone  Parents  *Problem Behavior  Puberty  Saliva  *Stress, Psychological  *cortisol  *externalizing  *institutions  *internalizing  *puberty  *stress Index. décimale : PER Périodiques Résumé : Megan Gunnar's pubertal stress recalibration hypothesis was supported in a recent study of previously institutionalized (PI) youth such that increases in pubertal stage were associated with increases in cortisol stress reactivity. This work provides evidence that puberty may open up a window of recalibration for PI youth, resulting in a shift from a blunted to a more typical cortisol stress response. Using the same sample (N = 132), the current study aimed to elucidate whether increases in cortisol are associated with increases in adaptive functioning or whether they further underlie potential links to developmental psychopathology. Specifically, we examined the bidirectional associations between cortisol stress reactivity and both internalizing and externalizing symptoms across three timepoints during the pubertal period. Youth reported on their own internalizing symptoms and parents reported on youths' externalizing symptoms. Cortisol reactivity was assessed during the Trier social stress test. Analyses revealed no associations between cortisol reactivity and externalizing symptoms across puberty for PI youth. However, longitudinal bidirectional associations did emerge for internalizing symptoms such that increases in cortisol reactivity predicted increases in internalizing symptoms and increases in internalizing symptoms predicted increases in cortisol reactivity. Findings suggest that recalibrating to more normative levels of cortisol reactivity may not always be associated with adaptive outcomes for PI youth. En ligne : http://dx.doi.org/10.1017/s0954579420001297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty / Katharina KIRCANSKI in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Titre : Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty Type de document : Texte imprimé et/ou numérique Auteurs : Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1011-1022 Langues : Anglais (eng) Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty [Texte imprimé et/ou numérique] / Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1011-1022. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms / Robin F. CHAN in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.802-809 Titre : A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Robin F. CHAN, Auteur ; William E. COPELAND, Auteur ; Min ZHAO, Auteur ; Lin Y. XIE, Auteur ; Jane COSTELLO, Auteur ; Karolina A. ABERG, Auteur ; Edwin J. C. G. VAN DEN OORD, Auteur Article en page(s) : p.802-809 Langues : Anglais (eng) Mots-clés : Brain  DNA Methylation  Depression/genetics  Female  Genome-Wide Association Study  Humans  Male  Puberty  Sex Characteristics  Affective disorders  biomarkers  epigenetics  sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Women are 1.5-3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation-wide association study (MWAS) to generate novel hypotheses. METHODS: We assayed nearly all 28 million possible methylation sites in blood in 595 blood samples from 487 participants aged 9-17. MWASs were performed to identify methylation sites associated with increasing sex differences in depression symptoms as a function of pubertal stage. Epigenetic deconvolution was applied to perform analyses on a cell-type specific level. RESULTS: In monocytes, a substantial number of significant associations were detected after controlling the FDR at 0.05. These results could not be explained by plasma testosterone/estradiol or current/lifetime trauma. Our top results in monocytes were significantly enriched (ratio of 2.48) for genes in the top of a large genome-wide association study (GWAS) meta-analysis of depression and neurodevelopment-related Gene Ontology (GO) terms that remained significant after correcting for multiple testing. Focusing on our most robust findings (70 genes overlapping with the GWAS meta-analysis and the significant GO terms), we find genes coding for members of each of the major classes of axon guidance molecules (netrins, slits, semaphorins, ephrins, and cell adhesion molecules). Many of these genes were previously implicated in rodent studies of brain development and depression-like phenotypes, as well as human methylation, gene expression and GWAS studies. CONCLUSIONS: Our study suggests that the emergence of sex differences in depression may be related to the differential rewiring of brain circuits between boys and girls during puberty. En ligne : http://dx.doi.org/10.1111/jcpp.13522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms [Texte imprimé et/ou numérique] / Robin F. CHAN, Auteur ; William E. COPELAND, Auteur ; Min ZHAO, Auteur ; Lin Y. XIE, Auteur ; Jane COSTELLO, Auteur ; Karolina A. ABERG, Auteur ; Edwin J. C. G. VAN DEN OORD, Auteur . - p.802-809. