Naturalistic outcomes of the facing your fears program for autistic youth with anxiety in an outpatient hospital setting / Marta PICOTO in Research in Autism, 133 (May 2026)  

Public ISBD [article]  inResearch in Autism > 133 (May 2026) . - p.202883 Titre : Naturalistic outcomes of the facing your fears program for autistic youth with anxiety in an outpatient hospital setting Type de document : texte imprimé Auteurs : Marta PICOTO, Auteur ; Daina M. TAGAVI, Auteur ; Stephanie PICKERING, Auteur ; Andrea B. LUPAÅž, Auteur ; Tara M. RUTTER, Auteur ; Alana J. MCVEY, Auteur Article en page(s) : p.202883 Langues : Anglais (eng) Mots-clés : Autism  Anxiety  Evidence-based treatment  CBT Index. décimale : PER Périodiques Résumé : Purpose Anxiety disorders are common among autistic youth, for which modified cognitive behavioral therapy (CBT) is an effective treatment. One such treatment is Facing Your Fears (FYF), a group-based CBT program. This was a naturalistic outcome study that evaluated changes in anxiety and OCD symptoms among autistic youth who participated in FYF in an outpatient hospital setting. We also examined self- and parent-reported discrepancies and moderating effects of age, gender, and intervention timing (pre- vs. post-COVID-19 onset). Methods Self- and parent-reported data were collected from 48 autistic youth (ages 8–14 years) who participated in FYF between 2018 and 2024 and completed the Multidimensional Anxiety Scale for Children, 2nd Ed. (MASC 2). Results Youth and parents reported decreases in anxiety symptoms from pre- to post-intervention. Youth reported improvements across all anxiety domains, including OCD symptoms, whereas parents reported positive changes in total and separation anxiety only. Parents consistently reported higher anxiety levels than youth; however, the magnitude of symptom change did not differ between reporters. No moderating effects of gender, age, or intervention timing were observed. Conclusion Findings indicated improvements in anxiety and OCD symptoms for autistic youth following FYF, regardless of demographic and contextual factors, although parents and youth reported differences in improvement. En ligne : https://doi.org/10.1016/j.reia.2026.202883 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Naturalistic outcomes of the facing your fears program for autistic youth with anxiety in an outpatient hospital setting [texte imprimé] / Marta PICOTO, Auteur ; Daina M. TAGAVI, Auteur ; Stephanie PICKERING, Auteur ; Andrea B. LUPAÅž, Auteur ; Tara M. RUTTER, Auteur ; Alana J. MCVEY, Auteur . - p.202883. Langues : Anglais (eng) in Research in Autism > 133 (May 2026) . - p.202883 Mots-clés : Autism  Anxiety  Evidence-based treatment  CBT Index. décimale : PER Périodiques Résumé : Purpose Anxiety disorders are common among autistic youth, for which modified cognitive behavioral therapy (CBT) is an effective treatment. One such treatment is Facing Your Fears (FYF), a group-based CBT program. This was a naturalistic outcome study that evaluated changes in anxiety and OCD symptoms among autistic youth who participated in FYF in an outpatient hospital setting. We also examined self- and parent-reported discrepancies and moderating effects of age, gender, and intervention timing (pre- vs. post-COVID-19 onset). Methods Self- and parent-reported data were collected from 48 autistic youth (ages 8–14 years) who participated in FYF between 2018 and 2024 and completed the Multidimensional Anxiety Scale for Children, 2nd Ed. (MASC 2). Results Youth and parents reported decreases in anxiety symptoms from pre- to post-intervention. Youth reported improvements across all anxiety domains, including OCD symptoms, whereas parents reported positive changes in total and separation anxiety only. Parents consistently reported higher anxiety levels than youth; however, the magnitude of symptom change did not differ between reporters. No moderating effects of gender, age, or intervention timing were observed. Conclusion Findings indicated improvements in anxiety and OCD symptoms for autistic youth following FYF, regardless of demographic and contextual factors, although parents and youth reported differences in improvement. En ligne : https://doi.org/10.1016/j.reia.2026.202883 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Transcriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder / Sandy TRINH in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1353-1361 Titre : Transcriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder Type de document : texte imprimé Auteurs : Sandy TRINH, Auteur ; Anne B. ARNETT, Auteur ; Evangeline C. KURTZ-NELSON, Auteur ; Jennifer BEIGHLEY, Auteur ; Marta PICOTO, Auteur ; Raphael A. BERNIER, Auteur Article en page(s) : p.1353-1361 Langues : Anglais (eng) Mots-clés : autism  genetics  mutation  organization or entity with any financial interest in the outcome of this project. Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by deficits in social communication and presence of restricted, repetitive behaviors, and interests. However, individuals with ASD vary significantly in their challenges and abilities in these and other developmental domains. Gene discovery in ASD has accelerated in the past decade, and genetic subtyping has yielded preliminary evidence of utility in parsing phenotypic heterogeneity through genomic subtypes. Recent advances in transcriptomics have provided additional dimensions with which to refine genetic subtyping efforts. In the current study, we investigate phenotypic differences among transcriptional subtypes defined by neurobiological spatiotemporal co-expression patterns. Of the four transcriptional subtypes examined, participants with mutations to genes typically expressed highly in all brain regions prenatally, and those with differential postnatal cerebellar expression relative to other brain regions, showed lower cognitive and adaptive skills, higher severity of social communication deficits, and later acquisition of speech and motor milestones, compared to those with mutations to genes highly expressed during the postnatal period across brain regions. These findings suggest higher-order characterization of genetic subtypes based on neurobiological expression patterns may be a promising approach to parsing phenotypic heterogeneity among those with ASD and related neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1017/s0954579420000784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Transcriptional subtyping explains phenotypic variability in genetic subtypes of autism spectrum disorder [texte imprimé] / Sandy TRINH, Auteur ; Anne B. ARNETT, Auteur ; Evangeline C. KURTZ-NELSON, Auteur ; Jennifer BEIGHLEY, Auteur ; Marta PICOTO, Auteur ; Raphael A. BERNIER, Auteur . - p.1353-1361. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1353-1361 Mots-clés : autism  genetics  mutation  organization or entity with any financial interest in the outcome of this project. Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by deficits in social communication and presence of restricted, repetitive behaviors, and interests. However, individuals with ASD vary significantly in their challenges and abilities in these and other developmental domains. Gene discovery in ASD has accelerated in the past decade, and genetic subtyping has yielded preliminary evidence of utility in parsing phenotypic heterogeneity through genomic subtypes. Recent advances in transcriptomics have provided additional dimensions with which to refine genetic subtyping efforts. In the current study, we investigate phenotypic differences among transcriptional subtypes defined by neurobiological spatiotemporal co-expression patterns. Of the four transcriptional subtypes examined, participants with mutations to genes typically expressed highly in all brain regions prenatally, and those with differential postnatal cerebellar expression relative to other brain regions, showed lower cognitive and adaptive skills, higher severity of social communication deficits, and later acquisition of speech and motor milestones, compared to those with mutations to genes highly expressed during the postnatal period across brain regions. These findings suggest higher-order characterization of genetic subtypes based on neurobiological expression patterns may be a promising approach to parsing phenotypic heterogeneity among those with ASD and related neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1017/s0954579420000784 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

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