Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study / Bastian SCHILLER ; Antonia VEHLEN ; Kathrin NICKEL ; Ludger TEBARTZ VAN ELST ; Gregor DOMES ; Markus HEINRICHS in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 12 Titre : Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study Type de document : texte imprimé Auteurs : Bastian SCHILLER, Auteur ; Antonia VEHLEN, Auteur ; Kathrin NICKEL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Gregor DOMES, Auteur ; Markus HEINRICHS, Auteur Article en page(s) : 12 Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Eye-Tracking Technology  Autistic Disorder/physiopathology/psychology  Fixation, Ocular  Adult  Young Adult  Social Interaction  Adolescent  Eye Movements  Case-Control Studies  Autism spectrum  Dual eye-tracking  Naturalistic gaze behavior  Social interaction  the University of Freiburg approved this study (reference number: EK-Freiburg:  439/15). All participants gave written informed consent before the experiment  took place. Autism-related language preferences: The authors of this paper aimed  to use terminology that aligns with the language preferences of autistic adults,  referring to [93]. Consent for publication: Not applicable. Competing interests:  The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous eye-tracking research on autistic individuals has mostly examined the gaze behavior of one individual in response to social stimuli presented on a computer screen, suggesting that there is atypical gaze behavior. However, it is unknown how these findings translate to the interactive dynamics of gaze behavior during "face-to-face" encounters between two individuals. Only by analyzing the gaze behaviour of both interaction partners is it possible to determine the frequency of actual eye-contact and who initiates or breaks such periods of mutual eye gaze. The knowledge gained from this analysis could contribute to theorizing about the psychological mechanisms (e.g., gaze avoidance vs. gaze indifference) underlying autism. METHODS: The present study applied a novel dual eye-tracking setup that allows the assessment and analysis of the interactive dynamics of gaze behavior regarding (i) mutual eye gaze (i.e., eye contact), (ii) initiations, and (iii) break-ups of eye contact. Participants (37 autistic individuals, 37 age- and IQ-matched neurotypical individuals) performed a semi-standardized social interaction (i.e., Fast Friends Procedure) with a confederate (trained to interact in a standardized manner). RESULTS: Eye contact was reduced in interactions involving autistic individuals. Additional analyses revealed that this reduction was primarily due to the more frequent breaking of eye contact by these individuals. We also found considerable heterogeneity among autistic individuals, with atypical gaze behavior present in only about half of the sample. LIMITATIONS: Further research is required to determine whether the interactive dynamics of gaze behavior observed in this dual eye-tracking setup can be generalized to real-world situations. Future studies could also include arousal-related physiological measures. CONCLUSIONS: By tracking the gaze behavior of two interacting individuals, this study reveals specific atypicalities in the interactive dynamics of gaze behavior in a subset of autistic individuals, potentially informing diagnostic and therapeutic decisions. More broadly, our study highlights the added value of dual eye-tracking in elucidating the interactive nature of social encounters in both neurodiverse and neurotypical individuals. TRIAL REGISTRATION: The study was registered as a clinical trial before starting data collection ( https://drks.de/search/en/trial/DRKS00018957 ; Registration Date: 12/17/2019). En ligne : https://dx.doi.org/10.1186/s13229-025-00645-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555 [article] Altered interactive dynamics of gaze behavior during face-to-face interaction in autistic individuals: a dual eye-tracking study [texte imprimé] / Bastian SCHILLER, Auteur ; Antonia VEHLEN, Auteur ; Kathrin NICKEL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Gregor DOMES, Auteur ; Markus HEINRICHS, Auteur . - 12. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 12 Mots-clés : Humans  Male  Female  Eye-Tracking Technology  Autistic Disorder/physiopathology/psychology  Fixation, Ocular  Adult  Young Adult  Social Interaction  Adolescent  Eye Movements  Case-Control Studies  Autism spectrum  Dual eye-tracking  Naturalistic gaze behavior  Social interaction  the University of Freiburg approved this study (reference number: EK-Freiburg:  439/15). All participants gave written informed consent before the experiment  took place. Autism-related language preferences: The authors of this paper aimed  to use terminology that aligns with the language preferences of autistic adults,  referring to [93]. Consent for publication: Not applicable. Competing interests:  The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous eye-tracking research on autistic individuals has mostly examined the gaze behavior of one individual in response to social stimuli