Examining the Temporal Limits of Enhanced Visual Feature Detection in Children With Autism / Justin KOPEC in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1561-1572 Titre : Examining the Temporal Limits of Enhanced Visual Feature Detection in Children With Autism Type de document : Texte imprimé et/ou numérique Auteurs : Justin KOPEC, Auteur ; Carl Erick HAGMANN, Auteur ; Nicole SHEA, Auteur ; Alyssa PRAWL, Auteur ; Daniel BATKIN, Auteur ; Natalie RUSSO, Auteur Article en page(s) : p.1561-1572 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The enhanced perceptual processing of visual features in children with autism spectrum disorder (ASD) is supported by an abundance of evidence in the spatial domain, with less robust evidence regarding whether this extends to information presented across time. The current study aimed to replicate and extend previous work finding that children with an ASD demonstrated enhanced perceptual accuracy in detecting feature-based (but not categorically defined) targets in time, when these were presented quickly, at a stimulus onset asynchrony (SOA) of 50?ms per item. Specifically, we extend the range of SOAs to examine the temporal boundaries of this enhanced accuracy and examine whether there is a relationship between ASD-related traits and detection accuracy on temporal visual search tasks. Individuals with autism perceived feature-based targets with statistically higher accuracy than their typically developing peers between SOAs of 39 and 65?ms and were numerically faster at all SOAs. No group differences were noted for category-based task accuracy. Our results also demonstrated that ASD-related traits measured by the autism spectrum quotient were positively correlated with accuracy on the feature-based task. Overall, results suggest that accurate visual perception of features (particularly color) is enhanced in children with ASD across time. Lay Summary Our results suggest that children with autism are able to process visual features, such as color, more accurately than typically developing children, even when these are presented very rapidly. Accuracy was higher in children with higher levels of autism-related traits and symptoms. Our findings suggest that more accurate visual perception exists not only across space in children with autism, as much of the existing literature demonstrates, but also over time. Autism Res 2020, 13: 1561–1572. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2361 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Examining the Temporal Limits of Enhanced Visual Feature Detection in Children With Autism [Texte imprimé et/ou numérique] / Justin KOPEC, Auteur ; Carl Erick HAGMANN, Auteur ; Nicole SHEA, Auteur ; Alyssa PRAWL, Auteur ; Daniel BATKIN, Auteur ; Natalie RUSSO, Auteur . - p.1561-1572. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1561-1572 Index. décimale : PER Périodiques Résumé : The enhanced perceptual processing of visual features in children with autism spectrum disorder (ASD) is supported by an abundance of evidence in the spatial domain, with less robust evidence regarding whether this extends to information presented across time. The current study aimed to replicate and extend previous work finding that children with an ASD demonstrated enhanced perceptual accuracy in detecting feature-based (but not categorically defined) targets in time, when these were presented quickly, at a stimulus onset asynchrony (SOA) of 50?ms per item. Specifically, we extend the range of SOAs to examine the temporal boundaries of this enhanced accuracy and examine whether there is a relationship between ASD-related traits and detection accuracy on temporal visual search tasks. Individuals with autism perceived feature-based targets with statistically higher accuracy than their typically developing peers between SOAs of 39 and 65?ms and were numerically faster at all SOAs. No group differences were noted for category-based task accuracy. Our results also demonstrated that ASD-related traits measured by the autism spectrum quotient were positively correlated with accuracy on the feature-based task. Overall, results suggest that accurate visual perception of features (particularly color) is enhanced in children with ASD across time. Lay Summary Our results suggest that children with autism are able to process visual features, such as color, more accurately than typically developing children, even when these are presented very rapidly. Accuracy was higher in children with higher levels of autism-related traits and symptoms. Our findings suggest that more accurate visual perception exists not only across space in children with autism, as much of the existing literature demonstrates, but also over time. Autism Res 2020, 13: 1561–1572. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2361 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder / David LEVITSKIY in Research in Autism Spectrum Disorders, 85 (July 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 85 (July 2021) . - 101788 Titre : Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : David LEVITSKIY, Auteur ; Alexandra CONFAIR, Auteur ; Kayla E. WAGNER, Auteur ; Samantha DEVITA, Auteur ; Nicole SHEA, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Justin KOPEC, Auteur ; Natalie RUSSO, Auteur ; Frank A. MIDDLETON, Auteur ; Steven D. HICKS, Auteur Article en page(s) : 101788 Langues : Anglais (eng) Mots-clés : Prognosis  Biomarkers  Saliva  RNA  microRNA  Autism Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurological condition with increasing prevalence. Few tools accurately predict the developmental trajectory of children with ASD. Such tools would allow clinicians to provide accurate prognoses and track the efficacy of therapeutic interventions. Salivary RNAs that reflect the genetic-environmental interactions underlying ASD may provide objective measures of symptom severity and developmental outcomes. This study investigated whether salivary RNAs previously identified in childhood ASD remain perturbed in older children. We also explored whether RNA candidates changed with therapeutic intervention. Method A case-control design was used to characterize levels of 78 saliva RNA candidates among 96 children (48 ASD, 48 non-ASD, mean age: 11 years). Thirty-one children (22 ASD, 9 non-ASD developmental delay, mean age: 4 years) were followed longitudinally to explore changes of RNA candidates during early intervention. Saliva RNA and standardized behavioral assessments were collected for each participant. Associations between candidate RNAs and behavioral scores were determined in both groups via Spearman Correlation. Changes in candidate RNAs across two time-points were assessed in the younger cohort via Wilcoxon rank-sum test. Results Seven RNAs were associated with VABS-II and BASC scores in the older group ([R] >0.25, FDR? En ligne : https://doi.org/10.1016/j.rasd.2021.101788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Longitudinal stability of salivary microRNA biomarkers in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / David LEVITSKIY, Auteur ; Alexandra CONFAIR, Auteur ; Kayla E. WAGNER, Auteur ; Samantha DEVITA, Auteur ; Nicole SHEA, Auteur ; Elizabeth P. MCKERNAN, Auteur ; Justin KOPEC, Auteur ; Natalie RUSSO, Auteur ; Frank A. MIDDLETON, Auteur ; Steven D. HICKS, Auteur . - 101788. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101788 Mots-clés : Prognosis  Biomarkers  Saliva  RNA  microRNA  Autism Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a complex neurological condition with increasing prevalence. Few tools accurately predict the developmental trajectory of children with ASD. Such tools would allow clinicians to provide accurate prognoses and track the efficacy of therapeutic interventions. Salivary RNAs that reflect the genetic-environmental interactions underlying ASD may provide objective measures of symptom severity and developmental outcomes. This study investigated whether salivary RNAs previously identified in childhood ASD remain perturbed in older children. We also explored whether RNA candidates changed with therapeutic intervention. Method A case-control design was used to characterize levels of 78 saliva RNA candidates among 96 children (48 ASD, 48 non-ASD, mean age: 11 years). Thirty-one children (22 ASD, 9 non-ASD developmental delay, mean age: 4 years) were followed longitudinally to explore changes of RNA candidates during early intervention. Saliva RNA and standardized behavioral assessments were collected for each participant. Associations between candidate RNAs and behavioral scores were determined in both groups via Spearman Correlation. Changes in candidate RNAs across two time-points were assessed in the younger cohort via Wilcoxon rank-sum test. Results Seven RNAs were associated with VABS-II and BASC scores in the older group ([R] >0.25, FDR? En ligne : https://doi.org/10.1016/j.rasd.2021.101788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

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