Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism / Emily A. ABEL in Journal of Autism and Developmental Disorders, 50-5 (May 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1834-1840 Titre : Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism Type de document : Texte imprimé et/ou numérique Auteurs : Emily A. ABEL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Olivia R MANNIN, Auteur ; Kristine MARCEAU, Auteur Article en page(s) : p.1834-1840 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Circadian  Gene  Melatonin  Sleep  Syndrome Index. décimale : PER Périodiques Résumé : Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. This overlapping gene set and the highlighted biological pathways may serve as a preliminary stepping-stone for new genetic investigations of SD and ASD comorbidity. En ligne : http://dx.doi.org/10.1007/s10803-019-03921-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism [Texte imprimé et/ou numérique] / Emily A. ABEL, Auteur ; A. J. SCHWICHTENBERG, Auteur ; Olivia R MANNIN, Auteur ; Kristine MARCEAU, Auteur . - p.1834-1840. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-5 (May 2020) . - p.1834-1840 Mots-clés : Autism spectrum disorder  Circadian  Gene  Melatonin  Sleep  Syndrome Index. décimale : PER Périodiques Résumé : Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. This overlapping gene set and the highlighted biological pathways may serve as a preliminary stepping-stone for new genetic investigations of SD and ASD comorbidity. En ligne : http://dx.doi.org/10.1007/s10803-019-03921-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

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