Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits / M. ARENELLA in Autism, 26-2 (February 2022)  

Public ISBD [article]  inAutism > 26-2 (February 2022) . - p.361-372 Titre : Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : M. ARENELLA, Auteur ; G. CADBY, Auteur ; W. DE WITTE, Auteur ; R. M. JONES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; E. K. MOSES, Auteur ; A. FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Z. HAWI, Auteur ; B. JOHNSON, Auteur ; J. TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; L. A. KIEMENEY, Auteur ; G. POELMANS, Auteur ; Janita B. BRALTEN, Auteur Article en page(s) : p.361-372 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  genetics  immune system  molecular and cellular biology  conflicts of interest with respect to the research, authorship and/or publication of  this article: In the past 3?years, J.K.B. has been a consultant to, member of  advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini  and Servier. He is not an employee of any of these companies, and a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patients and royalties. G.P. is the director of  Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits [Texte imprimé et/ou numérique] / M. ARENELLA, Auteur ; G. CADBY, Auteur ; W. DE WITTE, Auteur ; R. M. JONES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; E. K. MOSES, Auteur ; A. FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Z. HAWI, Auteur ; B. JOHNSON, Auteur ; J. TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; L. A. KIEMENEY, Auteur ; G. POELMANS, Auteur ; Janita B. BRALTEN, Auteur . - p.361-372. Langues : Anglais (eng) in Autism > 26-2 (February 2022) . - p.361-372 Mots-clés : autism spectrum disorders  genetics  immune system  molecular and cellular biology  conflicts of interest with respect to the research, authorship and/or publication of  this article: In the past 3?years, J.K.B. has been a consultant to, member of  advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini  and Servier. He is not an employee of any of these companies, and a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patients and royalties. G.P. is the director of  Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology / R. KNOTT in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 55 p. Titre : The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology Type de document : Texte imprimé et/ou numérique Auteurs : R. KNOTT, Auteur ; Beth P. JOHNSON, Auteur ; J. TIEGO, Auteur ; O. MELLAHN, Auteur ; A. FINLAY, Auteur ; K. KALLADY, Auteur ; M. KOUSPOS, Auteur ; V. P. MOHANAKUMAR SINDHU, Auteur ; Z. HAWI, Auteur ; A. ARNATKEVICIUTE, Auteur ; T. CHAU, Auteur ; D. MARON, Auteur ; E. C. MERCIECA, Auteur ; K. FURLEY, Auteur ; K. HARRIS, Auteur ; K. WILLIAMS, Auteur ; A. URE, Auteur ; A. FORNITO, Auteur ; K. GRAY, Auteur ; D. COGHILL, Auteur ; A. NICHOLSON, Auteur ; D. PHUNG, Auteur ; E. LOTH, Auteur ; L. MASON, Auteur ; D. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Mark A. BELLGROVE, Auteur Article en page(s) : 55 p. Langues : Anglais (eng) Mots-clés : Adhd  Asd  Cognition  Eye-tracking  Genetics  HiTOP  Neuroimaging  RDoC Index. décimale : PER Périodiques Résumé : BACKGROUND: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. METHODS: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. CONCLUSION: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. En ligne : http://dx.doi.org/10.1186/s13229-021-00457-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology [Texte imprimé et/ou numérique] / R. KNOTT, Auteur ; Beth P. JOHNSON, Auteur ; J. TIEGO, Auteur ; O. MELLAHN, Auteur ; A. FINLAY, Auteur ; K. KALLADY, Auteur ; M. KOUSPOS, Auteur ; V. P. MOHANAKUMAR SINDHU, Auteur ; Z. HAWI, Auteur ; A. ARNATKEVICIUTE, Auteur ; T. CHAU, Auteur ; D. MARON, Auteur ; E. C. MERCIECA, Auteur ; K. FURLEY, Auteur ; K. HARRIS, Auteur ; K. WILLIAMS, Auteur ; A. URE, Auteur ; A. FORNITO, Auteur ; K. GRAY, Auteur ; D. COGHILL, Auteur ; A. NICHOLSON, Auteur ; D. PHUNG, Auteur ; E. LOTH, Auteur ; L. MASON, Auteur ; D. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Mark A. BELLGROVE, Auteur . - 55 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 55 p. Mots-clés : Adhd  Asd  Cognition  Eye-tracking  Genetics  HiTOP  Neuroimaging  RDoC Index. décimale : PER Périodiques Résumé : BACKGROUND: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. METHODS: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. CONCLUSION: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. En ligne : http://dx.doi.org/10.1186/s13229-021-00457-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

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