Attachment security, environmental adversity, and fast life history behavioral profiles in human adolescents / Hui Jing LU in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1534-1542 Titre : Attachment security, environmental adversity, and fast life history behavioral profiles in human adolescents Type de document : texte imprimé Auteurs : Hui Jing LU, Auteur ; Jennifer E. LANSFORD, Auteur ; Yuan-Yuan LIU, Auteur ; Bin-Bin CHEN, Auteur ; Marc H. BORNSTEIN, Auteur ; Ann T. SKINNER, Auteur ; Kenneth A. DODGE, Auteur ; Laurence STEINBERG, Auteur ; Kirby DEATER-DECKARD, Auteur ; W. Andrew ROTHENBERG, Auteur ; Dario BACCHINI, Auteur ; Concetta PASTORELLI, Auteur ; Liane Peña ALAMPAY, Auteur ; Emma SORBRING, Auteur ; Sevtap GURDAL, Auteur ; Suha M. AL-HASSAN, Auteur ; Paul OBURU, Auteur ; Saengduean YOTANYAMANEEWONG, Auteur ; Sombat TAPANYA, Auteur ; Laura DI GIUNTA, Auteur ; Liliana Maria URIBE TIRADO, Auteur ; Lei CHANG, Auteur Article en page(s) : p.1534-1542 Langues : Anglais (eng) Mots-clés : caregiver-child attachment  extrinsic and intrinsic mortality risks  fast and slow life history behavioral profiles Index. décimale : PER Périodiques Résumé : One species-general life history (LH) principle posits that challenging childhood environments are coupled with a fast or faster LH strategy and associated behaviors, while secure and stable childhood environments foster behaviors conducive to a slow or slower LH strategy. This coupling between environments and LH strategies is based on the assumption that individuals' internal traits and states are independent of their external surroundings. In reality, individuals respond to external environmental conditions in alignment with their intrinsic vitality, encompassing both physical and mental states. The present study investigated attachment as an internal mental state, examining its role in mediating and moderating the association between external environmental adversity and fast LH strategies. A sample of 1169 adolescents (51% girls) from 9 countries was tracked over 10 years, starting from age 8. The results confirm both mediation and moderation and, for moderation, secure attachment nullified and insecure attachment maintained the environment-LH coupling. These findings suggest that attachment could act as an internal regulator, disrupting the contingent coupling between environmental adversity and a faster pace of life, consequently decelerating human LH. En ligne : https://www.cambridge.org/core/product/6ACC5F76124AB5D09F4161B347886014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Attachment security, environmental adversity, and fast life history behavioral profiles in human adolescents [texte imprimé] / Hui Jing LU, Auteur ; Jennifer E. LANSFORD, Auteur ; Yuan-Yuan LIU, Auteur ; Bin-Bin CHEN, Auteur ; Marc H. BORNSTEIN, Auteur ; Ann T. SKINNER, Auteur ; Kenneth A. DODGE, Auteur ; Laurence STEINBERG, Auteur ; Kirby DEATER-DECKARD, Auteur ; W. Andrew ROTHENBERG, Auteur ; Dario BACCHINI, Auteur ; Concetta PASTORELLI, Auteur ; Liane Peña ALAMPAY, Auteur ; Emma SORBRING, Auteur ; Sevtap GURDAL, Auteur ; Suha M. AL-HASSAN, Auteur ; Paul OBURU, Auteur ; Saengduean YOTANYAMANEEWONG, Auteur ; Sombat TAPANYA, Auteur ; Laura DI GIUNTA, Auteur ; Liliana Maria URIBE TIRADO, Auteur ; Lei CHANG, Auteur . - p.1534-1542. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1534-1542 Mots-clés : caregiver-child attachment  extrinsic and intrinsic mortality risks  fast and slow life history behavioral profiles Index. décimale : PER Périodiques Résumé : One species-general life history (LH) principle posits that challenging childhood environments are coupled with a fast or faster LH strategy and associated behaviors, while secure and stable childhood environments foster behaviors conducive to a slow or slower LH strategy. This coupling between environments and LH strategies is based on the assumption that individuals' internal traits and states are independent of their external surroundings. In reality, individuals respond to external environmental conditions in alignment with their intrinsic vitality, encompassing both physical and mental states. The present study investigated attachment as an internal mental state, examining its role in mediating and moderating the association between external environmental adversity and fast LH strategies. A sample of 1169 adolescents (51% girls) from 9 countries was tracked over 10 years, starting from age 8. The results confirm both mediation