presented on a computer screen, suggesting that there is atypical gaze behavior. However, it is unknown how these findings translate to the interactive dynamics of gaze behavior during "face-to-face" encounters between two individuals. Only by analyzing the gaze behaviour of both interaction partners is it possible to determine the frequency of actual eye-contact and who initiates or breaks such periods of mutual eye gaze. The knowledge gained from this analysis could contribute to theorizing about the psychological mechanisms (e.g., gaze avoidance vs. gaze indifference) underlying autism. METHODS: The present study applied a novel dual eye-tracking setup that allows the assessment and analysis of the interactive dynamics of gaze behavior regarding (i) mutual eye gaze (i.e., eye contact), (ii) initiations, and (iii) break-ups of eye contact. Participants (37 autistic individuals, 37 age- and IQ-matched neurotypical individuals) performed a semi-standardized social interaction (i.e., Fast Friends Procedure) with a confederate (trained to interact in a standardized manner). RESULTS: Eye contact was reduced in interactions involving autistic individuals. Additional analyses revealed that this reduction was primarily due to the more frequent breaking of eye contact by these individuals. We also found considerable heterogeneity among autistic individuals, with atypical gaze behavior present in only about half of the sample. LIMITATIONS: Further research is required to determine whether the interactive dynamics of gaze behavior observed in this dual eye-tracking setup can be generalized to real-world situations. Future studies could also include arousal-related physiological measures. CONCLUSIONS: By tracking the gaze behavior of two interacting individuals, this study reveals specific atypicalities in the interactive dynamics of gaze behavior in a subset of autistic individuals, potentially informing diagnostic and therapeutic decisions. More broadly, our study highlights the added value of dual eye-tracking in elucidating the interactive nature of social encounters in both neurodiverse and neurotypical individuals. TRIAL REGISTRATION: The study was registered as a clinical trial before starting data collection ( https://drks.de/search/en/trial/DRKS00018957 ; Registration Date: 12/17/2019). En ligne : https://dx.doi.org/10.1186/s13229-025-00645-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=555

Altered markers of mitochondrial function in adults with autism spectrum disorder / Mia MENKE ; Dominique ENDRES ; Kimon RUNGE ; Sara TUCCI ; Anke SCHUMANN ; Katharina DOMSCHKE ; Ludger TEBARTZ VAN ELST ; Simon MAIER in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2125-2138 Titre : Altered markers of mitochondrial function in adults with autism spectrum disorder Type de document : texte imprimé Auteurs : Mia MENKE, Auteur ; Dominique ENDRES, Auteur ; Kimon RUNGE, Auteur ; Sara TUCCI, Auteur ; Anke SCHUMANN, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Simon MAIER, Auteur Article en page(s) : p.2125-2138 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Previous research suggests potential mitochondrial dysfunction and changes in fatty acid metabolism in a subgroup of individuals with autism spectrum disorder (ASD), indicated by higher lactate, pyruvate levels, and mitochondrial disorder prevalence. This study aimed to further investigate potential mitochondrial dysfunction in ASD by assessing blood metabolite levels linked to mitochondrial metabolism. Blood levels of creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, pyruvate, free and total carnitine, as well as acylcarnitines were obtained in 73 adults with ASD (47 males, 26 females) and compared with those of 71 neurotypical controls (NTC) (44 males, 27 females). Correlations between blood parameters and psychometric ASD symptom scores were also explored. Lower CK (pcorr=0.045) levels were found exclusively in males with ASD compared to NTC, with no such variation in females. ALT and AST levels did not differ significantly between both groups. After correction for antipsychotic and antidepressant medication, CK remained significant. ASD participants had lower serum lactate levels (pcorr=0.036) compared to NTC, but pyruvate and carnitine concentrations showed no significant difference. ASD subjects had significantly increased levels of certain acylcarnitines, with a decrease in tetradecadienoyl-carnitine (C14:2), and certain acylcarnitines correlated significantly with autistic symptom scores. We found reduced serum lactate levels in ASD, in contrast to previous studies suggesting elevated lactate or pyruvate. This difference may reflect the focus of our study on high-functioning adults with ASD, who are likely to have fewer secondary genetic conditions associated with mitochondrial dysfunction. Our findings of significantly altered acylcarnitine levels in ASD support the hypothesis of altered fatty acid metabolism in a subset of ASD patients. En ligne : https://doi.org/10.1002/aur.3029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Altered markers of mitochondrial function in adults with autism spectrum disorder [texte imprimé] / Mia MENKE, Auteur ; Dominique ENDRES, Auteur ; Kimon RUNGE, Auteur ; Sara TUCCI, Auteur ; Anke SCHUMANN, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Simon MAIER, Auteur . - p.2125-2138. