Adaptation and Feasibility of the Mandarin Version of PEERS® for Autistic Adolescents / Yan LI ; Wuxia BAI ; Yu WANG ; Yongmei LI ; Yixiang XIE ; Xiaoqian HUANG ; Huilin ZHU ; Xiaobing ZOU in Journal of Autism and Developmental Disorders, 54-9 (September 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-9 (September 2024) . - p.3387-3399 Titre : Adaptation and Feasibility of the Mandarin Version of PEERS® for Autistic Adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Wuxia BAI, Auteur ; Yu WANG, Auteur ; Yongmei LI, Auteur ; Yixiang XIE, Auteur ; Xiaoqian HUANG, Auteur ; Huilin ZHU, Auteur ; Xiaobing ZOU, Auteur Article en page(s) : p.3387-3399 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Purpose: The Program for the Education and Enrichment of Relational Skills (PEERS®) is a group-based social skills training program for adolescents on the autism spectrum. Although the program has been shown to be effective in improving social skills in autistic adolescents, evidence of its effectiveness from the Mandarin-speaking Chinese population is sparse. The present study used a non-randomized, pre- and post-intervention research design to investigate the feasibility and cultural validity of the program, as well as examine the moderators of intervention outcomes. Methods: Thirty-three autistic adolescents with intelligence quotient above 70 (Mage = 13.57, SDage = 1.43; Male: Female 25:8) and their parents received 14 concurrent 90-minute sessions. Adolescents'autistic traits, challenging behaviors, emotional functioning, socio-cognitive process, social environment factors (school support), and caregivers'well-being were evaluated. Results: The findings suggest that with minor adjustments, the Mandarin version of PEERS® was generally acceptable and feasible for autistic adolescents and their parents. PEERS® may improve the social skills knowledge, reciprocal communication abilities, and emotional well-being of autistic adolescents. Also, participants with a higher level of school support, and parents with lower perceived subjective well-being at baseline may gain more benefits from PEERS®. The cultural adaptation and acceptability of the Mandarin Version of PEERS® were discussed. Conclusion: This feasibility study (Chinese Clinical Trial Registry: ChiCTR2200061417, 2022-06-23, retrospectively registered) provides a basis for further randomized control trials of the Mandarin version of PEERS®. En ligne : https://doi.org/10.1007/s10803-023-06056-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Adaptation and Feasibility of the Mandarin Version of PEERS® for Autistic Adolescents [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Wuxia BAI, Auteur ; Yu WANG, Auteur ; Yongmei LI, Auteur ; Yixiang XIE, Auteur ; Xiaoqian HUANG, Auteur ; Huilin ZHU, Auteur ; Xiaobing ZOU, Auteur . - p.3387-3399. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-9 (September 2024) . - p.3387-3399 Index. décimale : PER Périodiques Résumé : Purpose: The Program for the Education and Enrichment of Relational Skills (PEERS®) is a group-based social skills training program for adolescents on the autism spectrum. Although the program has been shown to be effective in improving social skills in autistic adolescents, evidence of its effectiveness from the Mandarin-speaking Chinese population is sparse. The present study used a non-randomized, pre- and post-intervention research design to investigate the feasibility and cultural validity of the program, as well as examine the moderators of intervention outcomes. Methods: Thirty-three autistic adolescents with intelligence quotient above 70 (Mage = 13.57, SDage = 1.43; Male: Female 25:8) and their parents received 14 concurrent 90-minute sessions. Adolescents'autistic traits, challenging behaviors, emotional functioning, socio-cognitive process, social environment factors (school support), and caregivers'well-being were evaluated. Results: The findings suggest that with minor adjustments, the Mandarin version of PEERS® was generally acceptable and feasible for autistic adolescents and their parents. PEERS® may improve the social skills knowledge, reciprocal communication abilities, and emotional well-being of autistic adolescents. Also, participants with a higher level of school support, and parents with lower perceived subjective well-being at baseline may gain more benefits from PEERS®. The cultural adaptation and acceptability of the Mandarin Version of PEERS® were discussed. Conclusion: This feasibility study (Chinese Clinical Trial Registry: ChiCTR2200061417, 2022-06-23, retrospectively registered) provides a basis for further randomized control trials of the Mandarin version of PEERS®. En ligne : https://doi.org/10.1007/s10803-023-06056-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809 Titre : Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3800-3809 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Shuang QIU, Auteur ; Weijing ZHONG, Auteur ; Yong LI, Auteur ; Yunkai LIU, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3800-3809. