[article] 
inResearch in Autism > 125 (July 2025) . - p.202618

Titre :	Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Kelsey TINDALL, Auteur ; Don ROJAS, Auteur
Article en page(s) :	p.202618
Langues :	Anglais (eng)
Mots-clés :	Autism  Anxiety  Sensory processing  Intolerance of uncertainty  Prediction  Cerebellum  Sensory cortex  Amygdala
Index. décimale :	PER Périodiques
Résumé :	Purpose Autistic children often experience higher levels of sensory difficulties and anxiety, compared to their non-autistic counterparts. Available evidence suggests that intolerance of uncertainty (IU) mediates the relationship between these factors. We aimed to further the examination of the interrelationship between these phenomena, as well as their underlying neural mechanisms, in children. Methods 30 autistic children (ages 6-11 years) and 26 age-matched neurotypical (NT) peers participated in resting-state fMRI, as well as various behavioral assessments of sensory processing, anxiety, and IU. Results Between-groups comparisons of behavioral scores showed higher levels of sensory processing differences, anxiety, and IU in autistic children. Mediation analysis also revealed that IU was a significant mediator between sensory difficulties and anxiety in this group. Network connectivity findings showed that connectivity between sensory cortices and cerebellar, higher order sensory, and limbic regions (esp. amygdala) were significantly correlated with sensory processing, anxiety, and IU. Conclusion We report novel behavioral and neurophysiologic findings concerning important interrelationships in autism. Our findings may be related to predictive coding accounts of autism. Our results have the potential to inform future clinical practice, in that addressing sensory and IU difficulties has the potential to lead to improvements in anxiety in autistic children.
En ligne :	https://doi.org/10.1016/j.reia.2025.202618
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

[article] Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children [Texte imprimé et/ou numérique] / Kelsey TINDALL, Auteur ; Don ROJAS, Auteur . - p.202618.
Langues : Anglais (eng)
in Research in Autism > 125 (July 2025) . - p.202618

Mots-clés :	Autism  Anxiety  Sensory processing  Intolerance of uncertainty  Prediction  Cerebellum  Sensory cortex  Amygdala
Index. décimale :	PER Périodiques
Résumé :	Purpose Autistic children often experience higher levels of sensory difficulties and anxiety, compared to their non-autistic counterparts. Available evidence suggests that intolerance of uncertainty (IU) mediates the relationship between these factors. We aimed to further the examination of the interrelationship between these phenomena, as well as their underlying neural mechanisms, in children. Methods 30 autistic children (ages 6-11 years) and 26 age-matched neurotypical (NT) peers participated in resting-state fMRI, as well as various behavioral assessments of sensory processing, anxiety, and IU. Results Between-groups comparisons of behavioral scores showed higher levels of sensory processing differences, anxiety, and IU in autistic children. Mediation analysis also revealed that IU was a significant mediator between sensory difficulties and anxiety in this group. Network connectivity findings showed that connectivity between sensory cortices and cerebellar, higher order sensory, and limbic regions (esp. amygdala) were significantly correlated with sensory processing, anxiety, and IU. Conclusion We report novel behavioral and neurophysiologic findings concerning important interrelationships in autism. Our findings may be related to predictive coding accounts of autism. Our results have the potential to inform future clinical practice, in that addressing sensory and IU difficulties has the potential to lead to improvements in anxiety in autistic children.
En ligne :	https://doi.org/10.1016/j.reia.2025.202618
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559