Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder / Maya G. MOSNER in Autism Research and Treatment, 2019 (2019)  

Public ISBD [article]  inAutism Research and Treatment > 2019 (2019) . - 10 p. Titre : Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Maya G. MOSNER, Auteur ; R. Edward MCLAURIN, Auteur ; Jessica L. KINARD, Auteur ; Shabnam HAKIMI, Auteur ; Jacob PARELMAN, Auteur ; Jasmine S. SHAH, Auteur ; Joshua BIZZELL, Auteur ; Rachel K. GREENE, Auteur ; Paul M. CERNASOV, Auteur ; Erin WALSH, Auteur ; Merideth A. ADDICOTT, Auteur ; Tory EISENLOHR-MOUL, Auteur ; R. McKell CARTER, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : 10 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Few studies have explored neural mechanisms of reward learning in ASD despite evidence of behavioral impairments of predictive abilities in ASD. To investigate the neural correlates of reward prediction errors in ASD, 16 adults with ASD and 14 typically developing controls performed a prediction error task during fMRI scanning. Results revealed greater activation in the ASD group in the left paracingulate gyrus during signed prediction errors and the left insula and right frontal pole during thresholded unsigned prediction errors. Findings support atypical neural processing of reward prediction errors in ASD in frontostriatal regions critical for prediction coding and reward learning. Results provide a neural basis for impairments in reward learning that may contribute to traits common in ASD (e.g., intolerance of unpredictability). En ligne : https://doi.org/10.1155/2019/5469191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Neural Mechanisms of Reward Prediction Error in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Maya G. MOSNER, Auteur ; R. Edward MCLAURIN, Auteur ; Jessica L. KINARD, Auteur ; Shabnam HAKIMI, Auteur ; Jacob PARELMAN, Auteur ; Jasmine S. SHAH, Auteur ; Joshua BIZZELL, Auteur ; Rachel K. GREENE, Auteur ; Paul M. CERNASOV, Auteur ; Erin WALSH, Auteur ; Merideth A. ADDICOTT, Auteur ; Tory EISENLOHR-MOUL, Auteur ; R. McKell CARTER, Auteur ; Gabriel S. DICHTER, Auteur . - 10 p. Langues : Anglais (eng) in Autism Research and Treatment > 2019 (2019) . - 10 p. Index. décimale : PER Périodiques Résumé : Few studies have explored neural mechanisms of reward learning in ASD despite evidence of behavioral impairments of predictive abilities in ASD. To investigate the neural correlates of reward prediction errors in ASD, 16 adults with ASD and 14 typically developing controls performed a prediction error task during fMRI scanning. Results revealed greater activation in the ASD group in the left paracingulate gyrus during signed prediction errors and the left insula and right frontal pole during thresholded unsigned prediction errors. Findings support atypical neural processing of reward prediction errors in ASD in frontostriatal regions critical for prediction coding and reward learning. Results provide a neural basis for impairments in reward learning that may contribute to traits common in ASD (e.g., intolerance of unpredictability). En ligne : https://doi.org/10.1155/2019/5469191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Neural Mechanisms of Social and Nonsocial Reward Prediction Errors in Adolescents with Autism Spectrum Disorder / Jessica Lynn KINARD in Autism Research, 13-5 (May 2020)  