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.802-809 Mots-clés : Brain  DNA Methylation  Depression/genetics  Female  Genome-Wide Association Study  Humans  Male  Puberty  Sex Characteristics  Affective disorders  biomarkers  epigenetics  sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Women are 1.5-3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation-wide association study (MWAS) to generate novel hypotheses. METHODS: We assayed nearly all 28 million possible methylation sites in blood in 595 blood samples from 487 participants aged 9-17. MWASs were performed to identify methylation sites associated with increasing sex differences in depression symptoms as a function of pubertal stage. Epigenetic deconvolution was applied to perform analyses on a cell-type specific level. RESULTS: In monocytes, a substantial number of significant associations were detected after controlling the FDR at 0.05. These results could not be explained by plasma testosterone/estradiol or current/lifetime trauma. Our top results in monocytes were significantly enriched (ratio of 2.48) for genes in the top of a large genome-wide association study (GWAS) meta-analysis of depression and neurodevelopment-related Gene Ontology (GO) terms that remained significant after correcting for multiple testing. Focusing on our most robust findings (70 genes overlapping with the GWAS meta-analysis and the significant GO terms), we find genes coding for members of each of the major classes of axon guidance molecules (netrins, slits, semaphorins, ephrins, and cell adhesion molecules). Many of these genes were previously implicated in rodent studies of brain development and depression-like phenotypes, as well as human methylation, gene expression and GWAS studies. CONCLUSIONS: Our study suggests that the emergence of sex differences in depression may be related to the differential rewiring of brain circuits between boys and girls during puberty. En ligne : http://dx.doi.org/10.1111/jcpp.13522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Supporting Minimally Verbal Autistic Girls with Intellectual Disabilities Through Puberty: Perspectives of Parents and Educators / Clare CUMMINS in Journal of Autism and Developmental Disorders, 50-7 (July 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2439-2448 Titre : Supporting Minimally Verbal Autistic Girls with Intellectual Disabilities Through Puberty: Perspectives of Parents and Educators Type de document : Texte imprimé et/ou numérique Auteurs : Clare CUMMINS, Auteur ; Elizabeth PELLICANO, Auteur ; Laura CRANE, Auteur Article en page(s) : p.2439-2448 Langues : Anglais (eng) Mots-clés : Autism  Intellectual disability  Minimally verbal  Parents  Puberty  Teachers Index. décimale : PER Périodiques Résumé : Limited research has examined puberty in autistic girls, yet alone those who are minimally verbal and with additional intellectual disabilities. In this study, ten parents and ten educators were interviewed about their views and experiences of supporting these girls through puberty. Results demonstrated that many parents had concerns prior to the onset of puberty in these girls. Yet, for most girls, experiences of puberty were felt to be positive, with the girls coping well with changes that they were experiencing (e.g. menstruation, breast development and developing body hair). Thematic analysis of interview data highlighted three main themes: a range of individual experiences and needs; the importance of promoting dignity and respect; and identifying ways to support these girls through puberty. En ligne : http://dx.doi.org/10.1007/s10803-018-3782-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Supporting Minimally Verbal Autistic Girls with Intellectual Disabilities Through Puberty: Perspectives of Parents and Educators [Texte imprimé et/ou numérique] / Clare CUMMINS, Auteur ; Elizabeth PELLICANO, Auteur ; Laura CRANE, Auteur . - p.2439-2448. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-7 (July 2020) . - p.2439-2448 Mots-clés : Autism  Intellectual disability  Minimally verbal  Parents  Puberty  Teachers Index. décimale : PER Périodiques Résumé : Limited research has examined puberty in autistic girls, yet alone those who are minimally verbal and with additional intellectual disabilities. In this study, ten parents and ten educators were interviewed about their views and experiences of supporting these girls through puberty. Results demonstrated that many parents had concerns prior to the onset of puberty in these girls. Yet, for most girls, experiences of puberty were felt to be positive, with the girls coping well with changes that they were experiencing (e.g. menstruation, breast development and developing body hair). Thematic analysis of interview data highlighted three main themes: a range of individual experiences and needs; the importance of promoting dignity and respect; and identifying ways to support these girls through puberty. En ligne : http://dx.doi.org/10.1007/s10803-018-3782-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth / Blythe A. CORBETT in Molecular Autism, 15 (2024)  

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Comparing the effects of age, pubertal development, and symptom profile on cortisol rhythm in children and adolescents with autism spectrum disorder / A. MUSCATELLO RACHAEL in Autism Research, 11-1 (January 2018)  

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Developmental changes in genetic and environmental influences on rule-breaking and aggression: age and pubertal development / K. Paige HARDEN in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

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Editorial: The critical need to assess pubertal development in studies of child and adolescent psychopathology / Kelly L. KLUMP in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

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Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth / Blythe A. CORBETT in Autism Research, 15-10 (October 2022)  

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