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2125-2138 Index. décimale : PER Périodiques Résumé : Abstract Previous research suggests potential mitochondrial dysfunction and changes in fatty acid metabolism in a subgroup of individuals with autism spectrum disorder (ASD), indicated by higher lactate, pyruvate levels, and mitochondrial disorder prevalence. This study aimed to further investigate potential mitochondrial dysfunction in ASD by assessing blood metabolite levels linked to mitochondrial metabolism. Blood levels of creatine kinase (CK), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, pyruvate, free and total carnitine, as well as acylcarnitines were obtained in 73 adults with ASD (47 males, 26 females) and compared with those of 71 neurotypical controls (NTC) (44 males, 27 females). Correlations between blood parameters and psychometric ASD symptom scores were also explored. Lower CK (pcorr=0.045) levels were found exclusively in males with ASD compared to NTC, with no such variation in females. ALT and AST levels did not differ significantly between both groups. After correction for antipsychotic and antidepressant medication, CK remained significant. ASD participants had lower serum lactate levels (pcorr=0.036) compared to NTC, but pyruvate and carnitine concentrations showed no significant difference. ASD subjects had significantly increased levels of certain acylcarnitines, with a decrease in tetradecadienoyl-carnitine (C14:2), and certain acylcarnitines correlated significantly with autistic symptom scores. We found reduced serum lactate levels in ASD, in contrast to previous studies suggesting elevated lactate or pyruvate. This difference may reflect the focus of our study on high-functioning adults with ASD, who are likely to have fewer secondary genetic conditions associated with mitochondrial dysfunction. Our findings of significantly altered acylcarnitine levels in ASD support the hypothesis of altered fatty acid metabolism in a subset of ASD patients. En ligne : https://doi.org/10.1002/aur.3029 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Electroretinography in adults with high-functioning autism spectrum disorder / Evelyne FRIEDEL in Autism Research, 15-11 (November 2022)  

Public ISBD [article]  inAutism Research > 15-11 (November 2022) . - p.2026-2037 Titre : Electroretinography in adults with high-functioning autism spectrum disorder Type de document : texte imprimé Auteurs : Evelyne FRIEDEL, Auteur ; Mirjam SCHAFER, Auteur ; Dominique ENDRES, Auteur ; Simon MAIER, Auteur ; Kimon RUNGE, Auteur ; Michael BACH, Auteur ; Sven P. HEINRICH, Auteur ; Dieter EBERT, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Kathrin NICKEL, Auteur Article en page(s) : p.2026-2037 Langues : Anglais (eng) Mots-clés : Adult  Humans  Electroretinography/methods  Retinal Ganglion Cells/physiology  Autism Spectrum Disorder  Photic Stimulation  Retina/physiology  Asd  Erg  PhNR  a-wave  autism spectrum disorder  b-wave  electroretinogram  photopic negative response Index. décimale : PER Périodiques Résumé : The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG. Light-adapted ERG measurements were obtained with the RETeval® system applying three different stimulation protocols. In the final analysis, the ERG parameters a-wave, b-wave, the photopic negative response (PhNR), the photopic hill parameters as well as additional amplitude ratios were compared between 32 adults with high-functioning ASD and 31 non-autistic controls. Both groups were matched with regard to sex and age. No significant functional retinal differences in amplitude or peak time of the a- or b-wave, PhNR, the photopic hill parameters or the ERG-amplitude ratios could be detected in individuals with ASD compared to non-autistic participants. The absence of electrophysiological functional retinal alterations in ASD, suggests that changes in visual perception, such as increased attention to detail or visual hypersensitivity in ASD, are not due to impairments at early levels of retinal signal processing. En ligne : http://dx.doi.org/10.1002/aur.2823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Electroretinography in adults with high-functioning autism spectrum disorder [texte imprimé] / Evelyne FRIEDEL, Auteur ; Mirjam SCHAFER, Auteur ; Dominique ENDRES, Auteur ; Simon MAIER, Auteur ; Kimon RUNGE, Auteur ; Michael BACH, Auteur ; Sven P. HEINRICH, Auteur ; Dieter EBERT, Auteur ; Katharina DOMSCHKE, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Kathrin NICKEL, Auteur . - p.2026-2037. Langues : Anglais (eng) in Autism Research > 15-11 (November 2022) . - p.2026-2037 Mots-clés : Adult  Humans  Electroretinography/methods  Retinal Ganglion Cells/physiology  Autism Spectrum Disorder  Photic Stimulation  Retina/physiology  Asd  Erg  PhNR  a-wave  autism spectrum disorder  b-wave  electroretinogram  photopic negative response Index. décimale : PER