Public ISBD [article]  inAutism Research > 13-5 (May 2020) . - p.715-728 Titre : Neural Mechanisms of Social and Nonsocial Reward Prediction Errors in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica Lynn KINARD, Auteur ; Maya Gelman MOSNER, Auteur ; Rachel Kirsten GREENE, Auteur ; Merideth A. ADDICOTT, Auteur ; Joshua BIZZELL, Auteur ; Chris PETTY, Auteur ; Paul M. CERNASOV, Auteur ; Erin WALSH, Auteur ; Tory EISENLOHR-MOUL, Auteur ; Ronald MCKELL CARTER, Auteur ; Marcy MCLAMB, Auteur ; Alissa HOPPER, Auteur ; Rebecca SUKHU, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.715-728 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  fMRI  reward prediction error  social  social-communication Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired predictive abilities; however, the neural mechanisms subsuming reward prediction errors in ASD are poorly understood. In the current study, we investigated neural responses during social and nonsocial reward prediction errors in 22 adolescents with ASD (ages 12-17) and 20 typically developing control adolescents (ages 12-18). Participants performed a reward prediction error task using both social (i.e., faces) and nonsocial (i.e., objects) rewards during a functional magnetic resonance imaging scan. Reward prediction errors were defined in two ways: (a) the signed prediction error, the difference between the experienced and expected reward; and (b) the thresholded unsigned prediction error, the difference between expected and unexpected outcomes regardless of magnitude. During social reward prediction errors, the ASD group demonstrated the following differences relative to the TD group: (a) signed prediction error: decreased activation in the right precentral gyrus and increased activation in the right frontal pole; and (b) thresholded unsigned prediction error: increased activation in the right anterior cingulate gyrus and bilateral precentral gyrus. Groups did not differ in brain activation during nonsocial reward prediction errors. Within the ASD group, exploratory analyses revealed that reaction times and social-communication impairments were related to precentral gyrus activation during social prediction errors. These findings elucidate the neural mechanisms of social reward prediction errors in ASD and suggest that ASD is characterized by greater neural atypicalities during social, relative to nonsocial, reward prediction errors in ASD. Autism Res 2020, 13: 715-728. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We used brain imaging to evaluate differences in brain activation in adolescents with autism while they performed tasks that involved learning about social and nonsocial information. We found no differences in brain responses during the nonsocial condition, but differences during the social condition of the learning task. This study provides evidence that autism may involve different patterns of brain activation when learning about social information. En ligne : http://dx.doi.org/10.1002/aur.2273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Neural Mechanisms of Social and Nonsocial Reward Prediction Errors in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jessica Lynn KINARD, Auteur ; Maya Gelman MOSNER, Auteur ; Rachel Kirsten GREENE, Auteur ; Merideth A. ADDICOTT, Auteur ; Joshua BIZZELL, Auteur ; Chris PETTY, Auteur ; Paul M. CERNASOV, Auteur ; Erin WALSH, Auteur ; Tory EISENLOHR-MOUL, Auteur ; Ronald MCKELL CARTER, Auteur ; Marcy MCLAMB, Auteur ; Alissa HOPPER, Auteur ; Rebecca SUKHU, Auteur ; Gabriel S. DICHTER, Auteur . - p.715-728. Langues : Anglais (eng) in Autism Research > 13-5 (May 2020) . - p.715-728 Mots-clés : autism spectrum disorder  fMRI  reward prediction error  social  social-communication Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired predictive abilities; however, the neural mechanisms subsuming reward prediction errors in ASD are poorly understood. In the current study, we investigated neural responses during social and nonsocial reward prediction errors in 22 adolescents with ASD (ages 12-17) and 20 typically developing control adolescents (ages 12-18). Participants performed a reward prediction error task using both social (i.e., faces) and nonsocial (i.e., objects) rewards during a functional magnetic resonance imaging scan. Reward prediction errors were defined in two ways: (a) the signed prediction error, the difference between the experienced and expected reward; and (b) the thresholded unsigned prediction error, the difference between expected and unexpected outcomes regardless of magnitude. During social reward prediction errors, the ASD group demonstrated the following differences relative to the TD group: (a) signed prediction error: decreased activation in the right precentral gyrus and increased activation in the right frontal pole; and (b) thresholded unsigned prediction error: increased activation in the right anterior cingulate gyrus and bilateral precentral gyrus. Groups did not differ in brain activation during nonsocial reward prediction errors. Within the ASD group, exploratory analyses revealed that reaction times and social-communication impairments were related to precentral gyrus activation during social prediction errors. These findings elucidate the neural mechanisms of social reward prediction errors in ASD and suggest that ASD is characterized by greater neural atypicalities during social, relative to nonsocial, reward prediction errors in ASD. Autism Res 2020, 13: 715-728. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We used brain imaging to evaluate differences in brain activation in adolescents with autism while they performed tasks that involved learning about social and nonsocial information. We found no differences in brain responses during the nonsocial condition, but differences during the social condition of the learning task. This study provides evidence that autism may involve different patterns of brain activation when learning about social information. En ligne : http://dx.doi.org/10.1002/aur.2273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Neural Mechanisms of Vicarious Reward Processing in Adults with Autism Spectrum Disorder / Rachel K. GREENE in Autism Research and Treatment, 2020 (2020)  

Public ISBD [article]  inAutism Research and Treatment > 2020 (2020) Titre : Neural Mechanisms of Vicarious Reward Processing in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rachel K. GREENE, Auteur ; Cara R. DAMIANO-GOODWIN, Auteur ; Erin WALSH, Auteur ; Joshua BIZZELL, Auteur ; Gabriel S. DICHTER, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous studies examining the neural substrates of reward processing in ASD have explored responses to rewards for oneself but not rewards earned for others (i.e., vicarious reward). This omission is notable given that vicarious reward processing is a critical component of creating and maintaining social relationships. The current study examined the neural mechanisms of vicarious reward processing in 15 adults with ASD and 15 age- and gender-matched typically developing controls. Individuals with ASD demonstrated attenuated activation of reward-related regions during vicarious reward processing. Altered connectivity was also observed in individuals with ASD during reward receipt. These findings of altered neural sensitivity to vicarious reward processing may represent a mechanism that hinders the development of social abilities in ASD. En ligne : https://doi.org/10.1155/2020/8014248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Neural Mechanisms of Vicarious Reward Processing in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Rachel K. GREENE, Auteur ; Cara R. DAMIANO-GOODWIN, Auteur ; Erin WALSH, Auteur ; Joshua BIZZELL, Auteur ; Gabriel S. DICHTER, Auteur. Langues : Anglais (eng) in Autism Research and Treatment > 2020 (2020) Index. décimale : PER Périodiques Résumé : Previous studies examining the neural substrates of reward processing in ASD have explored responses to rewards for oneself but not rewards earned for others (i.e., vicarious reward). This omission is notable given that vicarious reward processing is a critical component of creating and maintaining social relationships. The current study examined the neural mechanisms of vicarious reward processing in 15 adults with ASD and 15 age- and gender-matched typically developing controls. Individuals with ASD demonstrated attenuated activation of reward-related regions during vicarious reward processing. Altered connectivity was also observed in individuals with ASD during reward receipt. These findings of altered neural sensitivity to vicarious reward processing may represent a mechanism that hinders the development of social abilities in ASD. En ligne : https://doi.org/10.1155/2020/8014248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

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