and moderation and, for moderation, secure attachment nullified and insecure attachment maintained the environment-LH coupling. These findings suggest that attachment could act as an internal regulator, disrupting the contingent coupling between environmental adversity and a faster pace of life, consequently decelerating human LH. En ligne : https://www.cambridge.org/core/product/6ACC5F76124AB5D09F4161B347886014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons / Qiong XU in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 65 p. Titre : Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons Type de document : texte imprimé Auteurs : Qiong XU, Auteur ; Yuan-Yuan LIU, Auteur ; Xiaoming WANG, Auteur ; Guo-he TAN, Auteur ; Hui-Ping LI, Auteur ; Samuel W. HULBERT, Auteur ; Chun-Yang LI, Auteur ; Chun-Chun HU, Auteur ; Z.Q. XIONG, Auteur ; Xiu XU, Auteur ; Yong-hui JIANG, Auteur Article en page(s) : 65 p. Langues : Anglais (eng) Mots-clés : Animals  Autistic Disorder/*genetics/pathology  Cells, Cultured  Cerebral Cortex/cytology/growth & development  DNA-Binding Proteins/*genetics/metabolism  Humans  Mice  Mice, Inbred C57BL  *Neurogenesis  Neurons/cytology/*metabolism/physiology  *Autism spectrum disorder (ASD)  *chd8  *Chromatin remodeling  *Neurite growth  *Neurodevelopment  Animal Care and Use Committee-approved protocols both at Children's Hospital of  Fudan University ethics approval ID: 2015-87 and Duke University. Human  postmortem brain tissues: The use of archived human postmortem brain tissues is  approved by Institute Review Board at Duke University.Not applicableThe authors  declare that they have no competing interests.Springer Nature remains neutral  with regard to jurisdictional claims in published maps and institutional  affiliations. Index. décimale : PER Périodiques Résumé : Background: Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruiting histone H1 to target genes. The mechanism by which deficiency of CHD8 causes ASD has not been fully elucidated. Methods: We examined the expression of CHD8 in human and mouse brains using both immunohistochemistry and RNA in situ hybridization. We performed in utero electroporation, neuronal culture, and biochemical analysis using RNAi to examine the functional consequences of CHD8 deficiency. Results: We discovered that CHD8 is expressed highly in neurons and at low levels in glia cells in both humans and mice. Specifically, CHD8 is localized predominately in the nucleus of both MAP2 and parvalbumin-positive neurons. In the developing mouse brain, expression of Chd8 peaks from E16 to E18 and then decreases significantly at P14 to adulthood. Knockdown of Chd8 results in reduced axon and dendritic growth, disruption of axon projections to the contralateral cortex, and delayed neuronal migration at E18.5 which recovers by P3 and P7. Conclusion: Our findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. En ligne : https://dx.doi.org/10.1186/s13229-018-0244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons [texte imprimé] / Qiong XU, Auteur ; Yuan-Yuan LIU, Auteur ; Xiaoming WANG, Auteur ; Guo-he TAN, Auteur ; Hui-Ping LI, Auteur ; Samuel W. HULBERT, Auteur ; Chun-Yang LI, Auteur ; Chun-Chun HU, Auteur ; Z.Q. XIONG, Auteur ; Xiu XU, Auteur ; Yong-hui JIANG, Auteur . - 65 p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 65 p. Mots-clés : Animals  Autistic Disorder/*genetics/pathology  Cells, Cultured  Cerebral Cortex/cytology/growth & development  DNA-Binding Proteins/*genetics/metabolism  Humans  Mice  Mice, Inbred C57BL  *Neurogenesis  Neurons/cytology/*metabolism/physiology  *Autism spectrum disorder (ASD)  *chd8  *Chromatin remodeling  *Neurite growth  *Neurodevelopment  Animal Care and Use Committee-approved protocols both at Children's Hospital of  Fudan University ethics approval ID: 2015-87 and Duke University. Human  postmortem brain tissues: The use of archived human postmortem brain tissues is  approved by Institute Review Board at Duke University.Not applicableThe authors  declare that they have no competing interests.Springer Nature remains neutral  with regard to jurisdictional claims in published maps and institutional  affiliations. Index. décimale : PER Périodiques Résumé : Background: Mutations in CHD8, chromodomain helicase DNA-binding protein 8, are among the most replicated and common findings in genetic studies of autism spectrum disorder (ASD). The CHD8 protein is believed to act as a transcriptional regulator by remodeling