Périodiques Résumé : The electroretinogram (ERG) allows the investigation of retinal signaling pathways and has increasingly been applied in individuals with mental disorders in search for potential biomarkers of neurodevelopmental disorders. Preceding ERG examinations in individuals with autism spectrum disorders (ASD) showed inconsistent results, which might be due to the small number of participants, heterogeneity of the ASD population, differences in age ranges, and stimulation methods. The aim of this study was to investigate functional retinal responses in adults with ASD by means of the light-adapted (photopic) ERG. Light-adapted ERG measurements were obtained with the RETeval® system applying three different stimulation protocols. In the final analysis, the ERG parameters a-wave, b-wave, the photopic negative response (PhNR), the photopic hill parameters as well as additional amplitude ratios were compared between 32 adults with high-functioning ASD and 31 non-autistic controls. Both groups were matched with regard to sex and age. No significant functional retinal differences in amplitude or peak time of the a- or b-wave, PhNR, the photopic hill parameters or the ERG-amplitude ratios could be detected in individuals with ASD compared to non-autistic participants. The absence of electrophysiological functional retinal alterations in ASD, suggests that changes in visual perception, such as increased attention to detail or visual hypersensitivity in ASD, are not due to impairments at early levels of retinal signal processing. En ligne : http://dx.doi.org/10.1002/aur.2823 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Exploring autistic traits in adults with chronic depression: A clinical study / Martina RADTKE in Research in Autism Spectrum Disorders, 65 (September 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 65 (September 2019) . - p.34-45 Titre : Exploring autistic traits in adults with chronic depression: A clinical study Type de document : texte imprimé Auteurs : Martina RADTKE, Auteur ; Denisa WIECZOREKOVA, Auteur ; Claus NORMANN, Auteur ; Pavel HUMPOLICEK, Auteur ; Eva-Lotta BRAKEMEIER, Auteur ; Emanuel BUBL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Andreas RIEDEL, Auteur Article en page(s) : p.34-45 Langues : Anglais (eng) Mots-clés : Autistic traits  Chronic depression  Broader autistic phenotype  Autism spectrum disorder  Autism spectrum quotient  Empathy quotient Index. décimale : PER Périodiques Résumé : Background Chronic depression is characterized by persistent or recurrent depressive symptoms, defined according to DSM criteria, and is associated with lack of empathy; deficits in social perception, interaction, and communication; and social withdrawal. These symptoms are reminiscent of autism spectrum disorders, yet the co-occurrence of autistic traits and chronic depression has been rarely explored. We explored measures of autistic traits in chronically depressed adult patients in order to further define and delineate the overlap of symptoms between chronic depression and autism spectrum disorders. Method Three groups were tested: 31 patients with chronic depression, 27 patients with autism spectrum disorder, and 31 healthy controls. The Autism Spectrum Quotient (AQ) and the Empathy Quotient (EQ) were used to measure autistic traits. The severity of depression was measured by Beck’s Depression Inventory. Results The group of chronically depressed patients showed significantly elevated autistic traits according to both AQ and EQ measures. In addition, 48.4% of the patients with chronic depression showed AQ scores within the range of the broader autistic phenotype. Similar scores were found among 3.2% of the healthy controls and 100% of the patients with autism spectrum disorder. Conclusions About half of the chronically depressed patients showed elevated autistic or autism-like traits. It remained unclear whether this was due to the state of chronic depression or a kind of premorbid autistic personality trait. The findings illustrate the need for further research to clarify the possible role of autistic traits in the development of chronic depression. Furthermore, they reveal that it might be clinically useful to focus on autism-like social impairments in therapy for chronic depression. En ligne : https://doi.org/10.1016/j.rasd.2019.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Exploring autistic traits in adults with chronic depression: A clinical study [texte imprimé] / Martina RADTKE, Auteur ; Denisa WIECZOREKOVA, Auteur ; Claus NORMANN, Auteur ; Pavel HUMPOLICEK, Auteur ; Eva-Lotta BRAKEMEIER, Auteur ; Emanuel BUBL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Andreas RIEDEL, Auteur . - p.34-45. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 65 (September 2019) . - p.34-45 Mots-clés : Autistic traits  Chronic depression  Broader autistic phenotype  Autism spectrum disorder  Autism spectrum quotient  Empathy quotient Index. décimale : PER Périodiques Résumé : Background Chronic depression is characterized by persistent or recurrent depressive symptoms, defined according to DSM criteria, and is associated with lack of empathy; deficits in social perception, interaction, and communication; and social withdrawal. These symptoms are reminiscent of autism spectrum disorders, yet the co-occurrence of autistic traits and chronic depression has been rarely explored. We explored measures of autistic traits in chronically depressed adult patients in order to further define and delineate the overlap of symptoms between chronic depression and autism spectrum disorders. Method Three groups were tested: 31 patients with chronic depression, 27 patients with autism spectrum disorder, and 31 healthy controls. The Autism Spectrum Quotient (AQ) and the Empathy Quotient (EQ) were used to measure autistic traits. The severity of depression was measured by Beck’s Depression Inventory. Results The group of chronically depressed patients showed significantly elevated autistic traits according to both AQ and EQ measures. In addition, 48.4% of the patients with chronic depression showed AQ scores within the range of the broader autistic phenotype. Similar scores were found among 3.2% of the healthy controls and 100% of the patients with autism spectrum disorder. Conclusions About half of the chronically depressed patients showed elevated autistic or autism-like traits. It remained unclear whether this was due to the state of chronic depression or a kind of premorbid autistic personality trait. The findings illustrate the need for further research to clarify the possible role of autistic traits in the development of chronic depression. Furthermore, they reveal that it might be clinically useful to focus on autism-like social impairments in therapy for chronic depression. En ligne : https://doi.org/10.1016/j.rasd.2019.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study / Dominique ENDRES in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 10p. Titre : Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study Type de document : texte imprimé Auteurs : Dominique ENDRES, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Simon A. MEYER, Auteur ; Bernd FEIGE, Auteur ; Kathrin NICKEL, Auteur ; Anna BUBL, Auteur ; Andreas RIEDEL, Auteur ; Dieter EBERT, Auteur ; Thomas LANGE, Auteur ; Volkmar GLAUCHE, Auteur ; Monica BISCALDI, Auteur ; Alexandra PHILIPSEN, Auteur ; Simon J. MAIER, Auteur ; Evgeniy PERLOV, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/metabolism/*psychology  Female  Glutathione/*metabolism  Humans  Male  Middle Aged  Prefrontal Cortex/*metabolism  Proton Magnetic Resonance Spectroscopy/*methods  *Anterior cingulate cortex  *Asperger syndrome  *Autism spectrum disorder  *Dlpfc  *Glutathione  *MR spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. METHODS: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. RESULTS: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). CONCLUSIONS: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed. En ligne : http://dx.doi.org/10.1186/s13229-017-0122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study [texte imprimé] / Dominique ENDRES, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Simon A. MEYER, Auteur ; Bernd FEIGE, Auteur ; Kathrin NICKEL, Auteur ; Anna BUBL, Auteur ; Andreas RIEDEL, Auteur ; Dieter EBERT, Auteur ; Thomas LANGE, Auteur ; Volkmar GLAUCHE, Auteur ; Monica BISCALDI, Auteur ; Alexandra PHILIPSEN, Auteur ; Simon J. MAIER, Auteur ; Evgeniy PERLOV, Auteur . - 10p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 10p. Mots-clés : Adult  Autism Spectrum Disorder/metabolism/*psychology  Female  Glutathione/*metabolism  Humans  Male  Middle Aged  Prefrontal Cortex/*metabolism  Proton Magnetic Resonance Spectroscopy/*methods  *Anterior cingulate cortex  *Asperger syndrome  *Autism spectrum disorder  *Dlpfc  *Glutathione  *MR spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. METHODS: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. RESULTS: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). CONCLUSIONS: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed. En ligne : http://dx.doi.org/10.1186/s13229-017-0122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Increased cerebral lactate levels in adults with autism spectrum disorders compared to non-autistic controls: a magnetic resonance spectroscopy study / Kathrin NICKEL ; Thomas LANGE ; Georg OELTZSCHNER ; Michael DACKO ; Dominique ENDRES ; Kimon RUNGE ; Anke SCHUMANN ; Katharina DOMSCHKE ; Michalis ROUSOS ; Ludger TEBARTZ VAN ELST in Molecular Autism, 14 (2023)  

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Increased prefrontal GABA concentrations in adults with autism spectrum disorders / Simon MAIER in Autism Research, 15-7 (July 2022)  

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Intuitive Moral Reasoning in High-Functioning Autism Spectrum Disorder: A Matter of Social Schemas? / Ulrich Max SCHALLER in Journal of Autism and Developmental Disorders, 49-5 (May 2019)  

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Retinal Thinning in Adults with Autism Spectrum Disorder / Evelyne FRIEDEL in Journal of Autism and Developmental Disorders, 54-3 (March 2024)  

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