Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study / M. THORSEN in Journal of Autism and Developmental Disorders, 52-1 (January 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.275-282 Titre : Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study Type de document : Texte imprimé et/ou numérique Auteurs : M. THORSEN, Auteur ; Niels BILENBERG, Auteur ; L. THORSEN, Auteur ; T. M. MICHEL, Auteur Article en page(s) : p.275-282 Langues : Anglais (eng) Mots-clés : Adult  Antioxidants/metabolism  Autism Spectrum Disorder  Autistic Disorder  Case-Control Studies  Child  Female  Humans  Male  Oxidative Stress  Sex  Superoxide Dismutase  Xanthine Oxidase Index. décimale : PER Périodiques Résumé : Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females. En ligne : http://dx.doi.org/10.1007/s10803-021-04897-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Oxidative Stress in Adults with Autism Spectrum Disorder: A Case Control Study [Texte imprimé et/ou numérique] / M. THORSEN, Auteur ; Niels BILENBERG, Auteur ; L. THORSEN, Auteur ; T. M. MICHEL, Auteur . - p.275-282. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-1 (January 2022) . - p.275-282 Mots-clés : Adult  Antioxidants/metabolism  Autism Spectrum Disorder  Autistic Disorder  Case-Control Studies  Child  Female  Humans  Male  Oxidative Stress  Sex  Superoxide Dismutase  Xanthine Oxidase Index. décimale : PER Périodiques Résumé : Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females. En ligne : http://dx.doi.org/10.1007/s10803-021-04897-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

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