Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study / Adi ARAN in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1284-1288 Titre : Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study Type de document : Texte imprimé et/ou numérique Auteurs : Adi ARAN, Auteur ; Hanoch CASSUTO, Auteur ; A. LUBOTZKY, Auteur ; N. WATTAD, Auteur ; E. HAZAN, Auteur Article en page(s) : p.1284-1288 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Cannabidiol  Disruptive behavior  Medical cannabis  Medical marijuana Index. décimale : PER Périodiques Résumé : Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 +/- 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3808-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study [Texte imprimé et/ou numérique] / Adi ARAN, Auteur ; Hanoch CASSUTO, Auteur ; A. LUBOTZKY, Auteur ; N. WATTAD, Auteur ; E. HAZAN, Auteur . - p.1284-1288. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.1284-1288 Mots-clés : Autism spectrum disorder  Cannabidiol  Disruptive behavior  Medical cannabis  Medical marijuana Index. décimale : PER Périodiques Résumé : Anecdotal evidence of successful cannabis treatment in autism spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 +/- 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3808-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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