Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring / M. A. ROSENQVIST in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.665-675 Titre : Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring Type de document : Texte imprimé et/ou numérique Auteurs : M. A. ROSENQVIST, Auteur ; A. SJOLANDER, Auteur ; E. YSTROM, Auteur ; H. LARSSON, Auteur ; T. REICHBORN-KJENNERUD, Auteur Article en page(s) : p.665-675 Langues : Anglais (eng) Mots-clés : Adhd  MoBa  adverse life events  antenatal stress  delayed effects  prenatal exposures  the Norwegian Mother and Child Cohort Study Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal adverse life events has been associated with offspring ADHD, but the role of familial confounding is unclear. We aimed to clarify if adverse life events during pregnancy are related to ADHD symptoms in offspring, taking shared familial factors into account. METHOD: Data were collected on 34,751 children (including 6,427 siblings) participating in the population-based Norwegian Mother and Child Cohort Study. During pregnancy, mothers reported whether they had experienced specific life events. We assessed ADHD symptoms in five-year-old children with the Conners' Parent Rating Scale-Revised: short form. We modeled the associations between life events and mean ADHD scores with ordinary linear regression in the full cohort, and with fixed-effect linear regression in sibling comparisons to adjust for familial confounding. RESULTS: Children exposed to adverse life events had higher ADHD scores at age 5, with the strongest effect observed for financial problems (mean differences 0.10 [95% CI: 0.09, 0.11] in adjusted model), and the weakest for having lost someone close (0.02 [95% CI 0.01, 0.04] in adjusted model). Comparing exposure-discordant siblings resulted in attenuated estimates that were no longer statistically significant (e.g. mean difference for financial problems -0.03 [95% CI -0.07, 0.02]). ADHD scores increased if the mother had experienced the event as painful or difficult, and with the number of events, whereas sibling-comparison analyses resulted in estimates attenuated toward the null. CONCLUSIONS: These results suggest that the association between adverse life events during pregnancy and offspring ADHD symptoms is largely explained by familial factors. En ligne : http://dx.doi.org/10.1111/jcpp.12990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Adverse family life events during pregnancy and ADHD symptoms in five-year-old offspring [Texte imprimé et/ou numérique] / M. A. ROSENQVIST, Auteur ; A. SJOLANDER, Auteur ; E. YSTROM, Auteur ; H. LARSSON, Auteur ; T. REICHBORN-KJENNERUD, Auteur . - p.665-675. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-6 (June 2019) . - p.665-675 Mots-clés : Adhd  MoBa  adverse life events  antenatal stress  delayed effects  prenatal exposures  the Norwegian Mother and Child Cohort Study Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal adverse life events has been associated with offspring ADHD, but the role of familial confounding is unclear. We aimed to clarify if adverse life events during pregnancy are related to ADHD symptoms in offspring, taking shared familial factors into account. METHOD: Data were collected on 34,751 children (including 6,427 siblings) participating in the population-based Norwegian Mother and Child Cohort Study. During pregnancy, mothers reported whether they had experienced specific life events. We assessed ADHD symptoms in five-year-old children with the Conners' Parent Rating Scale-Revised: short form. We modeled the associations between life events and mean ADHD scores with ordinary linear regression in the full cohort, and with fixed-effect linear regression in sibling comparisons to adjust for familial confounding. RESULTS: Children exposed to adverse life events had higher ADHD scores at age 5, with the strongest effect observed for financial problems (mean differences 0.10 [95% CI: 0.09, 0.11] in adjusted model), and the weakest for having lost someone close (0.02 [95% CI 0.01, 0.04] in adjusted model). Comparing exposure-discordant siblings resulted in attenuated estimates that were no longer statistically significant (e.g. mean difference for financial problems -0.03 [95% CI -0.07, 0.02]). ADHD scores increased if the mother had experienced the event as painful or difficult, and with the number of events, whereas sibling-comparison analyses resulted in estimates attenuated toward the null. CONCLUSIONS: These results suggest that the association between adverse life events during pregnancy and offspring ADHD symptoms is largely explained by familial factors. En ligne : http://dx.doi.org/10.1111/jcpp.12990 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study / Y. GINSBERG in Journal of Child Psychology and Psychiatry, 60-2 (February 