[article] 
inJournal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.796-805

Titre :	A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Benjamin L. HANDEN, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Raun D. MELMED, Auteur ; David L. BURNHAM, Auteur ; Jon B. BRUSS, Auteur ; David J. HANSEN, Auteur
Année de publication :	2009
Article en page(s) :	p.796-805
Langues :	Anglais (eng)
Mots-clés :	Autism Gastrointestinal-symptoms Oral-human immunoglobulin
Index. décimale :	PER Périodiques
Résumé :	Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2–17 years) with autism and persistent GI symptoms. Endpoint analysis revealed no significant differences across treatment groups on a modified global improvement scale (validated in irritable bowel syndrome studies), number of daily bowel movements, days of constipation, or severity of problem behaviors. IGOH was well-tolerated; there were no serious adverse events. This study demonstrates the importance of conducting rigorous trials in children with autism and casts doubt on one GI mechanism presumed to exert etiological and/or symptomatic effects in this population.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0687-y
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=733

[article] A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder [Texte imprimé et/ou numérique] / Benjamin L. HANDEN, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Raun D. MELMED, Auteur ; David L. BURNHAM, Auteur ; Jon B. BRUSS, Auteur ; David J. HANSEN, Auteur . - 2009 . - p.796-805.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.796-805

Mots-clés :	Autism Gastrointestinal-symptoms Oral-human immunoglobulin
Index. décimale :	PER Périodiques
Résumé :	Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2–17 years) with autism and persistent GI symptoms. Endpoint analysis revealed no significant differences across treatment groups on a modified global improvement scale (validated in irritable bowel syndrome studies), number of daily bowel movements, days of constipation, or severity of problem behaviors. IGOH was well-tolerated; there were no serious adverse events. This study demonstrates the importance of conducting rigorous trials in children with autism and casts doubt on one GI mechanism presumed to exert etiological and/or symptomatic effects in this population.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0687-y
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=733