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3800-3809 Mots-clés : Autism spectrum disorder  Deleted in colorectal carcinoma gene  Haplotype analysis  Single nucleotide polymorphisms  Susceptibility Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) represents a group of childhood-onset lifelong neuro-developmental disorders. However, the association between single nucleotide polymorphisms (SNPs) in the deleted in colorectal carcinoma (DCC) gene and ASD susceptibility remains unclear. We investigated the association between ASD susceptibility and seven SNPs in DCC on the basis of a case-control study (231 ASD cases and 242 controls) in Chinese Han. We found that there was no association between ASD susceptibility and the seven SNPs in DCC; however, T-A haplotype (rs2229082-rs2270954), T-A-T-C haplotype (rs2229082-rs2270954-rs2292043-rs2292044), C-G-T-C-T haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043), C-G-T-C-T-G haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044), and G-G-T-C-C-C-C haplotype (rs934345-rs17753970-rs2229082-rs2270954-rs2292043-rs2292044-rs16956878) were associated with ASD susceptibility. Our results indicate that the haplotypes formed on the basis of the seven SNPs in DCC may be implicated in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04417-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China / Hua WEI in Research in Autism Spectrum Disorders, 54 (October 2018)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89 Titre : Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China Type de document : Texte imprimé et/ou numérique Auteurs : Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur Article en page(s) : p.83-89 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Head circumference  Body height  Body weight  Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Head circumference, body growth and development quotient in autism spectrum disorders are related in Chongqing, China [Texte imprimé et/ou numérique] / Hua WEI, Auteur ; Qian CHENG, Auteur ; Qixia MEI, Auteur ; Xuan ZHANG, Auteur ; Li CHEN, Auteur ; Xiao LIU, Auteur ; Ying DAI, Auteur ; Ting YU, Auteur ; Yan LI, Auteur ; Yu ZHANG, Auteur ; Jie CHEN, Auteur ; Yongjie MIAO, Auteur ; Tingyu LI, Auteur . - p.83-89. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 54 (October 2018) . - p.83-89 Mots-clés : Autism spectrum disorder  Head circumference  Body height  Body weight  Development quotient Index. décimale : PER Périodiques Résumé : Background It is unclear whether increased head circumference (HC) is actually an artifact of an overall overgrowth phenomenon or specific to the brain at all in autism spectrum disorders. This study compared the head circumferences, body weight and height of ASD children with a control group. We also discuss whether HC, body weight and height are correlated with development quotients in ASD children. Method We recruited 83 children with ASD (aged 2–5 years); they were gender and age matched to typically developing children in Chongqing (China) from 2013 to 2015. Their head circumference, body weight and height were collected. The ASD group was tested for the developmental quotient (DQ), which includes gross motor, fine motor, linguistic, personal-social and adaptive functioning. Results Our results showed that head circumference in the ASD group is significantly different from HC in the control group. The rate of macrocephaly was higher in the children with ASD compared with the control group. Some domains of DQ have statistically significant negative correlation with head circumference, weight and height. After adjusting for confounding factors, the fine motor was associated negatively with HC. Personal-social ability was associated negatively with weight. Gross motor was correlated negatively with the height. Conclusions Based on our results, we found significant HC differences in ASD group while lack of effect of either height or weight at the age of 2–5. HC, weight and height were separately negative correlated with some domains of development quotients. Further research is needed to understand the relationship between physical indicators and development level in autism. En ligne : https://doi.org/10.1016/j.rasd.2018.07.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing / Cristian PRECIADO in Autism Research, 17-12 (December 2024)  

Public ISBD [article]  inAutism Research > 17-12 (December 2024) . - p.2547-2557 Titre : Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing Type de document : Texte imprimé et/ou numérique Auteurs : Cristian PRECIADO, Auteur ; Maria BAIDA, Auteur ; Yi LI, Auteur ; Yan LI, Auteur ; Carly DEMOPOULOS, Auteur Article en page(s) : p.2547-2557 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  freesurfer  neurodevelopment  prenatal hypoxia  sensory processing  sleep disturbance  thalamus  third ventricle Index. décimale : PER Périodiques Résumé : Abstract There is a growing body of research that suggests conditions during the period of pregnancy and birth can affect how autism spectrum disorder (ASD) presents itself. This study aimed to investigate the incidence of oxygen deprivation during this period known as prenatal and perinatal hypoxic risk (HR) conditions in ASD compared with neurotypical control (NTC) youth. We also examined ventricular morphology variations associated with HR exposure, and to evaluate associations with clinical symptoms. Results from a cohort of 104 youth revealed a higher incidence of exposure to prenatal hypoxic conditions in the ASD group. Additionally, ASD individuals with prenatal hypoxic exposure (ASD?