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A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder / Benjamin L. HANDEN in Journal of Autism and Developmental Disorders, 39-5 (May 2009)
[article]
Titre : A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin L. HANDEN, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Raun D. MELMED, Auteur ; David L. BURNHAM, Auteur ; Jon B. BRUSS, Auteur ; David J. HANSEN, Auteur Année de publication : 2009 Article en page(s) : p.796-805 Langues : Anglais (eng) Mots-clés : Autism Gastrointestinal-symptoms Oral-human immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2–17 years) with autism and persistent GI symptoms. Endpoint analysis revealed no significant differences across treatment groups on a modified global improvement scale (validated in irritable bowel syndrome studies), number of daily bowel movements, days of constipation, or severity of problem behaviors. IGOH was well-tolerated; there were no serious adverse events. This study demonstrates the importance of conducting rigorous trials in children with autism and casts doubt on one GI mechanism presumed to exert etiological and/or symptomatic effects in this population. En ligne : http://dx.doi.org/10.1007/s10803-008-0687-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=733
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.796-805[article] A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder [Texte imprimé et/ou numérique] / Benjamin L. HANDEN, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Raun D. MELMED, Auteur ; David L. BURNHAM, Auteur ; Jon B. BRUSS, Auteur ; David J. HANSEN, Auteur . - 2009 . - p.796-805.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.796-805
Mots-clés : Autism Gastrointestinal-symptoms Oral-human immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2–17 years) with autism and persistent GI symptoms. Endpoint analysis revealed no significant differences across treatment groups on a modified global improvement scale (validated in irritable bowel syndrome studies), number of daily bowel movements, days of constipation, or severity of problem behaviors. IGOH was well-tolerated; there were no serious adverse events. This study demonstrates the importance of conducting rigorous trials in children with autism and casts doubt on one GI mechanism presumed to exert etiological and/or symptomatic effects in this population. En ligne : http://dx.doi.org/10.1007/s10803-008-0687-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=733