[article] 
inResearch in Autism > 120 (February 2025) . - 202531

Titre :	Brain functional connectivity with rehabilitation in children with co-occurring autism spectrum disorder and developmental coordination disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Jill G. ZWICKER, Auteur
Article en page(s) :	202531
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorder  Developmental coordination disorder  Motor skills disorder  Resting-state MRI  Occupational therapy  CO-OP
Index. décimale :	PER Périodiques
Résumé :	Background Children with co-occurring autism spectrum disorder (ASD) and developmental coordination disorder (DCD) show improved motor function after Cognitive Orientation to daily Occupational Performance (CO-OP) intervention; however, it is unknown whether CO-OP induces changes in brain function in this clinical population. The objectives of this study were to: (1) investigate changes in functional connectivity in children with ASD+DCD after CO-OP; (2) determine whether brain changes are maintained three months post-intervention; and (3) explore the relationship of functional connectivity changes with improved motor function. Method In this study, 24 children with ASD+DCD were randomly assigned to either a treatment or waitlist group and underwent three resting-state MRI scans over six months. The treatment group received intervention between the first and second scan; the waitlist group received intervention between the second and third scan. Results After CO-OP, participants showed increased functional connectivity in the left precentral gyrus and right middle frontal gyrus (Cohen?s d=0.76 and 0.79, respectively). Brain changes were maintained three months post-intervention. Regression analysis revealed increased connectivity between the sensorimotor network and left insular cortex, correlating with motor outcomes. Conclusions
En ligne :	https://doi.org/10.1016/j.reia.2025.202531
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

[article] Brain functional connectivity with rehabilitation in children with co-occurring autism spectrum disorder and developmental coordination disorder [Texte imprimé et/ou numérique] / Jill G. ZWICKER, Auteur . - 202531.
Langues : Anglais (eng)
in Research in Autism > 120 (February 2025) . - 202531

Mots-clés :	Autism spectrum disorder  Developmental coordination disorder  Motor skills disorder  Resting-state MRI  Occupational therapy  CO-OP
Index. décimale :	PER Périodiques
Résumé :	Background Children with co-occurring autism spectrum disorder (ASD) and developmental coordination disorder (DCD) show improved motor function after Cognitive Orientation to daily Occupational Performance (CO-OP) intervention; however, it is unknown whether CO-OP induces changes in brain function in this clinical population. The objectives of this study were to: (1) investigate changes in functional connectivity in children with ASD+DCD after CO-OP; (2) determine whether brain changes are maintained three months post-intervention; and (3) explore the relationship of functional connectivity changes with improved motor function. Method In this study, 24 children with ASD+DCD were randomly assigned to either a treatment or waitlist group and underwent three resting-state MRI scans over six months. The treatment group received intervention between the first and second scan; the waitlist group received intervention between the second and third scan. Results After CO-OP, participants showed increased functional connectivity in the left precentral gyrus and right middle frontal gyrus (Cohen?s d=0.76 and 0.79, respectively). Brain changes were maintained three months post-intervention. Regression analysis revealed increased connectivity between the sensorimotor network and left insular cortex, correlating with motor outcomes. Conclusions
En ligne :	https://doi.org/10.1016/j.reia.2025.202531
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555