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.160-168 Titre : Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study Type de document : Texte imprimé et/ou numérique Auteurs : Y. GINSBERG, Auteur ; B. M. D'ONOFRIO, Auteur ; M. E. RICKERT, Auteur ; Q. A. CLASS, Auteur ; M. A. ROSENQVIST, Auteur ; Catarina ALMQVIST, Auteur ; P. LICHTENSTEIN, Auteur ; H. LARSSON, Auteur Article en page(s) : p.160-168 Langues : Anglais (eng) Mots-clés : Maternal infection during pregnancy  attention-deficit/hyperactivity disorder  cousin comparisons  familial confounding  quasi-experimental  sibling comparisons Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal infection during pregnancy (IDP) has been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. However, infection is associated with social adversity, poor living conditions and other background familial factors. As such, there is a need to rule out whether the observed association between maternal IDP and ADHD might be attributed to such confounding. METHODS: This nationwide population-based cohort study using a family-based, quasi-experimental design included 1,066,956 individuals born in Sweden between 1992 and 2002. Data on maternal IDP (bacterial or viral) requiring hospitalization and ADHD diagnosis in offspring were gathered from Swedish National Registers, with individuals followed up through the end of 2009. Ordinary and stratified Cox regression models were used for estimation of hazard ratios (HRs) and several measured covariates were considered. Cousin- and sibling-comparisons accounted for unmeasured genetic and environmental factors shared by cousins and siblings. RESULTS: In the entire population, maternal IDP was associated with ADHD in offspring (HR = 2.31, 95% CI = 2.04-2.61). This association was attenuated when accounting for measured covariates (HR = 1.86, 95% CI = 1.65-2.10). The association was further attenuated when adjusting for unmeasured factors shared between cousins (HR = 1.52, 95% CI = 1.12-2.07). Finally, the association was fully attenuated in sibling comparisons (HR = 1.03, 95% CI = 0.76-1.41). CONCLUSIONS: This study suggests that the association between maternal IDP and offspring ADHD is largely due to unmeasured familial confounding. Our results underscore the importance of adjusting for unobserved familial risk factors when exploring risk factors for ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381 [article] Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study [Texte imprimé et/ou numérique] / Y. GINSBERG, Auteur ; B. M. D'ONOFRIO, Auteur ; M. E. RICKERT, Auteur ; Q. A. CLASS, Auteur ; M. A. ROSENQVIST, Auteur ; Catarina ALMQVIST, Auteur ; P. LICHTENSTEIN, Auteur ; H. LARSSON, Auteur . - p.160-168. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-2 (February 2019) . - p.160-168 Mots-clés : Maternal infection during pregnancy  attention-deficit/hyperactivity disorder  cousin comparisons  familial confounding  quasi-experimental  sibling comparisons Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal infection during pregnancy (IDP) has been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring. However, infection is associated with social adversity, poor living conditions and other background familial factors. As such, there is a need to rule out whether the observed association between maternal IDP and ADHD might be attributed to such confounding. METHODS: This nationwide population-based cohort study using a family-based, quasi-experimental design included 1,066,956 individuals born in Sweden between 1992 and 2002. Data on maternal IDP (bacterial or viral) requiring hospitalization and ADHD diagnosis in offspring were gathered from Swedish National Registers, with individuals followed up through the end of 2009. Ordinary and stratified Cox regression models were used for estimation of hazard ratios (HRs) and several measured covariates were considered. Cousin- and sibling-comparisons accounted for unmeasured genetic and environmental factors shared by cousins and siblings. RESULTS: In the entire population, maternal IDP was associated with ADHD in offspring (HR = 2.31, 95% CI = 2.04-2.61). This association was attenuated when accounting for measured covariates (HR = 1.86, 95% CI = 1.65-2.10). The association was further attenuated when adjusting for unmeasured factors shared between cousins (HR = 1.52, 95% CI = 1.12-2.07). Finally, the association was fully attenuated in sibling comparisons (HR = 1.03, 95% CI = 0.76-1.41). CONCLUSIONS: This study suggests that the association between maternal IDP and offspring ADHD is largely due to unmeasured familial confounding. Our results underscore the importance of adjusting for unobserved familial risk factors when exploring risk factors for ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=381

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