Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD / Calvin P. SJAARDA in Research in Autism Spectrum Disorders, 60 (April 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35 Titre : Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur Article en page(s) : p.25-35 Langues : Anglais (eng) Mots-clés : ASD  Autism  Electroencephalogram  DAT1  Dopamine  Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 [article] Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD [Texte imprimé et/ou numérique] / Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur . - p.25-35. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35 Mots-clés : ASD  Autism  Electroencephalogram  DAT1  Dopamine  Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387

Relationship of family history conditions and early signs of autism spectrum disorder in low and high-risk infants / Maurice A. FELDMAN in Research in Autism Spectrum Disorders, 65 (September 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 65 (September 2019) . - p.25-33 Titre : Relationship of family history conditions and early signs of autism spectrum disorder in low and high-risk infants Type de document : Texte imprimé et/ou numérique Auteurs : Maurice A. FELDMAN, Auteur ; Alicia AZZANO, Auteur ; Rebecca A. WARD, Auteur ; Melissa HUDSON, Auteur ; Calvin P. SJAARDA, Auteur ; Xudong LIU, Auteur Article en page(s) : p.25-33 Langues : Anglais (eng) Mots-clés : Infants  Siblings  Family history  Prediction  Early screening Index. décimale : PER Périodiques Résumé : Background Early identification and understanding of Autism Spectrum Disorder (ASD) could be facilitated by knowledge of family history of medical, developmental and psychiatric conditions associated with showing early signs of ASD. Method The current study used nonparametric analysis of covariance to compare the number of family history conditions n 69 high-risk (biological sibling with ASD) and 108 low-risk (no family history of ASD) infants. Spearman correlation was used to assess the relationship between family history of various conditions and early ASD signs as measured by an early screener, the Parent Observation of Early Markers Scale (POEMS). Results There were significantly more family history conditions in the families of the high-risk infants, and significant positive relationships between the number of family history problems and early markers of ASD in both groups. Conclusions The results suggest that family history conditions may play an important role in screening infants not yet diagnosed with ASD and reveal etiological pathways. En ligne : https://doi.org/10.1016/j.rasd.2019.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Relationship of family history conditions and early signs of autism spectrum disorder in low and high-risk infants [Texte imprimé et/ou numérique] / Maurice A. FELDMAN, Auteur ; Alicia AZZANO, Auteur ; Rebecca A. WARD, Auteur ; Melissa HUDSON, Auteur ; Calvin P. SJAARDA, Auteur ; Xudong LIU, Auteur . - p.25-33. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 65 (September 2019) . - p.25-33 Mots-clés : Infants  Siblings  Family history  Prediction  Early screening Index. décimale : PER Périodiques Résumé : Background Early identification and understanding of Autism Spectrum Disorder (ASD) could be facilitated by knowledge of family history of medical, developmental and psychiatric conditions associated with showing early signs of ASD. Method The current study used nonparametric analysis of covariance to compare the number of family history conditions n 69 high-risk (biological sibling with ASD) and 108 low-risk (no family history of ASD) infants. Spearman correlation was used to assess the relationship between family history of various conditions and early ASD signs as measured by an early screener, the Parent Observation of Early Markers Scale (POEMS). Results There were significantly more family history conditions in the families of the high-risk infants, and significant positive relationships between the number of family history problems and early markers of ASD in both groups. Conclusions The results suggest that family history conditions may play an important role in screening infants not yet diagnosed with ASD and reveal etiological pathways. En ligne : https://doi.org/10.1016/j.rasd.2019.05.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

---

1 (1 - 2 / 2)