chromatin structure and recruiting histone H1 to target genes. The mechanism by which deficiency of CHD8 causes ASD has not been fully elucidated. Methods: We examined the expression of CHD8 in human and mouse brains using both immunohistochemistry and RNA in situ hybridization. We performed in utero electroporation, neuronal culture, and biochemical analysis using RNAi to examine the functional consequences of CHD8 deficiency. Results: We discovered that CHD8 is expressed highly in neurons and at low levels in glia cells in both humans and mice. Specifically, CHD8 is localized predominately in the nucleus of both MAP2 and parvalbumin-positive neurons. In the developing mouse brain, expression of Chd8 peaks from E16 to E18 and then decreases significantly at P14 to adulthood. Knockdown of Chd8 results in reduced axon and dendritic growth, disruption of axon projections to the contralateral cortex, and delayed neuronal migration at E18.5 which recovers by P3 and P7. Conclusion: Our findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHD8 deficiency. En ligne : https://dx.doi.org/10.1186/s13229-018-0244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

Child attachment in adjusting the species-general contingency between environmental adversities and fast life history strategies / Hui Jing LU in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 719-730 Titre : Child attachment in adjusting the species-general contingency between environmental adversities and fast life history strategies Type de document : texte imprimé Auteurs : Hui Jing LU, Auteur ; Yuan-Yuan LIU, Auteur ; Lei CHANG, Auteur Article en page(s) : 719-730 Langues : Anglais (eng) Mots-clés : caregiver?child attachment  childhood environmental harshness and unpredictability  fast and slow human life history strategies  internal working models  risk aversion Index. décimale : PER Périodiques Résumé : Extrinsic mortality risks calibrating fast life history (LH) represent a species-general principle that applies to almost all animals including humans. However, empirical research also finds exceptions to the LH principle. The present study proposes a maternal socialization hypothesis, whereby we argue that the more human-relevant attachment system adds to the LH principle by up- and down-regulating environmental harshness and unpredictability and their calibration of LH strategies. Based on a longitudinal sample of 259 rural Chinese adolescents and their primary caregivers, the results support the statistical moderating effect of caregiver?child attachment on the relation between childhood environmental adversities (harshness and unpredictability) and LH strategies. Our theorizing and findings point to an additional mechanism likely involved in the organization and possibly the slowdown of human LH. En ligne : http://dx.doi.org/10.1017/s0954579421001413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Child attachment in adjusting the species-general contingency between environmental adversities and fast life history strategies [texte imprimé] / Hui Jing LU, Auteur ; Yuan-Yuan LIU, Auteur ; Lei CHANG, Auteur . - 719-730. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 719-730 Mots-clés : caregiver?child attachment  childhood environmental harshness and unpredictability  fast and slow human life history strategies  internal working models  risk aversion Index. décimale : PER Périodiques Résumé : Extrinsic mortality risks calibrating fast life history (LH) represent a species-general principle that applies to almost all animals including humans. However, empirical research also finds exceptions to the LH principle. The present study proposes a maternal socialization hypothesis, whereby we argue that the more human-relevant attachment system adds to the LH principle by up- and down-regulating environmental harshness and unpredictability and their calibration of LH strategies. Based on a longitudinal sample of 259 rural Chinese adolescents and their primary caregivers, the results support the statistical moderating effect of caregiver?child attachment on the relation between childhood environmental adversities (harshness and unpredictability) and LH strategies. Our theorizing and findings point to an additional mechanism likely involved in the organization and possibly the slowdown of human LH. En ligne : http://dx.doi.org/10.1017/s0954579421001413 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

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