+?HR) demonstrated larger third ventricle volumes compared with both ASD and NTC individuals without such exposure (ASD-HR and NTC-HR, respectively). Furthermore, associations were identified between prenatal hypoxic exposure, third ventricle volume, sensory dysfunction, and severity of sleep disturbances. These findings suggest exposure to prenatal hypoxic risk conditions may exacerbate or modify the neurodevelopmental trajectory and symptom severity in ASD, emphasizing the need for better prenatal care and specific interventions to reduce these risks. En ligne : https://dx.doi.org/10.1002/aur.3250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Prenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing [Texte imprimé et/ou numérique] / Cristian PRECIADO, Auteur ; Maria BAIDA, Auteur ; Yi LI, Auteur ; Yan LI, Auteur ; Carly DEMOPOULOS, Auteur . - p.2547-2557. Langues : Anglais (eng) in Autism Research > 17-12 (December 2024) . - p.2547-2557 Mots-clés : autism spectrum disorder  freesurfer  neurodevelopment  prenatal hypoxia  sensory processing  sleep disturbance  thalamus  third ventricle Index. décimale : PER Périodiques Résumé : Abstract There is a growing body of research that suggests conditions during the period of pregnancy and birth can affect how autism spectrum disorder (ASD) presents itself. This study aimed to investigate the incidence of oxygen deprivation during this period known as prenatal and perinatal hypoxic risk (HR) conditions in ASD compared with neurotypical control (NTC) youth. We also examined ventricular morphology variations associated with HR exposure, and to evaluate associations with clinical symptoms. Results from a cohort of 104 youth revealed a higher incidence of exposure to prenatal hypoxic conditions in the ASD group. Additionally, ASD individuals with prenatal hypoxic exposure (ASD?+?HR) demonstrated larger third ventricle volumes compared with both ASD and NTC individuals without such exposure (ASD-HR and NTC-HR, respectively). Furthermore, associations were identified between prenatal hypoxic exposure, third ventricle volume, sensory dysfunction, and severity of sleep disturbances. These findings suggest exposure to prenatal hypoxic risk conditions may exacerbate or modify the neurodevelopmental trajectory and symptom severity in ASD, emphasizing the need for better prenatal care and specific interventions to reduce these risks. En ligne : https://dx.doi.org/10.1002/aur.3250 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Reply to Comment on "Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder" / Yan LI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3811-3812 Titre : Reply to Comment on "Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder" Type de document : Texte imprimé et/ou numérique Auteurs : Yan LI, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur Article en page(s) : p.3811-3812 Langues : Anglais (eng) Mots-clés : Comment  Reason  Respond Index. décimale : PER Périodiques Résumé : The comments from Dr. Meisami about our article "Association between DCC polymorphisms and Susceptibility to Autism Spectrum Disorder", and we wish to respond to several points. First, 100% of detection rate for each SNP genotype cannot be obtained. Second, we listed the detection rates in Supplemental Table 1. Last, Dr. Meisami referred an article focused on two SNPs; however, our article focused on seven SNPs. If we marked the number of detected cases, we had to make a table for each result, occupying a large part of the layout. Moreover, if the number of detected cases was marked respectively, it was not in accordance with academic norms. For these reasons, we provided the actual number of cases in Table 3. En ligne : http://dx.doi.org/10.1007/s10803-020-04585-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Reply to Comment on "Association Between DCC Polymorphisms and Susceptibility to Autism Spectrum Disorder" [Texte imprimé et/ou numérique] / Yan LI, Auteur ; Yi CHENG, Auteur ; Yawen LIU, Auteur . - p.3811-3812. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3811-3812 Mots-clés : Comment  Reason  Respond Index. décimale : PER Périodiques Résumé : The comments from Dr. Meisami about our article "Association between DCC polymorphisms and Susceptibility to Autism Spectrum Disorder", and we wish to respond to several points. First, 100% of detection rate for each SNP genotype cannot be obtained. Second, we listed the detection rates in Supplemental Table 1. Last, Dr. Meisami referred an article focused on two SNPs; however, our article focused on seven SNPs. If we marked the number of detected cases, we had to make a table for each result, occupying a large part of the layout. Moreover, if the number of detected cases was marked respectively, it was not in accordance with academic norms. For these reasons, we provided the actual number of cases in Table 3. En ligne : http://dx.doi.org/10.1007/s10803-020-04585-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

rs1007893 and rs2070435 in DIP2A are associated with visual-reaction-behavior phenotype in Chinese Han population with autism spectrum disorder / Yan LI in Research in Autism Spectrum Disorders, 70 (February 2020)  

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